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Items: 13


P-Rex1 is dispensable for Erk activation and mitogenesis in breast cancer.

Barrio-Real L, Lopez-Haber C, Casado-Medrano V, Goglia AG, Toettcher JE, Caloca MJ, Kazanietz MG.

Oncotarget. 2018 Jun 19;9(47):28612-28624. doi: 10.18632/oncotarget.25584. eCollection 2018 Jun 19.


Characterization of AJH-836, a diacylglycerol-lactone with selectivity for novel PKC isozymes.

Cooke M, Zhou X, Casado-Medrano V, Lopez-Haber C, Baker MJ, Garg R, Ann J, Lee J, Blumberg PM, Kazanietz MG.

J Biol Chem. 2018 Jun 1;293(22):8330-8341. doi: 10.1074/jbc.RA117.000235. Epub 2018 Apr 10.


Discovery of a small-molecule protein kinase Cδ-selective activator with promising application in colon cancer therapy.

Bessa C, Soares J, Raimundo L, Loureiro JB, Gomes C, Reis F, Soares ML, Santos D, Dureja C, Chaudhuri SR, Lopez-Haber C, Kazanietz MG, Gonçalves J, Simões MF, Rijo P, Saraiva L.

Cell Death Dis. 2018 Jan 18;9(2):23. doi: 10.1038/s41419-017-0154-9.


The P-Rex1/Rac signaling pathway as a point of convergence for HER/ErbB receptor and GPCR responses.

Kazanietz MG, Barrio-Real L, Casado-Medrano V, Baker MJ, Lopez-Haber C.

Small GTPases. 2018 Jul 4;9(4):297-303. doi: 10.1080/21541248.2016.1221273. Epub 2016 Sep 2.


Heregulin/ErbB3 Signaling Enhances CXCR4-Driven Rac1 Activation and Breast Cancer Cell Motility via Hypoxia-Inducible Factor 1α.

Lopez-Haber C, Barrio-Real L, Casado-Medrano V, Kazanietz MG.

Mol Cell Biol. 2016 Jul 14;36(15):2011-26. doi: 10.1128/MCB.00180-16. Print 2016 Aug 1.


PKCε Is an Essential Mediator of Prostate Cancer Bone Metastasis.

Gutierrez-Uzquiza A, Lopez-Haber C, Jernigan DL, Fatatis A, Kazanietz MG.

Mol Cancer Res. 2015 Sep;13(9):1336-46. doi: 10.1158/1541-7786.MCR-15-0111. Epub 2015 May 28.


Transcriptional regulation of oncogenic protein kinase Cϵ (PKCϵ) by STAT1 and Sp1 proteins.

Wang H, Gutierrez-Uzquiza A, Garg R, Barrio-Real L, Abera MB, Lopez-Haber C, Rosemblit C, Lu H, Abba M, Kazanietz MG.

J Biol Chem. 2014 Jul 11;289(28):19823-38. doi: 10.1074/jbc.M114.548446. Epub 2014 May 13.


Non-small cell lung carcinoma cell motility, rac activation and metastatic dissemination are mediated by protein kinase C epsilon.

Caino MC, Lopez-Haber C, Kissil JL, Kazanietz MG.

PLoS One. 2012;7(2):e31714. doi: 10.1371/journal.pone.0031714. Epub 2012 Feb 27.


Proteins kinase Cɛ is required for non-small cell lung carcinoma growth and regulates the expression of apoptotic genes.

Caino MC, Lopez-Haber C, Kim J, Mochly-Rosen D, Kazanietz MG.

Oncogene. 2012 May 17;31(20):2593-600. doi: 10.1038/onc.2011.428. Epub 2011 Sep 26.


Rac signaling in breast cancer: a tale of GEFs and GAPs.

Wertheimer E, Gutierrez-Uzquiza A, Rosemblit C, Lopez-Haber C, Sosa MS, Kazanietz MG.

Cell Signal. 2012 Feb;24(2):353-62. doi: 10.1016/j.cellsig.2011.08.011. Epub 2011 Aug 27. Review.


Differential regulation of gene expression by protein kinase C isozymes as determined by genome-wide expression analysis.

Caino MC, von Burstin VA, Lopez-Haber C, Kazanietz MG.

J Biol Chem. 2011 Apr 1;286(13):11254-64. doi: 10.1074/jbc.M110.194332. Epub 2011 Jan 20.


Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

Sosa MS, Lopez-Haber C, Yang C, Wang H, Lemmon MA, Busillo JM, Luo J, Benovic JL, Klein-Szanto A, Yagi H, Gutkind JS, Parsons RE, Kazanietz MG.

Mol Cell. 2010 Dec 22;40(6):877-92. doi: 10.1016/j.molcel.2010.11.029.

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