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Items: 1 to 50 of 108

1.

Caspase-8 modulates physiological and pathological angiogenesis during retina development.

Tisch N, Freire-Valls A, Yerbes R, Paredes I, La Porta S, Wang X, Martín-Pérez R, Castro L, Wong WW, Coultas L, Strilic B, Gröne HJ, Hielscher T, Mogler C, Adams RH, Heiduschka P, Claesson-Welsh L, Mazzone M, López-Rivas A, Schmidt T, Augustin HG, Ruiz de Almodovar C.

J Clin Invest. 2019 Oct 22. pii: 122767. doi: 10.1172/JCI122767. [Epub ahead of print]

2.

Andrographolide induces DNA damage in prostate cancer cells.

Forestier-Román IS, López-Rivas A, Sánchez-Vázquez MM, Rohena-Rivera K, Nieves-Burgos G, Ortiz-Zuazaga H, Torres-Ramos CA, Martínez-Ferrer M.

Oncotarget. 2019 Feb 1;10(10):1085-1101. doi: 10.18632/oncotarget.26628. eCollection 2019 Feb 1.

3.

PIM kinases mediate resistance of glioblastoma cells to TRAIL by a p62/SQSTM1-dependent mechanism.

Serrano-Saenz S, Palacios C, Delgado-Bellido D, López-Jiménez L, Garcia-Diaz A, Soto-Serrano Y, Casal JI, Bartolomé RA, Fernández-Luna JL, López-Rivas A, Oliver FJ.

Cell Death Dis. 2019 Jan 18;10(2):51. doi: 10.1038/s41419-018-1293-3.

4.

Cytochrome c speeds up caspase cascade activation by blocking 14-3-3ε-dependent Apaf-1 inhibition.

Elena-Real CA, Díaz-Quintana A, González-Arzola K, Velázquez-Campoy A, Orzáez M, López-Rivas A, Gil-Caballero S, De la Rosa MÁ, Díaz-Moreno I.

Cell Death Dis. 2018 Mar 6;9(3):365. doi: 10.1038/s41419-018-0408-1.

5.

Glutamine metabolism regulates FLIP expression and sensitivity to TRAIL in triple-negative breast cancer cells.

Mauro-Lizcano M, López-Rivas A.

Cell Death Dis. 2018 Feb 12;9(2):205. doi: 10.1038/s41419-018-0263-0.

6.

Involvement of both caspase-8 and Noxa-activated pathways in endoplasmic reticulum stress-induced apoptosis in triple-negative breast tumor cells.

Cano-González A, Mauro-Lizcano M, Iglesias-Serret D, Gil J, López-Rivas A.

Cell Death Dis. 2018 Jan 26;9(2):134. doi: 10.1038/s41419-017-0164-7.

7.

Oncogenic p95HER2/611CTF primes human breast epithelial cells for metabolic stress-induced down-regulation of FLIP and activation of TRAIL-R/Caspase-8-dependent apoptosis.

Martín-Pérez R, Yerbes R, Mora-Molina R, Cano-González A, Arribas J, Mazzone M, López-Rivas A, Palacios C.

Oncotarget. 2017 Oct 3;8(55):93688-93703. doi: 10.18632/oncotarget.21458. eCollection 2017 Nov 7.

8.

A role for caspase-8 and TRAIL-R2/DR5 in ER-stress-induced apoptosis.

Muñoz-Pinedo C, López-Rivas A.

Cell Death Differ. 2018 Jan;25(1):226. doi: 10.1038/cdd.2017.155. Epub 2017 Oct 6. No abstract available.

9.

Autophagy requires poly(adp-ribosyl)ation-dependent AMPK nuclear export.

Rodríguez-Vargas JM, Rodríguez MI, Majuelos-Melguizo J, García-Diaz Á, González-Flores A, López-Rivas A, Virág L, Illuzzi G, Schreiber V, Dantzer F, Oliver FJ.

Cell Death Differ. 2016 Dec;23(12):2007-2018. doi: 10.1038/cdd.2016.80. Epub 2016 Sep 30.

10.

Opposing roles of TGF-β and EGF in the regulation of TRAIL-induced apoptosis in human breast epithelial cells.

Cano-González A, López-Rivas A.

Biochim Biophys Acta. 2016 Aug;1863(8):2104-14. doi: 10.1016/j.bbamcr.2016.05.011. Epub 2016 May 18.

11.

Structural basis for inhibition of the histone chaperone activity of SET/TAF-Iβ by cytochrome c.

González-Arzola K, Díaz-Moreno I, Cano-González A, Díaz-Quintana A, Velázquez-Campoy A, Moreno-Beltrán B, López-Rivas A, De la Rosa MA.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9908-13. doi: 10.1073/pnas.1508040112. Epub 2015 Jul 27.

12.

Deciphering the insights of poly(ADP-ribosylation) in tumor progression.

Rodríguez MI, Majuelos-Melguizo J, Martí Martín-Consuegra JM, Ruiz de Almodóvar M, López-Rivas A, Javier Oliver F.

Med Res Rev. 2015 Jul;35(4):678-97. doi: 10.1002/med.21339. Epub 2015 Jan 21. Review.

PMID:
25604534
13.

Delaying mitotic exit downregulates FLIP expression and strongly sensitizes tumor cells to TRAIL.

Sánchez-Pérez T, Medema RH, López-Rivas A.

Oncogene. 2015 Jan 29;34(5):661-9. doi: 10.1038/onc.2013.601. Epub 2014 Feb 3.

PMID:
24488010
14.

Activated ERBB2/HER2 licenses sensitivity to apoptosis upon endoplasmic reticulum stress through a PERK-dependent pathway.

Martín-Pérez R, Palacios C, Yerbes R, Cano-González A, Iglesias-Serret D, Gil J, Reginato MJ, López-Rivas A.

Cancer Res. 2014 Mar 15;74(6):1766-77. doi: 10.1158/0008-5472.CAN-13-1747. Epub 2014 Jan 22.

15.

The long and winding road to cancer treatment: the TRAIL system.

Palacios C, Yerbes R, Sanchez-Perez T, Martin-Perez R, Cano-Gonzalez A, Lopez-Rivas A.

Curr Pharm Des. 2014;20(17):2819-33. Review.

PMID:
23944369
16.

Control of FLIP(L) expression and TRAIL resistance by the extracellular signal-regulated kinase1/2 pathway in breast epithelial cells.

Yerbes R, López-Rivas A, Reginato MJ, Palacios C.

Cell Death Differ. 2012 Dec;19(12):1908-16. doi: 10.1038/cdd.2012.78. Epub 2012 Jun 22.

17.

The therapeutic potential of TRAIL receptor signalling in cancer cells.

Yerbes R, Palacios C, López-Rivas A.

Clin Transl Oncol. 2011 Dec;13(12):839-47. doi: 10.1007/s12094-011-0744-4. Review.

PMID:
22126726
18.

ER stress sensitizes cells to TRAIL through down-regulation of FLIP and Mcl-1 and PERK-dependent up-regulation of TRAIL-R2.

Martín-Pérez R, Niwa M, López-Rivas A.

Apoptosis. 2012 Apr;17(4):349-63. doi: 10.1007/s10495-011-0673-2.

19.

Itch/AIP4-independent proteasomal degradation of cFLIP induced by the histone deacetylase inhibitor SAHA sensitizes breast tumour cells to TRAIL.

Yerbes R, López-Rivas A.

Invest New Drugs. 2012 Apr;30(2):541-7. doi: 10.1007/s10637-010-9597-x. Epub 2010 Nov 25.

PMID:
21107885
20.

Cellular FLIP(L) plays a survival role and regulates morphogenesis in breast epithelial cells.

Yerbes R, Palacios C, Reginato MJ, López-Rivas A.

Biochim Biophys Acta. 2011 Jan;1813(1):168-78. doi: 10.1016/j.bbamcr.2010.10.003. Epub 2010 Oct 13.

21.

Autophagy inhibition sensitizes multiple myeloma cells to 17-dimethylaminoethylamino-17-demethoxygeldanamycin-induced apoptosis.

Palacios C, Martín-Pérez R, López-Pérez AI, Pandiella A, López-Rivas A.

Leuk Res. 2010 Nov;34(11):1533-8. doi: 10.1016/j.leukres.2010.07.002. Epub 2010 Jul 27.

PMID:
20667592
22.

Mitotic arrest and JNK-induced proteasomal degradation of FLIP and Mcl-1 are key events in the sensitization of breast tumor cells to TRAIL by antimicrotubule agents.

Sánchez-Pérez T, Ortiz-Ferrón G, López-Rivas A.

Cell Death Differ. 2010 May;17(5):883-94. doi: 10.1038/cdd.2009.176. Epub 2009 Nov 27.

23.

AMPK-independent down-regulation of cFLIP and sensitization to TRAIL-induced apoptosis by AMPK activators.

García-García C, Fumarola C, Navaratnam N, Carling D, López-Rivas A.

Biochem Pharmacol. 2010 Mar 15;79(6):853-63. doi: 10.1016/j.bcp.2009.10.022. Epub 2009 Nov 5.

PMID:
19896469
24.

Down-regulation of RIP expression by 17-dimethylaminoethylamino-17-demethoxygeldanamycin promotes TRAIL-induced apoptosis in breast tumor cells.

Palacios C, López-Pérez AI, López-Rivas A.

Cancer Lett. 2010 Jan 28;287(2):207-15. doi: 10.1016/j.canlet.2009.06.012. Epub 2009 Jul 25.

PMID:
19632771
25.

TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.

Herrero-Martín G, Høyer-Hansen M, García-García C, Fumarola C, Farkas T, López-Rivas A, Jäättelä M.

EMBO J. 2009 Mar 18;28(6):677-85. doi: 10.1038/emboj.2009.8. Epub 2009 Feb 5. Erratum in: EMBO J. 2009 May 20;28(10):1532.

26.

Statins activate a mitochondria-operated pathway of apoptosis in breast tumor cells by a mechanism regulated by ErbB2 and dependent on the prenylation of proteins.

Herrero-Martin G, López-Rivas A.

FEBS Lett. 2008 Jul 23;582(17):2589-94. doi: 10.1016/j.febslet.2008.06.034. Epub 2008 Jun 26.

27.

Roscovitine sensitizes breast cancer cells to TRAIL-induced apoptosis through a pleiotropic mechanism.

Ortiz-Ferrón G, Yerbes R, Eramo A, López-Pérez AI, De Maria R, López-Rivas A.

Cell Res. 2008 Jun;18(6):664-76. doi: 10.1038/cr.2008.54.

29.

Inhibition of proliferation and induction of apoptosis in human breast cancer cells by lauryl gallate.

Calcabrini A, García-Martínez JM, González L, Tendero MJ, Ortuño MT, Crateri P, Lopez-Rivas A, Arancia G, González-Porqué P, Martín-Pérez J.

Carcinogenesis. 2006 Aug;27(8):1699-712. Epub 2006 Apr 19.

PMID:
16624827
30.

The mitogen-activated protein kinase pathway can inhibit TRAIL-induced apoptosis by prohibiting association of truncated Bid with mitochondria.

Ortiz-Ferrón G, Tait SW, Robledo G, de Vries E, Borst J, López-Rivas A.

Cell Death Differ. 2006 Nov;13(11):1857-65. Epub 2006 Feb 17.

31.

Thymidylate synthase inhibition triggers glucose-dependent apoptosis in p53-negative leukemic cells.

Muñoz-Pinedo C, Robledo G, López-Rivas A.

FEBS Lett. 2004 Jul 16;570(1-3):205-10.

32.

Interferon-gamma and TRAIL in human breast tumor cells.

Ruiz de Almodóvar C, López-Rivas A, Ruiz-Ruiz C.

Vitam Horm. 2004;67:291-318. Review.

PMID:
15110183
33.

Transcriptional regulation of the TRAIL-R3 gene.

Ruiz de Almodóvar C, López-Rivas A, Redondo JM, Rodríguez A.

Vitam Horm. 2004;67:51-63. Review.

PMID:
15110171
34.

The up-regulation of human caspase-8 by interferon-gamma in breast tumor cells requires the induction and action of the transcription factor interferon regulatory factor-1.

Ruiz-Ruiz C, Ruiz de Almodóvar C, Rodríguez A, Ortiz-Ferrón G, Redondo JM, López-Rivas A.

J Biol Chem. 2004 May 7;279(19):19712-20. Epub 2004 Mar 1.

35.

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptor TRAIL-R3 is up-regulated by p53 in breast tumor cells through a mechanism involving an intronic p53-binding site.

Ruiz de Almodóvar C, Ruiz-Ruiz C, Rodríguez A, Ortiz-Ferrón G, Redondo JM, López-Rivas A.

J Biol Chem. 2004 Feb 6;279(6):4093-101. Epub 2003 Nov 17.

36.

Characterization of p53-mediated up-regulation of CD95 gene expression upon genotoxic treatment in human breast tumor cells.

Ruiz-Ruiz C, Robledo G, Cano E, Redondo JM, Lopez-Rivas A.

J Biol Chem. 2003 Aug 22;278(34):31667-75. Epub 2003 Jun 4.

37.

Inhibition of glucose metabolism sensitizes tumor cells to death receptor-triggered apoptosis through enhancement of death-inducing signaling complex formation and apical procaspase-8 processing.

Muñoz-Pinedo C, Ruiz-Ruiz C, Ruiz de Almodóvar C, Palacios C, López-Rivas A.

J Biol Chem. 2003 Apr 11;278(15):12759-68. Epub 2003 Jan 29.

38.

Transcription initiation sites and promoter structure of the human TRAIL-R3 gene.

Ruiz de Almodóvar C, López-Rivas A, Redondo JM, Rodríguez A.

FEBS Lett. 2002 Nov 6;531(2):304-8.

39.
41.

Doxorubicin induces apoptosis and CD95 gene expression in human primary endothelial cells through a p53-dependent mechanism.

Lorenzo E, Ruiz-Ruiz C, Quesada AJ, Hernández G, Rodríguez A, López-Rivas A, Redondo JM.

J Biol Chem. 2002 Mar 29;277(13):10883-92. Epub 2002 Jan 4.

42.

The differential sensitivity of Bc1-2-overexpressing human breast tumor cells to TRAIL or doxorubicin-induced apoptosis is dependent on Bc1-2 protein levels.

Ruiz de Almodóvar C, Ruiz-Ruiz C, Muñoz-Pinedo C, Robledo G, López-Rivas A.

Oncogene. 2001 Oct 25;20(48):7128-33.

43.
44.

Interferon-gamma sensitizes human myeloid leukemia cells to death receptor-mediated apoptosis by a pleiotropic mechanism.

Varela N, Munoz-Pinedo C, Ruiz-Ruiz C, Robledo G, Pedroso M, López-Rivas A.

J Biol Chem. 2001 May 25;276(21):17779-87. Epub 2001 Feb 14.

45.
47.

Protein kinase C inhibits CD95 (Fas/APO-1)-mediated apoptosis by at least two different mechanisms in Jurkat T cells.

Ruiz-Ruiz C, Robledo G, Font J, Izquierdo M, López-Rivas A.

J Immunol. 1999 Nov 1;163(9):4737-46.

48.
49.

Induction of apoptosis by valinomycin: mitochondrial permeability transition causes intracellular acidification.

Furlong IJ, Lopez Mediavilla C, Ascaso R, Lopez Rivas A, Collins MK.

Cell Death Differ. 1998 Mar;5(3):214-21.

50.

Activation of protein kinase C attenuates early signals in Fas-mediated apoptosis.

Ruiz-Ruiz MC, Izquierdo M, de Murcia G, López-Rivas A.

Eur J Immunol. 1997 Jun;27(6):1442-50.

PMID:
9209497

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