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Localised delineation uncertainty for iterative atlas selection in automatic cardiac segmentation.

Finnegan RN, Lorenzen E, Dowling JA, Holloway LC, Thwaites DI, Brink C.

Phys Med Biol. 2019 Dec 23. doi: 10.1088/1361-6560/ab652a. [Epub ahead of print]


Micro Methods for Megafauna: Novel Approaches to Late Quaternary Extinctions and Their Contributions to Faunal Conservation in the Anthropocene.

Swift JA, Bunce M, Dortch J, Douglass K, Faith JT, Fellows Yates JA, Field J, Haberle SG, Jacob E, Johnson CN, Lindsey E, Lorenzen ED, Louys J, Miller G, Mychajliw AM, Slon V, Villavicencio NA, Waters MR, Welker F, Wood R, Petraglia M, Boivin N, Roberts P.

Bioscience. 2019 Nov 1;69(11):877-887. doi: 10.1093/biosci/biz105. Epub 2019 Oct 2.


Multiplexed analysis of the secretin-like GPCR-RAMP interactome.

Lorenzen E, Dodig-Crnković T, Kotliar IB, Pin E, Ceraudo E, Vaughan RD, Uhlèn M, Huber T, Schwenk JM, Sakmar TP.

Sci Adv. 2019 Sep 18;5(9):eaaw2778. doi: 10.1126/sciadv.aaw2778. eCollection 2019 Sep.


Genomic analyses reveal an absence of contemporary introgressive admixture between fin whales and blue whales, despite known hybrids.

Westbury MV, Petersen B, Lorenzen ED.

PLoS One. 2019 Sep 25;14(9):e0222004. doi: 10.1371/journal.pone.0222004. eCollection 2019.


High-Affinity Binding of Chemokine Analogs that Display Ligand Bias at the HIV-1 Coreceptor CCR5.

Rico CA, Berchiche YA, Horioka M, Peeler JC, Lorenzen E, Tian H, Kazmi MA, Fürstenberg A, Gaertner H, Hartley O, Sakmar TP, Huber T.

Biophys J. 2019 Sep 3;117(5):903-919. doi: 10.1016/j.bpj.2019.07.043. Epub 2019 Aug 2.


Hybridization between two high Arctic cetaceans confirmed by genomic analysis.

Skovrind M, Castruita JAS, Haile J, Treadaway EC, Gopalakrishnan S, Westbury MV, Heide-Jørgensen MP, Szpak P, Lorenzen ED.

Sci Rep. 2019 Jun 20;9(1):7729. doi: 10.1038/s41598-019-44038-0.


Narwhal Genome Reveals Long-Term Low Genetic Diversity despite Current Large Abundance Size.

Westbury MV, Petersen B, Garde E, Heide-Jørgensen MP, Lorenzen ED.

iScience. 2019 May 31;15:592-599. doi: 10.1016/j.isci.2019.03.023. Epub 2019 May 1.


Hypothyroidism and the risk of breast cancer recurrence and all-cause mortality - a Danish population-based study.

Falstie-Jensen AM, Kjærsgaard A, Lorenzen EL, Jensen JD, Reinertsen KV, Dekkers OM, Ewertz M, Cronin-Fenton DP.

Breast Cancer Res. 2019 Mar 22;21(1):44. doi: 10.1186/s13058-019-1122-3.


Evolutionary history and palaeoecology of brown bear in North-East Siberia re-examined using ancient DNA and stable isotopes from skeletal remains.

Rey-Iglesia A, García-Vázquez A, Treadaway EC, van der Plicht J, Baryshnikov GF, Szpak P, Bocherens H, Boeskorov GG, Lorenzen ED.

Sci Rep. 2019 Mar 14;9(1):4462. doi: 10.1038/s41598-019-40168-7.


Genital Infiltrations of CD4+ and CD8+ T Lymphocytes, IgA+ and IgG+ Plasma Cells and Intra-Mucosal Lymphoid Follicles Associate With Protection Against Genital Chlamydia trachomatis Infection in Minipigs Intramuscularly Immunized With UV-Inactivated Bacteria Adjuvanted With CAF01.

Erneholm K, Lorenzen E, Bøje S, Olsen AW, Jungersen G, Jensen HE, Cassidy JP, Andersen P, Agerholm JS, Follmann F.

Front Microbiol. 2019 Feb 8;10:197. doi: 10.3389/fmicb.2019.00197. eCollection 2019.


Cardiac Structure Doses in Women Irradiated for Breast Cancer in the Past and Their Use in Epidemiological Studies.

Duane FK, McGale P, Brønnum D, Cutter DJ, Darby SC, Ewertz M, Hackett S, Hall P, Lorenzen EL, Rahimi K, Wang Z, Warren S, Taylor CW.

Pract Radiat Oncol. 2019 May;9(3):158-171. doi: 10.1016/j.prro.2019.01.004. Epub 2019 Jan 26.


Receptor Structures for a Caldron of Cannabinoids.

Lorenzen E, Sakmar TP.

Cell. 2019 Jan 24;176(3):409-411. doi: 10.1016/j.cell.2019.01.012.


Detection of Concordance between Transcriptional Levels of GPCRs and Receptor-Activity-Modifying Proteins.

Barbash S, Persson T, Lorenzen E, Kazmi MA, Huber T, Sakmar TP.

iScience. 2019 Jan 25;11:366-374. doi: 10.1016/j.isci.2018.12.024. Epub 2018 Dec 31.


G protein subtype-specific signaling bias in a series of CCR5 chemokine analogs.

Lorenzen E, Ceraudo E, Berchiche YA, Rico CA, Fürstenberg A, Sakmar TP, Huber T.

Sci Signal. 2018 Oct 16;11(552). pii: eaao6152. doi: 10.1126/scisignal.aao6152.


Time-course study of the protection induced by an interferon-inducible DNA vaccine against viral haemorrhagic septicaemia in rainbow trout.

Sepúlveda D, Lorenzen E, Rasmussen JS, Einer-Jensen K, Collet B, Secombes CJ, Lorenzen N.

Fish Shellfish Immunol. 2019 Feb;85:99-105. doi: 10.1016/j.fsi.2018.06.056. Epub 2018 Jun 30.


Big data little help in megafauna mysteries.

Price GJ, Louys J, Faith JT, Lorenzen E, Westaway MC.

Nature. 2018 Jun;558(7708):23-25. doi: 10.1038/d41586-018-05330-7. No abstract available.


Cardiac Structure Injury After Radiotherapy for Breast Cancer: Cross-Sectional Study With Individual Patient Data.

Taylor C, McGale P, Brønnum D, Correa C, Cutter D, Duane FK, Gigante B, Jensen MB, Lorenzen E, Rahimi K, Wang Z, Darby SC, Hall P, Ewertz M.

J Clin Oncol. 2018 Aug 1;36(22):2288-2296. doi: 10.1200/JCO.2017.77.6351. Epub 2018 May 23.


Protective Effect of Vaccine Promoted Neutralizing Antibodies against the Intracellular Pathogen Chlamydia trachomatis.

Olsen AW, Lorenzen EK, Rosenkrands I, Follmann F, Andersen P.

Front Immunol. 2017 Dec 11;8:1652. doi: 10.3389/fimmu.2017.01652. eCollection 2017.


Persistent organic pollutants, skull size and bone density of polar bears (Ursus maritimus) from East Greenland 1892-2015 and Svalbard 1964-2004.

Daugaard-Petersen T, Langebæk R, Rigét FF, Letcher RJ, Hyldstrup L, Jensen JB, Bechshoft T, Wiig Ø, Jenssen BM, Pertoldi C, Lorenzen ED, Dietz R, Sonne C.

Environ Res. 2018 Apr;162:74-80. doi: 10.1016/j.envres.2017.12.009. Epub 2017 Dec 26.


Thylacine tales.

Barnett R, Lorenzen E.

Nat Ecol Evol. 2018 Jan;2(1):7-8. doi: 10.1038/s41559-017-0384-3. No abstract available.


The potential benefits from respiratory gating for breast cancer patients regarding target coverage and dose to organs at risk when applying strict dose limits to the heart: results from the DBCG HYPO trial.

Berg M, Lorenzen EL, Jensen I, Thomsen MS, Lutz CM, Refsgaard L, Nissen HD, Offersen BV.

Acta Oncol. 2018 Jan;57(1):113-119. doi: 10.1080/0284186X.2017.1406139. Epub 2017 Dec 5.


DBCG hypo trial validation of radiotherapy parameters from a national data bank versus manual reporting.

Brink C, Lorenzen EL, Krogh SL, Westberg J, Berg M, Jensen I, Thomsen MS, Yates ES, Offersen BV.

Acta Oncol. 2018 Jan;57(1):107-112. doi: 10.1080/0284186X.2017.1406140. Epub 2017 Dec 5.


GPCRs globally coevolved with receptor activity-modifying proteins, RAMPs.

Barbash S, Lorenzen E, Persson T, Huber T, Sakmar TP.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):12015-12020. doi: 10.1073/pnas.1713074114. Epub 2017 Oct 23.


GISCOME - Genetics of Ischaemic Stroke Functional Outcome network: A protocol for an international multicentre genetic association study.

Maguire JM, Bevan S, Stanne TM, Lorenzen E, Fernandez-Cadenas I, Hankey GJ, Jimenez-Conde J, Jood K, Lee JM, Lemmens R, Levi C, Norrving B, Rannikmae K, Rost N, Rosand J, Rothwell PM, Scott R, Strbian D, Sturm J, Sudlow C, Traylor M, Thijs V, Tatlisumak T, Wieloch T, Woo D, Worrall BB, Jern C, Lindgren A.

Eur Stroke J. 2017 Sep;2(3):229-237. doi: 10.1177/2396987317704547. Epub 2017 Apr 19.


Population characteristics of a large whale shark aggregation inferred from seawater environmental DNA.

Sigsgaard EE, Nielsen IB, Bach SS, Lorenzen ED, Robinson DP, Knudsen SW, Pedersen MW, Jaidah MA, Orlando L, Willerslev E, Møller PR, Thomsen PF.

Nat Ecol Evol. 2016 Nov 21;1(1):4. doi: 10.1038/s41559-016-0004.


Contouring and dose calculation in head and neck cancer radiotherapy after reduction of metal artifacts in CT images.

Hansen CR, Christiansen RL, Lorenzen EL, Bertelsen AS, Asmussen JT, Gyldenkerne N, Eriksen JG, Johansen J, Brink C.

Acta Oncol. 2017 Jun;56(6):874-878. doi: 10.1080/0284186X.2017.1287427. Epub 2017 Feb 13.


Risk of heart disease in relation to radiotherapy and chemotherapy with anthracyclines among 19,464 breast cancer patients in Denmark, 1977-2005.

Rehammar JC, Jensen MB, McGale P, Lorenzen EL, Taylor C, Darby SC, Videbæk L, Wang Z, Ewertz M.

Radiother Oncol. 2017 May;123(2):299-305. doi: 10.1016/j.radonc.2017.03.012. Epub 2017 Mar 30.


A cardiac contouring atlas for radiotherapy.

Duane F, Aznar MC, Bartlett F, Cutter DJ, Darby SC, Jagsi R, Lorenzen EL, McArdle O, McGale P, Myerson S, Rahimi K, Vivekanandan S, Warren S, Taylor CW.

Radiother Oncol. 2017 Mar;122(3):416-422. doi: 10.1016/j.radonc.2017.01.008. Epub 2017 Feb 21.


Intrauterine inoculation of minipigs with Chlamydia trachomatis during diestrus establishes a longer lasting infection compared to vaginal inoculation during estrus.

Lorenzen E, Follmann F, Secher JO, Goericke-Pesch S, Hansen MS, Zakariassen H, Olsen AW, Andersen P, Jungersen G, Agerholm JS.

Microbes Infect. 2017 Jun;19(6):334-342. doi: 10.1016/j.micinf.2017.01.008. Epub 2017 Feb 9.


Internal and external validation of an ESTRO delineation guideline - dependent automated segmentation tool for loco-regional radiation therapy of early breast cancer.

Eldesoky AR, Yates ES, Nyeng TB, Thomsen MS, Nielsen HM, Poortmans P, Kirkove C, Krause M, Kamby C, Mjaaland I, Blix ES, Jensen I, Berg M, Lorenzen EL, Taheri-Kadkhoda Z, Offersen BV.

Radiother Oncol. 2016 Dec;121(3):424-430. doi: 10.1016/j.radonc.2016.09.005. Epub 2016 Sep 30.


Risk of pacemaker or implantable cardioverter defibrillator after radiotherapy for early-stage breast cancer in Denmark, 1982-2005.

Rehammar JC, Johansen JB, Jensen MB, Videbæk L, Jørgensen OD, Lorenzen E, Ewertz M.

Radiother Oncol. 2017 Jan;122(1):60-65. doi: 10.1016/j.radonc.2016.08.024. Epub 2016 Sep 15.


Genital tract lesions in sexually mature Göttingen minipigs during the initial stages of experimental vaginal infection with Chlamydia trachomatis serovar D.

Erneholm K, Lorenzen E, Bøje S, Olsen AW, Andersen P, Cassidy JP, Follmann F, Jensen HE, Agerholm JS.

BMC Vet Res. 2016 Sep 10;12(1):200. doi: 10.1186/s12917-016-0793-6.


Uncertainties in estimating heart doses from 2D-tangential breast cancer radiotherapy.

Lorenzen EL, Brink C, Taylor CW, Darby SC, Ewertz M.

Radiother Oncol. 2016 Apr;119(1):71-6. doi: 10.1016/j.radonc.2016.02.017. Epub 2016 Feb 27.


Characterization of cytological changes, IgA, IgG and IL-8 levels and pH value in the vagina of prepubertal and sexually mature Ellegaard Göttingen minipigs during an estrous cycle.

Lorenzen E, Agerholm JS, Grossi AB, Bojesen AM, Skytte C, Erneholm K, Follmann F, Jungersen G.

Dev Comp Immunol. 2016 Jun;59:57-62. doi: 10.1016/j.dci.2016.01.006. Epub 2016 Jan 20.


Sublethal concentrations of ichthyotoxic alga Prymnesium parvum affect rainbow trout susceptibility to viral haemorrhagic septicaemia virus.

Andersen NG, Lorenzen E, Snogdal Boutrup T, Hansen PJ, Lorenzen N.

Dis Aquat Organ. 2016 Jan 13;117(3):187-95. doi: 10.3354/dao02946.


Intramuscular Priming and Intranasal Boosting Induce Strong Genital Immunity Through Secretory IgA in Minipigs Infected with Chlamydia trachomatis.

Lorenzen E, Follmann F, Bøje S, Erneholm K, Olsen AW, Agerholm JS, Jungersen G, Andersen P.

Front Immunol. 2015 Dec 16;6:628. doi: 10.3389/fimmu.2015.00628. eCollection 2015.


Anomalous redispersibility behavior of glycerophosphate deyhydrogenase microparticles dried in an acoustic levitator or bench-top spray dryer.

Lorenzen E, Lee G.

Int J Pharm. 2016 Feb 10;498(1-2):316-7. doi: 10.1016/j.ijpharm.2015.12.039. Epub 2015 Dec 18.


The vaginal microbiome is stable in prepubertal and sexually mature Ellegaard Göttingen Minipigs throughout an estrous cycle.

Lorenzen E, Kudirkiene E, Gutman N, Grossi AB, Agerholm JS, Erneholm K, Skytte C, Dalgaard MD, Bojesen AM.

Vet Res. 2015 Oct 28;46:125. doi: 10.1186/s13567-015-0274-0.


Ichthyotoxicity of the microalga Pseudochattonella farcimen under laboratory and field conditions in Danish waters.

Andersen NG, Hansen PJ, Engell-Sørensen K, Nørremark LH, Andersen P, Lorenzen E, Lorenzen N.

Dis Aquat Organ. 2015 Oct 27;116(3):165-72. doi: 10.3354/dao02916.


Pros and cons of methylation-based enrichment methods for ancient DNA.

Seguin-Orlando A, Gamba C, Sarkissian C, Ermini L, Louvel G, Boulygina E, Sokolov A, Nedoluzhko A, Lorenzen ED, Lopez P, McDonald HG, Scott E, Tikhonov A, Stafford TW Jr, Alfarhan AH, Alquraishi SA, Al-Rasheid KAS, Shapiro B, Willerslev E, Prokhortchouk E, Orlando L.

Sci Rep. 2015 Jul 2;5:11826. doi: 10.1038/srep11826.


Enterohemorrhagic Escherichia coli Virulence Gene Regulation.

Mellies JL, Lorenzen E.

Microbiol Spectr. 2014 Aug;2(4):EHEC-0004-2013. doi: 10.1128/microbiolspec.EHEC-0004-2013. Review.


Variation of normal tissue complication probability (NTCP) estimates of radiation-induced hypothyroidism in relation to changes in delineation of the thyroid gland.

Rønjom MF, Brink C, Lorenzen EL, Hegedüs L, Johansen J.

Acta Oncol. 2015;54(8):1188-94. doi: 10.3109/0284186X.2014.1001034. Epub 2015 Jan 28.


Automatic segmentation of the heart in radiotherapy for breast cancer.

Lorenzen EL, Ewertz M, Brink C.

Acta Oncol. 2014 Oct;53(10):1366-72. doi: 10.3109/0284186X.2014.930170. Epub 2014 Sep 16.


Is diagnosability an indicator of speciation? Response to "Why one century of phenetics is enough".

Heller R, Frandsen P, Lorenzen ED, Siegismund HR.

Syst Biol. 2014 Sep;63(5):833-7. doi: 10.1093/sysbio/syu034. Epub 2014 May 15. No abstract available.


Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears.

Liu S, Lorenzen ED, Fumagalli M, Li B, Harris K, Xiong Z, Zhou L, Korneliussen TS, Somel M, Babbitt C, Wray G, Li J, He W, Wang Z, Fu W, Xiang X, Morgan CC, Doherty A, O'Connell MJ, McInerney JO, Born EW, Dalén L, Dietz R, Orlando L, Sonne C, Zhang G, Nielsen R, Willerslev E, Wang J.

Cell. 2014 May 8;157(4):785-94. doi: 10.1016/j.cell.2014.03.054.


Extinct New Zealand megafauna were not in decline before human colonization.

Allentoft ME, Heller R, Oskam CL, Lorenzen ED, Hale ML, Gilbert MT, Jacomb C, Holdaway RN, Bunce M.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):4922-7. doi: 10.1073/pnas.1314972111. Epub 2014 Mar 17.


Fifty thousand years of Arctic vegetation and megafaunal diet.

Willerslev E, Davison J, Moora M, Zobel M, Coissac E, Edwards ME, Lorenzen ED, Vestergård M, Gussarova G, Haile J, Craine J, Gielly L, Boessenkool S, Epp LS, Pearman PB, Cheddadi R, Murray D, Bråthen KA, Yoccoz N, Binney H, Cruaud C, Wincker P, Goslar T, Alsos IG, Bellemain E, Brysting AK, Elven R, Sønstebø JH, Murton J, Sher A, Rasmussen M, Rønn R, Mourier T, Cooper A, Austin J, Möller P, Froese D, Zazula G, Pompanon F, Rioux D, Niderkorn V, Tikhonov A, Savvinov G, Roberts RG, MacPhee RD, Gilbert MT, Kjær KH, Orlando L, Brochmann C, Taberlet P.

Nature. 2014 Feb 6;506(7486):47-51. doi: 10.1038/nature12921.


DNA vaccination against a fish rhabdovirus promotes an early chemokine-related recruitment of B cells to the muscle.

Castro R, Martínez-Alonso S, Fischer U, Haro NÁ, Soto-Lampe V, Wang T, Secombes CJ, Lorenzen N, Lorenzen E, Tafalla C.

Vaccine. 2014 Feb 26;32(10):1160-8. doi: 10.1016/j.vaccine.2013.11.062. Epub 2013 Nov 27.


Trehalose and sorbitol alter the kinetic pattern of inactivation of glutamate dehydrogenase during drying in levitated microdroplets.

Lorenzen E, Lee G.

J Pharm Sci. 2013 Dec;102(12):4268-73. doi: 10.1002/jps.23743. Epub 2013 Oct 10.


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