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[Arpp19 and ENSA, two PP2A-B55 phosphatase inhibitors that differentially control the cell cycle].

Hached K, Goguet-Rubio P, Charrasse S, Lorca T, Castro A.

Med Sci (Paris). 2019 Jun-Jul;35(6-7):504-506. doi: 10.1051/medsci/2019104. Epub 2019 Jul 5. French. No abstract available.


Nuclear import of Xenopus egg extract components into cultured cells for reprogramming purposes: a case study on goldfish fin cells.

Chênais N, Lorca T, Morin N, Guillet B, Rime H, Le Bail PY, Labbé C.

Sci Rep. 2019 Feb 27;9(1):2861. doi: 10.1038/s41598-019-39500-y.


ENSA and ARPP19 differentially control cell cycle progression and development.

Hached K, Goguet P, Charrasse S, Vigneron S, Sacristan MP, Lorca T, Castro A.

J Cell Biol. 2019 Feb 4;218(2):541-558. doi: 10.1083/jcb.201708105. Epub 2019 Jan 9.


Greatwall kinase at a glance.

Castro A, Lorca T.

J Cell Sci. 2018 Oct 24;131(20). pii: jcs222364. doi: 10.1242/jcs.222364. Review.


Cyclin A-cdk1-Dependent Phosphorylation of Bora Is the Triggering Factor Promoting Mitotic Entry.

Vigneron S, Sundermann L, Labbé JC, Pintard L, Radulescu O, Castro A, Lorca T.

Dev Cell. 2018 Jun 4;45(5):637-650.e7. doi: 10.1016/j.devcel.2018.05.005.


Ensa controls S-phase length by modulating Treslin levels.

Charrasse S, Gharbi-Ayachi A, Burgess A, Vera J, Hached K, Raynaud P, Schwob E, Lorca T, Castro A.

Nat Commun. 2017 Aug 8;8(1):206. doi: 10.1038/s41467-017-00339-4.


Arpp19 in prophase I resumption.

Castro A, Lorca T.

Cell Cycle. 2017;16(17):1564-1565. doi: 10.1080/15384101.2017.1348069. Epub 2017 Jul 27. No abstract available.


Correction for Vigneron et al., "Characterization of the Mechanisms Controlling Greatwall Activity".

Vigneron S, Gharbi-Ayachi A, Raymond AA, Burgess A, Labbé JC, Labesse G, Monsarrat B, Lorca T, Castro A.

Mol Cell Biol. 2017 Jun 29;37(14). pii: e00231-17. doi: 10.1128/MCB.00231-17. Print 2017 Jul 15. No abstract available.


Loss of Centromere Cohesion in Aneuploid Human Oocytes Correlates with Decreased Kinetochore Localization of the Sac Proteins Bub1 and Bubr1.

Lagirand-Cantaloube J, Ciabrini C, Charrasse S, Ferrieres A, Castro A, Anahory T, Lorca T.

Sci Rep. 2017 Mar 13;7:44001. doi: 10.1038/srep44001.


The master Greatwall kinase, a critical regulator of mitosis and meiosis.

Vigneron S, Robert P, Hached K, Sundermann L, Charrasse S, Labbé JC, Castro A, Lorca T.

Int J Dev Biol. 2016;60(7-8-9):245-254.


CDK1 Prevents Unscheduled PLK4-STIL Complex Assembly in Centriole Biogenesis.

Zitouni S, Francia ME, Leal F, Montenegro Gouveia S, Nabais C, Duarte P, Gilberto S, Brito D, Moyer T, Kandels-Lewis S, Ohta M, Kitagawa D, Holland AJ, Karsenti E, Lorca T, Lince-Faria M, Bettencourt-Dias M.

Curr Biol. 2016 May 9;26(9):1127-37. doi: 10.1016/j.cub.2016.03.055. Epub 2016 Apr 21.


Greatwall dephosphorylation and inactivation upon mitotic exit is triggered by PP1.

Ma S, Vigneron S, Robert P, Strub JM, Cianferani S, Castro A, Lorca T.

J Cell Sci. 2016 Apr 1;129(7):1329-39. doi: 10.1242/jcs.178855. Epub 2016 Feb 18.


Greatwall promotes cell transformation by hyperactivating AKT in human malignancies.

Vera J, Lartigue L, Vigneron S, Gadea G, Gire V, Del Rio M, Soubeyran I, Chibon F, Lorca T, Castro A.

Elife. 2015 Nov 27;4. pii: e10115. doi: 10.7554/eLife.10115.


Global Phosphoproteomic Mapping of Early Mitotic Exit in Human Cells Identifies Novel Substrate Dephosphorylation Motifs.

McCloy RA, Parker BL, Rogers S, Chaudhuri R, Gayevskiy V, Hoffman NJ, Ali N, Watkins DN, Daly RJ, James DE, Lorca T, Castro A, Burgess A.

Mol Cell Proteomics. 2015 Aug;14(8):2194-212. doi: 10.1074/mcp.M114.046938. Epub 2015 Jun 8.


Partial inhibition of Cdk1 in G 2 phase overrides the SAC and decouples mitotic events.

McCloy RA, Rogers S, Caldon CE, Lorca T, Castro A, Burgess A.

Cell Cycle. 2014;13(9):1400-12. doi: 10.4161/cc.28401. Epub 2014 Mar 6.


Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals.

Álvarez-Fernández M, Sánchez-Martínez R, Sanz-Castillo B, Gan PP, Sanz-Flores M, Trakala M, Ruiz-Torres M, Lorca T, Castro A, Malumbres M.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17374-9. doi: 10.1073/pnas.1310745110. Epub 2013 Oct 7.


Budding yeast greatwall and endosulfines control activity and spatial regulation of PP2A(Cdc55) for timely mitotic progression.

Juanes MA, Khoueiry R, Kupka T, Castro A, Mudrak I, Ogris E, Lorca T, Piatti S.

PLoS Genet. 2013;9(7):e1003575. doi: 10.1371/journal.pgen.1003575. Epub 2013 Jul 4.


Deciphering the New Role of the Greatwall/PP2A Pathway in Cell Cycle Control.

Lorca T, Castro A.

Genes Cancer. 2012 Nov;3(11-12):712-20. doi: 10.1177/1947601912473478.


Quantitative live imaging of endogenous DNA replication in mammalian cells.

Burgess A, Lorca T, Castro A.

PLoS One. 2012;7(9):e45726. doi: 10.1371/journal.pone.0045726. Epub 2012 Sep 20.


The Greatwall kinase: a new pathway in the control of the cell cycle.

Lorca T, Castro A.

Oncogene. 2013 Jan 31;32(5):537-43. doi: 10.1038/onc.2012.79. Epub 2012 Apr 2. Review.


CDK-dependent potentiation of MPS1 kinase activity is essential to the mitotic checkpoint.

Morin V, Prieto S, Melines S, Hem S, Rossignol M, Lorca T, Espeut J, Morin N, Abrieu A.

Curr Biol. 2012 Feb 21;22(4):289-95. doi: 10.1016/j.cub.2011.12.048. Epub 2012 Jan 12.


[Greatwall, a new guardian of mitosis].

Gharbi-Ayachi A, Burgess A, Vigneron S, Labbé JC, Castro A, Lorca T.

Med Sci (Paris). 2011 Apr;27(4):352-4. doi: 10.1051/medsci/2011274006. Epub 2011 Apr 28. French. No abstract available.


Characterization of the mechanisms controlling Greatwall activity.

Vigneron S, Gharbi-Ayachi A, Raymond AA, Burgess A, Labbé JC, Labesse G, Monsarrat B, Lorca T, Castro A.

Mol Cell Biol. 2011 Jun;31(11):2262-75. doi: 10.1128/MCB.00753-10. Epub 2011 Mar 28. Erratum in: Mol Cell Biol. 2017 Jun 29;37(14 ):.


The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A.

Gharbi-Ayachi A, Labbé JC, Burgess A, Vigneron S, Strub JM, Brioudes E, Van-Dorsselaer A, Castro A, Lorca T.

Science. 2010 Dec 17;330(6011):1673-7. doi: 10.1126/science.1197048.


Constant regulation of both the MPF amplification loop and the Greatwall-PP2A pathway is required for metaphase II arrest and correct entry into the first embryonic cell cycle.

Lorca T, Bernis C, Vigneron S, Burgess A, Brioudes E, Labbé JC, Castro A.

J Cell Sci. 2010 Jul 1;123(Pt 13):2281-91. doi: 10.1242/jcs.064527.


Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance.

Burgess A, Vigneron S, Brioudes E, Labbé JC, Lorca T, Castro A.

Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12564-9. doi: 10.1073/pnas.0914191107. Epub 2010 Jun 10.


RSK2 is a kinetochore-associated protein that participates in the spindle assembly checkpoint.

Vigneron S, Brioudes E, Burgess A, Labbé JC, Lorca T, Castro A.

Oncogene. 2010 Jun 17;29(24):3566-74. doi: 10.1038/onc.2010.105. Epub 2010 Apr 12.


Greatwall maintains mitosis through regulation of PP2A.

Vigneron S, Brioudes E, Burgess A, Labbé JC, Lorca T, Castro A.

EMBO J. 2009 Sep 16;28(18):2786-93. doi: 10.1038/emboj.2009.228. Epub 2009 Aug 13.


Chfr interacts and colocalizes with TCTP to the mitotic spindle.

Burgess A, Labbé JC, Vigneron S, Bonneaud N, Strub JM, Van Dorsselaer A, Lorca T, Castro A.

Oncogene. 2008 Sep 18;27(42):5554-66. doi: 10.1038/onc.2008.167. Epub 2008 May 26.


Pin1 stabilizes Emi1 during G2 phase by preventing its association with SCF(betatrcp).

Bernis C, Vigneron S, Burgess A, Labbé JC, Fesquet D, Castro A, Lorca T.

EMBO Rep. 2007 Jan;8(1):91-8. Epub 2006 Dec 8.


MyoD undergoes a distinct G2/M-specific regulation in muscle cells.

Batonnet-Pichon S, Tintignac LJ, Castro A, Sirri V, Leibovitch MP, Lorca T, Leibovitch SA.

Exp Cell Res. 2006 Dec 10;312(20):3999-4010. Epub 2006 Sep 8.


Meiotic regulation of the CDK activator RINGO/Speedy by ubiquitin-proteasome-mediated processing and degradation.

Gutierrez GJ, Vögtlin A, Castro A, Ferby I, Salvagiotto G, Ronai Z, Lorca T, Nebreda AR.

Nat Cell Biol. 2006 Oct;8(10):1084-94. Epub 2006 Sep 10.


Ubiquitin-mediated protein degradation in Xenopus egg extracts.

Castro A, Vigneron S, Bernis C, Labbé JC, Lorca T.

Methods Mol Biol. 2006;322:223-34. Review.


Multiple phosphorylation events control mitotic degradation of the muscle transcription factor Myf5.

Doucet C, Gutierrez GJ, Lindon C, Lorca T, Lledo G, Pinset C, Coux O.

BMC Biochem. 2005 Dec 1;6:27.


The zebrafish bcl-2 homologue Nrz controls development during somitogenesis and gastrulation via apoptosis-dependent and -independent mechanisms.

Arnaud E, Ferri KF, Thibaut J, Haftek-Terreau Z, Aouacheria A, Le Guellec D, Lorca T, Gillet G.

Cell Death Differ. 2006 Jul;13(7):1128-37. Epub 2005 Nov 11.


Exploring meiotic division in Cargèse. Meeting on meiotic divisions and checkpoints.

Castro A, Lorca T.

EMBO Rep. 2005 Sep;6(9):821-5. Review. No abstract available.


Differential regulation of Cdc2 and Aurora-A in Xenopus oocytes: a crucial role of phosphatase 2A.

Maton G, Lorca T, Girault JA, Ozon R, Jessus C.

J Cell Sci. 2005 Jun 1;118(Pt 11):2485-94.


The anaphase-promoting complex: a key factor in the regulation of cell cycle.

Castro A, Bernis C, Vigneron S, Labbé JC, Lorca T.

Oncogene. 2005 Jan 13;24(3):314-25. Review.


Kinetochore localization of spindle checkpoint proteins: who controls whom?

Vigneron S, Prieto S, Bernis C, Labbé JC, Castro A, Lorca T.

Mol Biol Cell. 2004 Oct;15(10):4584-96. Epub 2004 Jul 21.


XCdh1 is involved in progesterone-induced oocyte maturation.

Papin C, Rouget C, Lorca T, Castro A, Mandart E.

Dev Biol. 2004 Aug 1;272(1):66-75.


Bovine papillomavirus replicative helicase E1 is a target of the ubiquitin ligase APC.

Mechali F, Hsu CY, Castro A, Lorca T, Bonne-Andrea C.

J Virol. 2004 Mar;78(5):2615-9.


[Mitosis under control].

Castro A, Vigneron S, Lorca T, Labbé JC.

Med Sci (Paris). 2003 Mar;19(3):309-17. Review. French.


Xkid is degraded in a D-box, KEN-box, and A-box-independent pathway.

Castro A, Vigneron S, Bernis C, Labbé JC, Lorca T.

Mol Cell Biol. 2003 Jun;23(12):4126-38.


Cdc2-cyclin B triggers H3 kinase activation of Aurora-A in Xenopus oocytes.

Maton G, Thibier C, Castro A, Lorca T, Prigent C, Jessus C.

J Biol Chem. 2003 Jun 13;278(24):21439-49. Epub 2003 Apr 1.


Alterations of anaphase-promoting complex genes in human colon cancer cells.

Wang Q, Moyret-Lalle C, Couzon F, Surbiguet-Clippe C, Saurin JC, Lorca T, Navarro C, Puisieux A.

Oncogene. 2003 Mar 13;22(10):1486-90.


The D-Box-activating domain (DAD) is a new proteolysis signal that stimulates the silent D-Box sequence of Aurora-A.

Castro A, Vigneron S, Bernis C, Labbé JC, Prigent C, Lorca T.

EMBO Rep. 2002 Dec;3(12):1209-14. Epub 2002 Nov 21.


Involvement of Aurora A kinase during meiosis I-II transition in Xenopus oocytes.

Castro A, Mandart E, Lorca T, Galas S.

J Biol Chem. 2003 Jan 24;278(4):2236-41. Epub 2002 Nov 7.


Interaction between the antiapoptotic protein Nr-13 and cytochrome c. Antagonistic effect of the BH3 domain of Bax.

Moradi-Améli M, Lorca T, Ficheux D, di Pietro A, Gillet G.

Biochemistry. 2002 Jul 9;41(27):8540-50.


APC/Fizzy-Related targets Aurora-A kinase for proteolysis.

Castro A, Arlot-Bonnemains Y, Vigneron S, Labbé JC, Prigent C, Lorca T.

EMBO Rep. 2002 May;3(5):457-62. Epub 2002 Apr 18.

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