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Items: 1 to 50 of 113

1.

ANP32A regulates ATM expression and prevents oxidative stress in cartilage, brain, and bone.

Cornelis FMF, Monteagudo S, Guns LKA, den Hollander W, Nelissen RGHH, Storms L, Peeters T, Jonkers I, Meulenbelt I, Lories RJ.

Sci Transl Med. 2018 Sep 12;10(458). pii: eaar8426. doi: 10.1126/scitranslmed.aar8426.

PMID:
30209244
2.

A Notch in the joint that exacerbates osteoarthritis.

Monteagudo S, Lories RJ.

Nat Rev Rheumatol. 2018 Sep 5. doi: 10.1038/s41584-018-0076-7. [Epub ahead of print] No abstract available.

PMID:
30185988
3.

Suramin increases cartilage proteoglycan accumulation in vitro and protects against joint damage triggered by papain injection in mouse knees in vivo.

Guns LA, Monteagudo S, Kvasnytsia M, Kerckhofs G, Vandooren J, Opdenakker G, Lories RJ, Cailotto F.

RMD Open. 2017 Nov 30;3(2):e000604. doi: 10.1136/rmdopen-2017-000604. eCollection 2017.

4.

Enthesitis: from pathophysiology to treatment.

Schett G, Lories RJ, D'Agostino MA, Elewaut D, Kirkham B, Soriano ER, McGonagle D.

Nat Rev Rheumatol. 2017 Nov 21;13(12):731-741. doi: 10.1038/nrrheum.2017.188. Review.

PMID:
29158573
5.

Cushioning the cartilage: a canonical Wnt restricting matter.

Monteagudo S, Lories RJ.

Nat Rev Rheumatol. 2017 Nov;13(11):670-681. doi: 10.1038/nrrheum.2017.171. Epub 2017 Oct 12. Review.

PMID:
29021569
6.

DOT1L safeguards cartilage homeostasis and protects against osteoarthritis.

Monteagudo S, Cornelis FMF, Aznar-Lopez C, Yibmantasiri P, Guns LA, Carmeliet P, Cailotto F, Lories RJ.

Nat Commun. 2017 Jun 19;8:15889. doi: 10.1038/ncomms15889.

7.

Structural Disease Progression in Axial Spondyloarthritis: Still a Cause for Concern?

Neerinckx B, Lories RJ.

Curr Rheumatol Rep. 2017 Mar;19(3):14. doi: 10.1007/s11926-017-0639-7. Review.

PMID:
28265849
8.

Insulin-Like Growth Factor I Does Not Drive New Bone Formation in Experimental Arthritis.

van Tok MN, Yeremenko NG, Teitsma CA, Kream BE, Knaup VL, Lories RJ, Baeten DL, van Duivenvoorde LM.

PLoS One. 2016 Oct 3;11(10):e0163632. doi: 10.1371/journal.pone.0163632. eCollection 2016.

9.

Orthopaedic interventions in patients with psoriatic arthritis: a descriptive report from the SPAR cohort.

Haque N, Lories RJ, de Vlam K.

RMD Open. 2016 Aug 17;2(2):e000293. doi: 10.1136/rmdopen-2016-000293. eCollection 2016.

10.

MAIT cells: not just another brick in the wall.

Debusschere K, Lories RJ, Elewaut D.

Ann Rheum Dis. 2016 Dec;75(12):2057-2059. doi: 10.1136/annrheumdis-2016-209695. Epub 2016 Jul 29. No abstract available.

PMID:
27474762
11.

Aberrant Calreticulin Expression in Articular Cartilage of Dio2 Deficient Mice.

Bomer N, Cornelis FM, Ramos YF, den Hollander W, Lakenberg N, van der Breggen R, Storms L, Slagboom PE, Lories RJ, Meulenbelt I.

PLoS One. 2016 May 10;11(5):e0154999. doi: 10.1371/journal.pone.0154999. eCollection 2016.

12.

Safety and Efficacy of Biological Disease-Modifying Antirheumatic Drugs in Older Rheumatoid Arthritis Patients: Staying the Distance.

Ishchenko A, Lories RJ.

Drugs Aging. 2016 Jun;33(6):387-98. doi: 10.1007/s40266-016-0374-1. Review.

PMID:
27154398
13.

CRP and a biomarker of type I collagen degradation, C1M, can differentiate anti-inflammatory treatment response in ankylosing spondylitis.

Siebuhr AS, Bay-Jensen AC, Karsdal MA, Lories RJ, de Vlam K.

Biomark Med. 2016;10(2):197-208. doi: 10.2217/bmm.15.119. Epub 2016 Jan 14.

PMID:
26764293
14.

Microtrauma: no longer to be ignored in spondyloarthritis?

Van Mechelen M, Lories RJ.

Curr Opin Rheumatol. 2016 Mar;28(2):176-80. doi: 10.1097/BOR.0000000000000254. Review.

PMID:
26751839
15.

Comorbidities Associated with Psoriatic Arthritis Compared with Non-psoriatic Spondyloarthritis: A Cross-sectional Study.

Haque N, Lories RJ, de Vlam K.

J Rheumatol. 2016 Feb;43(2):376-82. doi: 10.3899/jrheum.141359. Epub 2015 Dec 15.

PMID:
26669922
16.

Longitudinal micro-CT provides biomarkers of lung disease that can be used to assess the effect of therapy in preclinical mouse models, and reveal compensatory changes in lung volume.

Vande Velde G, Poelmans J, De Langhe E, Hillen A, Vanoirbeek J, Himmelreich U, Lories RJ.

Dis Model Mech. 2016 Jan;9(1):91-8. doi: 10.1242/dmm.020321. Epub 2015 Nov 12.

17.

Review: animal models as a tool to dissect pivotal pathways driving spondyloarthritis.

Vieira-Sousa E, van Duivenvoorde LM, Fonseca JE, Lories RJ, Baeten DL.

Arthritis Rheumatol. 2015 Nov;67(11):2813-27. doi: 10.1002/art.39282. Review. No abstract available.

18.

Spreading spondyloarthritis: are ILCs cytokine shuttles from base camp gut?

Neerinckx B, Elewaut D, Lories RJ.

Ann Rheum Dis. 2015 Sep;74(9):1633-5. doi: 10.1136/annrheumdis-2015-207735. Epub 2015 Jul 21. No abstract available.

PMID:
26199396
19.

Enhanced endogenous bone morphogenetic protein signaling protects against bleomycin induced pulmonary fibrosis.

De Langhe E, Cailotto F, De Vooght V, Aznar-Lopez C, Vanoirbeek JA, Luyten FP, Lories RJ.

Respir Res. 2015 Mar 15;16:38. doi: 10.1186/s12931-015-0202-x.

20.

Targets, models and challenges in osteoarthritis research.

Thysen S, Luyten FP, Lories RJ.

Dis Model Mech. 2015 Jan;8(1):17-30. doi: 10.1242/dmm.016881. Review.

21.

The effect of forced exercise on knee joints in Dio2(-/-) mice: type II iodothyronine deiodinase-deficient mice are less prone to develop OA-like cartilage damage upon excessive mechanical stress.

Bomer N, Cornelis FM, Ramos YF, den Hollander W, Storms L, van der Breggen R, Lakenberg N, Slagboom PE, Meulenbelt I, Lories RJ.

Ann Rheum Dis. 2016 Mar;75(3):571-7. doi: 10.1136/annrheumdis-2014-206608. Epub 2014 Dec 30.

PMID:
25550340
22.

Bone formation in axial spondyloarthritis.

Lories RJ, Haroon N.

Best Pract Res Clin Rheumatol. 2014 Oct;28(5):765-77. doi: 10.1016/j.berh.2014.10.008. Epub 2014 Nov 1. Review.

PMID:
25488783
23.

Loss of Frzb and Sfrp1 differentially affects joint homeostasis in instability-induced osteoarthritis.

Thysen S, Luyten FP, Lories RJ.

Osteoarthritis Cartilage. 2015 Feb;23(2):275-9. doi: 10.1016/j.joca.2014.10.010. Epub 2014 Oct 30.

24.

Tumour necrosis factor inhibitors in the treatment of psoriatic arthritis: a view on effectiveness, clinical practice and toxicity.

Lories RJ, de Vlam K.

Expert Opin Biol Ther. 2014 Dec;14(12):1825-36. doi: 10.1517/14712598.2014.967211. Epub 2014 Nov 4. Review.

PMID:
25366335
25.

Secreted frizzled related proteins inhibit fibrosis in vitro but appear redundant in vivo.

De Langhe E, Aznar-Lopez C, De Vooght V, Vanoirbeek JA, Luyten FP, Lories RJ.

Fibrogenesis Tissue Repair. 2014 Oct 2;7:14. doi: 10.1186/1755-1536-7-14. eCollection 2014.

26.

Protective role of frizzled-related protein B on matrix metalloproteinase induction in mouse chondrocytes.

Bougault C, Priam S, Houard X, Pigenet A, Sudre L, Lories RJ, Jacques C, Berenbaum F.

Arthritis Res Ther. 2014 Jul 1;16(4):R137. doi: 10.1186/ar4599.

27.

Genome-wide association and functional studies identify a role for IGFBP3 in hip osteoarthritis.

Evans DS, Cailotto F, Parimi N, Valdes AM, Castaño-Betancourt MC, Liu Y, Kaplan RC, Bidlingmaier M, Vasan RS, Teumer A, Tranah GJ, Nevitt MC, Cummings SR, Orwoll ES, Barrett-Connor E, Renner JB, Jordan JM, Doherty M, Doherty SA, Uitterlinden AG, van Meurs JB, Spector TD, Lories RJ, Lane NE.

Ann Rheum Dis. 2015 Oct;74(10):1861-7. doi: 10.1136/annrheumdis-2013-205020. Epub 2014 Jun 13.

28.
29.

Anti-TNF therapy and malignancy in spondyloarthritis in the Leuven spondyloarthritis biologics cohort (BIOSPAR).

Westhovens I, Lories RJ, Westhovens R, Verschueren P, de Vlam K.

Clin Exp Rheumatol. 2014 Jan-Feb;32(1):71-6. Epub 2013 Dec 2.

PMID:
24295201
30.

The coupling of bone and cartilage turnover in osteoarthritis: opportunities for bone antiresorptives and anabolics as potential treatments?

Karsdal MA, Bay-Jensen AC, Lories RJ, Abramson S, Spector T, Pastoureau P, Christiansen C, Attur M, Henriksen K, Goldring SR, Kraus V.

Ann Rheum Dis. 2014 Feb;73(2):336-48. doi: 10.1136/annrheumdis-2013-204111. Epub 2013 Nov 27. Review.

PMID:
24285494
31.

No evidence for a critical role of the unfolded protein response in synovium and blood of patients with ankylosing spondylitis.

Neerinckx B, Carter S, Lories RJ.

Ann Rheum Dis. 2014 Mar;73(3):629-30. doi: 10.1136/annrheumdis-2013-204170. Epub 2013 Oct 8. No abstract available.

PMID:
24106049
32.

Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells.

Jacques P, Lambrecht S, Verheugen E, Pauwels E, Kollias G, Armaka M, Verhoye M, Van der Linden A, Achten R, Lories RJ, Elewaut D.

Ann Rheum Dis. 2014 Feb;73(2):437-45. doi: 10.1136/annrheumdis-2013-203643. Epub 2013 Aug 6.

PMID:
23921997
33.

The influence of ageing on the development and management of rheumatoid arthritis.

Boots AM, Maier AB, Stinissen P, Masson P, Lories RJ, De Keyser F.

Nat Rev Rheumatol. 2013 Oct;9(10):604-13. doi: 10.1038/nrrheum.2013.92. Epub 2013 Jun 18. Review.

PMID:
23774902
34.

To Wnt or not to Wnt: the bone and joint health dilemma.

Lories RJ, Corr M, Lane NE.

Nat Rev Rheumatol. 2013 Jun;9(6):328-39. doi: 10.1038/nrrheum.2013.25. Epub 2013 Mar 5. Review.

35.

Spontaneous arthritis and ankylosis in male DBA/1 mice: further evidence for a role of behavioral factors in "stress-induced arthritis".

Braem K, Carter S, Lories RJ.

Biol Proced Online. 2012 Dec 19;14(1):10. doi: 10.1186/1480-9222-14-10.

36.

Etoricoxib and the treatment of ankylosing spondylitis.

Lories RJ.

Expert Opin Drug Metab Toxicol. 2012 Dec;8(12):1599-608. doi: 10.1517/17425255.2012.741120. Epub 2012 Nov 6. Review.

PMID:
23126318
37.

Pathophysiology of new bone formation and ankylosis in spondyloarthritis.

Lories RJ, Schett G.

Rheum Dis Clin North Am. 2012 Aug;38(3):555-67. doi: 10.1016/j.rdc.2012.08.003. Epub 2012 Sep 7. Review.

PMID:
23083755
38.

Quantification of lung fibrosis and emphysema in mice using automated micro-computed tomography.

De Langhe E, Vande Velde G, Hostens J, Himmelreich U, Nemery B, Luyten FP, Vanoirbeek J, Lories RJ.

PLoS One. 2012;7(8):e43123. doi: 10.1371/journal.pone.0043123. Epub 2012 Aug 13.

39.

The role of bone morphogenetic proteins in ankylosing spondylitis.

Carter S, Braem K, Lories RJ.

Ther Adv Musculoskelet Dis. 2012 Aug;4(4):293-9. doi: 10.1177/1759720X12444175.

40.

Genetic deletion of low-density lipoprotein receptor-related protein 5 increases cartilage degradation in instability-induced osteoarthritis.

Lodewyckx L, Luyten FP, Lories RJ.

Rheumatology (Oxford). 2012 Nov;51(11):1973-8. doi: 10.1093/rheumatology/kes178. Epub 2012 Jul 31.

PMID:
22850184
41.

Primed for inflammation: enthesis-resident T cells.

Lories RJ, McInnes IB.

Nat Med. 2012 Jul 6;18(7):1018-9. doi: 10.1038/nm.2854. No abstract available.

PMID:
22772553
42.

Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis.

Castaño Betancourt MC, Cailotto F, Kerkhof HJ, Cornelis FM, Doherty SA, Hart DJ, Hofman A, Luyten FP, Maciewicz RA, Mangino M, Metrustry S, Muir K, Peters MJ, Rivadeneira F, Wheeler M, Zhang W, Arden N, Spector TD, Uitterlinden AG, Doherty M, Lories RJ, Valdes AM, van Meurs JB.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8218-23. doi: 10.1073/pnas.1119899109. Epub 2012 May 7.

43.

Is psoriatic arthritis a result of abnormalities in acquired or innate immunity?

Lories RJ, de Vlam K.

Curr Rheumatol Rep. 2012 Aug;14(4):375-82. doi: 10.1007/s11926-012-0257-3. Review.

PMID:
22527951
44.

Inhibition of inflammation but not ankylosis by glucocorticoids in mice: further evidence for the entheseal stress hypothesis.

Braem K, Deroose CM, Luyten FP, Lories RJ.

Arthritis Res Ther. 2012 Mar 12;14(2):R59. doi: 10.1186/ar3772.

45.

Inflammation and ankylosis: still an enigmatic relationship in spondyloarthritis.

Lories RJ, Dougados M.

Ann Rheum Dis. 2012 Mar;71(3):317-8. doi: 10.1136/annrheumdis-2011-200842. No abstract available.

PMID:
22315213
46.

Tight regulation of wingless-type signaling in the articular cartilage - subchondral bone biomechanical unit: transcriptomics in Frzb-knockout mice.

Lodewyckx L, Cailotto F, Thysen S, Luyten FP, Lories RJ.

Arthritis Res Ther. 2012 Jan 20;14(1):R16. doi: 10.1186/ar3695.

47.

Osteoarthritis, a disease bridging development and regeneration.

Lories RJ, Luyten FP.

Bonekey Rep. 2012 Aug 1;1:136. doi: 10.1038/bonekey.2012.136. eCollection 2012.

48.

Blocking p38 signalling inhibits chondrogenesis in vitro but not ankylosis in a model of ankylosing spondylitis in vivo.

Braem K, Luyten FP, Lories RJ.

Ann Rheum Dis. 2012 May;71(5):722-8. doi: 10.1136/annrheumdis-2011-200377. Epub 2011 Nov 25.

PMID:
22121131
49.

Insights into the pathophysiology of ankylosing spondylitis: contributions from animal models.

Braem K, Lories RJ.

Joint Bone Spine. 2012 May;79(3):243-8. doi: 10.1016/j.jbspin.2011.09.008. Epub 2011 Nov 12. Review.

PMID:
22079413
50.

Changing the outcome of osteoarthritis: still a challenge for cyclooxygenase 2 inhibitors.

Lories RJ.

Arthritis Rheum. 2012 Jan;64(1):37-9. doi: 10.1002/art.33330. No abstract available.

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