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Items: 38

1.

Perturbation of tubulin structure by stellate gold nanoparticles retards MDA-MB-231 breast cancer cell viability.

Nirmala JG, Beck A, Mehta S, Lopus M.

J Biol Inorg Chem. 2019 Aug 6. doi: 10.1007/s00775-019-01694-x. [Epub ahead of print]

PMID:
31388822
2.

Insights into the structure and tubulin-targeted anticancer potential of N-(3-bromobenzyl) noscapine.

Cheriyamundath S, Mahaddalkar T, Reddy Nagireddy PK, Sridhar B, Kantevari S, Lopus M.

Pharmacol Rep. 2019 Feb;71(1):48-53. doi: 10.1016/j.pharep.2018.09.002. Epub 2018 Sep 6.

PMID:
30465924
3.

Aqueous extract of Triphala inhibits cancer cell proliferation through perturbation of microtubule assembly dynamics.

Cheriyamundath S, Mahaddalkar T, Save SN, Choudhary S, Hosur RV, Lopus M.

Biomed Pharmacother. 2018 Feb;98:76-81. doi: 10.1016/j.biopha.2017.12.022. Epub 2017 Dec 12.

PMID:
29245069
4.

Safranal Inhibits HeLa Cell Viability by Perturbing the Reassembly Potential of Microtubules.

Cheriyamundath S, Choudhary S, Lopus M.

Phytother Res. 2018 Jan;32(1):170-173. doi: 10.1002/ptr.5938. Epub 2017 Oct 11.

PMID:
29024138
5.

Tryptone-stabilized gold nanoparticles target tubulin and inhibit cell viability by inducing an unusual form of cell cycle arrest.

Mahaddalkar T, Mehta S, Cheriyamundath S, Muthurajan H, Lopus M.

Exp Cell Res. 2017 Nov 15;360(2):163-170. doi: 10.1016/j.yexcr.2017.09.002. Epub 2017 Sep 5.

PMID:
28887025
6.

Editorial:Tubulin-targeted Cancer Chemotherapeutics: Advances and Challenges.

Lopus M.

Curr Top Med Chem. 2017;17(22):2522. doi: 10.2174/156802661722170726113614. No abstract available.

PMID:
28799508
7.

From Natural Products to Designer Drugs: Development and Molecular Mechanisms Action of Novel Anti-Microtubule Breast Cancer Therapeutics.

Mahaddalkar T, Lopus M.

Curr Top Med Chem. 2017;17(22):2559-2568. doi: 10.2174/1568026617666170104144240. Review.

PMID:
28056739
8.

Elucidation of the Tubulin-targeted Mechanism of Action of 9-(3-pyridyl) Noscapine.

Pradhan S, Mahaddalkar T, Choudhary S, Manhcukonda N, Nagireddy PR, Kantevari S, Lopus M.

Curr Top Med Chem. 2017;17(22):2569-2574. doi: 10.2174/1568026617666170104150304. Review.

PMID:
28056737
9.

Elucidation of the anticancer potential and tubulin isotype-specific interactions of β-sitosterol.

Pradhan M, Suri C, Choudhary S, Naik PK, Lopus M.

J Biomol Struct Dyn. 2018 Jan;36(1):195-208. doi: 10.1080/07391102.2016.1271749. Epub 2016 Dec 29.

PMID:
27960611
10.

Induction of acetylation and bundling of cellular microtubules by 9-(4-vinylphenyl) noscapine elicits S-phase arrest in MDA-MB-231 cells.

Cheriyamundath S, Mahaddalkar T, Kantevari S, Lopus M.

Biomed Pharmacother. 2017 Feb;86:74-80. doi: 10.1016/j.biopha.2016.11.143. Epub 2016 Dec 7.

PMID:
27939522
11.

Structural investigations into the binding mode of a novel noscapine analogue, 9-(4-vinylphenyl) noscapine, with tubulin by biochemical analyses and molecular dynamic simulations.

Mahaddalkar T, Naik PK, Choudhary S, Manchukonda N, Kantevari S, Lopus M.

J Biomol Struct Dyn. 2017 Aug;35(11):2475-2484. doi: 10.1080/07391102.2016.1222969. Epub 2016 Aug 31. No abstract available.

PMID:
27576773
12.

Chemical synthesis, pharmacological evaluation and in silico analysis of new 2,3,3a,4,5,6-hexahydrocyclopenta[c]pyrazole derivatives as potential anti-mitotic agents.

Minu M, Singh D, Mahaddalkar T, Lopus M, Winter P, Ayoub AT, Missiaen K, Tilli TM, Pasdar M, Tuszynski J.

Bioorg Med Chem Lett. 2016 Aug 15;26(16):3855-61. doi: 10.1016/j.bmcl.2016.07.025. Epub 2016 Jul 9.

PMID:
27449957
13.

Unraveling the Deleterious Effects of Cancer-Driven STK11 Mutants Through Conformational Sampling Approach.

Lopus M, Paul DM, Rajasekaran R.

Cancer Inform. 2016 Apr 4;15:35-44. doi: 10.4137/CIN.S38044. eCollection 2016.

14.

Effects of eribulin on microtubule binding and dynamic instability are strengthened in the absence of the βIII tubulin isotype.

Wilson L, Lopus M, Miller HP, Azarenko O, Riffle S, Smith JA, Jordan MA.

Biochemistry. 2015 Oct 27;54(42):6482-9. doi: 10.1021/acs.biochem.5b00745. Epub 2015 Oct 9.

PMID:
26435331
15.

Mechanism of action of ixabepilone and its interactions with the βIII-tubulin isotype.

Lopus M, Smiyun G, Miller H, Oroudjev E, Wilson L, Jordan MA.

Cancer Chemother Pharmacol. 2015 Nov;76(5):1013-24. doi: 10.1007/s00280-015-2863-z. Epub 2015 Sep 28.

PMID:
26416565
16.

Biochemical characterization and molecular dynamic simulation of β-sitosterol as a tubulin-binding anticancer agent.

Mahaddalkar T, Suri C, Naik PK, Lopus M.

Eur J Pharmacol. 2015 Aug 5;760:154-62. doi: 10.1016/j.ejphar.2015.04.014. Epub 2015 Apr 23.

PMID:
25912799
17.

Design, synthesis and biological evaluation of di-substituted noscapine analogs as potent and microtubule-targeted anticancer agents.

Mishra RC, Gundala SR, Karna P, Lopus M, Gupta KK, Nagaraju M, Hamelberg D, Tandon V, Panda D, Reid MD, Aneja R.

Bioorg Med Chem Lett. 2015;25(10):2133-40. doi: 10.1016/j.bmcl.2015.03.076. Epub 2015 Mar 31.

18.

Taking aim at a dynamic target: Noscapinoids as microtubule-targeted cancer therapeutics.

Lopus M, Naik PK.

Pharmacol Rep. 2015 Feb;67(1):56-62. doi: 10.1016/j.pharep.2014.09.003. Epub 2014 Sep 20. Review.

PMID:
25560576
19.

Rational design of biaryl pharmacophore inserted noscapine derivatives as potent tubulin binding anticancer agents.

Santoshi S, Manchukonda NK, Suri C, Sharma M, Sridhar B, Joseph S, Lopus M, Kantevari S, Baitharu I, Naik PK.

J Comput Aided Mol Des. 2015 Mar;29(3):249-70. doi: 10.1007/s10822-014-9820-5. Epub 2014 Dec 7.

PMID:
25481458
20.

The taccalonolides and paclitaxel cause distinct effects on microtubule dynamics and aster formation.

Risinger AL, Riffle SM, Lopus M, Jordan MA, Wilson L, Mooberry SL.

Mol Cancer. 2014 Feb 28;13:41. doi: 10.1186/1476-4598-13-41.

21.

Rational design, synthesis, and biological evaluation of third generation α-noscapine analogues as potent tubulin binding anti-cancer agents.

Manchukonda NK, Naik PK, Santoshi S, Lopus M, Joseph S, Sridhar B, Kantevari S.

PLoS One. 2013 Oct 21;8(10):e77970. doi: 10.1371/journal.pone.0077970. eCollection 2013.

22.

Mechanism of mitotic arrest induced by dolastatin 15 involves loss of tension across kinetochore pairs.

Lopus M.

Mol Cell Biochem. 2013 Oct;382(1-2):93-102. doi: 10.1007/s11010-013-1721-8. Epub 2013 Jun 7.

PMID:
23744533
23.

Induction of robust de novo centrosome amplification, high-grade spindle multipolarity and metaphase catastrophe: a novel chemotherapeutic approach.

Pannu V, Rida PC, Ogden A, Clewley R, Cheng A, Karna P, Lopus M, Mishra RC, Zhou J, Aneja R.

Cell Death Dis. 2012 Jul 12;3:e346. doi: 10.1038/cddis.2012.82.

24.

Cooperative stabilization of microtubule dynamics by EB1 and CLIP-170 involves displacement of stably bound P(i) at microtubule ends.

Lopus M, Manatschal C, Buey RM, Bjelić S, Miller HP, Steinmetz MO, Wilson L.

Biochemistry. 2012 Apr 10;51(14):3021-30. doi: 10.1021/bi300038t. Epub 2012 Mar 28.

PMID:
22424550
25.

In silico inspired design and synthesis of a novel tubulin-binding anti-cancer drug: folate conjugated noscapine (Targetin).

Naik PK, Lopus M, Aneja R, Vangapandu SN, Joshi HC.

J Comput Aided Mol Des. 2012 Feb;26(2):233-47. doi: 10.1007/s10822-011-9508-z. Epub 2011 Dec 15.

PMID:
22170255
26.

Modeling the effects of drug binding on the dynamic instability of microtubules.

Hinow P, Rezania V, Lopus M, Jordan MA, Tuszyński JA.

Phys Biol. 2011 Oct;8(5):056004. doi: 10.1088/1478-3975/8/5/056004. Epub 2011 Aug 12.

27.

Second generation benzofuranone ring substituted noscapine analogs: synthesis and biological evaluation.

Mishra RC, Karna P, Gundala SR, Pannu V, Stanton RA, Gupta KK, Robinson MH, Lopus M, Wilson L, Henary M, Aneja R.

Biochem Pharmacol. 2011 Jul 15;82(2):110-21. doi: 10.1016/j.bcp.2011.03.029. Epub 2011 Apr 8.

28.

Antibody-DM1 conjugates as cancer therapeutics.

Lopus M.

Cancer Lett. 2011 Aug 28;307(2):113-8. doi: 10.1016/j.canlet.2011.03.017. Epub 2011 Apr 9. Review.

29.

A molecular and structural mechanism for G protein-mediated microtubule destabilization.

Davé RH, Saengsawang W, Lopus M, Davé S, Wilson L, Rasenick MM.

J Biol Chem. 2011 Feb 11;286(6):4319-28. doi: 10.1074/jbc.M110.196436. Epub 2010 Nov 26.

30.

Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability.

Oroudjev E, Lopus M, Wilson L, Audette C, Provenzano C, Erickson H, Kovtun Y, Chari R, Jordan MA.

Mol Cancer Ther. 2010 Oct;9(10):2700-13. doi: 10.1158/1535-7163.MCT-10-0645.

31.

Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules.

Lopus M, Oroudjev E, Wilson L, Wilhelm S, Widdison W, Chari R, Jordan MA.

Mol Cancer Ther. 2010 Oct;9(10):2689-99. doi: 10.1158/1535-7163.MCT-10-0644.

32.

Analysis of dynamic instability of steady-state microtubules in vitro by video-enhanced differential interference contrast microscopy with an appendix by Emin Oroudjev.

Yenjerla M, Lopus M, Wilson L.

Methods Cell Biol. 2010;95:189-206. doi: 10.1016/S0091-679X(10)95011-5. Review.

PMID:
20466136
33.

The neuroprotective peptide NAP does not directly affect polymerization or dynamics of reconstituted neural microtubules.

Yenjerla M, LaPointe NE, Lopus M, Cox C, Jordan MA, Feinstein SC, Wilson L.

J Alzheimers Dis. 2010;19(4):1377-86. doi: 10.3233/JAD-2010-1335.

34.

Synthesis of microtubule-interfering halogenated noscapine analogs that perturb mitosis in cancer cells followed by cell death.

Aneja R, Vangapandu SN, Lopus M, Viswesarappa VG, Dhiman N, Verma A, Chandra R, Panda D, Joshi HC.

Biochem Pharmacol. 2006 Aug 14;72(4):415-26. Epub 2006 May 10.

PMID:
16780803
36.

Rational design of the microtubule-targeting anti-breast cancer drug EM015.

Aneja R, Lopus M, Zhou J, Vangapandu SN, Ghaleb A, Yao J, Nettles JH, Zhou B, Gupta M, Panda D, Chandra R, Joshi HC.

Cancer Res. 2006 Apr 1;66(7):3782-91.

37.

Development of a novel nitro-derivative of noscapine for the potential treatment of drug-resistant ovarian cancer and T-cell lymphoma.

Aneja R, Vangapandu SN, Lopus M, Chandra R, Panda D, Joshi HC.

Mol Pharmacol. 2006 Jun;69(6):1801-9. Epub 2006 Mar 3. Erratum in: Mol Pharmacol. 2007 Aug;72(2):486.

PMID:
16517755
38.

Phenylalanine metabolites as indicators of dietary compliance in children with phenylketonuria.

Michals K, Lopus M, Matalon R.

Biochem Med Metab Biol. 1988 Feb;39(1):18-23.

PMID:
3355711

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