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Items: 1 to 50 of 74

1.

Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects.

Klotz L, Eschborn M, Lindner M, Liebmann M, Herold M, Janoschka C, Torres Garrido B, Schulte-Mecklenbeck A, Gross CC, Breuer J, Hundehege P, Posevitz V, Pignolet B, Nebel G, Glander S, Freise N, Austermann J, Wirth T, Campbell GR, Schneider-Hohendorf T, Eveslage M, Brassat D, Schwab N, Loser K, Roth J, Busch KB, Stoll M, Mahad DJ, Meuth SG, Turner T, Bar-Or A, Wiendl H.

Sci Transl Med. 2019 May 1;11(490). pii: eaao5563. doi: 10.1126/scitranslmed.aao5563.

PMID:
31043571
2.

LEKTI domains D6, D7 and D8+9 serve as substrates for transglutaminase 1: implications for targeted therapy of Netherton syndrome.

Wiegmann H, Valentin F, Tarinski T, Liebau E, Loser K, Traupe H, Oji V.

Br J Dermatol. 2019 Feb 22. doi: 10.1111/bjd.17820. [Epub ahead of print]

PMID:
30801672
3.

Development of Novel Quinoxaline-Based κ-Opioid Receptor Agonists for the Treatment of Neuroinflammation.

Tangherlini G, Kalinin DV, Schepmann D, Che T, Mykicki N, Ständer S, Loser K, Wünsch B.

J Med Chem. 2019 Jan 24;62(2):893-907. doi: 10.1021/acs.jmedchem.8b01609. Epub 2019 Jan 9.

PMID:
30543421
4.

The Phenotype of Monocytes in Anterior Uveitis Depends on the HLA-B27 Status.

Kasper M, Walscheid K, Laffer B, Bauer D, Busch M, Wildschütz L, Wang B, Loser K, Vogl T, Grajewski RS, Langmann T, Heiligenhaus A.

Front Immunol. 2018 Jul 30;9:1773. doi: 10.3389/fimmu.2018.01773. eCollection 2018.

5.

45th meeting of the Arbeitsgemeinschaft Dermatologische Forschung.

Loser K, Eming R, Eyerich K, Gebhardt C, Ludwig R, Baghin V, Baurecht H, Forsthuber A, Glodde N, Schmidt E, Schmidt T, Shridhar N, Simon B, Gaffal E.

Exp Dermatol. 2018 Jul;27(7):798-802. doi: 10.1111/exd.13695. No abstract available.

PMID:
29953698
6.

Cyclosporine A-Loaded Nanocarriers for Topical Treatment of Murine Experimental Autoimmune Uveoretinitis.

Kasper M, Gabriel D, Möller M, Bauer D, Wildschütz L, Courthion H, Rodriguez-Aller M, Busch M, Böhm MRR, Loser K, Thanos S, Gurny R, Heiligenhaus A.

Mol Pharm. 2018 Jul 2;15(7):2539-2547. doi: 10.1021/acs.molpharmaceut.8b00014. Epub 2018 Jun 18.

PMID:
29912566
7.

Does the environment influence multiple sclerosis pathogenesis via UVB light and/or induction of vitamin D?

Breuer J, Loser K, Mykicki N, Wiendl H, Schwab N.

J Neuroimmunol. 2019 Apr 15;329:1-8. doi: 10.1016/j.jneuroim.2018.05.006. Epub 2018 May 18. Review.

PMID:
29793727
8.

Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation.

Vogl T, Stratis A, Wixler V, Völler T, Thurainayagam S, Jorch SK, Zenker S, Dreiling A, Chakraborty D, Fröhling M, Paruzel P, Wehmeyer C, Hermann S, Papantonopoulou O, Geyer C, Loser K, Schäfers M, Ludwig S, Stoll M, Leanderson T, Schultze JL, König S, Pap T, Roth J.

J Clin Invest. 2018 May 1;128(5):1852-1866. doi: 10.1172/JCI89867. Epub 2018 Apr 3.

9.

Novel everolimus-loaded nanocarriers for topical treatment of murine experimental autoimmune uveoretinitis (EAU).

Kasper M, Gabriel D, Möller M, Bauer D, Wildschütz L, Courthion H, Böhm MRR, Busch M, Loser K, Thanos S, Gurny R, Heiligenhaus A.

Exp Eye Res. 2018 Mar;168:49-56. doi: 10.1016/j.exer.2018.01.003. Epub 2018 Jan 8.

PMID:
29326066
10.

Acetyl-CoA carboxylase 1 regulates endothelial cell migration by shifting the phospholipid composition.

Glatzel DK, Koeberle A, Pein H, Löser K, Stark A, Keksel N, Werz O, Müller R, Bischoff I, Fürst R.

J Lipid Res. 2018 Feb;59(2):298-311. doi: 10.1194/jlr.M080101. Epub 2017 Dec 5.

11.

Dual action by fumaric acid esters synergistically reduces adhesion to human endothelium.

Breuer J, Herich S, Schneider-Hohendorf T, Chasan AI, Wettschureck N, Gross CC, Loser K, Zarbock A, Roth J, Klotz L, Wiendl H, Schwab N.

Mult Scler. 2017 Oct 1:1352458517735189. doi: 10.1177/1352458517735189. [Epub ahead of print]

PMID:
28984166
12.

Novel insights into the pathogenesis of psoriasis.

Luger TA, Loser K.

Clin Immunol. 2018 Jan;186:43-45. doi: 10.1016/j.clim.2017.07.014. Epub 2017 Jul 21. Review. No abstract available.

PMID:
28736273
13.

There is no functional small-fibre neuropathy in prurigo nodularis despite neuroanatomical alterations.

Pereira MP, Pogatzki-Zahn E, Snels C, Vu TH, Üçeyler N, Loser K, Sommer C, Evers AWM, van Laarhoven AIM, Agelopoulos K, Ständer S.

Exp Dermatol. 2017 Oct;26(10):969-971. doi: 10.1111/exd.13343. Epub 2017 Jul 10.

PMID:
28370394
14.

Dihydroavenanthramide D inhibits mast cell degranulation and exhibits anti-inflammatory effects through the activation of neurokinin-1 receptor.

Lotts T, Agelopoulos K, Phan NQ, Loser K, Schmaus G, Luger TA, Ständer S.

Exp Dermatol. 2017 Aug;26(8):739-742. doi: 10.1111/exd.13265. Epub 2017 Mar 16.

PMID:
27892633
15.

ADF Winter School-An exciting concept of the Arbeitsgemeinschaft Dermatologische Forschung to connect young scientists and clinician scientists in Dermatology at the top of Germany.

Yazdi AS, Barlin M, Böhm K, Gendrisch F, Ghorbanalipoor S, Häberle S, Hamel A, Hüning S, Hüttner C, Iwanova I, Kanaki T, Kimeswenger S, Lohmann N, Munir S, Muzumdar S, Pereira MP, Peking P, Plesser K, Rendon A, Rentschler M, Schlumprecht C, Smorodchenko A, Stock M, Tillmanns J, Uslu U, Ghoreschi K, Glatz M, Grabbe S, Kunz M, Ludwig R, Scharffetter-Kochanek K, Loser K.

Exp Dermatol. 2017 Mar;26(3):292-294. doi: 10.1111/exd.13241. Epub 2016 Nov 3. No abstract available.

PMID:
27808431
16.

Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease.

Mykicki N, Herrmann AM, Schwab N, Deenen R, Sparwasser T, Limmer A, Wachsmuth L, Klotz L, Köhrer K, Faber C, Wiendl H, Luger TA, Meuth SG, Loser K.

Sci Transl Med. 2016 Oct 26;8(362):362ra146.

PMID:
27797962
17.

FRT - FONDATION RENE TOURAINE: An International Foundation For Dermatology.

Bosch TC, Zengler K, Naik S, Biedermann T, Kong HH, Loser K, Brüggeman H, Calleawert C, Lambert J, Van de Wiele T.

Exp Dermatol. 2016 Nov;25(11):917-932. doi: 10.1111/exd.13160. No abstract available.

PMID:
27792248
18.

Antibody production using a ciliate generates unusual antibody glycoforms displaying enhanced cell-killing activity.

Calow J, Behrens AJ, Mader S, Bockau U, Struwe WB, Harvey DJ, Cormann KU, Nowaczyk MM, Loser K, Schinor D, Hartmann MW, Crispin M.

MAbs. 2016 Nov/Dec;8(8):1498-1511. Epub 2016 Sep 3.

19.

Macrophage-mediated psoriasis can be suppressed by regulatory T lymphocytes.

Leite Dantas R, Masemann D, Schied T, Bergmeier V, Vogl T, Loser K, Brachvogel B, Varga G, Ludwig S, Wixler V.

J Pathol. 2016 Nov;240(3):366-377. doi: 10.1002/path.4786.

PMID:
27555499
20.

Stearoyl-CoA desaturase-1 and adaptive stress signaling.

Koeberle A, Löser K, Thürmer M.

Biochim Biophys Acta. 2016 Nov;1861(11):1719-1726. doi: 10.1016/j.bbalip.2016.08.009. Epub 2016 Aug 24. Review.

PMID:
27550503
21.

The tripeptide KdPT ameliorates ongoing psoriasis-like skin inflammation in murine and human skin.

Mykicki N, Klenner L, Baumann C, Auriemma M, Sternemann C, Soeberdt M, Elliott GR, Abels C, Luger TA, Loser K.

Exp Dermatol. 2017 Apr;26(4):328-334. doi: 10.1111/exd.13145. Epub 2016 Dec 9.

PMID:
27376341
22.

Round Table - new concept of the Arbeitsgemeinschaft Dermatologische Forschung to foster regional exchange between young clinician scientists in dermatology.

Ali N, Baumann C, de Castro Kroner J, Do NN, Friedrich HC, Haas K, Klaeschen AS, Pfaff C, Plesser K, Pollet M, Schmidt J, Schneeweiss M, Siewert MM, Stock M, Sucker N, Üstün Y, Vollmer V, Wachsmuth E, Wang J, Schilling B, Fabri M, Loser K, Eming SA.

Exp Dermatol. 2016 Oct;25(10):827-8. doi: 10.1111/exd.13052. Epub 2016 Jun 1. No abstract available.

PMID:
27245706
23.

Laminin α5 in the keratinocyte basement membrane is required for epidermal-dermal intercommunication.

Wegner J, Loser K, Apsite G, Nischt R, Eckes B, Krieg T, Werner S, Sorokin L.

Matrix Biol. 2016 Dec;56:24-41. doi: 10.1016/j.matbio.2016.05.001. Epub 2016 May 24.

PMID:
27234307
24.

Sensitive skin.

Misery L, Loser K, Ständer S.

J Eur Acad Dermatol Venereol. 2016 Feb;30 Suppl 1:2-8. doi: 10.1111/jdv.13532. Review.

PMID:
26805416
25.

The single-chain anti-TNF-α antibody DLX105 induces clinical and biomarker responses upon local administration in patients with chronic plaque-type psoriasis.

Tsianakas A, Brunner PM, Ghoreschi K, Berger C, Loser K, Röcken M, Stingl G, Luger T, Jung T.

Exp Dermatol. 2016 Jun;25(6):428-33. doi: 10.1111/exd.12927. Epub 2016 Feb 13.

PMID:
26738450
26.

B7-H1 Selectively Controls TH17 Differentiation and Central Nervous System Autoimmunity via a Novel Non-PD-1-Mediated Pathway.

Herold M, Posevitz V, Chudyka D, Hucke S, Groß C, Kurth F, Leder C, Loser K, Kurts C, Knolle P, Klotz L, Wiendl H.

J Immunol. 2015 Oct 15;195(8):3584-95. doi: 10.4049/jimmunol.1402746. Epub 2015 Sep 16.

27.

Cutaneous RANK-RANKL Signaling Upregulates CD8-Mediated Antiviral Immunity during Herpes simplex Virus Infection by Preventing Virus-Induced Langerhans Cell Apoptosis.

Klenner L, Hafezi W, Clausen BE, Lorentzen EU, Luger TA, Beissert S, Kühn JE, Loser K.

J Invest Dermatol. 2015 Nov;135(11):2676-2687. doi: 10.1038/jid.2015.225. Epub 2015 Jun 15.

28.

Ultraviolet B light attenuates the systemic immune response in central nervous system autoimmunity.

Breuer J, Schwab N, Schneider-Hohendorf T, Marziniak M, Mohan H, Bhatia U, Gross CC, Clausen BE, Weishaupt C, Luger TA, Meuth SG, Loser K, Wiendl H.

Ann Neurol. 2014 May;75(5):739-58. doi: 10.1002/ana.24165. Epub 2014 May 13.

PMID:
24771567
29.

The LIM-only protein FHL2 attenuates lung inflammation during bleomycin-induced fibrosis.

Alnajar A, Nordhoff C, Schied T, Chiquet-Ehrismann R, Loser K, Vogl T, Ludwig S, Wixler V.

PLoS One. 2013 Nov 18;8(11):e81356. doi: 10.1371/journal.pone.0081356. eCollection 2013.

30.

The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3.

Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, Gao Z, Tian H, Li Y, Yao Z, Zheng Y, Park BV, Pan Z, Zhang J, Dang E, Li Z, Wang H, Luo W, Li L, Semenza GL, Zheng SG, Loser K, Tsun A, Greene MI, Pardoll DM, Pan F, Li B.

Immunity. 2013 Aug 22;39(2):272-85. doi: 10.1016/j.immuni.2013.08.006.

31.

Inhibition of the prohormone convertase subtilisin-kexin isoenzyme-1 induces apoptosis in human melanoma cells.

Weiß N, Stegemann A, Elsayed MAT, Schallreuter KU, Luger TA, Loser K, Metze D, Weishaupt C, Böhm M.

J Invest Dermatol. 2014 Jan;134(1):168-175. doi: 10.1038/jid.2013.282. Epub 2013 Jun 27.

32.

Doxycycline-induced expression of transgenic human tumor necrosis factor α in adult mice results in psoriasis-like arthritis.

Retser E, Schied T, Skryabin BV, Vogl T, Kanczler JM, Hamann N, Niehoff A, Hermann S, Eisenblätter M, Wachsmuth L, Pap T, van Lent PL, Loser K, Roth J, Zaucke F, Ludwig S, Wixler V.

Arthritis Rheum. 2013 Sep;65(9):2290-300. doi: 10.1002/art.38026.

33.

Bacteria tracking by in vivo magnetic resonance imaging.

Hoerr V, Tuchscherr L, Hüve J, Nippe N, Loser K, Glyvuk N, Tsytsyura Y, Holtkamp M, Sunderkötter C, Karst U, Klingauf J, Peters G, Löffler B, Faber C.

BMC Biol. 2013 May 28;11:63. doi: 10.1186/1741-7007-11-63.

34.

Tc9 cells, a new subset of CD8(+) T cells, support Th2-mediated airway inflammation.

Visekruna A, Ritter J, Scholz T, Campos L, Guralnik A, Poncette L, Raifer H, Hagner S, Garn H, Staudt V, Bopp T, Reuter S, Taube C, Loser K, Huber M.

Eur J Immunol. 2013 Mar;43(3):606-18. doi: 10.1002/eji.201242825. Epub 2013 Jan 31.

35.

The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis.

Petersen B, Wolf M, Austermann J, van Lent P, Foell D, Ahlmann M, Kupas V, Loser K, Sorg C, Roth J, Vogl T.

EMBO J. 2013 Jan 9;32(1):100-11. doi: 10.1038/emboj.2012.309. Epub 2012 Nov 27.

36.

α-MSH-stimulated tolerogenic dendritic cells induce functional regulatory T cells and ameliorate ongoing skin inflammation.

Auriemma M, Brzoska T, Klenner L, Kupas V, Goerge T, Voskort M, Zhao Z, Sparwasser T, Luger TA, Loser K.

J Invest Dermatol. 2012 Jul;132(7):1814-24. doi: 10.1038/jid.2012.59. Epub 2012 Mar 15.

37.

Regulatory T cells: banned cells for decades.

Loser K, Beissert S.

J Invest Dermatol. 2012 Mar;132(3 Pt 2):864-71. doi: 10.1038/jid.2011.375. Epub 2011 Dec 8. Review.

38.

In vitro induced CD8+ regulatory T cells inhibit skin inflammation.

Fleissner D, Loser K, Hansen W, Dissemond J, Körber A, Beissert S, Buer J, Westendorf AM.

Eur J Microbiol Immunol (Bp). 2011 Sep;1(3):208-14. doi: 10.1556/EuJMI.1.2011.3.4. Epub 2011 Sep 9.

39.

Tissue microarray analysis of RANKL in cutaneous lupus erythematosus and psoriasis.

Toberer F, Sykora J, Göttel D, Ruland V, Hartschuh W, Enk A, Luger TA, Beissert S, Loser K, Joos S, Krammer PH, Kuhn A.

Exp Dermatol. 2011 Jul;20(7):600-2. doi: 10.1111/j.1600-0625.2011.01303.x.

PMID:
21692859
40.

RANK is expressed in metastatic melanoma and highly upregulated on melanoma-initiating cells.

Kupas V, Weishaupt C, Siepmann D, Kaserer ML, Eickelmann M, Metze D, Luger TA, Beissert S, Loser K.

J Invest Dermatol. 2011 Apr;131(4):944-55. doi: 10.1038/jid.2010.377. Epub 2011 Jan 27.

41.

Terminal signal: anti-inflammatory effects of α-melanocyte-stimulating hormone related peptides beyond the pharmacophore.

Brzoska T, Böhm M, Lügering A, Loser K, Luger TA.

Adv Exp Med Biol. 2010;681:107-16. doi: 10.1007/978-1-4419-6354-3_8. Review.

PMID:
21222263
42.

The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells.

Loser K, Vogl T, Voskort M, Lueken A, Kupas V, Nacken W, Klenner L, Kuhn A, Foell D, Sorokin L, Luger TA, Roth J, Beissert S.

Nat Med. 2010 Jun;16(6):713-7. doi: 10.1038/nm.2150. Epub 2010 May 9.

PMID:
20473308
43.

The neuropeptide alpha-melanocyte-stimulating hormone is critically involved in the development of cytotoxic CD8+ T cells in mice and humans.

Loser K, Brzoska T, Oji V, Auriemma M, Voskort M, Kupas V, Klenner L, Mensing C, Hauschild A, Beissert S, Luger TA.

PLoS One. 2010 Feb 1;5(2):e8958. doi: 10.1371/journal.pone.0008958.

44.

Regulation of cutaneous immunity by the environment: an important role for UV irradiation and vitamin D.

Loser K, Beissert S.

Int Immunopharmacol. 2009 May;9(5):587-9. doi: 10.1016/j.intimp.2009.01.024. Epub 2009 Feb 1. Review.

PMID:
19539561
45.

Sialoadhesin-positive macrophages bind regulatory T cells, negatively controlling their expansion and autoimmune disease progression.

Wu C, Rauch U, Korpos E, Song J, Loser K, Crocker PR, Sorokin LM.

J Immunol. 2009 May 15;182(10):6508-16. doi: 10.4049/jimmunol.0804247.

46.

Endothelial basement membrane laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain.

Wu C, Ivars F, Anderson P, Hallmann R, Vestweber D, Nilsson P, Robenek H, Tryggvason K, Song J, Korpos E, Loser K, Beissert S, Georges-Labouesse E, Sorokin LM.

Nat Med. 2009 May;15(5):519-27. doi: 10.1038/nm.1957. Epub 2009 Apr 26.

PMID:
19396173
47.

Galectin-2 suppresses contact allergy by inducing apoptosis in activated CD8+ T cells.

Loser K, Sturm A, Voskort M, Kupas V, Balkow S, Auriemma M, Sternemann C, Dignass AU, Luger TA, Beissert S.

J Immunol. 2009 May 1;182(9):5419-29. doi: 10.4049/jimmunol.0802308.

48.

Ichthyosis vulgaris: novel FLG mutations in the German population and high presence of CD1a+ cells in the epidermis of the atopic subgroup.

Oji V, Seller N, Sandilands A, Gruber R, Gerss J, Hüffmeier U, Hamm H, Emmert S, Aufenvenne K, Metze D, Luger T, Loser K, Hausser I, Traupe H, McLean WH.

Br J Dermatol. 2009 Apr;160(4):771-81. doi: 10.1111/j.1365-2133.2008.08999.x. Epub 2009 Jan 13.

PMID:
19183181
49.

Dendritic cell activation by combined exposure to anti-CD40 plus interleukin (IL)-12 and IL-18 efficiently stimulates anti-tumor immunity.

Balkow S, Loser K, Krummen M, Higuchi T, Rothoeft T, Apelt J, Tuettenberg A, Weishaupt C, Beissert S, Grabbe S.

Exp Dermatol. 2009 Jan;18(1):78-87. doi: 10.1111/j.1600-0625.2008.00800.x. Epub 2008 Oct 22.

PMID:
19054060
50.

Molecular and cellular mechanisms of photocarcinogenesis.

Beissert S, Loser K.

Photochem Photobiol. 2008 Jan-Feb;84(1):29-34. doi: 10.1111/j.1751-1097.2007.00231.x. Review.

PMID:
18173698

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