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KDEL Receptor 1 Contributes to Cell Surface Association of Protein Disulfide Isomerases.

Bartels AK, Göttert S, Desel C, Schäfer M, Krossa S, Scheidig AJ, Grötzinger J, Lorenzen I.

Cell Physiol Biochem. 2019;52(4):850-868. doi: 10.33594/000000059.


CD9 Controls Integrin α5β1-Mediated Cell Adhesion by Modulating Its Association With the Metalloproteinase ADAM17.

Machado-Pineda Y, Cardeñes B, Reyes R, López-Martín S, Toribio V, Sánchez-Organero P, Suarez H, Grötzinger J, Lorenzen I, Yáñez-Mó M, Cabañas C.

Front Immunol. 2018 Nov 5;9:2474. doi: 10.3389/fimmu.2018.02474. eCollection 2018.


Redundancy of protein disulfide isomerases in the catalysis of the inactivating disulfide switch in A Disintegrin and Metalloprotease 17.

Krossa S, Scheidig AJ, Grötzinger J, Lorenzen I.

Sci Rep. 2018 Jan 18;8(1):1103. doi: 10.1038/s41598-018-19429-4.


Redox Regulation of Inflammatory Processes Is Enzymatically Controlled.

Lorenzen I, Mullen L, Bekeschus S, Hanschmann EM.

Oxid Med Cell Longev. 2017;2017:8459402. doi: 10.1155/2017/8459402. Epub 2017 Oct 8. Review.


GRP78 protects a disintegrin and metalloprotease 17 against protein-disulfide isomerase A6 catalyzed inactivation.

Schäfer M, Granato DC, Krossa S, Bartels AK, Yokoo S, Düsterhöft S, Koudelka T, Scheidig AJ, Tholey A, Paes Leme AF, Grötzinger J, Lorenzen I.

FEBS Lett. 2017 Nov;591(21):3567-3587. doi: 10.1002/1873-3468.12858. Epub 2017 Oct 11.


Molecular insights into the multilayered regulation of ADAM17: The role of the extracellular region.

Grötzinger J, Lorenzen I, Düsterhöft S.

Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt B):2088-2095. doi: 10.1016/j.bbamcr.2017.05.024. Epub 2017 May 29. Review.


Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.

Riethmueller S, Somasundaram P, Ehlers JC, Hung CW, Flynn CM, Lokau J, Agthe M, Düsterhöft S, Zhu Y, Grötzinger J, Lorenzen I, Koudelka T, Yamamoto K, Pickhinke U, Wichert R, Becker-Pauly C, Rädisch M, Albrecht A, Hessefort M, Stahnke D, Unverzagt C, Rose-John S, Tholey A, Garbers C.

PLoS Biol. 2017 Jan 6;15(1):e2000080. doi: 10.1371/journal.pbio.2000080. eCollection 2017 Jan.


Erratum: Control of ADAM17 activity by regulation of its cellular localisation.

Lorenzen I, Lokau J, Korpys Y, Oldefest M, Flynn CM, Künzel U, Garbers C, Freeman M, Grötzinger J, Düsterhöft S.

Sci Rep. 2016 Nov 21;6:37364. doi: 10.1038/srep37364. No abstract available.


Control of ADAM17 activity by regulation of its cellular localisation.

Lorenzen I, Lokau J, Korpys Y, Oldefest M, Flynn CM, Künzel U, Garbers C, Freeman M, Grötzinger J, Düsterhöft S.

Sci Rep. 2016 Oct 12;6:35067. doi: 10.1038/srep35067. Erratum in: Sci Rep. 2016 Nov 21;6:37364.


Stimulated release and functional activity of surface expressed metalloproteinase ADAM17 in exosomes.

Groth E, Pruessmeyer J, Babendreyer A, Schumacher J, Pasqualon T, Dreymueller D, Higashiyama S, Lorenzen I, Grötzinger J, Cataldo D, Ludwig A.

Biochim Biophys Acta. 2016 Nov;1863(11):2795-2808. doi: 10.1016/j.bbamcr.2016.09.002. Epub 2016 Sep 4.


Phosphatidylserine exposure is required for ADAM17 sheddase function.

Sommer A, Kordowski F, Büch J, Maretzky T, Evers A, Andrä J, Düsterhöft S, Michalek M, Lorenzen I, Somasundaram P, Tholey A, Sönnichsen FD, Kunzelmann K, Heinbockel L, Nehls C, Gutsmann T, Grötzinger J, Bhakdi S, Reiss K.

Nat Commun. 2016 May 10;7:11523. doi: 10.1038/ncomms11523.


RAID3--An interleukin-6 receptor-binding aptamer with post-selective modification-resistant affinity.

Mittelberger F, Meyer C, Waetzig GH, Zacharias M, Valentini E, Svergun DI, Berg K, Lorenzen I, Grötzinger J, Rose-John S, Hahn U.

RNA Biol. 2015;12(9):1043-53. doi: 10.1080/15476286.2015.1079681.


Extracellular Juxtamembrane Segment of ADAM17 Interacts with Membranes and Is Essential for Its Shedding Activity.

Düsterhöft S, Michalek M, Kordowski F, Oldefest M, Sommer A, Röseler J, Reiss K, Grötzinger J, Lorenzen I.

Biochemistry. 2015 Sep 29;54(38):5791-801. doi: 10.1021/acs.biochem.5b00497. Epub 2015 Sep 17.


Secreted Frizzled-related protein 3 (sFRP3)-mediated suppression of interleukin-6 receptor release by A disintegrin and metalloprotease 17 (ADAM17) is abrogated in the osteoarthritis-associated rare double variant of sFRP3.

Oldefest M, Düsterhöft S, Desel C, Thysen S, Fink C, Rabe B, Lories R, Grötzinger J, Lorenzen I.

Biochem J. 2015 Jun 15;468(3):507-18. doi: 10.1042/BJ20141231. Epub 2015 Apr 7.


A disintegrin and metalloprotease 17 dynamic interaction sequence, the sweet tooth for the human interleukin 6 receptor.

Düsterhöft S, Höbel K, Oldefest M, Lokau J, Waetzig GH, Chalaris A, Garbers C, Scheller J, Rose-John S, Lorenzen I, Grötzinger J.

J Biol Chem. 2014 Jun 6;289(23):16336-48. doi: 10.1074/jbc.M114.557322. Epub 2014 Apr 30.


Differential aggregation properties of alpha-synuclein isoforms.

Bungeroth M, Appenzeller S, Regulin A, Völker W, Lorenzen I, Grötzinger J, Pendziwiat M, Kuhlenbäumer G.

Neurobiol Aging. 2014 Aug;35(8):1913-9. doi: 10.1016/j.neurobiolaging.2014.02.009. Epub 2014 Feb 19.


Stabilized Interleukin-6 receptor binding RNA aptamers.

Meyer C, Berg K, Eydeler-Haeder K, Lorenzen I, Grötzinger J, Rose-John S, Hahn U.

RNA Biol. 2014;11(1):57-65. doi: 10.4161/rna.27447. Epub 2013 Dec 20.


Upd3--an ancestor of the four-helix bundle cytokines.

Oldefest M, Nowinski J, Hung CW, Neelsen D, Trad A, Tholey A, Grötzinger J, Lorenzen I.

Biochem Biophys Res Commun. 2013 Jun 21;436(1):66-72. doi: 10.1016/j.bbrc.2013.04.107. Epub 2013 May 22.


The disintegrin domain of ADAM17 antagonises fibroblast‑carcinoma cell interactions.

Trad A, Riese M, Shomali M, Hedeman N, Effenberger T, Grötzinger J, Lorenzen I.

Int J Oncol. 2013 May;42(5):1793-800. doi: 10.3892/ijo.2013.1864. Epub 2013 Mar 26.


Membrane-proximal domain of a disintegrin and metalloprotease-17 represents the putative molecular switch of its shedding activity operated by protein-disulfide isomerase.

Düsterhöft S, Jung S, Hung CW, Tholey A, Sönnichsen FD, Grötzinger J, Lorenzen I.

J Am Chem Soc. 2013 Apr 17;135(15):5776-81. doi: 10.1021/ja400340u. Epub 2013 Apr 5.


d(GGGT) 4 and r(GGGU) 4 are both HIV-1 inhibitors and interleukin-6 receptor aptamers.

Magbanua E, Zivkovic T, Hansen B, Beschorner N, Meyer C, Lorenzen I, Grötzinger J, Hauber J, Torda AE, Mayer G, Rose-John S, Hahn U.

RNA Biol. 2013 Feb;10(2):216-27. doi: 10.4161/rna.22951. Epub 2012 Dec 12.


An interleukin-6 receptor-dependent molecular switch mediates signal transduction of the IL-27 cytokine subunit p28 (IL-30) via a gp130 protein receptor homodimer.

Garbers C, Spudy B, Aparicio-Siegmund S, Waetzig GH, Sommer J, Hölscher C, Rose-John S, Grötzinger J, Lorenzen I, Scheller J.

J Biol Chem. 2013 Feb 8;288(6):4346-54. doi: 10.1074/jbc.M112.432955. Epub 2012 Dec 3.


Structure and function of a unique pore-forming protein from a pathogenic acanthamoeba.

Michalek M, Sönnichsen FD, Wechselberger R, Dingley AJ, Hung CW, Kopp A, Wienk H, Simanski M, Herbst R, Lorenzen I, Marciano-Cabral F, Gelhaus C, Gutsmann T, Tholey A, Grötzinger J, Leippe M.

Nat Chem Biol. 2013 Jan;9(1):37-42. doi: 10.1038/nchembio.1116. Epub 2012 Nov 11.


ADAM17-overexpressing breast cancer cells selectively targeted by antibody-toxin conjugates.

Trad A, Hansen HP, Shomali M, Peipp M, Klausz K, Hedemann N, Yamamoto K, Mauermann A, Desel C, Lorenzen I, Lemke H, Rose-John S, Grötzinger J.

Cancer Immunol Immunother. 2013 Mar;62(3):411-21. doi: 10.1007/s00262-012-1346-x. Epub 2012 Sep 1.


The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II.

Lorenzen I, Lokau J, Düsterhöft S, Trad A, Garbers C, Scheller J, Rose-John S, Grötzinger J.

FEBS Lett. 2012 Apr 24;586(8):1093-100. doi: 10.1016/j.febslet.2012.03.012. Epub 2012 Mar 21.


A novel bispecific single-chain antibody for ADAM17 and CD3 induces T-cell-mediated lysis of prostate cancer cells.

Yamamoto K, Trad A, Baumgart A, Hüske L, Lorenzen I, Chalaris A, Grötzinger J, Dechow T, Scheller J, Rose-John S.

Biochem J. 2012 Jul 1;445(1):135-44. doi: 10.1042/BJ20120433.


Interleukin-6 receptor specific RNA aptamers for cargo delivery into target cells.

Meyer C, Eydeler K, Magbanua E, Zivkovic T, Piganeau N, Lorenzen I, Grötzinger J, Mayer G, Rose-John S, Hahn U.

RNA Biol. 2012 Jan;9(1):67-80. doi: 10.4161/rna.9.1.18062. Epub 2012 Jan 1.


Multimerisation of A disintegrin and metalloprotease protein-17 (ADAM17) is mediated by its EGF-like domain.

Lorenzen I, Trad A, Grötzinger J.

Biochem Biophys Res Commun. 2011 Nov 18;415(2):330-6. doi: 10.1016/j.bbrc.2011.10.056. Epub 2011 Oct 18.


Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor.

Garbers C, Thaiss W, Jones GW, Waetzig GH, Lorenzen I, Guilhot F, Lissilaa R, Ferlin WG, Grötzinger J, Jones SA, Rose-John S, Scheller J.

J Biol Chem. 2011 Dec 16;286(50):42959-70. doi: 10.1074/jbc.M111.295758. Epub 2011 Oct 11.


Development of sandwich ELISA for detection and quantification of human and murine a disintegrin and metalloproteinase17.

Trad A, Hedemann N, Shomali M, Pawlak V, Grötzinger J, Lorenzen I.

J Immunol Methods. 2011 Aug 31;371(1-2):91-6. doi: 10.1016/j.jim.2011.06.015. Epub 2011 Jun 24.


Human beta-defensin 2 and beta-defensin 3 chimeric peptides reveal the structural basis of the pathogen specificity of their parent molecules.

Jung S, Mysliwy J, Spudy B, Lorenzen I, Reiss K, Gelhaus C, Podschun R, Leippe M, Grötzinger J.

Antimicrob Agents Chemother. 2011 Mar;55(3):954-60. doi: 10.1128/AAC.00872-10. Epub 2010 Dec 28.


The structure of the unliganded extracellular domain of the interleukin-6 signal transducer gp130 in solution.

Lorenzen I, Shang W, Perbandt M, Petoukhov MV, Svergun DI, Waetzig GH, Rose-John S, Hilgenfeld R, Grötzinger J.

Eur J Cell Biol. 2011 Jun-Jul;90(6-7):515-20. doi: 10.1016/j.ejcb.2010.09.012. Epub 2010 Oct 30.


Forced homo- and heterodimerization of all gp130-type receptor complexes leads to constitutive ligand-independent signaling and cytokine-independent growth.

Suthaus J, Tillmann A, Lorenzen I, Bulanova E, Rose-John S, Scheller J.

Mol Biol Cell. 2010 Aug 1;21(15):2797-807. doi: 10.1091/mbc.E10-03-0240. Epub 2010 Jun 16. Erratum in: Mol Biol Cell. 2011 Jun;22(12):2132.


Caenopore-5: the three-dimensional structure of an antimicrobial protein from Caenorhabditis elegans.

Mysliwy J, Dingley AJ, Stanisak M, Jung S, Lorenzen I, Roeder T, Leippe M, Grötzinger J.

Dev Comp Immunol. 2010 Mar;34(3):323-30. doi: 10.1016/j.dci.2009.11.003. Epub 2009 Nov 26.


Functional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism.

Egli RJ, Southam L, Wilkins JM, Lorenzen I, Pombo-Suarez M, Gonzalez A, Carr A, Chapman K, Loughlin J.

Arthritis Rheum. 2009 Jul;60(7):2055-64. doi: 10.1002/art.24616.


NMR analysis of viral protein structures.

Dingley AJ, Lorenzen I, Grötzinger J.

Methods Mol Biol. 2008;451:441-62. doi: 10.1007/978-1-59745-102-4_30.


A novel fluorescent pH probe for expression in plants.

Schulte A, Lorenzen I, Böttcher M, Plieth C.

Plant Methods. 2006 Apr 6;2:7.


The structure of the interleukin-15 alpha receptor and its implications for ligand binding.

Lorenzen I, Dingley AJ, Jacques Y, Grötzinger J.

J Biol Chem. 2006 Mar 10;281(10):6642-7. Epub 2005 Dec 23.


Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins.

Mortier E, Quéméner A, Vusio P, Lorenzen I, Boublik Y, Grötzinger J, Plet A, Jacques Y.

J Biol Chem. 2006 Jan 20;281(3):1612-9. Epub 2005 Nov 11.


New radiographic bone erosions in the wrists of patients with rheumatoid arthritis are detectable with magnetic resonance imaging a median of two years earlier.

Østergaard M, Hansen M, Stoltenberg M, Jensen KE, Szkudlarek M, Pedersen-Zbinden B, Lorenzen I.

Arthritis Rheum. 2003 Aug;48(8):2128-31.


Studies on YKL-40 in knee joints of patients with rheumatoid arthritis and osteoarthritis. Involvement of YKL-40 in the joint pathology.

Volck B, Johansen JS, Stoltenberg M, Garbarsch C, Price PA, Ostergaard M, Ostergaard K, Løvgreen-Nielsen P, Sonne-Holm S, Lorenzen I.

Osteoarthritis Cartilage. 2001 Apr;9(3):203-14.


[Magnetic resonance imaging as a marker of inflammation, destruction and prognosis in rheumatoid arthritis wrists].

Ostergaard M, Hansen MS, Stoltenberg MB, Gideon P, Jensen KE, Klarlund M, Lorenzen I.

Ugeskr Laeger. 2000 Jul 31;162(31):4145-9. Danish.


Magnetic resonance imaging, radiography, and scintigraphy of the finger joints: one year follow up of patients with early arthritis. The TIRA Group.

Klarlund M, Ostergaard M, Jensen KE, Madsen JL, Skjødt H, Lorenzen I.

Ann Rheum Dis. 2000 Jul;59(7):521-8.


Dynamic magnetic resonance imaging of the metacarpophalangeal joints in rheumatoid arthritis, early unclassified polyarthritis, and healthy controls.

Klarlund M, Ostergaard M, Rostrup E, Skjødt H, Lorenzen I.

Scand J Rheumatol. 2000;29(2):108-15.


[History, present and future of medicine].

Hemmingsen RP, Lorenzen I, Stadil F.

Ugeskr Laeger. 2000 Jan 3;162(1):11-9. Danish. No abstract available.


YKL-40 in giant cells and macrophages from patients with giant cell arteritis.

Johansen JS, Baslund B, Garbarsch C, Hansen M, Stoltenberg M, Lorenzen I, Price PA.

Arthritis Rheum. 1999 Dec;42(12):2624-30.


Serum YKL-40 concentrations in patients with rheumatoid arthritis: relation to disease activity.

Johansen JS, Stoltenberg M, Hansen M, Florescu A, Hørslev-Petersen K, Lorenzen I, Price PA.

Rheumatology (Oxford). 1999 Jul;38(7):618-26.


Wrist and finger joint MR imaging in rheumatoid arthritis.

Klarlund M, Ostergaard M, Gideon P, Sørensen K, Jensen KE, Lorenzen I.

Acta Radiol. 1999 Jul;40(4):400-9.


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