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Items: 41

1.

Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms).

de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M, Chen J, Cacace A, Hams E, Maingot C, McLoughlin A, Brennan E, Leroy X, Loscher CE, Fallon P, Perretti M, Godson C, Guiry PJ.

Eur J Med Chem. 2019 Jan 15;162:80-108. doi: 10.1016/j.ejmech.2018.10.049. Epub 2018 Oct 23.

PMID:
30419493
2.

Erratum to: Surface layer proteins from virulent Clostridium difficile ribotypes exhibit signatures of positive selection with consequences for innate immune response.

Lynch M, Walsh TA, Marszalowska I, Webb AE, Mac Aogáin M, Rogers TR, Windle H, Kelleher D, O'Connell MJ, Loscher CE.

BMC Evol Biol. 2017 Jun 12;17(1):135. doi: 10.1186/s12862-017-0990-3. No abstract available.

3.

Surface layer proteins from virulent Clostridium difficile ribotypes exhibit signatures of positive selection with consequences for innate immune response.

Lynch M, Walsh TA, Marszalowska I, Webb AE, Mac Aogain M, Rogers TR, Windle H, Kelleher D, O'Connell MJ, Loscher CE.

BMC Evol Biol. 2017 Mar 23;17(1):90. doi: 10.1186/s12862-017-0937-8. Erratum in: BMC Evol Biol. 2017 Jun 12;17 (1):135.

4.

Protective antibodies against Clostridium difficile are present in intravenous immunoglobulin and are retained in humans following its administration.

Negm OH, MacKenzie B, Hamed MR, Ahmad OAJ, Shone CC, Humphreys DP, Ravi Acharya K, Loscher CE, Marszalowska I, Lynch M, Wilcox MH, Monaghan TM.

Clin Exp Immunol. 2017 Jun;188(3):437-443. doi: 10.1111/cei.12946. Epub 2017 Mar 16.

5.

Schizophrenia interactome with 504 novel protein-protein interactions.

Ganapathiraju MK, Thahir M, Handen A, Sarkar SN, Sweet RA, Nimgaonkar VL, Loscher CE, Bauer EM, Chaparala S.

NPJ Schizophr. 2016 Apr 27;2:16012. doi: 10.1038/npjschz.2016.12. eCollection 2016.

6.

Profiling Humoral Immune Responses to Clostridium difficile-Specific Antigens by Protein Microarray Analysis.

Negm OH, Hamed MR, Dilnot EM, Shone CC, Marszalowska I, Lynch M, Loscher CE, Edwards LJ, Tighe PJ, Wilcox MH, Monaghan TM.

Clin Vaccine Immunol. 2015 Sep;22(9):1033-9. doi: 10.1128/CVI.00190-15. Epub 2015 Jul 15.

7.

An Emerging Role for SNARE Proteins in Dendritic Cell Function.

Collins LE, DeCourcey J, Soledad di Luca M, Rochfort KD, Loscher CE.

Front Immunol. 2015 Mar 31;6:133. doi: 10.3389/fimmu.2015.00133. eCollection 2015. Review.

8.

Adaptive Evolution as a Predictor of Species-Specific Innate Immune Response.

Webb AE, Gerek ZN, Morgan CC, Walsh TA, Loscher CE, Edwards SV, O'Connell MJ.

Mol Biol Evol. 2015 Jul;32(7):1717-29. doi: 10.1093/molbev/msv051. Epub 2015 Mar 10.

9.

A role for syntaxin 3 in the secretion of IL-6 from dendritic cells following activation of toll-like receptors.

Collins LE, DeCourcey J, Rochfort KD, Kristek M, Loscher CE.

Front Immunol. 2015 Jan 26;5:691. doi: 10.3389/fimmu.2014.00691. eCollection 2014.

10.

Soluble factors from colonic epithelial cells contribute to gut homeostasis by modulating macrophage phenotype.

Kristek M, Collins LE, DeCourcey J, McEvoy FA, Loscher CE.

Innate Immun. 2015 May;21(4):358-69. doi: 10.1177/1753425914538294. Epub 2014 Oct 7.

PMID:
25298104
11.

Adult vascular smooth muscle cells in culture express neural stem cell markers typical of resident multipotent vascular stem cells.

Kennedy E, Mooney CJ, Hakimjavadi R, Fitzpatrick E, Guha S, Collins LE, Loscher CE, Morrow D, Redmond EM, Cahill PA.

Cell Tissue Res. 2014 Oct;358(1):203-16. doi: 10.1007/s00441-014-1937-2. Epub 2014 Jul 4.

PMID:
24992927
12.

Intracellular pH-sensing using core/shell silica nanoparticles.

Korzeniowska B, Woolley R, DeCourcey J, Wencel D, Loscher CE, McDonagh C.

J Biomed Nanotechnol. 2014 Jul;10(7):1336-45.

PMID:
24804554
13.

Conjugated linoleic acid suppresses dendritic cell activation and subsequent Th17 responses.

Draper E, DeCourcey J, Higgins SC, Canavan M, McEvoy F, Lynch M, Keogh B, Reynolds C, Roche HM, Mills KH, Loscher CE.

J Nutr Biochem. 2014 Jul;25(7):741-9. doi: 10.1016/j.jnutbio.2014.03.004. Epub 2014 Mar 27.

PMID:
24794016
14.

Embryonic rat vascular smooth muscle cells revisited - a model for neonatal, neointimal SMC or differentiated vascular stem cells?

Kennedy E, Hakimjavadi R, Greene C, Mooney CJ, Fitzpatrick E, Collins LE, Loscher CE, Guha S, Morrow D, Redmond EM, Cahill PA.

Vasc Cell. 2014 Mar 15;6(1):6. doi: 10.1186/2045-824X-6-6.

15.

Surface layer proteins isolated from Clostridium difficile induce clearance responses in macrophages.

Collins LE, Lynch M, Marszalowska I, Kristek M, Rochfort K, O'Connell M, Windle H, Kelleher D, Loscher CE.

Microbes Infect. 2014 May;16(5):391-400. doi: 10.1016/j.micinf.2014.02.001. Epub 2014 Feb 19.

PMID:
24560642
16.

Syntaxin-4 is essential for IgE secretion by plasma cells.

Rahman A, Decourcey J, Larbi NB, Loughran ST, Walls D, Loscher CE.

Biochem Biophys Res Commun. 2013 Oct 11;440(1):163-7. doi: 10.1016/j.bbrc.2013.09.058. Epub 2013 Sep 18.

PMID:
24055037
17.

Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-κBp50.

Canavan M, McCarthy C, Larbi NB, Dowling JK, Collins L, O'Sullivan F, Hurley G, Murphy C, Quinlan A, Moloney G, Darby T, MacSharry J, Kagechika H, Moynagh P, Melgar S, Loscher CE.

Innate Immun. 2014 Oct;20(7):675-87. doi: 10.1177/1753425913501915. Epub 2013 Sep 17.

PMID:
24045337
18.

Conjugated linoleic acid suppresses IRF3 activation via modulation of CD14.

Dowling JK, McCoy CE, Doyle SL, BenLarbi N, Canavan M, O'Neill LA, Loscher CE.

J Nutr Biochem. 2013 May;24(5):920-8. doi: 10.1016/j.jnutbio.2012.06.010. Epub 2012 Aug 15.

PMID:
22901688
19.

Colon cancer associated genes exhibit signatures of positive selection at functionally significant positions.

Morgan CC, Shakya K, Webb A, Walsh TA, Lynch M, Loscher CE, Ruskin HJ, O'Connell MJ.

BMC Evol Biol. 2012 Jul 12;12:114. doi: 10.1186/1471-2148-12-114.

20.

Aflatoxins B(1), B(2) and G(1) modulate cytokine secretion and cell surface marker expression in J774A.1 murine macrophages.

Bruneau JC, Stack E, O'Kennedy R, Loscher CE.

Toxicol In Vitro. 2012 Aug;26(5):686-93. doi: 10.1016/j.tiv.2012.03.003. Epub 2012 Mar 16.

PMID:
22445859
21.

A role for TLR4 in Clostridium difficile infection and the recognition of surface layer proteins.

Ryan A, Lynch M, Smith SM, Amu S, Nel HJ, McCoy CE, Dowling JK, Draper E, O'Reilly V, McCarthy C, O'Brien J, Ní Eidhin D, O'Connell MJ, Keogh B, Morton CO, Rogers TR, Fallon PG, O'Neill LA, Kelleher D, Loscher CE.

PLoS Pathog. 2011 Jun;7(6):e1002076. doi: 10.1371/journal.ppat.1002076. Epub 2011 Jun 30.

22.

Omega-3 fatty acids attenuate dendritic cell function via NF-κB independent of PPARγ.

Draper E, Reynolds CM, Canavan M, Mills KH, Loscher CE, Roche HM.

J Nutr Biochem. 2011 Aug;22(8):784-90. doi: 10.1016/j.jnutbio.2010.06.009. Epub 2010 Nov 26.

PMID:
21111596
23.

Synthesis and biological evaluation of pyridine-containing lipoxin A4 analogues.

Duffy CD, Maderna P, McCarthy C, Loscher CE, Godson C, Guiry PJ.

ChemMedChem. 2010 Apr 6;5(4):517-22. doi: 10.1002/cmdc.200900533. No abstract available.

PMID:
20127785
24.

A conjugated linoleic acid-enriched beef diet attenuates lipopolysaccharide-induced inflammation in mice in part through PPARgamma-mediated suppression of toll-like receptor 4.

Reynolds CM, Draper E, Keogh B, Rahman A, Moloney AP, Mills KH, Loscher CE, Roche HM.

J Nutr. 2009 Dec;139(12):2351-7. doi: 10.3945/jn.109.113035. Epub 2009 Oct 21.

PMID:
19846417
25.

Attenuation of inflammation and cellular stress-related pathways maintains insulin sensitivity in obese type I interleukin-1 receptor knockout mice on a high-fat diet.

de Roos B, Rungapamestry V, Ross K, Rucklidge G, Reid M, Duncan G, Horgan G, Toomey S, Browne J, Loscher CE, Mills KH, Roche HM.

Proteomics. 2009 Jun;9(12):3244-56. doi: 10.1002/pmic.200800761.

PMID:
19562798
26.

Anti-inflammatory effects of EPA and DHA are dependent upon time and dose-response elements associated with LPS stimulation in THP-1-derived macrophages.

Mullen A, Loscher CE, Roche HM.

J Nutr Biochem. 2010 May;21(5):444-50. doi: 10.1016/j.jnutbio.2009.02.008. Epub 2009 May 8.

PMID:
19427777
27.

The Fasciola hepatica tegumental antigen suppresses dendritic cell maturation and function.

Hamilton CM, Dowling DJ, Loscher CE, Morphew RM, Brophy PM, O'Neill SM.

Infect Immun. 2009 Jun;77(6):2488-98. doi: 10.1128/IAI.00919-08. Epub 2009 Mar 30.

28.

Cis-9, trans-11-conjugated linoleic acid but not its precursor trans-vaccenic acid attenuate inflammatory markers in the human colonic epithelial cell line Caco-2.

Reynolds CM, Loscher CE, Moloney AP, Roche HM.

Br J Nutr. 2008 Jul;100(1):13-7. doi: 10.1017/S0007114508894329.

PMID:
18275620
29.

Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissue.

Moloney F, Toomey S, Noone E, Nugent A, Allan B, Loscher CE, Roche HM.

Diabetes. 2007 Mar;56(3):574-82.

30.

Docosahexaenoic acid induces an anti-inflammatory profile in lipopolysaccharide-stimulated human THP-1 macrophages more effectively than eicosapentaenoic acid.

Weldon SM, Mullen AC, Loscher CE, Hurley LA, Roche HM.

J Nutr Biochem. 2007 Apr;18(4):250-8. Epub 2006 Jun 16.

PMID:
16781858
31.

Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction.

Loscher CE, Draper E, Leavy O, Kelleher D, Mills KH, Roche HM.

J Immunol. 2005 Oct 15;175(8):4990-8.

32.

Proinflammatory responses in the murine brain after intranasal delivery of cholera toxin: implications for the use of AB toxins as adjuvants in intranasal vaccines.

Armstrong ME, Lavelle EC, Loscher CE, Lynch MA, Mills KH.

J Infect Dis. 2005 Nov 1;192(9):1628-33. Epub 2005 Sep 23.

PMID:
16206078
33.

Divergent mechanisms of cis9, trans11-and trans10, cis12-conjugated linoleic acid affecting insulin resistance and inflammation in apolipoprotein E knockout mice: a proteomics approach.

de Roos B, Rucklidge G, Reid M, Ross K, Duncan G, Navarro MA, Arbones-Mainar JM, Guzman-Garcia MA, Osada J, Browne J, Loscher CE, Roche HM.

FASEB J. 2005 Oct;19(12):1746-8. Epub 2005 Jul 29.

PMID:
16055499
34.
35.
36.

Activation of p38 plays a pivotal role in the inhibitory effect of lipopolysaccharide and interleukin-1 beta on long term potentiation in rat dentate gyrus.

Kelly A, Vereker E, Nolan Y, Brady M, Barry C, Loscher CE, Mills KH, Lynch MA.

J Biol Chem. 2003 May 23;278(21):19453-62. Epub 2003 Feb 27.

38.

Interleukin-1beta-dependent changes in the hippocampus following parenteral immunization with a whole cell pertussis vaccine.

Loscher CE, Donnelly S, Mills KH, Lynch MA.

J Neuroimmunol. 2000 Nov 1;111(1-2):68-76.

PMID:
11063823
39.

Induction of inflammatory cytokines in the brain following respiratory infection with Bordetella pertussis.

Loscher CE, Donnelly S, Lynch MA, Mills KH.

J Neuroimmunol. 2000 Jan 24;102(2):172-81.

PMID:
10636486
40.

Proinflammatory cytokines in the adverse systemic and neurologic effects associated with parenteral injection of a whole cell pertussis vaccine.

Loscher CE, Donnelly S, McBennett S, Lynch MA, Mills KH.

Ann N Y Acad Sci. 1998 Sep 29;856:274-7. No abstract available.

PMID:
9917889
41.

Degradation of pyroglutamyl-phenylalanyl-proline amide by a pyroglutamyl aminopeptidase purified from membrane fractions of bovine brain.

Kelly JA, Loscher CE, Gallagher S, O'Connor B.

Biochem Soc Trans. 1997 Feb;25(1):114S. No abstract available.

PMID:
9057012

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