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Items: 1 to 50 of 615

1.

A Disturbing Decline.

Braun DA, Henderson GV, Sax PE, Miller AL, Loscalzo J.

N Engl J Med. 2019 Jun 6;380(23):2257-2262. doi: 10.1056/NEJMcps1807619. No abstract available.

PMID:
31167056
2.

Systems pharmacogenomics - gene, disease, drug and placebo interactions: a case study in COMT.

Hall KT, Loscalzo J, Kaptchuk TJ.

Pharmacogenomics. 2019 May;20(7):529-551. doi: 10.2217/pgs-2019-0001.

PMID:
31124409
3.

Network Medicine in Pathobiology.

Lee LY, Loscalzo J.

Am J Pathol. 2019 Apr 20. pii: S0002-9440(19)30093-8. doi: 10.1016/j.ajpath.2019.03.009. [Epub ahead of print] Review.

PMID:
31014954
4.

Moving Beyond the Sarcomere to Explain Heterogeneity in Hypertrophic Cardiomyopathy: JACC Review Topic of the Week.

Maron BJ, Maron MS, Maron BA, Loscalzo J.

J Am Coll Cardiol. 2019 Apr 23;73(15):1978-1986. doi: 10.1016/j.jacc.2019.01.061. Review.

PMID:
31000001
5.

A Dangerous Detour.

Berg DD, Kirshenbaum JM, Gay E, Miller AL, Loscalzo J.

N Engl J Med. 2019 Apr 4;380(14):1360-1365. doi: 10.1056/NEJMcps1803916. No abstract available.

PMID:
30943341
6.

Precision Medicine.

Loscalzo J.

Circ Res. 2019 Mar 29;124(7):987-989. doi: 10.1161/CIRCRESAHA.119.314403. No abstract available.

PMID:
30920923
7.

A Dangerous Detour.

Berg DD, Kirshenbaum J, Gay E, Vaidya A, Loscalzo J.

N Engl J Med. 2019 Mar 28;380(13):e18. doi: 10.1056/NEJMimc1804660. No abstract available.

PMID:
30917263
8.

Reported environmental exposures are inversely associated with obtaining a genetic diagnosis in the Undiagnosed Diseases Network.

Silverman EK, Allard P, Loscalzo J, Mulvihill JJ, Korrick SA; Undiagnosed Diseases Network.

Am J Med Genet A. 2019 Jun;179(6):958-965. doi: 10.1002/ajmg.a.61132. Epub 2019 Mar 23.

PMID:
30903737
9.

Gasping for a Diagnosis.

D'Silva K, Brown S, Hunninghake GM, Vivero M, Loscalzo J.

N Engl J Med. 2019 Mar 7;380(10):961-967. doi: 10.1056/NEJMcps1809942. No abstract available.

PMID:
30855747
10.

Epigenetic Inheritance Underlying Pulmonary Arterial Hypertension.

Napoli C, Benincasa G, Loscalzo J.

Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):653-664. doi: 10.1161/ATVBAHA.118.312262.

PMID:
30727752
11.

A Breath-Taking Diagnosis.

DeFilippis EM, Nohria A, Burstein HJ, Doyle LA, Miller AL, Loscalzo J.

N Engl J Med. 2019 Jan 3;380(1):81-87. doi: 10.1056/NEJMcps1807721. No abstract available.

PMID:
30601740
12.

Determinants of drug-target interactions at the single cell level.

Elgart V, Lin JR, Loscalzo J.

PLoS Comput Biol. 2018 Dec 20;14(12):e1006601. doi: 10.1371/journal.pcbi.1006601. eCollection 2018 Dec.

13.

Complements from the Lung.

Downing NS, McMullan CJ, Rennke HG, Levy BD, Loscalzo J.

N Engl J Med. 2018 Nov 1;379(18):1767-1773. doi: 10.1056/NEJMcps1802644. No abstract available.

PMID:
30380383
14.

Inflammation, Immunity, and Infection in Atherothrombosis: JACC Review Topic of the Week.

Libby P, Loscalzo J, Ridker PM, Farkouh ME, Hsue PY, Fuster V, Hasan AA, Amar S.

J Am Coll Cardiol. 2018 Oct 23;72(17):2071-2081. doi: 10.1016/j.jacc.2018.08.1043. Review.

PMID:
30336831
15.

Effect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease.

Splinter K, Adams DR, Bacino CA, Bellen HJ, Bernstein JA, Cheatle-Jarvela AM, Eng CM, Esteves C, Gahl WA, Hamid R, Jacob HJ, Kikani B, Koeller DM, Kohane IS, Lee BH, Loscalzo J, Luo X, McCray AT, Metz TO, Mulvihill JJ, Nelson SF, Palmer CGS, Phillips JA 3rd, Pick L, Postlethwait JH, Reuter C, Shashi V, Sweetser DA, Tifft CJ, Walley NM, Wangler MF, Westerfield M, Wheeler MT, Wise AL, Worthey EA, Yamamoto S, Ashley EA; Undiagnosed Diseases Network.

N Engl J Med. 2018 Nov 29;379(22):2131-2139. doi: 10.1056/NEJMoa1714458. Epub 2018 Oct 10.

16.

Analysis of redox landscapes and dynamics in living cells and in vivo using genetically encoded fluorescent sensors.

Zou Y, Wang A, Shi M, Chen X, Liu R, Li T, Zhang C, Zhang Z, Zhu L, Ju Z, Loscalzo J, Yang Y, Zhao Y.

Nat Protoc. 2018 Oct;13(10):2362-2386. doi: 10.1038/s41596-018-0042-5.

PMID:
30258175
17.

GAPDH inhibits intracellular pathways during starvation for cellular energy homeostasis.

Yang JS, Hsu JW, Park SY, Li J, Oldham WM, Beznoussenko GV, Mironov AA, Loscalzo J, Hsu VW.

Nature. 2018 Sep;561(7722):263-267. doi: 10.1038/s41586-018-0475-6. Epub 2018 Sep 12.

18.

An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery.

Haghighi A, Krier JB, Toth-Petroczy A, Cassa CA, Frank NY, Carmichael N, Fieg E, Bjonnes A, Mohanty A, Briere LC, Lincoln S, Lucia S, Gupta VA, Söylemez O, Sutti S, Kooshesh K, Qiu H, Fay CJ, Perroni V, Valerius J, Hanna M, Frank A, Ouahed J, Snapper SB, Pantazi A, Chopra SS, Leshchiner I, Stitziel NO, Feldweg A, Mannstadt M, Loscalzo J, Sweetser DA, Liao E, Stoler JM, Nowak CB, Sanchez-Lara PA, Klein OD, Perry H, Patsopoulos NA, Raychaudhuri S, Goessling W, Green RC, Seidman CE, MacRae CA, Sunyaev SR, Maas RL, Vuzman D; Undiagnosed Diseases Network, Brigham and Women’s Hospital FaceBase Project, Brigham Genomic Medicine (BGM).

NPJ Genom Med. 2018 Aug 13;3:21. doi: 10.1038/s41525-018-0060-9. eCollection 2018. Review.

19.

A Headache of a Diagnosis.

Stern RM, Luskin MR, Clark RP, Miller AL, Loscalzo J.

N Engl J Med. 2018 Aug 2;379(5):475-479. doi: 10.1056/NEJMcps1803584. No abstract available.

PMID:
30067932
20.

Network-based approach to prediction and population-based validation of in silico drug repurposing.

Cheng F, Desai RJ, Handy DE, Wang R, Schneeweiss S, Barabási AL, Loscalzo J.

Nat Commun. 2018 Jul 12;9(1):2691. doi: 10.1038/s41467-018-05116-5.

21.

Controllability in an islet specific regulatory network identifies the transcriptional factor NFATC4, which regulates Type 2 Diabetes associated genes.

Sharma A, Halu A, Decano JL, Padi M, Liu YY, Prasad RB, Fadista J, Santolini M, Menche J, Weiss ST, Vidal M, Silverman EK, Aikawa M, Barabási AL, Groop L, Loscalzo J.

NPJ Syst Biol Appl. 2018 Jul 3;4:25. doi: 10.1038/s41540-018-0057-0. eCollection 2018.

22.

Dyspnea and Edema in a Woman With Antiphospholipid Syndrome.

DeFilippis EM, Tsao AL, Loscalzo J.

JAMA Cardiol. 2018 Nov 1;3(11):1123-1124. doi: 10.1001/jamacardio.2018.1704. No abstract available.

PMID:
29955809
23.

NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension.

Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA.

Sci Transl Med. 2018 Jun 13;10(445). pii: eaap7294. doi: 10.1126/scitranslmed.aap7294.

24.

A Shocking Turn of Events.

DeFilippis EM, Sobieszczyk P, Lakdawala NK, Miller AL, Loscalzo J.

N Engl J Med. 2018 Jun 7;378(23):2225-2230. doi: 10.1056/NEJMcps1714590. No abstract available.

PMID:
29874538
25.

Case 8-2018: A Woman with Shock and Labile Blood Pressure.

Loscalzo J, Roy N, Tsai JN.

N Engl J Med. 2018 May 31;378(22):2146-2147. doi: 10.1056/NEJMc1804983. No abstract available.

PMID:
29847755
26.

Interdisciplinary Models for Research and Clinical Endeavors in Genomic Medicine: A Scientific Statement From the American Heart Association.

Musunuru K, Arora P, Cooke JP, Ferguson JF, Hershberger RE, Hickey KT, Lee JM, Lima JAC, Loscalzo J, Pereira NL, Russell MW, Shah SH, Sheikh F, Wang TJ, MacRae CA; American Heart Association Council on Genomic and Precision Medicine; Council on Cardiovascular Disease in the Young; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; Council on Peripheral Vascular Disease; Council on Quality of Care and Outcomes Research; and Stroke Council.

Circ Genom Precis Med. 2018 Jun;11(6):e000046. doi: 10.1161/HCG.0000000000000046. Review.

PMID:
29844141
27.

Network-Based Disease Module Discovery by a Novel Seed Connector Algorithm with Pathobiological Implications.

Wang RS, Loscalzo J.

J Mol Biol. 2018 Sep 14;430(18 Pt A):2939-2950. doi: 10.1016/j.jmb.2018.05.016. Epub 2018 May 20.

PMID:
29791871
28.

MicroRNA Dysregulation in Pulmonary Arteries from Chronic Obstructive Pulmonary Disease. Relationships with Vascular Remodeling.

Musri MM, Coll-Bonfill N, Maron BA, Peinado VI, Wang RS, Altirriba J, Blanco I, Oldham WM, Tura-Ceide O, García-Lucio J, de la Cruz-Thea B, Meister G, Loscalzo J, Barberà JA.

Am J Respir Cell Mol Biol. 2018 Oct;59(4):490-499. doi: 10.1165/rcmb.2017-0040OC.

PMID:
29757677
29.

Emerging Role of Precision Medicine in Cardiovascular Disease.

Leopold JA, Loscalzo J.

Circ Res. 2018 Apr 27;122(9):1302-1315. doi: 10.1161/CIRCRESAHA.117.310782. Review.

30.

A Systems Approach to Refine Disease Taxonomy by Integrating Phenotypic and Molecular Networks.

Zhou X, Lei L, Liu J, Halu A, Zhang Y, Li B, Guo Z, Liu G, Sun C, Loscalzo J, Sharma A, Wang Z.

EBioMedicine. 2018 May;31:79-91. doi: 10.1016/j.ebiom.2018.04.002. Epub 2018 Apr 6.

31.

Stream of Consciousness.

Blum SM, Prust ML, Patel R, Miller AL, Loscalzo J.

N Engl J Med. 2018 Apr 5;378(14):1336-1342. doi: 10.1056/NEJMcps1714950. No abstract available.

PMID:
29617591
32.

Spatiotemporal Multi-Omics Mapping Generates a Molecular Atlas of the Aortic Valve and Reveals Networks Driving Disease.

Schlotter F, Halu A, Goto S, Blaser MC, Body SC, Lee LH, Higashi H, DeLaughter DM, Hutcheson JD, Vyas P, Pham T, Rogers MA, Sharma A, Seidman CE, Loscalzo J, Seidman JG, Aikawa M, Singh SA, Aikawa E.

Circulation. 2018 Jul 24;138(4):377-393. doi: 10.1161/CIRCULATIONAHA.117.032291.

PMID:
29588317
33.

Efficient Computational Modeling of Human Ventricular Activation and Its Electrocardiographic Representation: A Sensitivity Study.

Cranford JP, O'Hara TJ, Villongco CT, Hafez OM, Blake RC, Loscalzo J, Fattebert JL, Richards DF, Zhang X, Glosli JN, McCulloch AD, Krummen DE, Lightstone FC, Wong SE.

Cardiovasc Eng Technol. 2018 Sep;9(3):447-467. doi: 10.1007/s13239-018-0347-0. Epub 2018 Mar 16.

34.

Case 8-2018: A 55-Year-Old Woman with Shock and Labile Blood Pressure.

Loscalzo J, Roy N, Shah RV, Tsai JN, Cahalane AM, Steiner J, Stone JR.

N Engl J Med. 2018 Mar 15;378(11):1043-1053. doi: 10.1056/NEJMcpc1712225. No abstract available.

PMID:
29539275
35.

Pharmacogenomics and the Placebo Response.

Hall KT, Loscalzo J, Kaptchuk T.

ACS Chem Neurosci. 2018 Apr 18;9(4):633-635. doi: 10.1021/acschemneuro.8b00078. Epub 2018 Mar 2. Review.

36.

An Unexpected Expectoration.

Casey JD, Englert JA, Katz JT, Miller AL, Loscalzo J.

N Engl J Med. 2018 Mar 1;378(9):853-858. doi: 10.1056/NEJMcps1711048. No abstract available.

PMID:
29490174
37.

Network Analysis to Risk Stratify Patients With Exercise Intolerance.

Oldham WM, Oliveira RKF, Wang RS, Opotowsky AR, Rubins DM, Hainer J, Wertheim BM, Alba GA, Choudhary G, Tornyos A, MacRae CA, Loscalzo J, Leopold JA, Waxman AB, Olschewski H, Kovacs G, Systrom DM, Maron BA.

Circ Res. 2018 Mar 16;122(6):864-876. doi: 10.1161/CIRCRESAHA.117.312482. Epub 2018 Feb 5.

38.

Pulmonary Comorbidity in Lung Cancer.

Cheng F, Loscalzo J.

Trends Mol Med. 2018 Mar;24(3):239-241. doi: 10.1016/j.molmed.2018.01.005. Epub 2018 Feb 1.

39.

The NEAT Predictive Model for Survival in Patients with Advanced Cancer.

Zucker A, Tsai CJ, Loscalzo J, Calves P, Kao J.

Cancer Res Treat. 2018 Oct;50(4):1433-1443. doi: 10.4143/crt.2017.223. Epub 2018 Jan 24.

40.

Nitric Oxide Signaling and Atherothrombosis Redux: Evidence From Experiments of Nature and Implications for Therapy.

Loscalzo J.

Circulation. 2018 Jan 16;137(3):233-236. doi: 10.1161/CIRCULATIONAHA.117.032901. No abstract available.

PMID:
29335284
41.

Putting the Patient Back Together - Social Medicine, Network Medicine, and the Limits of Reductionism.

Greene JA, Loscalzo J.

N Engl J Med. 2017 Dec 21;377(25):2493-2499. doi: 10.1056/NEJMms1706744. No abstract available.

PMID:
29262277
42.

Pre-clinical model of severe glutathione peroxidase-3 deficiency and chronic kidney disease results in coronary artery thrombosis and depressed left ventricular function.

Pang P, Abbott M, Abdi M, Fucci QA, Chauhan N, Mistri M, Proctor B, Chin M, Wang B, Yin W, Lu TS, Halim A, Lim K, Handy DE, Loscalzo J, Siedlecki AM.

Nephrol Dial Transplant. 2018 Jun 1;33(6):923-934. doi: 10.1093/ndt/gfx304.

43.

An Unusual Cause of Leg Pain.

Kelly NP, Gerhard-Herman M, Desai AS, Miller AL, Loscalzo J.

N Engl J Med. 2017 Dec 7;377(23):2267-2272. doi: 10.1056/NEJMcps1703534. No abstract available.

PMID:
29211675
44.

Systems Biology Approaches to Redox Metabolism in Stress and Disease States.

Wang RS, Oldham WM, Maron BA, Loscalzo J.

Antioxid Redox Signal. 2018 Oct 1;29(10):953-972. doi: 10.1089/ars.2017.7256. Epub 2017 Dec 20.

PMID:
29121773
45.

The Role of Nitroglycerin and Other Nitrogen Oxides in Cardiovascular Therapeutics.

Divakaran S, Loscalzo J.

J Am Coll Cardiol. 2017 Nov 7;70(19):2393-2410. doi: 10.1016/j.jacc.2017.09.1064. Review.

46.

Is Oxygen Therapy Beneficial in Acute Myocardial Infarction? Simple Question, Complicated Mechanism, Simple Answer.

Loscalzo J.

N Engl J Med. 2017 Sep 28;377(13):1286-1287. doi: 10.1056/NEJMe1709250. Epub 2017 Aug 28. No abstract available.

PMID:
28844195
47.

NIH Centers for Accelerated Innovations Program: principles, practices, successes and challenges.

Antman EM, Di Corleto PE, Freeman MW, Ganz T, Golan DE, Kitterman R, Loscalzo J, Low M, McKenna E, O'Connor AC, Palazzolo M, Parrish J, Reizes O, Ross RS, Vaughan C, Vince DG, Watts L; NIH Centers for Accelerated Innovations.

Nat Rev Drug Discov. 2017 Oct;16(10):663-664. doi: 10.1038/nrd.2017.131. Epub 2017 Aug 4. No abstract available.

48.

All That Wheezes….

Divakaran S, Dellaripa P, Kobzik L, Levy B, Loscalzo J.

N Engl J Med. 2017 Aug 3;377(5):477-484. doi: 10.1056/NEJMcps1607526. No abstract available.

PMID:
28767340
49.

Categorizing biomedical research: the basics of translation.

Flier JS, Loscalzo J.

FASEB J. 2017 Aug;31(8):3210-3215. doi: 10.1096/fj.201700303R. Review.

50.

Hypoxia-induced suppression of c-Myc by HIF-2α in human pulmonary endothelial cells attenuates TFAM expression.

Zarrabi AJ, Kao D, Nguyen DT, Loscalzo J, Handy DE.

Cell Signal. 2017 Oct;38:230-237. doi: 10.1016/j.cellsig.2017.07.008. Epub 2017 Jul 12.

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