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Items: 38


Synthesis and Structure-Activity Relationship Study of Biliatresone, a Plant Isoflavonoid That Causes Biliary Atresia.

Estrada MA, Zhao X, Lorent K, Kriegermeier A, Nagao SA, Berritt S, Wells RG, Pack M, Winkler JD.

ACS Med Chem Lett. 2017 Dec 14;9(1):61-64. doi: 10.1021/acsmedchemlett.7b00479. eCollection 2018 Jan 11.


Glutathione antioxidant pathway activity and reserve determine toxicity and specificity of the biliary toxin biliatresone in zebrafish.

Zhao X, Lorent K, Wilkins BJ, Marchione DM, Gillespie K, Waisbourd-Zinman O, So J, Koo KA, Shin D, Porter JR, Wells RG, Blair I, Pack M.

Hepatology. 2016 Sep;64(3):894-907. doi: 10.1002/hep.28603. Epub 2016 Jun 11.


Biliatresone, a Reactive Natural Toxin from Dysphania glomulifera and D. littoralis: Discovery of the Toxic Moiety 1,2-Diaryl-2-Propenone.

Koo KA, Lorent K, Gong W, Windsor P, Whittaker SJ, Pack M, Wells RG, Porter JR.

Chem Res Toxicol. 2015 Aug 17;28(8):1519-21. doi: 10.1021/acs.chemrestox.5b00227. Epub 2015 Jul 20.


Identification of a plant isoflavonoid that causes biliary atresia.

Lorent K, Gong W, Koo KA, Waisbourd-Zinman O, Karjoo S, Zhao X, Sealy I, Kettleborough RN, Stemple DL, Windsor PA, Whittaker SJ, Porter JR, Wells RG, Pack M.

Sci Transl Med. 2015 May 6;7(286):286ra67. doi: 10.1126/scitranslmed.aaa1652.


p53-mediated biliary defects caused by knockdown of cirh1a, the zebrafish homolog of the gene responsible for North American Indian Childhood Cirrhosis.

Wilkins BJ, Lorent K, Matthews RP, Pack M.

PLoS One. 2013 Oct 11;8(10):e77670. doi: 10.1371/journal.pone.0077670. eCollection 2013.


The tumor suppressor gene retinoblastoma-1 is required for retinotectal development and visual function in zebrafish.

Gyda M, Wolman M, Lorent K, Granato M.

PLoS Genet. 2012;8(11):e1003106. doi: 10.1371/journal.pgen.1003106. Epub 2012 Nov 29.


DNA hypomethylation causes bile duct defects in zebrafish and is a distinguishing feature of infantile biliary atresia.

Matthews RP, Eauclaire SF, Mugnier M, Lorent K, Cui S, Ross MM, Zhang Z, Russo P, Pack M.

Hepatology. 2011 Mar;53(3):905-14. doi: 10.1002/hep.24106. Epub 2011 Feb 11.


The nuclear pore complex protein Elys is required for genome stability in mouse intestinal epithelial progenitor cells.

Gao N, Davuluri G, Gong W, Seiler C, Lorent K, Furth EE, Kaestner KH, Pack M.

Gastroenterology. 2011 May;140(5):1547-55.e10. doi: 10.1053/j.gastro.2011.01.048. Epub 2011 Mar 21.


Reiterative use of the notch signal during zebrafish intrahepatic biliary development.

Lorent K, Moore JC, Siekmann AF, Lawson N, Pack M.

Dev Dyn. 2010 Mar;239(3):855-64. doi: 10.1002/dvdy.22220.


TNFalpha-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish S-adenosylhomocysteine hydrolase.

Matthews RP, Lorent K, Mañoral-Mobias R, Huang Y, Gong W, Murray IV, Blair IA, Pack M.

Development. 2009 Mar;136(5):865-75. doi: 10.1242/dev.027565.


Mutation of the zebrafish nucleoporin elys sensitizes tissue progenitors to replication stress.

Davuluri G, Gong W, Yusuff S, Lorent K, Muthumani M, Dolan AC, Pack M.

PLoS Genet. 2008 Oct;4(10):e1000240. doi: 10.1371/journal.pgen.1000240. Epub 2008 Oct 31.


Transcription factor onecut3 regulates intrahepatic biliary development in zebrafish.

Matthews RP, Lorent K, Pack M.

Dev Dyn. 2008 Jan;237(1):124-31.


Mutation of RNA Pol III subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and disrupts zebrafish digestive development.

Yee NS, Gong W, Huang Y, Lorent K, Dolan AC, Maraia RJ, Pack M.

PLoS Biol. 2007 Nov;5(11):e312.


Zebrafish fat-free is required for intestinal lipid absorption and Golgi apparatus structure.

Ho SY, Lorent K, Pack M, Farber SA.

Cell Metab. 2006 Apr;3(4):289-300.


Exocrine pancreas development in zebrafish.

Yee NS, Lorent K, Pack M.

Dev Biol. 2005 Aug 1;284(1):84-101.


Intestinal growth and differentiation in zebrafish.

Wallace KN, Akhter S, Smith EM, Lorent K, Pack M.

Mech Dev. 2005 Feb;122(2):157-73.


Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy.

Lorent K, Yeo SY, Oda T, Chandrasekharappa S, Chitnis A, Matthews RP, Pack M.

Development. 2004 Nov;131(22):5753-66.


Differential expression of mRNA coding for the alpha-2-macroglobulin family and the LRP receptor system in C57BL/6J and C3H/HeJ male mice.

Correia Soeiro MN, Paiva MM, Waghabi M, Meirelles MN, Lorent K, Araújo-Jorge TC, Van Leuven F.

Cell Struct Funct. 2001 Jun;26(3):161-7.


The zebrafish space cadet gene controls axonal pathfinding of neurons that modulate fast turning movements.

Lorent K, Liu KS, Fetcho JR, Granato M.

Development. 2001 Jun;128(11):2131-42.


Trypanosoma cruzi: acute infection affects expression of alpha-2-macroglobulin and A2MR/LRP receptor differently in C3H and C57BL/6 mice.

Soeiro Mde N, Paiva MM, Waghabi MC, Meirelles Mde N, Lorent K, Henriques-Pons A, Coutinho CM, Van Leuven F, Araújo-Jorge TC.

Exp Parasitol. 2000 Oct;96(2):97-107.


Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain.

Moechars D, Dewachter I, Lorent K, Reversé D, Baekelandt V, Naidu A, Tesseur I, Spittaels K, Haute CV, Checler F, Godaux E, Cordell B, Van Leuven F.

J Biol Chem. 1999 Mar 5;274(10):6483-92.


Transgenic mice expressing an alpha-secretion mutant of the amyloid precursor protein in the brain develop a progressive CNS disorder.

Moechars D, Lorent K, Dewachter I, Baekelandt V, De Strooper B, Van Leuven F.

Behav Brain Res. 1998 Sep;95(1):55-64.


Targeted inactivation of the mouse alpha 2-macroglobulin gene.

Umans L, Serneels L, Overbergh L, Lorent K, Van Leuven F, Van den Berghe H.

J Biol Chem. 1995 Aug 25;270(34):19778-85.


Expression of mouse alpha-macroglobulins, lipoprotein receptor-related protein, LDL receptor, apolipoprotein E, and lipoprotein lipase in pregnancy.

Overbergh L, Lorent K, Torrekens S, Van Leuven F, Van den Berghe H.

J Lipid Res. 1995 Aug;36(8):1774-86.


Structure of the gene (LRP1) coding for the human alpha 2-macroglobulin receptor lipoprotein receptor-related protein.

Van Leuven F, Stas L, Hilliker C, Lorent K, Umans L, Serneels L, Overbergh L, Torrekens S, Moechars D, De Strooper B, et al.

Genomics. 1994 Nov 1;24(1):78-89.


Expression of mouse alpha 2M and its receptor in vivo.

Lorent K, Overbergh L, Van Leuven F.

Ann N Y Acad Sci. 1994 Sep 10;737:498-9. No abstract available.


Characterization of the genes coding for the murinoglobulins and expression in vivo.

Overbergh L, Lorent K, Hilliker C, Van Leuven F.

Ann N Y Acad Sci. 1994 Sep 10;737:496-7. No abstract available.


Molecular analysis of the human and mouse alpha 2M family.

Van Leuven F, Umans L, Lorent K, Hilliker C, Serneels L, Overbergh L, Stas L, Raymakers L.

Ann N Y Acad Sci. 1994 Sep 10;737:163-71. Review. No abstract available.


Molecular cloning and sequencing of the murine alpha-2-macroglobulin receptor cDNA.

Van Leuven F, Stas L, Raymakers L, Overbergh L, De Strooper B, Hilliker C, Lorent K, Fias E, Umans L, Torrekens S, et al.

Biochim Biophys Acta. 1993 Apr 29;1173(1):71-4.


The primary sequence and the subunit structure of mouse alpha-2-macroglobulin, deduced from protein sequencing of the isolated subunits and from molecular cloning of the cDNA.

van Leuven F, Torrekens S, Overbergh L, Lorent K, de Strooper B, van den Berghe H.

Eur J Biochem. 1992 Nov 15;210(1):319-27.

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