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Tapentadol Prevents Motor Impairments in a Mouse Model of Dyskinesia.

Vaz RL, Chapela D, Coelho JE, Lopes LV, Ferreira JJ, Afonso ND, Sousa S, Outeiro TF.

Neuroscience. 2019 Nov 1. pii: S0306-4522(19)30628-1. doi: 10.1016/j.neuroscience.2019.08.046. [Epub ahead of print]


Meningeal γδ T cell-derived IL-17 controls synaptic plasticity and short-term memory.

Ribeiro M, Brigas HC, Temido-Ferreira M, Pousinha PA, Regen T, Santa C, Coelho JE, Marques-Morgado I, Valente CA, Omenetti S, Stockinger B, Waisman A, Manadas B, Lopes LV, Silva-Santos B, Ribot JC.

Sci Immunol. 2019 Oct 11;4(40). pii: eaay5199. doi: 10.1126/sciimmunol.aay5199.


Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor.

Carvalho K, Faivre E, Pietrowski MJ, Marques X, Gomez-Murcia V, Deleau A, Huin V, Hansen JN, Kozlov S, Danis C, Temido-Ferreira M, Coelho JE, Mériaux C, Eddarkaoui S, Gras SL, Dumoulin M, Cellai L; NeuroCEB Brain Bank, Landrieu I, Chern Y, Hamdane M, Buée L, Boutillier AL, Levi S, Halle A, Lopes LV, Blum D.

Brain. 2019 Nov 1;142(11):3636-3654. doi: 10.1093/brain/awz288.


The Amyloid Precursor Protein C-Terminal Domain Alters CA1 Neuron Firing, Modifying Hippocampus Oscillations and Impairing Spatial Memory Encoding.

Pousinha PA, Mouska X, Bianchi D, Temido-Ferreira M, Rajão-Saraiva J, Gomes R, Fernandez SP, Salgueiro-Pereira AR, Gandin C, Raymond EF, Barik J, Goutagny R, Bethus I, Lopes LV, Migliore M, Marie H.

Cell Rep. 2019 Oct 8;29(2):317-331.e5. doi: 10.1016/j.celrep.2019.08.103.


Novel Players in the Aging Synapse: Impact on Cognition.

Temido-Ferreira M, Coelho JE, Pousinha PA, Lopes LV.

J Caffeine Adenosine Res. 2019 Sep 1;9(3):104-127. doi: 10.1089/caff.2019.0013. Epub 2019 Sep 17. Review.


Sensing α-Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration.

Brás IC, Lopes LV, Outeiro TF.

Mov Disord. 2018 Nov;33(11):1675-1684. doi: 10.1002/mds.27478. Epub 2018 Nov 13.


Health-related quality of life assessment among people living with HIV in Rio de Janeiro, Brazil: a cross-sectional study.

Castro R, De Boni RB, Luz PM, Velasque L, Lopes LV, Medina-Lara A, Cardoso SW, De Oliveira MS, Friedman RK, Grinsztejn B, Veloso VG.

Qual Life Res. 2019 Apr;28(4):1035-1045. doi: 10.1007/s11136-018-2044-8. Epub 2018 Nov 10.


Beneficial Effect of a Selective Adenosine A2A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease.

Faivre E, Coelho JE, Zornbach K, Malik E, Baqi Y, Schneider M, Cellai L, Carvalho K, Sebda S, Figeac M, Eddarkaoui S, Caillierez R, Chern Y, Heneka M, Sergeant N, Müller CE, Halle A, Buée L, Lopes LV, Blum D.

Front Mol Neurosci. 2018 Jul 12;11:235. doi: 10.3389/fnmol.2018.00235. eCollection 2018.


Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors.

Temido-Ferreira M, Ferreira DG, Batalha VL, Marques-Morgado I, Coelho JE, Pereira P, Gomes R, Pinto A, Carvalho S, Canas PM, Cuvelier L, Buée-Scherrer V, Faivre E, Baqi Y, Müller CE, Pimentel J, Schiffmann SN, Buée L, Bader M, Outeiro TF, Blum D, Cunha RA, Marie H, Pousinha PA, Lopes LV.

Mol Psychiatry. 2018 Jun 27. doi: 10.1038/s41380-018-0110-9. [Epub ahead of print]


Inhibition of NMDA Receptors Prevents the Loss of BDNF Function Induced by Amyloid β.

Tanqueiro SR, Ramalho RM, Rodrigues TM, Lopes LV, Sebastião AM, Diógenes MJ.

Front Pharmacol. 2018 Apr 11;9:237. doi: 10.3389/fphar.2018.00237. eCollection 2018.


α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B.

Ferreira DG, Temido-Ferreira M, Vicente Miranda H, Batalha VL, Coelho JE, Szegö ÉM, Marques-Morgado I, Vaz SH, Rhee JS, Schmitz M, Zerr I, Lopes LV, Outeiro TF.

Nat Neurosci. 2017 Nov;20(11):1569-1579. doi: 10.1038/nn.4648. Epub 2017 Sep 25.


Breast cancer in Angola, molecular subtypes: a first glance.

Miguel F, Lopes LV, Ferreira E, Ribas E, Pelaez AF, Leal C, Amaro T, Lopes P, Santos CM, Lopes C, Santos LL.

Ecancermedicalscience. 2017 Aug 30;11:763. doi: 10.3332/ecancer.2017.763. eCollection 2017.


Design, synthesis and evaluation of 2-aryl benzoxazoles as promising hit for the A2A receptor.

Duroux R, Renault N, Cuelho JE, Agouridas L, Blum D, Lopes LV, Melnyk P, Yous S.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):850-864. doi: 10.1080/14756366.2017.1334648.


Prolactin-induced neuroprotection against glutamate excitotoxicity is mediated by the reduction of [Ca2+]i overload and NF-κB activation.

Rivero-Segura NA, Flores-Soto E, García de la Cadena S, Coronado-Mares I, Gomez-Verjan JC, Ferreira DG, Cabrera-Reyes EA, Lopes LV, Massieu L, Cerbón M.

PLoS One. 2017 May 5;12(5):e0176910. doi: 10.1371/journal.pone.0176910. eCollection 2017.


Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.

Vicente Miranda H, Szego ÉM, Oliveira LMA, Breda C, Darendelioglu E, de Oliveira RM, Ferreira DG, Gomes MA, Rott R, Oliveira M, Munari F, Enguita FJ, Simões T, Rodrigues EF, Heinrich M, Martins IC, Zamolo I, Riess O, Cordeiro C, Ponces-Freire A, Lashuel HA, Santos NC, Lopes LV, Xiang W, Jovin TM, Penque D, Engelender S, Zweckstetter M, Klucken J, Giorgini F, Quintas A, Outeiro TF.

Brain. 2017 May 1;140(5):1399-1419. doi: 10.1093/brain/awx056.


Chronic and acute adenosine A2A receptor blockade prevents long-term episodic memory disruption caused by acute cannabinoid CB1 receptor activation.

Mouro FM, Batalha VL, Ferreira DG, Coelho JE, Baqi Y, Müller CE, Lopes LV, Ribeiro JA, Sebastião AM.

Neuropharmacology. 2017 May 1;117:316-327. doi: 10.1016/j.neuropharm.2017.02.021. Epub 2017 Feb 21.


Glycation potentiates neurodegeneration in models of Huntington's disease.

Vicente Miranda H, Gomes MA, Branco-Santos J, Breda C, Lázaro DF, Lopes LV, Herrera F, Giorgini F, Outeiro TF.

Sci Rep. 2016 Nov 18;6:36798. doi: 10.1038/srep36798.


Mutant A53T α-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways.

Guerreiro PS, Coelho JE, Sousa-Lima I, Macedo P, Lopes LV, Outeiro TF, Pais TF.

Neuromolecular Med. 2017 Mar;19(1):113-121. doi: 10.1007/s12017-016-8435-5. Epub 2016 Aug 17.


The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.

Batalha VL, Ferreira DG, Coelho JE, Valadas JS, Gomes R, Temido-Ferreira M, Shmidt T, Baqi Y, Buée L, Müller CE, Hamdane M, Outeiro TF, Bader M, Meijsing SH, Sadri-Vakili G, Blum D, Lopes LV.

Sci Rep. 2016 Aug 11;6:31493. doi: 10.1038/srep31493.


Oncology pharmacy units: a safety policy for handling hazardous drugs and related waste in low- and middle-income African countries-Angolan experience.

da Conceição AV, Bernardo D, Lopes LV, Miguel F, Bessa F, Monteiro F, Santos C, Oliveira B, Santos LL.

Ecancermedicalscience. 2015 Oct 1;9:575. doi: 10.3332/ecancer.2015.575. eCollection 2015.


Adenosine A2A Receptors Modulate α-Synuclein Aggregation and Toxicity.

Ferreira DG, Batalha VL, Vicente Miranda H, Coelho JE, Gomes R, Gonçalves FQ, Real JI, Rino J, Albino-Teixeira A, Cunha RA, Outeiro TF, Lopes LV.

Cereb Cortex. 2017 Jan 1;27(1):718-730. doi: 10.1093/cercor/bhv268.


Stage at presentation of breast cancer in Luanda, Angola - a retrospective study.

Lopes LV, Miguel F, Freitas H, Tavares A, Pangui S, Castro C, Lacerda GF, Longatto-Filho A, Weiderpass E, Santos LL.

BMC Health Serv Res. 2015 Oct 15;15:471. doi: 10.1186/s12913-015-1092-9.


A2A adenosine receptor deletion is protective in a mouse model of Tauopathy.

Laurent C, Burnouf S, Ferry B, Batalha VL, Coelho JE, Baqi Y, Malik E, Marciniak E, Parrot S, Van der Jeugd A, Faivre E, Flaten V, Ledent C, D'Hooge R, Sergeant N, Hamdane M, Humez S, Müller CE, Lopes LV, Buée L, Blum D.

Mol Psychiatry. 2016 Jan;21(1):149. doi: 10.1038/mp.2015.115. Epub 2015 Jul 28. No abstract available.


A2A adenosine receptor deletion is protective in a mouse model of Tauopathy.

Laurent C, Burnouf S, Ferry B, Batalha VL, Coelho JE, Baqi Y, Malik E, Mariciniak E, Parrot S, Van der Jeugd A, Faivre E, Flaten V, Ledent C, D'Hooge R, Sergeant N, Hamdane M, Humez S, Müller CE, Lopes LV, Buée L, Blum D.

Mol Psychiatry. 2016 Jan;21(1):97-107. doi: 10.1038/mp.2014.151. Epub 2014 Dec 2. Erratum in: Mol Psychiatry. 2016 Jan;21(1):149. Mariciniak, E [Corrected to Marciniak, E].


Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety.

Coelho JE, Alves P, Canas PM, Valadas JS, Shmidt T, Batalha VL, Ferreira DG, Ribeiro JA, Bader M, Cunha RA, do Couto FS, Lopes LV.

Front Psychiatry. 2014 Jun 13;5:67. doi: 10.3389/fpsyt.2014.00067. eCollection 2014.


Impact of in vivo chronic blockade of adenosine A2A receptors on the BDNF-mediated facilitation of LTP.

Jerónimo-Santos A, Batalha VL, Müller CE, Baqi Y, Sebastião AM, Lopes LV, Diógenes MJ.

Neuropharmacology. 2014 Aug;83:99-106. doi: 10.1016/j.neuropharm.2014.04.006. Epub 2014 Apr 18.


From epidemiology to pathophysiology: what about caffeine in Alzheimer's disease?

Flaten V, Laurent C, Coelho JE, Sandau U, Batalha VL, Burnouf S, Hamdane M, Humez S, Boison D, Lopes LV, Buée L, Blum D.

Biochem Soc Trans. 2014 Apr;42(2):587-92. doi: 10.1042/BST20130229. Review.


Maternal separation impairs long term-potentiation in CA1-CA3 synapses and hippocampal-dependent memory in old rats.

Sousa VC, Vital J, Costenla AR, Batalha VL, Sebastião AM, Ribeiro JA, Lopes LV.

Neurobiol Aging. 2014 Jul;35(7):1680-5. doi: 10.1016/j.neurobiolaging.2014.01.024. Epub 2014 Jan 25.


Establishing of cancer units in low or middle income African countries: Angolan experience--a preliminary report.

Miguel F, Conceição AV, Lopes LV, Bernardo D, Monteiro F, Bessa F, Santos C, Oliveira JB, Santos LL.

Pan Afr Med J. 2014 Nov 17;19:291. doi: 10.11604/pamj.2014.19.291.5320. eCollection 2014.


A comparative clinical study of the failure rate of orthodontic brackets bonded with two adhesive systems: conventional and self-etching primer (SEP).

Dominguez GC, Tortamano A, Lopes LV, Catharino PC, Morea C.

Dental Press J Orthod. 2013 Mar-Apr;18(2):55-60.


Neuroprotection afforded by adenosine A2A receptor blockade is modulated by corticotrophin-releasing factor (CRF) in glutamate injured cortical neurons.

Valadas JS, Batalha VL, Ferreira DG, Gomes R, Coelho JE, Sebastião AM, Diógenes MJ, Lopes LV.

J Neurochem. 2012 Dec;123(6):1030-40. doi: 10.1111/jnc.12050. Epub 2012 Nov 1.


Escitalopram improves memory deficits induced by maternal separation in the rat.

Couto FS, Batalha VL, Valadas JS, Data-Franca J, Ribeiro JA, Lopes LV.

Eur J Pharmacol. 2012 Nov 15;695(1-3):71-5. doi: 10.1016/j.ejphar.2012.08.020. Epub 2012 Sep 7.


Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.

Diógenes MJ, Dias RB, Rombo DM, Vicente Miranda H, Maiolino F, Guerreiro P, Näsström T, Franquelim HG, Oliveira LM, Castanho MA, Lannfelt L, Bergström J, Ingelsson M, Quintas A, Sebastião AM, Lopes LV, Outeiro TF.

J Neurosci. 2012 Aug 22;32(34):11750-62.


Cancer in Angola, resources and strategy for its control.

Lopes LV, Conceição AV, Oliveira JB, Tavares A, Domingos C, Santos LL.

Pan Afr Med J. 2012;12:13. Epub 2012 May 23.


Adenosine A(2A) receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation.

Batalha VL, Pego JM, Fontinha BM, Costenla AR, Valadas JS, Baqi Y, Radjainia H, Müller CE, Sebastião AM, Lopes LV.

Mol Psychiatry. 2013 Mar;18(3):320-31. doi: 10.1038/mp.2012.8. Epub 2012 Feb 28.


Proteomics at the interface of psychology, gut physiology and dysfunction: an underexploited approach that deserves expansion.

Lopes LV, Kussmann M.

Expert Rev Proteomics. 2011 Oct;8(5):605-14. doi: 10.1586/epr.11.50. Review.


Enhancement of LTP in aged rats is dependent on endogenous BDNF.

Diógenes MJ, Costenla AR, Lopes LV, Jerónimo-Santos A, Sousa VC, Fontinha BM, Ribeiro JA, Sebastião AM.

Neuropsychopharmacology. 2011 Aug;36(9):1823-36. doi: 10.1038/npp.2011.64. Epub 2011 Apr 27.


Modulating Alzheimer's disease through caffeine: a putative link to epigenetics.

Marques S, Batalha VL, Lopes LV, Outeiro TF.

J Alzheimers Dis. 2011;24 Suppl 2:161-71. doi: 10.3233/JAD-2011-110032. Review.


Adenosine and related drugs in brain diseases: present and future in clinical trials.

Lopes LV, Sebastião AM, Ribeiro JA.

Curr Top Med Chem. 2011;11(8):1087-101. Review.


The variability of polychlorinated biphenyls levels in urban soils from five European cities.

Cachada A, Lopes LV, Hursthouse AS, Biasioli M, Grcman H, Otabbong E, Davidson CM, Duarte AC.

Environ Pollut. 2009 Feb;157(2):511-8. doi: 10.1016/j.envpol.2008.09.002. Epub 2008 Oct 26.


Maternal deprivation affects the neuromuscular protein profile of the rat colon in response to an acute stressor later in life.

Lopes LV, Marvin-Guy LF, Fuerholz A, Affolter M, Ramadan Z, Kussmann M, Fay LB, Bergonzelli GE.

J Proteomics. 2008 Apr 30;71(1):80-8. doi: 10.1016/j.jprot.2008.01.007. Epub 2008 Jan 18.


Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and "fine tuning" modulation.

Chen JF, Sonsalla PK, Pedata F, Melani A, Domenici MR, Popoli P, Geiger J, Lopes LV, de Mendonça A.

Prog Neurobiol. 2007 Dec;83(5):310-31. Epub 2007 Sep 29. Review.


Modification of adenosine modulation of acetylcholine release in the hippocampus of aged rats.

Rodrigues RJ, Canas PM, Lopes LV, Oliveira CR, Cunha RA.

Neurobiol Aging. 2008 Oct;29(10):1597-601. Epub 2007 May 3.


-Omics for prevention: gene, protein and metabolite profiling to better understand individual disposition to disease.

Affolter M, Bergonzelli GE, Blaser K, Blum-Sperisen S, Corthésy B, Fay LB, Garcia-Rodenas C, Lopes LV, Marvin-Guy L, Mercenier A, Mutch DM, Panchaud A, Raymond F, Schmidt-Weber C, Schumann A, Spertini F, Williamson G, Kussmann M.

Nestle Nutr Workshop Ser Pediatr Program. 2006;57:247-50; discussion 250-5. Review. No abstract available.


Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortex.

Rebola N, Porciúncula LO, Lopes LV, Oliveira CR, Soares-da-Silva P, Cunha RA.

Epilepsia. 2005;46 Suppl 5:159-65.


Proteomics of the rat gut: analysis of the myenteric plexus-longitudinal muscle preparation.

Marvin-Guy L, Lopes LV, Affolter M, Courtet-Compondu MC, Wagnière S, Bergonzelli GE, Fay LB, Kussmann M.

Proteomics. 2005 Jul;5(10):2561-9.


Adenosine A1 and A2A receptors are co-expressed in pyramidal neurons and co-localized in glutamatergic nerve terminals of the rat hippocampus.

Rebola N, Rodrigues RJ, Lopes LV, Richardson PJ, Oliveira CR, Cunha RA.

Neuroscience. 2005;133(1):79-83.


Binding of adenosine receptor ligands to brain of adenosine receptor knock-out mice: evidence that CGS 21680 binds to A1 receptors in hippocampus.

Halldner L, Lopes LV, Daré E, Lindström K, Johansson B, Ledent C, Cunha RA, Fredholm BB.

Naunyn Schmiedebergs Arch Pharmacol. 2004 Oct;370(4):270-8. Epub 2004 Sep 18.


Binding of the prototypical adenosine A(2A) receptor agonist CGS 21680 to the cerebral cortex of adenosine A(1) and A(2A) receptor knockout mice.

Lopes LV, Halldner L, Rebola N, Johansson B, Ledent C, Chen JF, Fredholm BB, Cunha RA.

Br J Pharmacol. 2004 Mar;141(6):1006-14. Epub 2004 Mar 1.


Adenosine A3 receptors are located in neurons of the rat hippocampus.

Lopes LV, Rebola N, Pinheiro PC, Richardson PJ, Oliveira CR, Cunha RA.

Neuroreport. 2003 Aug 26;14(12):1645-8.


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