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Items: 1 to 50 of 81

1.

Overcoming adaptive therapy resistance in AML by targeting immune response pathways.

Melgar K, Walker MM, Jones LM, Bolanos LC, Hueneman K, Wunderlich M, Jiang JK, Wilson KM, Zhang X, Sutter P, Wang A, Xu X, Choi K, Tawa G, Lorimer D, Abendroth J, O'Brien E, Hoyt SB, Berman E, Famulare CA, Mulloy JC, Levine RL, Perentesis JP, Thomas CJ, Starczynowski DT.

Sci Transl Med. 2019 Sep 4;11(508). pii: eaaw8828. doi: 10.1126/scitranslmed.aaw8828.

PMID:
31484791
2.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.

Baragaña B, Forte B, Choi R, Nakazawa Hewitt S, Bueren-Calabuig JA, Pisco JP, Peet C, Dranow DM, Robinson DA, Jansen C, Norcross NR, Vinayak S, Anderson M, Brooks CF, Cooper CA, Damerow S, Delves M, Dowers K, Duffy J, Edwards TE, Hallyburton I, Horst BG, Hulverson MA, Ferguson L, Jiménez-Díaz MB, Jumani RS, Lorimer DD, Love MS, Maher S, Matthews H, McNamara CW, Miller P, O'Neill S, Ojo KK, Osuna-Cabello M, Pinto E, Post J, Riley J, Rottmann M, Sanz LM, Scullion P, Sharma A, Shepherd SM, Shishikura Y, Simeons FRC, Stebbins EE, Stojanovski L, Straschil U, Tamaki FK, Tamjar J, Torrie LS, Vantaux A, Witkowski B, Wittlin S, Yogavel M, Zuccotto F, Angulo-Barturen I, Sinden R, Baum J, Gamo FJ, Mäser P, Kyle DE, Winzeler EA, Myler PJ, Wyatt PG, Floyd D, Matthews D, Sharma A, Striepen B, Huston CD, Gray DW, Fairlamb AH, Pisliakov AV, Walpole C, Read KD, Van Voorhis WC, Gilbert IH.

Proc Natl Acad Sci U S A. 2019 Apr 2;116(14):7015-7020. doi: 10.1073/pnas.1814685116. Epub 2019 Mar 20.

3.

Crystal structures of thiamine monophosphate kinase from Acinetobacter baumannii in complex with substrates and products.

Sullivan AH, Dranow DM, Horanyi PS, Lorimer DD, Edwards TE, Abendroth J.

Sci Rep. 2019 Mar 13;9(1):4392. doi: 10.1038/s41598-019-40558-x.

4.

Ab initio structure solution of a proteolytic fragment using ARCIMBOLDO.

Abendroth J, Sankaran B, Myler PJ, Lorimer DD, Edwards TE.

Acta Crystallogr F Struct Biol Commun. 2018 Sep 1;74(Pt 9):530-535. doi: 10.1107/S2053230X18010063. Epub 2018 Aug 29.

5.

Universality of free fall from the orbital motion of a pulsar in a stellar triple system.

Archibald AM, Gusinskaia NV, Hessels JWT, Deller AT, Kaplan DL, Lorimer DR, Lynch RS, Ransom SM, Stairs IH.

Nature. 2018 Jul;559(7712):73-76. doi: 10.1038/s41586-018-0265-1. Epub 2018 Jul 4.

PMID:
29973733
6.

Crystal structure of chorismate mutase from Burkholderia phymatum.

Asojo OA, Subramanian S, Abendroth J, Exley I, Lorimer DD, Edwards TE, Myler PJ.

Acta Crystallogr F Struct Biol Commun. 2018 Apr 1;74(Pt 4):187-192. doi: 10.1107/S2053230X18002868. Epub 2018 Mar 22.

7.

Flashes in the Night.

Lorimer D, McLaughlin M.

Sci Am. 2018 Mar 20;318(4):42-47. doi: 10.1038/scientificamerican0418-42. No abstract available.

PMID:
29557949
8.

Structure of acid deoxyribonuclease.

Varela-Ramirez A, Abendroth J, Mejia AA, Phan IQ, Lorimer DD, Edwards TE, Aguilera RJ.

Nucleic Acids Res. 2017 Jun 2;45(10):6217-6227. doi: 10.1093/nar/gkx222.

9.

Ligand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms.

Moen SO, Edwards TE, Dranow DM, Clifton MC, Sankaran B, Van Voorhis WC, Sharma A, Manoil C, Staker BL, Myler PJ, Lorimer DD.

Sci Rep. 2017 Mar 16;7(1):223. doi: 10.1038/s41598-017-00367-6.

10.

Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors.

Haft DH, Pierce PG, Mayclin SJ, Sullivan A, Gardberg AS, Abendroth J, Begley DW, Phan IQ, Staker BL, Myler PJ, Marathias VM, Lorimer DD, Edwards TE.

Sci Rep. 2017 Jan 25;7:41074. doi: 10.1038/srep41074.

11.

Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase.

Hewitt SN, Dranow DM, Horst BG, Abendroth JA, Forte B, Hallyburton I, Jansen C, Baragaña B, Choi R, Rivas KL, Hulverson MA, Dumais M, Edwards TE, Lorimer DD, Fairlamb AH, Gray DW, Read KD, Lehane AM, Kirk K, Myler PJ, Wernimont A, Walpole C, Stacy R, Barrett LK, Gilbert IH, Van Voorhis WC.

ACS Infect Dis. 2017 Jan 13;3(1):34-44. doi: 10.1021/acsinfecdis.6b00078. Epub 2016 Nov 16.

12.

Correction: Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.

Ojo KK, Ranade RM, Zhang Z, Dranow DM, Myers JB, Choi R, Nakazawa Hewitt S, Edwards TE, Davies DR, Lorimer D, Boyle SM, Barrett LK, Buckner FS, Fan E, Van Voorhis WC.

PLoS One. 2016 Sep 22;11(9):e0163641. doi: 10.1371/journal.pone.0163641. eCollection 2016.

13.

Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.

Ojo KK, Ranade RM, Zhang Z, Dranow DM, Myers JB, Choi R, Nakazawa Hewitt S, Edwards TE, Davies DR, Lorimer D, Boyle SM, Barrett LK, Buckner FS, Fan E, Van Voorhis WC.

PLoS One. 2016 Aug 8;11(8):e0160350. doi: 10.1371/journal.pone.0160350. eCollection 2016. Erratum in: PLoS One. 2016;11(9):e0163641.

14.

Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts.

Guaitoli G, Raimondi F, Gilsbach BK, Gómez-Llorente Y, Deyaert E, Renzi F, Li X, Schaffner A, Jagtap PK, Boldt K, von Zweydorf F, Gotthardt K, Lorimer DD, Yue Z, Burgin A, Janjic N, Sattler M, Versées W, Ueffing M, Ubarretxena-Belandia I, Kortholt A, Gloeckner CJ.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):E4357-66. doi: 10.1073/pnas.1523708113. Epub 2016 Jun 29.

15.

Cosmology: Home of a fast radio burst.

Lorimer D.

Nature. 2016 Feb 25;530(7591):427-8. doi: 10.1038/530427a. No abstract available.

PMID:
26911780
16.

Evaluating pharmacy leader development through the seven action logics.

Philip A, Desai A, Nguyen PA, Birney P, Colavecchia A, Karralli R, Smith L, Lorimer D, Burgess G, Munch K, Daniel N, Lionetti J, Garey KW.

Am J Health Syst Pharm. 2016 Jan 15;73(2):82-5. doi: 10.2146/ajhp150162.

PMID:
26721538
17.

Some of the most interesting CASP11 targets through the eyes of their authors.

Kryshtafovych A, Moult J, Baslé A, Burgin A, Craig TK, Edwards RA, Fass D, Hartmann MD, Korycinski M, Lewis RJ, Lorimer D, Lupas AN, Newman J, Peat TS, Piepenbrink KH, Prahlad J, van Raaij MJ, Rohwer F, Segall AM, Seguritan V, Sundberg EJ, Singh AK, Wilson MA, Schwede T.

Proteins. 2016 Sep;84 Suppl 1:34-50. doi: 10.1002/prot.24942. Epub 2015 Nov 16.

18.

Pharmacy Practice Model Initiative task force report: Improving participation in a survey on hospital pharmacy practices in Texas.

Philip A, Gessner-Wharton M, Birney P, Blee J, Desai A, Gorbach C, Karralli R, Lorimer D, Munch K, Nweke G, Parekh S, Puebla M, Cox R, Pitman EP, Garey KW.

Am J Health Syst Pharm. 2015 Jun 15;72(12):1053-7. doi: 10.2146/ajhp140471.

PMID:
26025997
19.

High-resolution Crystal Structure of Dimeric VP40 From Sudan ebolavirus.

Clifton MC, Bruhn JF, Atkins K, Webb TL, Baydo RO, Raymond A, Lorimer DD, Edwards TE, Myler PJ, Saphire EO.

J Infect Dis. 2015 Oct 1;212 Suppl 2:S167-71. doi: 10.1093/infdis/jiv090. Epub 2015 May 9.

20.

Structures of prostaglandin F synthase from the protozoa Leishmania major and Trypanosoma cruzi with NADP.

Moen SO, Fairman JW, Barnes SR, Sullivan A, Nakazawa-Hewitt S, Van Voorhis WC, Staker BL, Lorimer DD, Myler PJ, Edwards TE.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):609-14. doi: 10.1107/S2053230X15006883. Epub 2015 Apr 21.

21.

Structures of a histidine triad family protein from Entamoeba histolytica bound to sulfate, AMP and GMP.

Lorimer DD, Choi R, Abramov A, Nakazawa Hewitt S, Gardberg AS, Van Voorhis WC, Staker BL, Myler PJ, Edwards TE.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):572-6. doi: 10.1107/S2053230X1500237X. Epub 2015 Apr 21.

22.

Structures of aspartate aminotransferases from Trypanosoma brucei, Leishmania major and Giardia lamblia.

Abendroth J, Choi R, Wall A, Clifton MC, Lukacs CM, Staker BL, Van Voorhis W, Myler P, Lorimer DD, Edwards TE.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):566-71. doi: 10.1107/S2053230X15001831. Epub 2015 Apr 21.

23.

Structure of uridine diphosphate N-acetylglucosamine pyrophosphorylase from Entamoeba histolytica.

Edwards TE, Gardberg AS, Phan IQ, Zhang Y, Staker BL, Myler PJ, Lorimer DD.

Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):560-5. doi: 10.1107/S2053230X1500179X. Epub 2015 Apr 21.

24.

Crystal structures of Mycobacterial MeaB and MMAA-like GTPases.

Edwards TE, Baugh L, Bullen J, Baydo RO, Witte P, Thompkins K, Phan IQ, Abendroth J, Clifton MC, Sankaran B, Van Voorhis WC, Myler PJ, Staker BL, Grundner C, Lorimer DD.

J Struct Funct Genomics. 2015 Jun;16(2):91-9. doi: 10.1007/s10969-015-9197-2. Epub 2015 Apr 2.

25.

Increasing the structural coverage of tuberculosis drug targets.

Baugh L, Phan I, Begley DW, Clifton MC, Armour B, Dranow DM, Taylor BM, Muruthi MM, Abendroth J, Fairman JW, Fox D 3rd, Dieterich SH, Staker BL, Gardberg AS, Choi R, Hewitt SN, Napuli AJ, Myers J, Barrett LK, Zhang Y, Ferrell M, Mundt E, Thompkins K, Tran N, Lyons-Abbott S, Abramov A, Sekar A, Serbzhinskiy D, Lorimer D, Buchko GW, Stacy R, Stewart LJ, Edwards TE, Van Voorhis WC, Myler PJ.

Tuberculosis (Edinb). 2015 Mar;95(2):142-8. doi: 10.1016/j.tube.2014.12.003. Epub 2014 Dec 19.

26.

Tyrosine aminotransferase from Leishmania infantum: A new drug target candidate.

Moreno MA, Alonso A, Alcolea PJ, Abramov A, de Lacoba MG, Abendroth J, Zhang S, Edwards T, Lorimer D, Myler PJ, Larraga V.

Int J Parasitol Drugs Drug Resist. 2014 Jul 30;4(3):347-54. doi: 10.1016/j.ijpddr.2014.06.001. eCollection 2014 Dec.

27.

Structural analysis of H1N1 and H7N9 influenza A virus PA in the absence of PB1.

Moen SO, Abendroth J, Fairman JW, Baydo RO, Bullen J, Kirkwood JL, Barnes SR, Raymond AC, Begley DW, Henkel G, McCormack K, Tam VC, Phan I, Staker BL, Stacy R, Myler PJ, Lorimer D, Edwards TE.

Sci Rep. 2014 Aug 4;4:5944. doi: 10.1038/srep05944.

28.

Structure of tyrosine aminotransferase from Leishmania infantum.

Moreno MA, Abramov A, Abendroth J, Alonso A, Zhang S, Alcolea PJ, Edwards T, Lorimer D, Myler PJ, Larraga V.

Acta Crystallogr F Struct Biol Commun. 2014 May;70(Pt 5):583-7. doi: 10.1107/S2053230X14007845. Epub 2014 Apr 25.

29.

Structure of the Reston ebolavirus VP30 C-terminal domain.

Clifton MC, Kirchdoerfer RN, Atkins K, Abendroth J, Raymond A, Grice R, Barnes S, Moen S, Lorimer D, Edwards TE, Myler PJ, Saphire EO.

Acta Crystallogr F Struct Biol Commun. 2014 Apr;70(Pt 4):457-60. doi: 10.1107/S2053230X14003811. Epub 2014 Mar 25.

30.

A millisecond pulsar in a stellar triple system.

Ransom SM, Stairs IH, Archibald AM, Hessels JW, Kaplan DL, van Kerkwijk MH, Boyles J, Deller AT, Chatterjee S, Schechtman-Rook A, Berndsen A, Lynch RS, Lorimer DR, Karako-Argaman C, Kaspi VM, Kondratiev VI, McLaughlin MA, van Leeuwen J, Rosen R, Roberts MS, Stovall K.

Nature. 2014 Jan 23;505(7484):520-4. doi: 10.1038/nature12917. Epub 2014 Jan 5.

PMID:
24390352
31.

A structural biology approach enables the development of antimicrobials targeting bacterial immunophilins.

Begley DW, Fox D 3rd, Jenner D, Juli C, Pierce PG, Abendroth J, Muruthi M, Safford K, Anderson V, Atkins K, Barnes SR, Moen SO, Raymond AC, Stacy R, Myler PJ, Staker BL, Harmer NJ, Norville IH, Holzgrabe U, Sarkar-Tyson M, Edwards TE, Lorimer DD.

Antimicrob Agents Chemother. 2014;58(3):1458-67. doi: 10.1128/AAC.01875-13. Epub 2013 Dec 23.

32.

Challenging the state of the art in protein structure prediction: Highlights of experimental target structures for the 10th Critical Assessment of Techniques for Protein Structure Prediction Experiment CASP10.

Kryshtafovych A, Moult J, Bales P, Bazan JF, Biasini M, Burgin A, Chen C, Cochran FV, Craig TK, Das R, Fass D, Garcia-Doval C, Herzberg O, Lorimer D, Luecke H, Ma X, Nelson DC, van Raaij MJ, Rohwer F, Segall A, Seguritan V, Zeth K, Schwede T.

Proteins. 2014 Feb;82 Suppl 2:26-42. doi: 10.1002/prot.24489. Erratum in: Proteins. 2015 Jun;83(6):1198.

33.

Multi-target parallel processing approach for gene-to-structure determination of the influenza polymerase PB2 subunit.

Armour BL, Barnes SR, Moen SO, Smith E, Raymond AC, Fairman JW, Stewart LJ, Staker BL, Begley DW, Edwards TE, Lorimer DD.

J Vis Exp. 2013 Jun 28;(76). doi: 10.3791/4225.

34.

Structure and function of a cyanophage-encoded peptide deformylase.

Frank JA, Lorimer D, Youle M, Witte P, Craig T, Abendroth J, Rohwer F, Edwards RA, Segall AM, Burgin AB Jr.

ISME J. 2013 Jun;7(6):1150-60. doi: 10.1038/ismej.2013.4. Epub 2013 Feb 14.

35.

Artificial neural networks trained to detect viral and phage structural proteins.

Seguritan V, Alves N Jr, Arnoult M, Raymond A, Lorimer D, Burgin AB Jr, Salamon P, Segall AM.

PLoS Comput Biol. 2012;8(8):e1002657. doi: 10.1371/journal.pcbi.1002657. Epub 2012 Aug 23.

36.

A centenary year.

Lorimer DL.

Foot (Edinb). 2012 Jun;22(2):55. doi: 10.1016/j.foot.2012.04.006. Epub 2012 May 4. No abstract available.

PMID:
22560260
37.

Dr. Vince Hetherington and the Federation Internacionale des Podologues.

Lorimer DL.

Foot (Edinb). 2011 Dec;21(4):165. doi: 10.1016/j.foot.2011.10.001. Epub 2011 Nov 9. No abstract available.

PMID:
22078100
38.

Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis.

Begley DW, Edwards TE, Raymond AC, Smith ER, Hartley RC, Abendroth J, Sankaran B, Lorimer DD, Myler PJ, Staker BL, Stewart LJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):1070-7. doi: 10.1107/S1744309111029009. Epub 2011 Aug 16.

39.

Gene design, cloning and protein-expression methods for high-value targets at the Seattle Structural Genomics Center for Infectious Disease.

Raymond A, Haffner T, Ng N, Lorimer D, Staker B, Stewart L.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):992-7. doi: 10.1107/S1744309111026698. Epub 2011 Aug 13.

40.

Gene Composer in a structural genomics environment.

Lorimer D, Raymond A, Mixon M, Burgin A, Staker B, Stewart L.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt 9):985-91. doi: 10.1107/S1744309111027424. Epub 2011 Aug 13.

41.

Dr jeffrey page.

Lorimer D.

Foot (Edinb). 2011 Jun;21(2):58. doi: 10.1016/j.foot.2011.04.003. Epub 2011 May 8. No abstract available.

PMID:
21550795
42.

The foot represents a unique inter-professional forum for a world-wide focus.

Page J, Lorimer D.

Foot (Edinb). 2011 Jun;21(2):59. doi: 10.1016/j.foot.2011.04.002. Epub 2011 May 7. No abstract available.

PMID:
21550228
43.

Pulsar discovery by global volunteer computing.

Knispel B, Allen B, Cordes JM, Deneva JS, Anderson D, Aulbert C, Bhat ND, Bock O, Bogdanov S, Brazier A, Camilo F, Champion DJ, Chatterjee S, Crawford F, Demorest PB, Fehrmann H, Freire PC, Gonzalez ME, Hammer D, Hessels JW, Jenet FA, Kasian L, Kaspi VM, Kramer M, Lazarus P, van Leeuwen J, Lorimer DR, Lyne AG, Machenschalk B, McLaughlin MA, Messenger C, Nice DJ, Papa MA, Pletsch HJ, Prix R, Ransom SM, Siemens X, Stairs IH, Stappers BW, Stovall K, Venkataraman A.

Science. 2010 Sep 10;329(5997):1305. doi: 10.1126/science.1195253. Epub 2010 Aug 12. Erratum in: Science. 2010 Nov 5;330(6005):756.

44.

A radio pulsar/x-ray binary link.

Archibald AM, Stairs IH, Ransom SM, Kaspi VM, Kondratiev VI, Lorimer DR, McLaughlin MA, Boyles J, Hessels JW, Lynch R, van Leeuwen J, Roberts MS, Jenet F, Champion DJ, Rosen R, Barlow BN, Dunlap BH, Remillard RA.

Science. 2009 Jun 12;324(5933):1411-4. doi: 10.1126/science.1172740. Epub 2009 May 21.

45.

Combined protein construct and synthetic gene engineering for heterologous protein expression and crystallization using Gene Composer.

Raymond A, Lovell S, Lorimer D, Walchli J, Mixon M, Wallace E, Thompkins K, Archer K, Burgin A, Stewart L.

BMC Biotechnol. 2009 Apr 21;9:37. doi: 10.1186/1472-6750-9-37.

46.

Gene composer: database software for protein construct design, codon engineering, and gene synthesis.

Lorimer D, Raymond A, Walchli J, Mixon M, Barrow A, Wallace E, Grice R, Burgin A, Stewart L.

BMC Biotechnol. 2009 Apr 21;9:36. doi: 10.1186/1472-6750-9-36.

47.

An eccentric binary millisecond pulsar in the galactic plane.

Champion DJ, Ransom SM, Lazarus P, Camilo F, Bassa C, Kaspi VM, Nice DJ, Freire PC, Stairs IH, van Leeuwen J, Stappers BW, Cordes JM, Hessels JW, Lorimer DR, Arzoumanian Z, Backer DC, Bhat ND, Chatterjee S, Cognard I, Deneva JS, Faucher-Giguère CA, Gaensler BM, Han J, Jenet FA, Kasian L, Kondratiev VI, Kramer M, Lazio J, McLaughlin MA, Venkataraman A, Vlemmings W.

Science. 2008 Jun 6;320(5881):1309-12. doi: 10.1126/science.1157580. Epub 2008 May 15.

48.

Binary and Millisecond Pulsars.

Lorimer DR.

Living Rev Relativ. 2008;11(1):8. doi: 10.12942/lrr-2008-8. Epub 2008 Nov 4. Review.

49.

A bright millisecond radio burst of extragalactic origin.

Lorimer DR, Bailes M, McLaughlin MA, Narkevic DJ, Crawford F.

Science. 2007 Nov 2;318(5851):777-80. Epub 2007 Sep 27.

50.

Tests of general relativity from timing the double pulsar.

Kramer M, Stairs IH, Manchester RN, McLaughlin MA, Lyne AG, Ferdman RD, Burgay M, Lorimer DR, Possenti A, D'Amico N, Sarkissian JM, Hobbs GB, Reynolds JE, Freire PC, Camilo F.

Science. 2006 Oct 6;314(5796):97-102. Epub 2006 Sep 14.

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