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Items: 18


KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice.

Polson ES, Kuchler VB, Abbosh C, Ross EM, Mathew RK, Beard HA, da Silva B, Holding AN, Ballereau S, Chuntharpursat-Bon E, Williams J, Griffiths HBS, Shao H, Patel A, Davies AJ, Droop A, Chumas P, Short SC, Lorger M, Gestwicki JE, Roberts LD, Bon RS, Allison SJ, Zhu S, Markowetz F, Wurdak H.

Sci Transl Med. 2018 Aug 15;10(454). pii: eaar2718. doi: 10.1126/scitranslmed.aar2718.


Anti-PD-1/anti-CTLA-4 efficacy in melanoma brain metastases depends on extracranial disease and augmentation of CD8+ T cell trafficking.

Taggart D, Andreou T, Scott KJ, Williams J, Rippaus N, Brownlie RJ, Ilett EJ, Salmond RJ, Melcher A, Lorger M.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1540-E1549. doi: 10.1073/pnas.1714089115. Epub 2018 Jan 31.


TRPA1-FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p.

Berrout J, Kyriakopoulou E, Moparthi L, Hogea AS, Berrout L, Ivan C, Lorger M, Boyle J, Peers C, Muench S, Gomez JE, Hu X, Hurst C, Hall T, Umamaheswaran S, Wesley L, Gagea M, Shires M, Manfield I, Knowles MA, Davies S, Suhling K, Gonzalez YT, Carragher N, Macleod K, Abbott NJ, Calin GA, Gamper N, Zygmunt PM, Timsah Z.

Nat Commun. 2017 Oct 16;8(1):947. doi: 10.1038/s41467-017-00983-w.


Metastatic site-specific polarization of macrophages in intracranial breast cancer metastases.

Rippaus N, Taggart D, Williams J, Andreou T, Wurdak H, Wronski K, Lorger M.

Oncotarget. 2016 Jul 5;7(27):41473-41487. doi: 10.18632/oncotarget.9445.


Activated tumor cell integrin αvβ3 cooperates with platelets to promote extravasation and metastasis from the blood stream.

Weber MR, Zuka M, Lorger M, Tschan M, Torbett BE, Zijlstra A, Quigley JP, Staflin K, Eliceiri BP, Krueger JS, Marchese P, Ruggeri ZM, Felding BH.

Thromb Res. 2016 Apr;140 Suppl 1:S27-36. doi: 10.1016/S0049-3848(16)30095-0.


A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis.

Abraham S, Scarcia M, Bagshaw RD, McMahon K, Grant G, Harvey T, Yeo M, Esteves FO, Thygesen HH, Jones PF, Speirs V, Hanby AM, Selby PJ, Lorger M, Dear TN, Pawson T, Marshall CJ, Mavria G.

Nat Commun. 2015 Jul 1;6:7286. doi: 10.1038/ncomms8286.


Tumor microenvironment in the brain.

Lorger M.

Cancers (Basel). 2012 Feb 22;4(1):218-43. doi: 10.3390/cancers4010218.


Comparison of in vitro and in vivo approaches to studying brain colonization by breast cancer cells.

Lorger M, Lee H, Forsyth JS, Felding-Habermann B.

J Neurooncol. 2011 Sep;104(3):689-96. doi: 10.1007/s11060-011-0550-4. Epub 2011 Feb 27.


Capturing changes in the brain microenvironment during initial steps of breast cancer brain metastasis.

Lorger M, Felding-Habermann B.

Am J Pathol. 2010 Jun;176(6):2958-71. doi: 10.2353/ajpath.2010.090838. Epub 2010 Apr 9.


Targeting activated integrin alphavbeta3 with patient-derived antibodies impacts late-stage multiorgan metastasis.

Staflin K, Krueger JS, Hachmann J, Forsyth JS, Lorger M, Steiniger SC, Mee J, Pop C, Salvesen GS, Janda KD, Felding-Habermann B.

Clin Exp Metastasis. 2010 Apr;27(4):217-31. doi: 10.1007/s10585-010-9320-5. Epub 2010 Mar 12.


An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation.

Wurdak H, Zhu S, Romero A, Lorger M, Watson J, Chiang CY, Zhang J, Natu VS, Lairson LL, Walker JR, Trussell CM, Harsh GR, Vogel H, Felding-Habermann B, Orth AP, Miraglia LJ, Rines DR, Skirboll SL, Schultz PG.

Cell Stem Cell. 2010 Jan 8;6(1):37-47. doi: 10.1016/j.stem.2009.11.002.


Activation of tumor cell integrin alphavbeta3 controls angiogenesis and metastatic growth in the brain.

Lorger M, Krueger JS, O'Neal M, Staflin K, Felding-Habermann B.

Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10666-71. doi: 10.1073/pnas.0903035106. Epub 2009 Jun 16.


c-Src-mediated epithelial cell migration and invasion regulated by PDZ binding site.

Baumgartner M, Radziwill G, Lorger M, Weiss A, Moelling K.

Mol Cell Biol. 2008 Jan;28(2):642-55. Epub 2007 Nov 26.


Role of AF6 protein in cell-to-cell spread of Herpes simplex virus 1.

Keyser J, Lorger M, Pavlovic J, Radziwill G, Moelling K.

FEBS Lett. 2007 Nov 27;581(28):5349-54. Epub 2007 Oct 29.


Serum-stable RNA aptamers to an invariant surface domain of live African trypanosomes.

Homann M, Lorger M, Engstler M, Zacharias M, Göringer HU.

Comb Chem High Throughput Screen. 2006 Aug;9(7):491-9.


Regulation of epithelial wound closure and intercellular adhesion by interaction of AF6 with actin cytoskeleton.

Lorger M, Moelling K.

J Cell Sci. 2006 Aug 15;119(Pt 16):3385-98. Epub 2006 Aug 1.


In vitro selection of high-affinity nucleic acid ligands to parasite target molecules.

Göringer HU, Homann M, Lorger M.

Int J Parasitol. 2003 Oct;33(12):1309-17.


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