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Items: 1 to 50 of 97

1.

Skin immunisation activates an innate lymphoid cell-monocyte axis regulating CD8+ effector recruitment to mucosal tissues.

Zaric M, Becker PD, Hervouet C, Kalcheva P, Doszpoly A, Blattman N, A O' Neill L, Yus BI, Cocita C, Kwon SY, Baker AH, Lord GM, Klavinskis LS.

Nat Commun. 2019 May 17;10(1):2214. doi: 10.1038/s41467-019-09969-2.

2.

The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population.

Stapleton CP, Heinzel A, Guan W, van der Most PJ, van Setten J, Lord GM, Keating BJ, Israni AK, de Borst MH, Bakker SJL, Snieder H, Weale ME, Delaney F, Hernandez-Fuentes MP, Reindl-Schwaighofer R, Oberbauer R, Jacobson PA, Mark PB, Chapman FA, Phelan PJ, Kennedy C, Sexton D, Murray S, Jardine A, Traynor JP, McKnight AJ, Maxwell AP, Smyth LJ, Oetting WS, Matas AJ, Mannon RB, Schladt DP, Iklé DN, Cavalleri GL, Conlon PJ; UK Ireland Renal Transplant Consortium; DeKAF Genomics and GEN03 Studies; International Genetics and Translational Research in Transplantation Network.

Am J Transplant. 2019 Feb 27. doi: 10.1111/ajt.15326. [Epub ahead of print]

PMID:
30920136
3.

Development of a multivariable gene-expression signature targeting T-cell-mediated rejection in peripheral blood of kidney transplant recipients validated in cross-sectional and longitudinal samples.

Christakoudi S, Runglall M, Mobillo P, Tsui TL, Duff C, Domingo-Vila C, Kamra Y, Delaney F, Montero R, Spiridou A, Kassimatis T, Phin-Kon S, Tucker B, Farmer C, Strom TB, Lord GM, Rebollo-Mesa I, Stahl D, Sacks S, Hernandez-Fuentes MP, Chowdhury P.

EBioMedicine. 2019 Mar;41:571-583. doi: 10.1016/j.ebiom.2019.01.060. Epub 2019 Mar 2.

4.

microRNA-142-mediated repression of phosphodiesterase 3B critically regulates peripheral immune tolerance.

Anandagoda N, Willis JC, Hertweck A, Roberts LB, Jackson I, Gökmen MR, Jenner RG, Howard JK, Lord GM.

J Clin Invest. 2019 Mar 1;129(3):1257-1271. doi: 10.1172/JCI124725. Epub 2019 Feb 11.

5.

Correction of Defective T-Regulatory Cells From Patients With Crohn's Disease by Ex Vivo Ligation of Retinoic Acid Receptor-α.

Goldberg R, Scotta C, Cooper D, Nissim-Eliraz E, Nir E, Tasker S, Irving PM, Sanderson J, Lavender P, Ibrahim F, Corcoran J, Prevost T, Shpigel NY, Marelli-Berg F, Lombardi G, Lord GM.

Gastroenterology. 2019 May;156(6):1775-1787. doi: 10.1053/j.gastro.2019.01.025. Epub 2019 Jan 30.

PMID:
30710527
6.

T-bet controls intestinal mucosa immune responses via repression of type 2 innate lymphoid cell function.

Garrido-Mesa N, Schroeder JH, Stolarczyk E, Gallagher AL, Lo JW, Bailey C, Campbell L, Sexl V, MacDonald TT, Howard JK, Grencis RK, Powell N, Lord GM.

Mucosal Immunol. 2019 Jan;12(1):51-63. doi: 10.1038/s41385-018-0092-6. Epub 2018 Oct 24.

7.

Immunomodulatory role of Keratin 76 in oral and gastric cancer.

Sequeira I, Neves JF, Carrero D, Peng Q, Palasz N, Liakath-Ali K, Lord GM, Morgan PR, Lombardi G, Watt FM.

Nat Commun. 2018 Aug 24;9(1):3437. doi: 10.1038/s41467-018-05872-4.

8.

The genetic determinants of renal allograft rejection.

Hernandez-Fuentes M, Stapleton CP, Cavalleri GL, Conlon P, Weale ME, Lord GM; United Kingdom and Ireland Renal Transplant Consortium (UKIRTC).

Am J Transplant. 2018 Aug;18(8):2100-2101. doi: 10.1111/ajt.14909. Epub 2018 May 28. No abstract available.

9.

Steroid regulation: An overlooked aspect of tolerance and chronic rejection in kidney transplantation.

Christakoudi S, Runglall M, Mobillo P, Rebollo-Mesa I, Tsui TL, Nova-Lamperti E, Norris S, Kamra Y, Hilton R, Bhandari S, Baker R, Berglund D, Carr S, Game D, Griffin S, Kalra PA, Lewis R, Mark PB, Marks SD, Macphee I, McKane W, Mohaupt MG, Pararajasingam R, Kon SP, Serón D, Sinha M, Tucker B, Viklický O, Lechler RI, Lord GM, Stahl D, Hernandez-Fuentes MP.

Mol Cell Endocrinol. 2018 Sep 15;473:205-216. doi: 10.1016/j.mce.2018.01.021. Epub 2018 Feb 7.

10.

Long- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study.

Hernandez-Fuentes MP, Franklin C, Rebollo-Mesa I, Mollon J, Delaney F, Perucha E, Stapleton C, Borrows R, Byrne C, Cavalleri G, Clarke B, Clatworthy M, Feehally J, Fuggle S, Gagliano SA, Griffin S, Hammad A, Higgins R, Jardine A, Keogan M, Leach T, MacPhee I, Mark PB, Marsh J, Maxwell P, McKane W, McLean A, Newstead C, Augustine T, Phelan P, Powis S, Rowe P, Sheerin N, Solomon E, Stephens H, Thuraisingham R, Trembath R, Topham P, Vaughan R, Sacks SH, Conlon P, Opelz G, Soranzo N, Weale ME, Lord GM; United Kingdom and Ireland Renal Transplant Consortium (UKIRTC) and the Wellcome Trust Case Control Consortium (WTCCC)-3.

Am J Transplant. 2018 Jun;18(6):1370-1379. doi: 10.1111/ajt.14594. Epub 2018 Feb 1.

11.

Genetic variants alter T-bet binding and gene expression in mucosal inflammatory disease.

Soderquest K, Hertweck A, Giambartolomei C, Henderson S, Mohamed R, Goldberg R, Perucha E, Franke L, Herrero J, Plagnol V, Jenner RG, Lord GM.

PLoS Genet. 2017 Feb 10;13(2):e1006587. doi: 10.1371/journal.pgen.1006587. eCollection 2017 Feb.

12.

Genomic and clinical profiling of a national nephrotic syndrome cohort advocates a precision medicine approach to disease management.

Bierzynska A, McCarthy HJ, Soderquest K, Sen ES, Colby E, Ding WY, Nabhan MM, Kerecuk L, Hegde S, Hughes D, Marks S, Feather S, Jones C, Webb NJ, Ognjanovic M, Christian M, Gilbert RD, Sinha MD, Lord GM, Simpson M, Koziell AB, Welsh GI, Saleem MA.

Kidney Int. 2017 Apr;91(4):937-947. doi: 10.1016/j.kint.2016.10.013. Epub 2017 Jan 20.

PMID:
28117080
13.

Retinoic Acid Signaling in B Cells Is Required for the Generation of an Effective T-Independent Immune Response.

Marks E, Ortiz C, Pantazi E, Bailey CS, Lord GM, Waldschmidt TJ, Noelle RJ, Elgueta R.

Front Immunol. 2016 Dec 23;7:643. doi: 10.3389/fimmu.2016.00643. eCollection 2016.

14.

MAGI2 Mutations Cause Congenital Nephrotic Syndrome.

Bierzynska A, Soderquest K, Dean P, Colby E, Rollason R, Jones C, Inward CD, McCarthy HJ, Simpson MA, Lord GM, Williams M, Welsh GI, Koziell AB, Saleem MA; NephroS; UK study of Nephrotic Syndrome.

J Am Soc Nephrol. 2017 May;28(5):1614-1621. doi: 10.1681/ASN.2016040387. Epub 2016 Dec 8.

15.

Boosting translational research in the U.K.

Anandagoda N, Lord GM.

Sci Transl Med. 2016 Sep 21;8(357):357fs15. doi: 10.1126/scitranslmed.aag1172. Review.

PMID:
27655847
16.

Increased CD40 Ligation and Reduced BCR Signalling Leads to Higher IL-10 Production in B Cells From Tolerant Kidney Transplant Patients.

Nova-Lamperti E, Chana P, Mobillo P, Runglall M, Kamra Y, McGregor R, Lord GM, Lechler RI, Lombardi G, Hernandez-Fuentes MP; GAMBIT Study.

Transplantation. 2017 Mar;101(3):541-547. doi: 10.1097/TP.0000000000001341.

17.

A global call for action to include gender in research impact assessment.

Ovseiko PV, Greenhalgh T, Adam P, Grant J, Hinrichs-Krapels S, Graham KE, Valentine PA, Sued O, Boukhris OF, Al Olaqi NM, Al Rahbi IS, Dowd AM, Bice S, Heiden TL, Fischer MD, Dopson S, Norton R, Pollitt A, Wooding S, Balling GV, Jakobsen U, Kuhlmann E, Klinge I, Pololi LH, Jagsi R, Smith HL, Etzkowitz H, Nielsen MW, Carrion C, Solans-Domènech M, Vizcaino E, Naing L, Cheok QH, Eckelmann B, Simuyemba MC, Msiska T, Declich G, Edmunds LD, Kiparoglou V, Buchan AM, Williamson C, Lord GM, Channon KM, Surender R, Buchan AM.

Health Res Policy Syst. 2016 Jul 19;14(1):50. doi: 10.1186/s12961-016-0126-z.

18.

Biomarkers of Tolerance in Kidney Transplantation: Are We Predicting Tolerance or Response to Immunosuppressive Treatment?

Rebollo-Mesa I, Nova-Lamperti E, Mobillo P, Runglall M, Christakoudi S, Norris S, Smallcombe N, Kamra Y, Hilton R; Indices of Tolerance EU Consortium, Bhandari S, Baker R, Berglund D, Carr S, Game D, Griffin S, Kalra PA, Lewis R, Mark PB, Marks S, Macphee I, McKane W, Mohaupt MG, Pararajasingam R, Kon SP, Serón D, Sinha MD, Tucker B, Viklický O, Lechler RI, Lord GM, Hernandez-Fuentes MP.

Am J Transplant. 2016 Dec;16(12):3443-3457. doi: 10.1111/ajt.13932. Epub 2016 Aug 8.

19.

T-bet Activates Th1 Genes through Mediator and the Super Elongation Complex.

Hertweck A, Evans CM, Eskandarpour M, Lau JC, Oleinika K, Jackson I, Kelly A, Ambrose J, Adamson P, Cousins DJ, Lavender P, Calder VL, Lord GM, Jenner RG.

Cell Rep. 2016 Jun 21;15(12):2756-70. doi: 10.1016/j.celrep.2016.05.054. Epub 2016 Jun 9.

20.

IL-10-produced by human transitional B-cells down-regulates CD86 expression on B-cells leading to inhibition of CD4+T-cell responses.

Nova-Lamperti E, Fanelli G, Becker PD, Chana P, Elgueta R, Dodd PC, Lord GM, Lombardi G, Hernandez-Fuentes MP.

Sci Rep. 2016 Jan 22;6:20044. doi: 10.1038/srep20044.

21.

Markers of achievement for assessing and monitoring gender equity in translational research organisations: a rationale and study protocol.

Ovseiko PV, Edmunds LD, Pololi LH, Greenhalgh T, Kiparoglou V, Henderson LR, Williamson C, Grant J, Lord GM, Channon KM, Lechler RI, Buchan AM.

BMJ Open. 2016 Jan 7;6(1):e009022. doi: 10.1136/bmjopen-2015-009022.

22.

T-bet as a key regulator of mucosal immunity.

Mohamed R, Lord GM.

Immunology. 2016 Apr;147(4):367-76. doi: 10.1111/imm.12575. Epub 2016 Feb 23. Review.

23.

Diversity of gut microflora is required for the generation of B cell with regulatory properties in a skin graft model.

Alhabbab R, Blair P, Elgueta R, Stolarczyk E, Marks E, Becker PD, Ratnasothy K, Smyth L, Safinia N, Sharif-Paghaleh E, O'Connell S, Noelle RJ, Lord GM, Howard JK, Spencer J, Lechler RI, Lombardi G.

Sci Rep. 2015 Jun 25;5:11554. doi: 10.1038/srep11554.

24.

The unusual suspects--innate lymphoid cells as novel therapeutic targets in IBD.

Goldberg R, Prescott N, Lord GM, MacDonald TT, Powell N.

Nat Rev Gastroenterol Hepatol. 2015 May;12(5):271-83. doi: 10.1038/nrgastro.2015.52. Review.

PMID:
25971811
25.

Interleukin 6 Increases Production of Cytokines by Colonic Innate Lymphoid Cells in Mice and Patients With Chronic Intestinal Inflammation.

Powell N, Lo JW, Biancheri P, Vossenkämper A, Pantazi E, Walker AW, Stolarczyk E, Ammoscato F, Goldberg R, Scott P, Canavan JB, Perucha E, Garrido-Mesa N, Irving PM, Sanderson JD, Hayee B, Howard JK, Parkhill J, MacDonald TT, Lord GM.

Gastroenterology. 2015 Aug;149(2):456-67.e15. doi: 10.1053/j.gastro.2015.04.017. Epub 2015 Apr 25.

26.

Immune biomarkers: the promises and pitfalls of personalized medicine.

Willis JC, Lord GM.

Nat Rev Immunol. 2015 May;15(5):323-9. doi: 10.1038/nri3820. Epub 2015 Mar 27. Review.

PMID:
25814400
27.

Retinoic acid is essential for Th1 cell lineage stability and prevents transition to a Th17 cell program.

Brown CC, Esterhazy D, Sarde A, London M, Pullabhatla V, Osma-Garcia I, Al-Bader R, Ortiz C, Elgueta R, Arno M, de Rinaldis E, Mucida D, Lord GM, Noelle RJ.

Immunity. 2015 Mar 17;42(3):499-511. doi: 10.1016/j.immuni.2015.02.003. Epub 2015 Mar 10.

28.

Developing in vitro expanded CD45RA+ regulatory T cells as an adoptive cell therapy for Crohn's disease.

Canavan JB, Scottà C, Vossenkämper A, Goldberg R, Elder MJ, Shoval I, Marks E, Stolarczyk E, Lo JW, Powell N, Fazekasova H, Irving PM, Sanderson JD, Howard JK, Yagel S, Afzali B, MacDonald TT, Hernandez-Fuentes MP, Shpigel NY, Lombardi G, Lord GM.

Gut. 2016 Apr;65(4):584-94. doi: 10.1136/gutjnl-2014-306919. Epub 2015 Feb 24.

29.

Preventing aristolochic acid nephropathy.

Anandagoda N, Lord GM.

Clin J Am Soc Nephrol. 2015 Feb 6;10(2):167-8. doi: 10.2215/CJN.12391214. Epub 2015 Jan 13. No abstract available.

30.

Role and species-specific expression of colon T cell homing receptor GPR15 in colitis.

Nguyen LP, Pan J, Dinh TT, Hadeiba H, O'Hara E 3rd, Ebtikar A, Hertweck A, Gökmen MR, Lord GM, Jenner RG, Butcher EC, Habtezion A.

Nat Immunol. 2015 Feb;16(2):207-213. doi: 10.1038/ni.3079. Epub 2014 Dec 22.

31.

CCR6-dependent positioning of memory B cells is essential for their ability to mount a recall response to antigen.

Elgueta R, Marks E, Nowak E, Menezes S, Benson M, Raman VS, Ortiz C, O'Connell S, Hess H, Lord GM, Noelle R.

J Immunol. 2015 Jan 15;194(2):505-13. doi: 10.4049/jimmunol.1401553. Epub 2014 Dec 12.

32.

The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression.

Male V, Nisoli I, Kostrzewski T, Allan DS, Carlyle JR, Lord GM, Wack A, Brady HJ.

J Exp Med. 2014 Apr 7;211(4):635-42. doi: 10.1084/jem.20132398. Epub 2014 Mar 24.

33.

How might a diagnostic microRNA signature be used to speed up the diagnosis of sepsis?

Shankar-Hari M, Lord GM.

Expert Rev Mol Diagn. 2014 Apr;14(3):249-51. doi: 10.1586/14737159.2014.899151.

PMID:
24649814
34.

The immune cell transcription factor T-bet: A novel metabolic regulator.

Stolarczyk E, Lord GM, Howard JK.

Adipocyte. 2014 Jan 1;3(1):58-62. doi: 10.4161/adip.26220. Epub 2013 Aug 28.

35.

Genome-wide regulatory analysis reveals that T-bet controls Th17 lineage differentiation through direct suppression of IRF4.

Gökmen MR, Dong R, Kanhere A, Powell N, Perucha E, Jackson I, Howard JK, Hernandez-Fuentes M, Jenner RG, Lord GM.

J Immunol. 2013 Dec 15;191(12):5925-32. doi: 10.4049/jimmunol.1202254. Epub 2013 Nov 18.

36.

Genome-wide sequencing of cellular microRNAs identifies a combinatorial expression signature diagnostic of sepsis.

Ma Y, Vilanova D, Atalar K, Delfour O, Edgeworth J, Ostermann M, Hernandez-Fuentes M, Razafimahatratra S, Michot B, Persing DH, Ziegler I, Törös B, Mölling P, Olcén P, Beale R, Lord GM.

PLoS One. 2013 Oct 16;8(10):e75918. doi: 10.1371/journal.pone.0075918. eCollection 2013.

37.

T-bet: a bridge between innate and adaptive immunity.

Lazarevic V, Glimcher LH, Lord GM.

Nat Rev Immunol. 2013 Nov;13(11):777-89. doi: 10.1038/nri3536. Epub 2013 Oct 11. Review.

38.

Comparison of regulatory T cells in hemodialysis patients and healthy controls: implications for cell therapy in transplantation.

Afzali B, Edozie FC, Fazekasova H, Scottà C, Mitchell PJ, Canavan JB, Kordasti SY, Chana PS, Ellis R, Lord GM, John S, Hilton R, Lechler RI, Lombardi G.

Clin J Am Soc Nephrol. 2013 Aug;8(8):1396-405. doi: 10.2215/CJN.12931212. Epub 2013 Apr 11.

39.

Improved insulin sensitivity despite increased visceral adiposity in mice deficient for the immune cell transcription factor T-bet.

Stolarczyk E, Vong CT, Perucha E, Jackson I, Cawthorne MA, Wargent ET, Powell N, Canavan JB, Lord GM, Howard JK.

Cell Metab. 2013 Apr 2;17(4):520-33. doi: 10.1016/j.cmet.2013.02.019.

40.

The epidemiology, diagnosis, and management of aristolochic acid nephropathy: a narrative review.

Gökmen MR, Cosyns JP, Arlt VM, Stiborová M, Phillips DH, Schmeiser HH, Simmonds MS, Cook HT, Vanherweghem JL, Nortier JL, Lord GM.

Ann Intern Med. 2013 Mar 19;158(6):469-77. doi: 10.7326/0003-4819-158-6-201303190-00006. Review.

PMID:
23552405
41.

Assessment of regulatory T-cell function in forthcoming clinical trials of cell therapy.

Canavan JB, Afzali B, Lord GM, Lombardi G.

Expert Rev Mol Diagn. 2013 Jan;13(1):5-7. doi: 10.1586/erm.12.133. No abstract available.

42.

T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements.

Kanhere A, Hertweck A, Bhatia U, Gökmen MR, Perucha E, Jackson I, Lord GM, Jenner RG.

Nat Commun. 2012;3:1268. doi: 10.1038/ncomms2260.

43.

Helicobacter pylori induces in-vivo expansion of human regulatory T cells through stimulating interleukin-1β production by dendritic cells.

Mitchell PJ, Afzali B, Fazekasova H, Chen D, Ali N, Powell N, Lord GM, Lechler RI, Lombardi G.

Clin Exp Immunol. 2012 Dec;170(3):300-9. doi: 10.1111/j.1365-2249.2012.04659.x.

44.

The transcription factor T-bet regulates intestinal inflammation mediated by interleukin-7 receptor+ innate lymphoid cells.

Powell N, Walker AW, Stolarczyk E, Canavan JB, Gökmen MR, Marks E, Jackson I, Hashim A, Curtis MA, Jenner RG, Howard JK, Parkhill J, MacDonald TT, Lord GM.

Immunity. 2012 Oct 19;37(4):674-84. doi: 10.1016/j.immuni.2012.09.008. Epub 2012 Oct 11.

45.

Aristolochic acid nephropathy.

Gökmen MR, Lord GM.

BMJ. 2012 Jun 15;344:e4000. doi: 10.1136/bmj.e4000. No abstract available.

PMID:
22705815
46.

A rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy.

Canavan JB, Afzali B, Scottà C, Fazekasova H, Edozie FC, Macdonald TT, Hernandez-Fuentes MP, Lombardi G, Lord GM.

Blood. 2012 Feb 23;119(8):e57-66. doi: 10.1182/blood-2011-09-380048. Epub 2012 Jan 4.

47.

Molecular genetic characterization of SMAD signaling molecules in pulmonary arterial hypertension.

Nasim MT, Ogo T, Ahmed M, Randall R, Chowdhury HM, Snape KM, Bradshaw TY, Southgate L, Lee GJ, Jackson I, Lord GM, Gibbs JS, Wilkins MR, Ohta-Ogo K, Nakamura K, Girerd B, Coulet F, Soubrier F, Humbert M, Morrell NW, Trembath RC, Machado RD.

Hum Mutat. 2011 Dec;32(12):1385-9. doi: 10.1002/humu.21605. Epub 2011 Oct 11.

PMID:
21898662
48.

Transcriptional control of natural killer cell differentiation and function.

Martín-Fontecha A, Lord GM, Brady HJ.

Cell Mol Life Sci. 2011 Nov;68(21):3495-503. doi: 10.1007/s00018-011-0800-9. Epub 2011 Aug 24. Review.

PMID:
21863375
49.

Relative resistance of human CD4(+) memory T cells to suppression by CD4(+) CD25(+) regulatory T cells.

Afzali B, Mitchell PJ, Scottà C, Canavan J, Edozie FC, Fazekasova H, Lord GM, John S, Barber LD, Hernandez-Fuentes MP, Lechler RI, Lombardi G.

Am J Transplant. 2011 Aug;11(8):1734-42. doi: 10.1111/j.1600-6143.2011.03635.x. Epub 2011 Jul 12.

50.

An imaging flow cytometric method for measuring cell division history and molecular symmetry during mitosis.

Filby A, Perucha E, Summers H, Rees P, Chana P, Heck S, Lord GM, Davies D.

Cytometry A. 2011 Jul;79(7):496-506. doi: 10.1002/cyto.a.21091. Epub 2011 Jun 2.

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