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Items: 1 to 50 of 704

1.

A novel tankyrase inhibitor, MSC2504877, enhances the effects of clinical CDK4/6 inhibitors.

Menon M, Elliott R, Bowers L, Balan N, Rafiq R, Costa-Cabral S, Munkonge F, Trinidade I, Porter R, Campbell AD, Johnson ER, Esdar C, Buchstaller HP, Leuthner B, Rohdich F, Schneider R, Sansom O, Wienke D, Ashworth A, Lord CJ.

Sci Rep. 2019 Jan 17;9(1):201. doi: 10.1038/s41598-018-36447-4.

2.

How effective is LENA in detecting speech vocalizations and language produced by children and adolescents with ASD in different contexts?

Jones RM, Plesa Skwerer D, Pawar R, Hamo A, Carberry C, Ajodan EL, Caulley D, Silverman MR, McAdoo S, Meyer S, Yoder A, Clements M, Lord C, Tager-Flusberg H.

Autism Res. 2019 Jan 14. doi: 10.1002/aur.2071. [Epub ahead of print]

PMID:
30638310
3.

PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer.

Chabanon RM, Muirhead G, Krastev DB, Adam J, Morel D, Garrido M, Lamb A, Hénon C, Dorvault N, Rouanne M, Marlow R, Bajrami I, Cardeñosa ML, Konde A, Besse B, Ashworth A, Pettitt SJ, Haider S, Marabelle A, Tutt AN, Soria JC, Lord CJ, Postel-Vinay S.

J Clin Invest. 2018 Dec 27. pii: 123319. doi: 10.1172/JCI123319. [Epub ahead of print]

4.

Changing Developmental Trajectories of Toddlers With Autism Spectrum Disorder: Strategies for Bridging Research to Community Practice.

Wetherby AM, Woods J, Guthrie W, Delehanty A, Brown JA, Morgan L, Holland RD, Schatschneider C, Lord C.

J Speech Lang Hear Res. 2018 Nov 8;61(11):2615-2628. doi: 10.1044/2018_JSLHR-L-RSAUT-18-0028.

PMID:
30418491
5.

Variability in Autism Symptom Trajectories Using Repeated Observations From 14 to 36 Months of Age.

Kim SH, Bal VH, Benrey N, Choi YB, Guthrie W, Colombi C, Lord C.

J Am Acad Child Adolesc Psychiatry. 2018 Nov;57(11):837-848.e2. doi: 10.1016/j.jaac.2018.05.026. Epub 2018 Sep 5.

PMID:
30392625
6.

For Better or for Worse? Later Diagnoses of Autism Spectrum Disorder in Some Younger Siblings of Already Diagnosed Children.

Lord C.

J Am Acad Child Adolesc Psychiatry. 2018 Nov;57(11):822-823. doi: 10.1016/j.jaac.2018.08.008.

PMID:
30392621
7.

Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer.

Rodrigues DN, Rescigno P, Liu D, Yuan W, Carreira S, Lambros MB, Seed G, Mateo J, Riisnaes R, Mullane S, Margolis C, Miao D, Miranda S, Dolling D, Clarke M, Bertan C, Crespo M, Boysen G, Ferreira A, Sharp A, Figueiredo I, Keliher D, Aldubayan S, Burke KP, Sumanasuriya S, Fontes MS, Bianchini D, Zafeiriou Z, Mendes LST, Mouw K, Schweizer MT, Pritchard CC, Salipante S, Taplin ME, Beltran H, Rubin MA, Cieslik M, Robinson D, Heath E, Schultz N, Armenia J, Abida W, Scher H, Lord C, D'Andrea A, Sawyers CL, Chinnaiyan AM, Alimonti A, Nelson PS, Drake CG, Van Allen EM, de Bono JS.

J Clin Invest. 2018 Nov 1;128(11):5185. doi: 10.1172/JCI125184. Epub 2018 Nov 1. No abstract available.

8.

Ghrelin Receptor Agonist Rescues Excess Neonatal Mortality in a Prader-Willi Syndrome Mouse Model.

Rodriguez JA, Bruggeman EC, Mani BK, Osborne-Lawrence S, Lord CC, Roseman HF, Viroslav HL, Vijayaraghavan P, Metzger NP, Gupta D, Shankar K, Pietra C, Liu C, Zigman JM.

Endocrinology. 2018 Dec 1;159(12):4006-4022. doi: 10.1210/en.2018-00801.

PMID:
30380028
9.

Cells Lacking the RB1 Tumor Suppressor Gene are Hyperdependent on Aurora B Kinase for Survival.

Oser MG, Fonseca R, Chakraborty AA, Brough R, Spektor A, Jennings RB, Flaifel A, Novak JS, Gulati A, Buss E, Younger ST, McBrayer SK, Cowley GS, Bonal DM, Nguyen QD, Brulle-Soumare L, Taylor P, Cairo S, Ryan CJ, Pease EJ, Maratea K, Travers J, Root DE, Signoretti S, Pellman D, Ashton S, Lord CJ, Barry ST, Kaelin WG.

Cancer Discov. 2018 Oct 29. pii: CD-18-0389. doi: 10.1158/2159-8290.CD-18-0389. [Epub ahead of print]

PMID:
30373918
10.

Correction: Correction: CDK1 Is a Synthetic Lethal Target for KRAS Mutant Tumours.

Costa-Cabral S, Brough R, Konde A, Aarts M, Campbell J, Marinari E, Riffell J, Bardelli A, Torrance C, Lord CJ, Ashworth A.

PLoS One. 2018 Oct 26;13(10):e0206729. doi: 10.1371/journal.pone.0206729. eCollection 2018.

11.

A Four-gene Decision Tree Signature Classification of Triple-negative Breast Cancer: Implications for Targeted Therapeutics.

Quist J, Mirza H, Cheang MCU, Telli ML, O'Shaughnessy JA, Lord CJ, Tutt ANJ, Grigoriadis A.

Mol Cancer Ther. 2019 Jan;18(1):204-212. doi: 10.1158/1535-7163.MCT-18-0243. Epub 2018 Oct 10.

PMID:
30305342
12.

Measuring treatment response in children with autism spectrum disorder: Applications of the Brief Observation of Social Communication Change to the Autism Diagnostic Observation Schedule.

Kim SH, Grzadzinski R, Martinez K, Lord C.

Autism. 2018 Oct 10:1362361318793253. doi: 10.1177/1362361318793253. [Epub ahead of print]

PMID:
30303398
13.

Synthetic Lethality and Cancer - Penetrance as the Major Barrier.

Ryan CJ, Bajrami I, Lord CJ.

Trends Cancer. 2018 Oct;4(10):671-683. doi: 10.1016/j.trecan.2018.08.003. Epub 2018 Sep 15. Review.

PMID:
30292351
14.

Immunogenomic analyses associate immunological alterations with mismatch repair defects in prostate cancer.

Nava Rodrigues D, Rescigno P, Liu D, Yuan W, Carreira S, Lambros MB, Seed G, Mateo J, Riisnaes R, Mullane S, Margolis C, Miao D, Miranda S, Dolling D, Clarke M, Bertan C, Crespo M, Boysen G, Ferreira A, Sharp A, Figueiredo I, Keliher D, Aldubayan S, Burke KP, Sumanasuriya S, Fontes MS, Bianchini D, Zafeiriou Z, Teixeira Mendes LS, Mouw K, Schweizer MT, Pritchard CC, Salipante S, Taplin ME, Beltran H, Rubin MA, Cieslik M, Robinson D, Heath E, Schultz N, Armenia J, Abida W, Scher H, Lord C, D'Andrea A, Sawyers CL, Chinnaiyan AM, Alimonti A, Nelson PS, Drake CG, Van Allen EM, de Bono JS.

J Clin Invest. 2018 Oct 1;128(10):4441-4453. doi: 10.1172/JCI121924. Epub 2018 Sep 4.

15.

Author Correction: Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness.

Holme H, Gulati A, Brough R, Fleuren EDG, Bajrami I, Campbell J, Chong IY, Costa-Cabral S, Elliott R, Fenton T, Frankum J, Jones SE, Menon M, Miller R, Pemberton HN, Postel-Vinay S, Rafiq R, Selfe JL, von Kriegsheim A, Munoz AG, Rodriguez J, Shipley J, van der Graaf WTA, Williamson CT, Ryan CJ, Pettitt S, Ashworth A, Strauss SJ, Lord CJ.

Sci Rep. 2018 Aug 21;8(1):12771. doi: 10.1038/s41598-018-30922-8.

16.

Autism spectrum disorder symptoms from ages 2 to 19 years: Implications for diagnosing adolescents and young adults.

Bal VH, Kim SH, Fok M, Lord C.

Autism Res. 2019 Jan;12(1):89-99. doi: 10.1002/aur.2004. Epub 2018 Aug 12.

PMID:
30101492
17.

Autism spectrum disorder.

Lord C, Elsabbagh M, Baird G, Veenstra-Vanderweele J.

Lancet. 2018 Aug 11;392(10146):508-520. doi: 10.1016/S0140-6736(18)31129-2. Epub 2018 Aug 2. Review.

PMID:
30078460
18.

Determinants of parent-delivered therapy interventions in children with cerebral palsy: A qualitative synthesis and checklist.

Lord C, Rapley T, Marcroft C, Pearse J, Basu A.

Child Care Health Dev. 2018 Sep;44(5):659-669. doi: 10.1111/cch.12592. Epub 2018 Jul 23. Review.

PMID:
30033521
19.

Greater loss of horizontal force after a repeated-sprint test in footballers with a previous hamstring injury.

Lord C, Blazevich AJ, Drinkwater EJ, Ma'ayah F.

J Sci Med Sport. 2019 Jan;22(1):16-21. doi: 10.1016/j.jsams.2018.06.008. Epub 2018 Jun 20.

PMID:
30025916
20.

The shieldin complex mediates 53BP1-dependent DNA repair.

Noordermeer SM, Adam S, Setiaputra D, Barazas M, Pettitt SJ, Ling AK, Olivieri M, Álvarez-Quilón A, Moatti N, Zimmermann M, Annunziato S, Krastev DB, Song F, Brandsma I, Frankum J, Brough R, Sherker A, Landry S, Szilard RK, Munro MM, McEwan A, Goullet de Rugy T, Lin ZY, Hart T, Moffat J, Gingras AC, Martin A, van Attikum H, Jonkers J, Lord CJ, Rottenberg S, Durocher D.

Nature. 2018 Aug;560(7716):117-121. doi: 10.1038/s41586-018-0340-7. Epub 2018 Jul 18.

21.

Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness.

Holme H, Gulati A, Brough R, Fleuren EDG, Bajrami I, Campbell J, Chong IY, Costa-Cabral S, Elliott R, Fenton T, Frankum J, Jones SE, Menon M, Miller R, Pemberton HN, Postel-Vinay S, Rafiq R, Selfe JL, von Kriegsheim A, Munoz AG, Rodriguez J, Shipley J, van der Graaf WTA, Williamson CT, Ryan CJ, Pettitt S, Ashworth A, Strauss SJ, Lord CJ.

Sci Rep. 2018 Jul 13;8(1):10614. doi: 10.1038/s41598-018-29043-z. Erratum in: Sci Rep. 2018 Aug 21;8(1):12771.

22.

CD177-mediated nanoparticle targeting of human and mouse neutrophils.

Miettinen HM, Gripentrog JM, Lord CI, Nagy JO.

PLoS One. 2018 Jul 10;13(7):e0200444. doi: 10.1371/journal.pone.0200444. eCollection 2018.

23.

Wild pigs as sentinels for hard ticks: A case study from south-central Florida.

Merrill MM, Boughton RK, Lord CC, Sayler KA, Wight B, Anderson WM, Wisely SM.

Int J Parasitol Parasites Wildl. 2018 Apr 30;7(2):161-170. doi: 10.1016/j.ijppaw.2018.04.003. eCollection 2018 Aug.

24.

Functional diversity and cooperativity between subclonal populations of pediatric glioblastoma and diffuse intrinsic pontine glioma cells.

Vinci M, Burford A, Molinari V, Kessler K, Popov S, Clarke M, Taylor KR, Pemberton HN, Lord CJ, Gutteridge A, Forshew T, Carvalho D, Marshall LV, Qin EY, Ingram WJ, Moore AS, Ng HK, Trabelsi S, H'mida-Ben Brahim D, Entz-Werle N, Zacharoulis S, Vaidya S, Mandeville HC, Bridges LR, Martin AJ, Al-Sarraj S, Chandler C, Sunol M, Mora J, de Torres C, Cruz O, Carcaboso AM, Monje M, Mackay A, Jones C.

Nat Med. 2018 Aug;24(8):1204-1215. doi: 10.1038/s41591-018-0086-7. Epub 2018 Jul 2.

25.

Synthetic lethal therapies for cancer: what's next after PARP inhibitors?

Ashworth A, Lord CJ.

Nat Rev Clin Oncol. 2018 Sep;15(9):564-576. doi: 10.1038/s41571-018-0055-6. Review.

PMID:
29955114
26.

Whole exome sequencing in the rat.

Foley JF, Phadke DP, Hardy O, Hardy S, Miller V, Madan A, Howard K, Kruse K, Lord C, Ramaiahgari S, Solomon GG, Shah RR, Pandiri AR, Herbert RA, Sills RC, Merrick BA.

BMC Genomics. 2018 Jun 20;19(1):487. doi: 10.1186/s12864-018-4858-8.

27.

Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer.

Brough R, Gulati A, Haider S, Kumar R, Campbell J, Knudsen E, Pettitt SJ, Ryan CJ, Lord CJ.

Oncogene. 2018 Jun 18. doi: 10.1038/s41388-018-0368-z. [Epub ahead of print]

28.

Hepatocyte toll-like receptor 4 deficiency protects against alcohol-induced fatty liver disease.

Jia L, Chang X, Qian S, Liu C, Lord CC, Ahmed N, Lee CE, Lee S, Gautron L, Mitchell MC, Horton JD, Scherer PE, Elmquist JK.

Mol Metab. 2018 Aug;14:121-129. doi: 10.1016/j.molmet.2018.05.015. Epub 2018 May 23.

29.

Statistical Learning is Associated with Autism Symptoms and Verbal Abilities in Young Children with Autism.

Jones RM, Tarpey T, Hamo A, Carberry C, Brouwer G, Lord C.

J Autism Dev Disord. 2018 Oct;48(10):3551-3561. doi: 10.1007/s10803-018-3625-7.

PMID:
29855756
30.

Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets.

Krastev DB, Pettitt SJ, Campbell J, Song F, Tanos BE, Stoynov SS, Ashworth A, Lord CJ.

Nat Commun. 2018 May 22;9(1):2016. doi: 10.1038/s41467-018-04466-4.

31.

The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells.

Barazas M, Annunziato S, Pettitt SJ, de Krijger I, Ghezraoui H, Roobol SJ, Lutz C, Frankum J, Song FF, Brough R, Evers B, Gogola E, Bhin J, van de Ven M, van Gent DC, Jacobs JJL, Chapman R, Lord CJ, Jonkers J, Rottenberg S.

Cell Rep. 2018 May 15;23(7):2107-2118. doi: 10.1016/j.celrep.2018.04.046.

32.

Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance.

Pettitt SJ, Krastev DB, Brandsma I, Dréan A, Song F, Aleksandrov R, Harrell MI, Menon M, Brough R, Campbell J, Frankum J, Ranes M, Pemberton HN, Rafiq R, Fenwick K, Swain A, Guettler S, Lee JM, Swisher EM, Stoynov S, Yusa K, Ashworth A, Lord CJ.

Nat Commun. 2018 May 10;9(1):1849. doi: 10.1038/s41467-018-03917-2.

33.

Optimised ARID1A immunohistochemistry is an accurate predictor of ARID1A mutational status in gynaecological cancers.

Khalique S, Naidoo K, Attygalle AD, Kriplani D, Daley F, Lowe A, Campbell J, Jones T, Hubank M, Fenwick K, Matthews N, Rust AG, Lord CJ, Banerjee S, Natrajan R.

J Pathol Clin Res. 2018 Jul;4(3):154-166. doi: 10.1002/cjp2.103. Epub 2018 Jul 20.

34.

E-Cadherin/ROS1 Inhibitor Synthetic Lethality in Breast Cancer.

Bajrami I, Marlow R, van de Ven M, Brough R, Pemberton HN, Frankum J, Song F, Rafiq R, Konde A, Krastev DB, Menon M, Campbell J, Gulati A, Kumar R, Pettitt SJ, Gurden MD, Cardenosa ML, Chong I, Gazinska P, Wallberg F, Sawyer EJ, Martin LA, Dowsett M, Linardopoulos S, Natrajan R, Ryan CJ, Derksen PWB, Jonkers J, Tutt ANJ, Ashworth A, Lord CJ.

Cancer Discov. 2018 Apr;8(4):498-515. doi: 10.1158/2159-8290.CD-17-0603.

35.

POMC neurons expressing leptin receptors coordinate metabolic responses to fasting via suppression of leptin levels.

Caron A, Dungan Lemko HM, Castorena CM, Fujikawa T, Lee S, Lord CC, Ahmed N, Lee CE, Holland WL, Liu C, Elmquist JK.

Elife. 2018 Mar 12;7. pii: e33710. doi: 10.7554/eLife.33710.

36.

Post-operative arterio-venous fistula blood flow influences primary and secondary patency following access surgery.

Benaragama KS, Barwell J, Lord C, John BJ, Babber A, Sandoval S, Lindsey B, Fernando B.

J Ren Care. 2018 Mar 9. doi: 10.1111/jorc.12238. [Epub ahead of print]

PMID:
29520968
37.

Driver Oncogenes but Not as We Know Them: Targetable Fusion Genes in Breast Cancer.

Natrajan R, Tutt ANJ, Lord CJ.

Cancer Discov. 2018 Mar;8(3):272-275. doi: 10.1158/2159-8290.CD-18-0091.

PMID:
29500329
38.

DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade.

Touat M, Sourisseau T, Dorvault N, Chabanon RM, Garrido M, Morel D, Krastev DB, Bigot L, Adam J, Frankum JR, Durand S, Pontoizeau C, Souquère S, Kuo MS, Sauvaigo S, Mardakheh F, Sarasin A, Olaussen KA, Friboulet L, Bouillaud F, Pierron G, Ashworth A, Lombès A, Lord CJ, Soria JC, Postel-Vinay S.

J Clin Invest. 2018 Apr 2;128(4):1671-1687. doi: 10.1172/JCI90277. Epub 2018 Mar 19.

39.

Damaging de novo mutations diminish motor skills in children on the autism spectrum.

Buja A, Volfovsky N, Krieger AM, Lord C, Lash AE, Wigler M, Iossifov I.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1859-E1866. doi: 10.1073/pnas.1715427115. Epub 2018 Feb 6.

40.

Promoting Interprofessional Collaborative Practice Through Simulation.

Alfes CM, Rutherford-Hemming T, Schroeder-Jenkinson CM, Lord CB, Zimmermann E.

Nurs Educ Perspect. 2018 Sep/Oct;39(5):322-323. doi: 10.1097/01.NEP.0000000000000285.

PMID:
29420330
41.

Targeting the Vulnerability of RB Tumor Suppressor Loss in Triple-Negative Breast Cancer.

Witkiewicz AK, Chung S, Brough R, Vail P, Franco J, Lord CJ, Knudsen ES.

Cell Rep. 2018 Jan 30;22(5):1185-1199. doi: 10.1016/j.celrep.2018.01.022.

42.

Identifying Genetic Dependencies in Cancer by Analyzing siRNA Screens in Tumor Cell Line Panels.

Campbell J, Ryan CJ, Lord CJ.

Methods Mol Biol. 2018;1711:83-99. doi: 10.1007/978-1-4939-7493-1_5.

PMID:
29344886
43.

An open resource for transdiagnostic research in pediatric mental health and learning disorders.

Alexander LM, Escalera J, Ai L, Andreotti C, Febre K, Mangone A, Vega-Potler N, Langer N, Alexander A, Kovacs M, Litke S, O'Hagan B, Andersen J, Bronstein B, Bui A, Bushey M, Butler H, Castagna V, Camacho N, Chan E, Citera D, Clucas J, Cohen S, Dufek S, Eaves M, Fradera B, Gardner J, Grant-Villegas N, Green G, Gregory C, Hart E, Harris S, Horton M, Kahn D, Kabotyanski K, Karmel B, Kelly SP, Kleinman K, Koo B, Kramer E, Lennon E, Lord C, Mantello G, Margolis A, Merikangas KR, Milham J, Minniti G, Neuhaus R, Levine A, Osman Y, Parra LC, Pugh KR, Racanello A, Restrepo A, Saltzman T, Septimus B, Tobe R, Waltz R, Williams A, Yeo A, Castellanos FX, Klein A, Paus T, Leventhal BL, Craddock RC, Koplewicz HS, Milham MP.

Sci Data. 2017 Dec 19;4:170181. doi: 10.1038/sdata.2017.181.

44.

Evaluation of CDK12 Protein Expression as a Potential Novel Biomarker for DNA Damage Response-Targeted Therapies in Breast Cancer.

Naidoo K, Wai PT, Maguire SL, Daley F, Haider S, Kriplani D, Campbell J, Mirza H, Grigoriadis A, Tutt A, Moseley PM, Abdel-Fatah TMA, Chan SYT, Madhusudan S, Rhaka EA, Ellis IO, Lord CJ, Yuan Y, Green AR, Natrajan R.

Mol Cancer Ther. 2018 Jan;17(1):306-315. doi: 10.1158/1535-7163.MCT-17-0760. Epub 2017 Nov 13.

45.

Change in knee flexor torque after fatiguing exercise identifies previous hamstring injury in football players.

Lord C, Ma'ayah F, Blazevich AJ.

Scand J Med Sci Sports. 2018 Mar;28(3):1235-1243. doi: 10.1111/sms.13007. Epub 2018 Jan 8.

PMID:
29117428
46.

Distribution and host associations of ixodid ticks collected from wildlife in Florida, USA.

Hertz JC, Ferree Clemons BC, Lord CC, Allan SA, Kaufman PE.

Exp Appl Acarol. 2017 Oct;73(2):223-236. doi: 10.1007/s10493-017-0183-1. Epub 2017 Nov 6.

PMID:
29110170
47.

ATR Is a Therapeutic Target in Synovial Sarcoma.

Jones SE, Fleuren EDG, Frankum J, Konde A, Williamson CT, Krastev DB, Pemberton HN, Campbell J, Gulati A, Elliott R, Menon M, Selfe JL, Brough R, Pettitt SJ, Niedzwiedz W, van der Graaf WTA, Shipley J, Ashworth A, Lord CJ.

Cancer Res. 2017 Dec 15;77(24):7014-7026. doi: 10.1158/0008-5472.CAN-17-2056. Epub 2017 Oct 16.

48.

A Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events.

Ryan CJ, Kennedy S, Bajrami I, Matallanas D, Lord CJ.

Cell Syst. 2017 Oct 25;5(4):399-409.e5. doi: 10.1016/j.cels.2017.09.011. Epub 2017 Oct 11.

49.

Directing the use of DDR kinase inhibitors in cancer treatment.

Brandsma I, Fleuren EDG, Williamson CT, Lord CJ.

Expert Opin Investig Drugs. 2017 Dec;26(12):1341-1355. doi: 10.1080/13543784.2017.1389895. Epub 2017 Oct 14. Review.

50.

Serotonergic Control of Metabolic Homeostasis.

Wyler SC, Lord CC, Lee S, Elmquist JK, Liu C.

Front Cell Neurosci. 2017 Sep 20;11:277. doi: 10.3389/fncel.2017.00277. eCollection 2017. Review.

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