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Items: 31

1.

Safety, pharmacokinetics, and immunogenicity of the combination of the broadly neutralizing anti-HIV-1 antibodies 3BNC117 and 10-1074 in healthy adults: A randomized, phase 1 study.

Cohen YZ, Butler AL, Millard K, Witmer-Pack M, Levin R, Unson-O'Brien C, Patel R, Shimeliovich I, Lorenzi JCC, Horowitz J, Walsh SR, Lin S, Weiner JA, Tse A, Sato A, Bennett C, Mayer B, Seaton KE, Yates NL, Baden LR, deCamp AC, Ackerman ME, Seaman MS, Tomaras GD, Nussenzweig MC, Caskey M.

PLoS One. 2019 Aug 8;14(8):e0219142. doi: 10.1371/journal.pone.0219142. eCollection 2019.

2.

Combination of quadruplex qPCR and next-generation sequencing for qualitative and quantitative analysis of the HIV-1 latent reservoir.

Gaebler C, Lorenzi JCC, Oliveira TY, Nogueira L, Ramos V, Lu CL, Pai JA, Mendoza P, Jankovic M, Caskey M, Nussenzweig MC.

J Exp Med. 2019 Oct 7;216(10):2253-2264. doi: 10.1084/jem.20190896. Epub 2019 Jul 26.

3.

Characterization of Intact Proviruses in Blood and Lymph Node from HIV-Infected Individuals Undergoing Analytical Treatment Interruption.

Vibholm LK, Lorenzi JCC, Pai JA, Cohen YZ, Oliveira TY, Barton JP, Garcia Noceda M, Lu CL, Ablanedo-Terrazas Y, Del Rio Estrada PM, Reyes-Teran G, Tolstrup M, Denton PW, Damsgaard T, Søgaard OS, Nussenzweig MC.

J Virol. 2019 Apr 3;93(8). pii: e01920-18. doi: 10.1128/JVI.01920-18. Print 2019 Apr 15.

4.

Relationship between intact HIV-1 proviruses in circulating CD4+ T cells and rebound viruses emerging during treatment interruption.

Lu CL, Pai JA, Nogueira L, Mendoza P, Gruell H, Oliveira TY, Barton J, Lorenzi JCC, Cohen YZ, Cohn LB, Klein F, Caskey M, Nussenzweig MC, Jankovic M.

Proc Natl Acad Sci U S A. 2018 Nov 27;115(48):E11341-E11348. doi: 10.1073/pnas.1813512115. Epub 2018 Nov 12.

5.

Combination therapy with anti-HIV-1 antibodies maintains viral suppression.

Mendoza P, Gruell H, Nogueira L, Pai JA, Butler AL, Millard K, Lehmann C, Suárez I, Oliveira TY, Lorenzi JCC, Cohen YZ, Wyen C, Kümmerle T, Karagounis T, Lu CL, Handl L, Unson-O'Brien C, Patel R, Ruping C, Schlotz M, Witmer-Pack M, Shimeliovich I, Kremer G, Thomas E, Seaton KE, Horowitz J, West AP Jr, Bjorkman PJ, Tomaras GD, Gulick RM, Pfeifer N, Fätkenheuer G, Seaman MS, Klein F, Caskey M, Nussenzweig MC.

Nature. 2018 Sep;561(7724):479-484. doi: 10.1038/s41586-018-0531-2. Epub 2018 Sep 26.

6.

A non-functional galanin receptor-2 in a multiple sclerosis patient.

Garcia-Rosa S, Trivella DB, Marques VD, Serafim RB, Pereira JG, Lorenzi JC, Molfetta GA, Christo PP, Olival GS, Marchitto VB, Brum DG, Sabedot TS, Noushmehr H, Farias AS, Santos LM, Nogueira-Machado JA, Souza JE, Romano CM, Conde RM, Santos AC, Guerreiro CT, Schreuder WH, Gleber-Netto FO, Amorim M, Valieris R, Silva ITD, Silva WA Jr, Nunes DN, Oliveira PS, Valente V, Arruda MA, Hill SJ, Barreira AA, Dias-Neto E.

Pharmacogenomics J. 2019 Feb;19(1):72-82. doi: 10.1038/s41397-018-0032-6. Epub 2018 Aug 22.

PMID:
30131588
7.

Relationship between latent and rebound viruses in a clinical trial of anti-HIV-1 antibody 3BNC117.

Cohen YZ, Lorenzi JCC, Krassnig L, Barton JP, Burke L, Pai J, Lu CL, Mendoza P, Oliveira TY, Sleckman C, Millard K, Butler AL, Dizon JP, Belblidia SA, Witmer-Pack M, Shimeliovich I, Gulick RM, Seaman MS, Jankovic M, Caskey M, Nussenzweig MC.

J Exp Med. 2018 Sep 3;215(9):2311-2324. doi: 10.1084/jem.20180936. Epub 2018 Aug 2.

8.

Highly expressed placental miRNAs control key biological processes in human cancer cell lines.

Vidal DO, Ramão A, Pinheiro DG, Muys BR, Lorenzi JCC, de Pádua Alves C, Zanette DL, de Molfetta GA, Duarte G, Silva WA Jr.

Oncotarget. 2018 May 4;9(34):23554-23563. doi: 10.18632/oncotarget.25264. eCollection 2018 May 4.

9.

Clonal CD4+ T cells in the HIV-1 latent reservoir display a distinct gene profile upon reactivation.

Cohn LB, da Silva IT, Valieris R, Huang AS, Lorenzi JCC, Cohen YZ, Pai JA, Butler AL, Caskey M, Jankovic M, Nussenzweig MC.

Nat Med. 2018 May;24(5):604-609. doi: 10.1038/s41591-018-0017-7. Epub 2018 Apr 23.

10.

Neutralizing Activity of Broadly Neutralizing Anti-HIV-1 Antibodies against Clade B Clinical Isolates Produced in Peripheral Blood Mononuclear Cells.

Cohen YZ, Lorenzi JCC, Seaman MS, Nogueira L, Schoofs T, Krassnig L, Butler A, Millard K, Fitzsimons T, Daniell X, Dizon JP, Shimeliovich I, Montefiori DC, Caskey M, Nussenzweig MC.

J Virol. 2018 Feb 12;92(5). pii: e01883-17. doi: 10.1128/JVI.01883-17. Print 2018 Mar 1.

11.

Exome sequencing of multiple-sclerosis patients and their unaffected first-degree relatives.

Garcia-Rosa S, de Amorim MG, Valieris R, Marques VD, Lorenzi JCC, Toller VB, do Olival GS, da Silva Júnior WA, da Silva IT, Barreira AA, Nunes DN, Dias-Neto E.

BMC Res Notes. 2017 Dec 12;10(1):735. doi: 10.1186/s13104-017-3072-0.

12.

Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo.

Horwitz JA, Bar-On Y, Lu CL, Fera D, Lockhart AAK, Lorenzi JCC, Nogueira L, Golijanin J, Scheid JF, Seaman MS, Gazumyan A, Zolla-Pazner S, Nussenzweig MC.

Cell. 2017 Aug 10;170(4):637-648.e10. doi: 10.1016/j.cell.2017.06.048. Epub 2017 Jul 27.

13.

Decreased platelet responsiveness to clopidogrel correlates with CYP2C19 and PON1 polymorphisms in atherosclerotic patients.

Marchini JF, Pinto MR, Novaes GC, Badran AV, Pavão RB, Figueiredo GL, Lago IM, Lima-Filho MO, Lemos DC, Tonani M, Antloga CM, Oliveira L, Lorenzi JC, Marin-Neto JA.

Braz J Med Biol Res. 2017 Jan 9;50(1):e5660. doi: 10.1590/1414-431X20165660.

14.

Paired quantitative and qualitative assessment of the replication-competent HIV-1 reservoir and comparison with integrated proviral DNA.

Lorenzi JC, Cohen YZ, Cohn LB, Kreider EF, Barton JP, Learn GH, Oliveira T, Lavine CL, Horwitz JA, Settler A, Jankovic M, Seaman MS, Chakraborty AK, Hahn BH, Caskey M, Nussenzweig MC.

Proc Natl Acad Sci U S A. 2016 Dec 6;113(49):E7908-E7916. Epub 2016 Nov 21. Erratum in: Proc Natl Acad Sci U S A. 2017 Jan 17;:.

15.

MicroRNA expression signatures in lungs of mice infected with Mycobacterium tuberculosis.

Malardo T, Gardinassi LG, Moreira BP, Padilha É, Lorenzi JC, Soares LS, Gembre AF, Fontoura IC, de Almeida LP, de Miranda Santos IK, Silva CL, Coelho-Castelo AA.

Tuberculosis (Edinb). 2016 Dec;101:151-159. doi: 10.1016/j.tube.2016.09.003. Epub 2016 Oct 7.

PMID:
27865387
16.

HIV-1 antibody 3BNC117 suppresses viral rebound in humans during treatment interruption.

Scheid JF, Horwitz JA, Bar-On Y, Kreider EF, Lu CL, Lorenzi JC, Feldmann A, Braunschweig M, Nogueira L, Oliveira T, Shimeliovich I, Patel R, Burke L, Cohen YZ, Hadrigan S, Settler A, Witmer-Pack M, West AP Jr, Juelg B, Keler T, Hawthorne T, Zingman B, Gulick RM, Pfeifer N, Learn GH, Seaman MS, Bjorkman PJ, Klein F, Schlesinger SJ, Walker BD, Hahn BH, Nussenzweig MC, Caskey M.

Nature. 2016 Jul 28;535(7613):556-60. Epub 2016 Jun 22.

17.

HIV-1 therapy with monoclonal antibody 3BNC117 elicits host immune responses against HIV-1.

Schoofs T, Klein F, Braunschweig M, Kreider EF, Feldmann A, Nogueira L, Oliveira T, Lorenzi JC, Parrish EH, Learn GH, West AP Jr, Bjorkman PJ, Schlesinger SJ, Seaman MS, Czartoski J, McElrath MJ, Pfeifer N, Hahn BH, Caskey M, Nussenzweig MC.

Science. 2016 May 20;352(6288):997-1001. doi: 10.1126/science.aaf0972. Epub 2016 May 5.

18.

Osteoblastic differentiation of bone marrow mesenchymal stromal cells in Bruck Syndrome.

Kaneto CM, Lima PS, Zanette DL, Oliveira TY, de Assis Pereira F, Lorenzi JC, Dos Santos JL, Prata KL, Neto JM, de Paula FJ, Silva WA Jr.

BMC Med Genet. 2016 May 4;17(1):38. doi: 10.1186/s12881-016-0301-7.

19.

Placenta-Enriched LincRNAs MIR503HG and LINC00629 Decrease Migration and Invasion Potential of JEG-3 Cell Line.

Muys BR, Lorenzi JC, Zanette DL, Lima e Bueno Rde B, de Araújo LF, Dinarte-Santos AR, Alves CP, Ramão A, de Molfetta GA, Vidal DO, Silva WA Jr.

PLoS One. 2016 Mar 29;11(3):e0151560. doi: 10.1371/journal.pone.0151560. eCollection 2016.

20.

Corrigendum: Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.

Caskey M, Klein F, Lorenzi JC, Seaman MS, West AP, Buckley N, Kremer G, Nogueira L, Braunschweig M, Scheid JF, Horwitz JA, Shimeliovich I, Ben-Avraham S, Witmer-Pack M, Platten M, Lehmann C, Burke LA, Hawthorne T, Gorelick RJ, Walker BD, Keler T, Gulick RM, Fätkenheuer G, Schlesinger SJ, Nussenzweig MC.

Nature. 2016 Jul 28;535(7613):580. doi: 10.1038/nature17642. Epub 2016 Mar 23. No abstract available.

PMID:
27007847
21.

B cells expressing IL-10 mRNA modulate memory T cells after DNA-Hsp65 immunization.

Fontoura IC, Trombone AP, Almeida LP, Lorenzi JC, Rossetti RA, Malardo T, Padilha E, Schluchting W, Silva RL, Gembre AF, Fiuza JE, Silva CL, Panunto-Castelo A, Coelho-Castelo AA.

Braz J Med Biol Res. 2015 Dec;48(12):1095-100. doi: 10.1590/1414-431X20154409. Epub 2015 Sep 18.

22.

Mitochondrial genome instability in colorectal adenoma and adenocarcinoma.

de Araujo LF, Fonseca AS, Muys BR, Plaça JR, Bueno RB, Lorenzi JC, Santos AR, Molfetta GA, Zanette DL, Souza JE, Valente V, Silva WA Jr.

Tumour Biol. 2015 Nov;36(11):8869-79. doi: 10.1007/s13277-015-3640-7. Epub 2015 Jun 12.

PMID:
26069104
23.

Simvastatin modulates mesenchymal stromal cell proliferation and gene expression.

Zanette DL, Lorenzi JC, Panepucci RA, Palma PV, Dos Santos DF, Prata KL, Silva WA Jr.

PLoS One. 2015 Apr 13;10(4):e0120137. doi: 10.1371/journal.pone.0120137. eCollection 2015.

24.

Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117.

Caskey M, Klein F, Lorenzi JC, Seaman MS, West AP Jr, Buckley N, Kremer G, Nogueira L, Braunschweig M, Scheid JF, Horwitz JA, Shimeliovich I, Ben-Avraham S, Witmer-Pack M, Platten M, Lehmann C, Burke LA, Hawthorne T, Gorelick RJ, Walker BD, Keler T, Gulick RM, Fätkenheuer G, Schlesinger SJ, Nussenzweig MC.

Nature. 2015 Jun 25;522(7557):487-91. doi: 10.1038/nature14411. Epub 2015 Apr 8. Erratum in: Nature. 2016 Jul 28;535(7613):580.

25.

Autologous hematopoietic SCT normalizes miR-16, -155 and -142-3p expression in multiple sclerosis patients.

Arruda LC, Lorenzi JC, Sousa AP, Zanette DL, Palma PV, Panepucci RA, Brum DS, Barreira AA, Covas DT, Simões BP, Silva WA Jr, Oliveira MC, Malmegrim KC.

Bone Marrow Transplant. 2015 Mar;50(3):380-9. doi: 10.1038/bmt.2014.277. Epub 2014 Dec 8.

PMID:
25486582
26.

Microarray profiles of ex vivo expanded hematopoietic stem cells show induction of genes involved in noncanonical Wnt signaling.

Zanette DL, Lorenzi JC, Panepucci RA, Santos AR, Molfetta GA, Araujo AG, Silva Junior WA, Zago MA.

Genet Mol Res. 2013 May 15;12(2):1691-7. doi: 10.4238/2013.May.15.1.

27.

Antigen-presenting cells transfected with Hsp65 messenger RNA fail to treat experimental tuberculosis.

Rocha CD, Trombone AP, Lorenzi JC, Almeida LP, Gembre AF, Padilha E, Ramos SG, Silva CL, Coelho-Castelo AA.

Braz J Med Biol Res. 2012 Dec;45(12):1183-94. Epub 2012 Sep 18.

28.

miR-15a and 16-1 are downregulated in CD4+ T cells of multiple sclerosis relapsing patients.

Lorenzi JC, Brum DG, Zanette DL, de Paula Alves Souza A, Barbuzano FG, Dos Santos AC, Barreira AA, da Silva WA.

Int J Neurosci. 2012 Aug;122(8):466-71. doi: 10.3109/00207454.2012.678444. Epub 2012 May 1.

PMID:
22463747
29.

B cells Can Modulate the CD8 Memory T Cell after DNA Vaccination Against Experimental Tuberculosis.

Almeida LP, Trombone AP, Lorenzi JC, Rocha CD, Malardo T, Fontoura IC, Gembre AF, Silva RL, Silva CL, Castelo AP, Coelho-Castelo AA.

Genet Vaccines Ther. 2011 Mar 14;9:5. doi: 10.1186/1479-0556-9-5.

30.

Intranasal vaccination with messenger RNA as a new approach in gene therapy: use against tuberculosis.

Lorenzi JC, Trombone AP, Rocha CD, Almeida LP, Lousada RL, Malardo T, Fontoura IC, Rossetti RA, Gembre AF, Silva AM, Silva CL, Coelho-Castelo AA.

BMC Biotechnol. 2010 Oct 20;10:77. doi: 10.1186/1472-6750-10-77.

31.

Genetic vaccine for tuberculosis (pVAXhsp65) primes neonate mice for a strong immune response at the adult stage.

Pelizon AC, Martins DR, Zorzella SF, Trombone AP, Lorenzi JC, Carvalho RF, Brandão IT, Coelho-Castelo AA, Silva CL, Sartori A.

Genet Vaccines Ther. 2007 Nov 29;5:12.

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