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Discovery of Imidazo[1,2-a]pyrazines and Pyrazolo[1,5-c]pyrimidines as TARP γ-8 Selective AMPAR Negative Modulators.

Savall BM, Wu D, Swanson DM, Seierstad M, Wu N, Vives Martinez J, García Olmos B, Lord B, Coe K, Koudriakova T, Lovenberg TW, Carruthers NI, Maher MP, Ameriks MK.

ACS Med Chem Lett. 2018 Dec 26;10(3):267-272. doi: 10.1021/acsmedchemlett.8b00599. eCollection 2019 Mar 14.


1H-Pyrrolo[3,2-b]pyridine GluN2B-Selective Negative Allosteric Modulators.

Chrovian CC, Soyode-Johnson A, Wall JL, Rech JC, Schoellerman J, Lord B, Coe KJ, Carruthers NI, Nguyen L, Jiang X, Koudriakova T, Balana B, Letavic MA.

ACS Med Chem Lett. 2019 Jan 10;10(3):261-266. doi: 10.1021/acsmedchemlett.8b00542. eCollection 2019 Mar 14.


Palliative care in paramedic practice: A retrospective cohort study.

Lord B, Andrew E, Henderson A, Anderson DJ, Smith K, Bernard S.

Palliat Med. 2019 Feb 5:269216319828278. doi: 10.1177/0269216319828278. [Epub ahead of print]


α6-Containing Nicotinic Acetylcholine Receptor Reconstitution Involves Mechanistically Distinct Accessory Components.

Gu S, Matta JA, Davini WB, Dawe GB, Lord B, Bredt DS.

Cell Rep. 2019 Jan 22;26(4):866-874.e3. doi: 10.1016/j.celrep.2018.12.103.


Making Meaning After the Death of a Child.

Clancy S, Lord B.

Child Adolesc Psychiatr Clin N Am. 2018 Oct;27(4):xv-xxiv. doi: 10.1016/j.chc.2018.05.011. Epub 2018 Jul 29. Review.


Lead Optimization of 5-Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ-8.

Ravula S, Savall BM, Wu N, Lord B, Coe K, Wang K, Seierstad M, Swanson DM, Ziff J, Nguyen M, Leung P, Rynberg R, La D, Pippel DJ, Koudriakova T, Lovenberg TW, Carruthers NI, Maher MP, Ameriks MK.

ACS Med Chem Lett. 2018 Jul 13;9(8):821-826. doi: 10.1021/acsmedchemlett.8b00215. eCollection 2018 Aug 9.


Neuropsychopharmacology of JNJ-55308942: evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia.

Bhattacharya A, Lord B, Grigoleit JS, He Y, Fraser I, Campbell SN, Taylor N, Aluisio L, O'Connor JC, Papp M, Chrovian C, Carruthers N, Lovenberg TW, Letavic MA.

Neuropsychopharmacology. 2018 Dec;43(13):2586-2596. doi: 10.1038/s41386-018-0141-6. Epub 2018 Jul 9.


Patient and clinician factors associated with prehospital pain treatment and outcomes: cross sectional study.

Siriwardena AN, Asghar Z, Lord B, Pocock H, Phung VH, Foster T, Williams J, Snooks H.

Am J Emerg Med. 2019 Feb;37(2):266-271. doi: 10.1016/j.ajem.2018.05.041. Epub 2018 May 23.


ACL graft compression: a method to allow reduced tunnel sizes in ACL reconstruction.

Lord BR, Colaco HB, Gupte CM, Wilson AJ, Amis AA.

Knee Surg Sports Traumatol Arthrosc. 2018 Aug;26(8):2430-2437. doi: 10.1007/s00167-018-4932-4. Epub 2018 Apr 5.


Challenges for environmental hygiene practices in Australian paramedic-led health care: A brief report.

Barr N, Holmes M, Roiko A, Dunn P, Lord B.

Am J Infect Control. 2018 Jun;46(6):723-725. doi: 10.1016/j.ajic.2017.11.007. Epub 2018 Jan 3.


Is unplanned out-of-hospital birth managed by paramedics 'infrequent', 'normal' and 'uncomplicated'?

Flanagan B, Lord B, Barnes M.

BMC Pregnancy Childbirth. 2017 Dec 22;17(1):436. doi: 10.1186/s12884-017-1617-9.


Description of vital signs data measurement frequency in a medical/surgical unit at a community hospital in United States.

Ghosh E, Eshelman L, Yang L, Carlson E, Lord B.

Data Brief. 2017 Nov 21;16:612-616. doi: 10.1016/j.dib.2017.11.053. eCollection 2018 Feb.


A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate.

Chrovian CC, Soyode-Johnson A, Peterson AA, Gelin CF, Deng X, Dvorak CA, Carruthers NI, Lord B, Fraser I, Aluisio L, Coe KJ, Scott B, Koudriakova T, Schoetens F, Sepassi K, Gallacher DJ, Bhattacharya A, Letavic MA.

J Med Chem. 2018 Jan 11;61(1):207-223. doi: 10.1021/acs.jmedchem.7b01279. Epub 2017 Dec 20.


Effects of the Introduction of Intranasal Fentanyl on Reduction of Pain Severity Score in Children: An Interrupted Time-Series Analysis.

Lord B, Jennings PA, Smith K.

Pediatr Emerg Care. 2017 Dec 1. doi: 10.1097/PEC.0000000000001376. [Epub ahead of print]


Early Deterioration Indicator: Data-driven approach to detecting deterioration in general ward.

Ghosh E, Eshelman L, Yang L, Carlson E, Lord B.

Resuscitation. 2018 Jan;122:99-105. doi: 10.1016/j.resuscitation.2017.10.026. Epub 2017 Nov 6.


Assessment of pose repeatability and specimen repositioning of a robotic joint testing platform.

El Daou H, Lord B, Amis A, Rodriguez Y Baena F.

Med Eng Phys. 2017 Sep;47:210-213. doi: 10.1016/j.medengphy.2017.06.012. Epub 2017 Jun 24.


Evaluation of JNJ-54717793 a Novel Brain Penetrant Selective Orexin 1 Receptor Antagonist in Two Rat Models of Panic Attack Provocation.

Bonaventure P, Dugovic C, Shireman B, Preville C, Yun S, Lord B, Nepomuceno D, Wennerholm M, Lovenberg T, Carruthers N, Fitz SD, Shekhar A, Johnson PL.

Front Pharmacol. 2017 Jun 9;8:357. doi: 10.3389/fphar.2017.00357. eCollection 2017.


4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate.

Letavic MA, Savall BM, Allison BD, Aluisio L, Andres JI, De Angelis M, Ao H, Beauchamp DA, Bonaventure P, Bryant S, Carruthers NI, Ceusters M, Coe KJ, Dvorak CA, Fraser IC, Gelin CF, Koudriakova T, Liang J, Lord B, Lovenberg TW, Otieno MA, Schoetens F, Swanson DM, Wang Q, Wickenden AD, Bhattacharya A.

J Med Chem. 2017 Jun 8;60(11):4559-4572. doi: 10.1021/acs.jmedchem.7b00408. Epub 2017 May 25.


NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain.

Matta JA, Gu S, Davini WB, Lord B, Siuda ER, Harrington AW, Bredt DS.

Cell Rep. 2017 Apr 25;19(4):688-696. doi: 10.1016/j.celrep.2017.04.008.


'Popping nana back into bed' - a qualitative exploration of paramedic decision making when caring for older people who have fallen.

Simpson P, Thomas R, Bendall J, Lord B, Lord S, Close J.

BMC Health Serv Res. 2017 Apr 21;17(1):299. doi: 10.1186/s12913-017-2243-y.


Self-reported behaviors and perceptions of Australian paramedics in relation to hand hygiene and gloving practices in paramedic-led health care.

Barr N, Holmes M, Roiko A, Dunn P, Lord B.

Am J Infect Control. 2017 Jul 1;45(7):771-778. doi: 10.1016/j.ajic.2017.02.020. Epub 2017 Apr 3.


Biomechanical properties of bovine tendon xenografts treated with a modern processing method.

Colaço HB, Lord BR, Back DL, Davies AJ, Amis AA, Ajuied A.

J Biomech. 2017 Feb 28;53:144-147. doi: 10.1016/j.jbiomech.2017.01.011. Epub 2017 Jan 13.


Lateral soft-tissue structures contribute to cruciate-retaining total knee arthroplasty stability.

Athwal KK, El Daou H, Lord B, Davies AJ, Manning W, Rodriguez Y Baena F, Deehan DJ, Amis AA.

J Orthop Res. 2017 Sep;35(9):1902-1909. doi: 10.1002/jor.23477. Epub 2016 Nov 21.


Erratum to: Biomechanical comparison of graft structures in anterior cruciate ligament reconstruction.

Lord BR, El-Daou H, Sabnis BM, Gupte CM, Wilson AJ, Amis AA.

Knee Surg Sports Traumatol Arthrosc. 2017 Mar;25(3):988. doi: 10.1007/s00167-016-4353-1. No abstract available.


Biomechanical comparison of graft structures in anterior cruciate ligament reconstruction.

Lord BR, El-Daou H, Sabnis BM, Gupte CM, Wilson AM, Amis AA.

Knee Surg Sports Traumatol Arthrosc. 2017 Feb;25(2):559-568. doi: 10.1007/s00167-016-4316-6. Epub 2016 Sep 16. Erratum in: Knee Surg Sports Traumatol Arthrosc. 2017 Mar;25(3):988.


Enhancing Nursing and Midwifery Student Learning Through the Use of QR Codes.

Downer T, Oprescu F, Forbes H, Phillips N, McTier L, Lord B, Barr N, Bright P, Simbag V.

Nurs Educ Perspect. 2016 Jul/Aug;37(4):242-243.


Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor.

Swanson DM, Savall BM, Coe KJ, Schoetens F, Koudriakova T, Skaptason J, Wall J, Rech J, Deng X, De Angelis M, Everson A, Lord B, Wang Q, Ao H, Scott B, Sepassi K, Lovenberg TW, Carruthers NI, Bhattacharya A, Letavic MA.

J Med Chem. 2016 Sep 22;59(18):8535-48. doi: 10.1021/acs.jmedchem.6b00989. Epub 2016 Sep 8.


Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models.

Fischer W, Franke H, Krügel U, Müller H, Dinkel K, Lord B, Letavic MA, Henshall DC, Engel T.

PLoS One. 2016 Jun 9;11(6):e0156468. doi: 10.1371/journal.pone.0156468. eCollection 2016.


Use of videos to support teaching and learning of clinical skills in nursing education: A review.

Forbes H, Oprescu FI, Downer T, Phillips NM, McTier L, Lord B, Barr N, Alla K, Bright P, Dayton J, Simbag V, Visser I.

Nurse Educ Today. 2016 Jul;42:53-6. doi: 10.1016/j.nedt.2016.04.010. Epub 2016 Apr 27. Review.


The epidemiology of pain in children treated by paramedics.

Lord B, Jennings PA, Smith K.

Emerg Med Australas. 2016 Jun;28(3):319-24. doi: 10.1111/1742-6723.12586. Epub 2016 May 5.


Paediatric ACL repair reinforced with temporary internal bracing.

Smith JO, Yasen SK, Palmer HC, Lord BR, Britton EM, Wilson AJ.

Knee Surg Sports Traumatol Arthrosc. 2016 Jun;24(6):1845-51. doi: 10.1007/s00167-016-4150-x. Epub 2016 May 3.


Discovery and Characterization of AMPA Receptor Modulators Selective for TARP-γ8.

Maher MP, Wu N, Ravula S, Ameriks MK, Savall BM, Liu C, Lord B, Wyatt RM, Matta JA, Dugovic C, Yun S, Ver Donck L, Steckler T, Wickenden AD, Carruthers NI, Lovenberg TW.

J Pharmacol Exp Ther. 2016 May;357(2):394-414. doi: 10.1124/jpet.115.231712. Epub 2016 Mar 17.


Brain α7 Nicotinic Acetylcholine Receptor Assembly Requires NACHO.

Gu S, Matta JA, Lord B, Harrington AW, Sutton SW, Davini WB, Bredt DS.

Neuron. 2016 Mar 2;89(5):948-55. doi: 10.1016/j.neuron.2016.01.018. Epub 2016 Feb 11.


P2X7 receptor antagonism reduces the severity of spontaneous seizures in a chronic model of temporal lobe epilepsy.

Amhaoul H, Ali I, Mola M, Van Eetveldt A, Szewczyk K, Missault S, Bielen K, Kumar-Singh S, Rech J, Lord B, Ceusters M, Bhattacharya A, Dedeurwaerdere S.

Neuropharmacology. 2016 Jun;105:175-185. doi: 10.1016/j.neuropharm.2016.01.018. Epub 2016 Jan 15.


Substituted 5,6-(Dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)-methanones as P2X7 Antagonists.

Ziff J, Rudolph DA, Stenne B, Koudriakova T, Lord B, Bonaventure P, Lovenberg TW, Carruthers NI, Bhattacharya A, Letavic MA, Shireman BT.

ACS Chem Neurosci. 2016 Apr 20;7(4):498-504. doi: 10.1021/acschemneuro.5b00304. Epub 2016 Jan 19.


Novel Phenyl-Substituted 5,6-Dihydro-[1,2,4]triazolo[4,3-a]pyrazine P2X7 Antagonists with Robust Target Engagement in Rat Brain.

Chrovian CC, Soyode-Johnson A, Ao H, Bacani GM, Carruthers NI, Lord B, Nguyen L, Rech JC, Wang Q, Bhattacharya A, Letavic MA.

ACS Chem Neurosci. 2016 Apr 20;7(4):490-7. doi: 10.1021/acschemneuro.5b00303. Epub 2016 Jan 15.


Preclinical characterization of substituted 6,7-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-8(5H)-one P2X7 receptor antagonists.

Ameriks MK, Ao H, Carruthers NI, Lord B, Ravula S, Rech JC, Savall BM, Wall JL, Wang Q, Bhattacharya A, Letavic MA.

Bioorg Med Chem Lett. 2016 Jan 15;26(2):257-261. doi: 10.1016/j.bmcl.2015.12.052. Epub 2015 Dec 17.


Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor.

Dvorak CA, Coate H, Nepomuceno D, Wennerholm M, Kuei C, Lord B, Woody D, Bonaventure P, Liu C, Lovenberg T, Carruthers NI.

ACS Med Chem Lett. 2015 Jul 20;6(9):1015-8. doi: 10.1021/acsmedchemlett.5b00247. eCollection 2015 Sep 10.


Combined anterolateral ligament and anatomic anterior cruciate ligament reconstruction of the knee.

Smith JO, Yasen SK, Lord B, Wilson AJ.

Knee Surg Sports Traumatol Arthrosc. 2015 Nov;23(11):3151-6. doi: 10.1007/s00167-015-3783-5. Epub 2015 Sep 19.


A novel radioligand for the ATP-gated ion channel P2X7: [3H] JNJ-54232334.

Lord B, Ameriks MK, Wang Q, Fourgeaud L, Vliegen M, Verluyten W, Haspeslagh P, Carruthers NI, Lovenberg TW, Bonaventure P, Letavic MA, Bhattacharya A.

Eur J Pharmacol. 2015 Oct 15;765:551-9. doi: 10.1016/j.ejphar.2015.09.026. Epub 2015 Sep 18.


The role of religious affiliation in Christian and unaffiliated bereaved emerging adults' use of religious coping.

Collison EA, Gramling SE, Lord BD.

Death Stud. 2016;40(2):102-12. doi: 10.1080/07481187.2015.1077355. Epub 2015 Aug 27.


Clinically meaningful reduction in pain severity in children treated by paramedics: a retrospective cohort study.

Jennings PA, Lord B, Smith K.

Am J Emerg Med. 2015 Nov;33(11):1587-90. doi: 10.1016/j.ajem.2015.06.026. Epub 2015 Jun 17.


Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia.

Bonaventure P, Shelton J, Yun S, Nepomuceno D, Sutton S, Aluisio L, Fraser I, Lord B, Shoblock J, Welty N, Chaplan SR, Aguilar Z, Halter R, Ndifor A, Koudriakova T, Rizzolio M, Letavic M, Carruthers NI, Lovenberg T, Dugovic C.

J Pharmacol Exp Ther. 2015 Sep;354(3):471-82. doi: 10.1124/jpet.115.225466. Epub 2015 Jul 15.


Synthesis, SAR, and Pharmacological Characterization of Brain Penetrant P2X7 Receptor Antagonists.

Savall BM, Wu D, De Angelis M, Carruthers NI, Ao H, Wang Q, Lord B, Bhattacharya A, Letavic MA.

ACS Med Chem Lett. 2015 Apr 24;6(6):671-6. doi: 10.1021/acsmedchemlett.5b00089. eCollection 2015 Jun 11.


Novel methyl substituted 1-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanones are P2X7 antagonists.

Rudolph DA, Alcazar J, Ameriks MK, Anton AB, Ao H, Bonaventure P, Carruthers NI, Chrovian CC, De Angelis M, Lord B, Rech JC, Wang Q, Bhattacharya A, Andres JI, Letavic MA.

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3157-63. doi: 10.1016/j.bmcl.2015.06.004. Epub 2015 Jun 9.


Novel Octahydropyrrolo[3,4-c]pyrroles Are Selective Orexin-2 Antagonists: SAR Leading to a Clinical Candidate.

Letavic MA, Bonaventure P, Carruthers NI, Dugovic C, Koudriakova T, Lord B, Lovenberg TW, Ly KS, Mani NS, Nepomuceno D, Pippel DJ, Rizzolio M, Shelton JE, Shah CR, Shireman BT, Young LK, Yun S.

J Med Chem. 2015 Jul 23;58(14):5620-36. doi: 10.1021/acs.jmedchem.5b00742. Epub 2015 Jul 8.


Nonpharmacological interventions for pain management in paramedicine and the emergency setting: a review of the literature.

Pak SC, Micalos PS, Maria SJ, Lord B.

Evid Based Complement Alternat Med. 2015;2015:873039. doi: 10.1155/2015/873039. Epub 2015 Mar 31. Review.


Novel benzamide-based histamine h3 receptor antagonists: the identification of two candidates for clinical development.

Letavic MA, Aluisio L, Apodaca R, Bajpai M, Barbier AJ, Bonneville A, Bonaventure P, Carruthers NI, Dugovic C, Fraser IC, Kramer ML, Lord B, Lovenberg TW, Li LY, Ly KS, Mcallister H, Mani NS, Morton KL, Ndifor A, Nepomuceno SD, Pandit CR, Sands SB, Shah CR, Shelton JE, Snook SS, Swanson DM, Xiao W.

ACS Med Chem Lett. 2015 Mar 13;6(4):450-4. doi: 10.1021/ml5005156. eCollection 2015 Apr 9.


A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects.

Bonaventure P, Yun S, Johnson PL, Shekhar A, Fitz SD, Shireman BT, Lebold TP, Nepomuceno D, Lord B, Wennerholm M, Shelton J, Carruthers N, Lovenberg T, Dugovic C.

J Pharmacol Exp Ther. 2015 Mar;352(3):590-601. doi: 10.1124/jpet.114.220392. Epub 2015 Jan 12.

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