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Items: 43


Effects of the serine protease inhibitor rBmTI-A in an experimental mouse model of chronic allergic pulmonary inflammation.

Florencio AC, de Almeida RS, Arantes-Costa FM, Saraiva-Romanholo BM, Duran AF, Sasaki SD, Martins MA, Lopes FDTQS, Tibério IFLC, Leick EA.

Sci Rep. 2019 Sep 2;9(1):12624. doi: 10.1038/s41598-019-48577-4.


iNOS Inhibition Reduces Lung Mechanical Alterations and Remodeling Induced by Particulate Matter in Mice.

Prado CM, Righetti RF, Lopes FDTQDS, Leick EA, Arantes-Costa FM, de Almeida FM, Saldiva PHN, Mauad T, Tibério IFLC, Martins MA.

Pulm Med. 2019 Mar 11;2019:4781528. doi: 10.1155/2019/4781528. eCollection 2019.


Extracellular Matrix Component Remodeling in Respiratory Diseases: What Has Been Found in Clinical and Experimental Studies?

Ito JT, Lourenço JD, Righetti RF, Tibério IFLC, Prado CM, Lopes FDTQS.

Cells. 2019 Apr 11;8(4). pii: E342. doi: 10.3390/cells8040342. Review.


Microenvironmental stimuli induce different macrophage polarizations in experimental models of emphysema.

Kohler JB, Cervilha DAB, Riani Moreira A, Santana FR, Farias TM, Alonso Vale MIC, Martins MA, Prado CM, Tibério IC, Ito JT, Lopes FDTQDS.

Biol Open. 2019 Apr 26;8(4). pii: bio040808. doi: 10.1242/bio.040808.


The Th17/Treg Cytokine Imbalance in Chronic Obstructive Pulmonary Disease Exacerbation in an Animal Model of Cigarette Smoke Exposure and Lipopolysaccharide Challenge Association.

Cervilha DAB, Ito JT, Lourenço JD, Olivo CR, Saraiva-Romanholo BM, Volpini RA, Oliveira-Junior MC, Mauad T, Martins MA, Tibério IFLC, Vieira RP, Lopes FDTQS.

Sci Rep. 2019 Feb 13;9(1):1921. doi: 10.1038/s41598-019-38600-z.


Th17/Treg imbalance in COPD progression: A temporal analysis using a CS-induced model.

Ito JT, Cervilha DAB, Lourenço JD, Gonçalves NG, Volpini RA, Caldini EG, Landman G, Lin CJ, Velosa APP, Teodoro WPR, Tibério IFLC, Mauad T, Martins MA, Macchione M, Lopes FDTQDS.

PLoS One. 2019 Jan 10;14(1):e0209351. doi: 10.1371/journal.pone.0209351. eCollection 2019.


Pre- and postnatal exposure of mice to concentrated urban PM2.5 decreases the number of alveoli and leads to altered lung function at an early stage of life.

de Barros Mendes Lopes T, Groth EE, Veras M, Furuya TK, de Souza Xavier Costa N, Ribeiro Júnior G, Lopes FD, de Almeida FM, Cardoso WV, Saldiva PHN, Chammas R, Mauad T.

Environ Pollut. 2018 Oct;241:511-520. doi: 10.1016/j.envpol.2018.05.055. Epub 2018 Jun 5.


Chitayat-Hall and Schaaf-Yang syndromes:a common aetiology: expanding the phenotype of MAGEL2-related disorders.

Jobling R, Stavropoulos DJ, Marshall CR, Cytrynbaum C, Axford MM, Londero V, Moalem S, Orr J, Rossignol F, Lopes FD, Gauthier J, Alos N, Rupps R, McKinnon M, Adam S, Nowaczyk MJM, Walker S, Scherer SW, Nassif C, Hamdan FF, Deal CL, Soucy JF, Weksberg R, Macleod P, Michaud JL, Chitayat D.

J Med Genet. 2018 May;55(5):316-321. doi: 10.1136/jmedgenet-2017-105222. Epub 2018 Mar 29.


rBmTI-6 attenuates pathophysiological and inflammatory parameters of induced emphysema in mice.

Duran AFA, Neves LP, da Silva FRS, Machado GC, Ferreira GC, Lourenço JD, Tanaka AS, Martins MA, Lopes FDTQS, Sasaki SD.

Int J Biol Macromol. 2018 May;111:1214-1221. doi: 10.1016/j.ijbiomac.2018.01.066. Epub 2018 Jan 13.


The tick-derived rBmTI-A protease inhibitor attenuates the histological and functional changes induced by cigarette smoke exposure.

Lourenço JD, Ito JT, Cervilha DAB, Sales DS, Riani A, Suehiro CL, Genaro IS, Duran A, Puzer L, Martins MA, Sasaki SD, Lopes FDTQS.

Histol Histopathol. 2018 Mar;33(3):289-298. doi: 10.14670/HH-11-927. Epub 2017 Sep 4.


Compensatory lung growth after bilobectomy in emphysematous rats.

Almeida FM, Saraiva-Romanholo BM, Vieira RP, Moriya HT, Ligeiro-de-Oliveira AP, Lopes FD, Castro-Faria-Neto HC, Mauad T, Martins MA, Pazetti R.

PLoS One. 2017 Jul 27;12(7):e0181819. doi: 10.1371/journal.pone.0181819. eCollection 2017.


Regulatory T-Cell Distribution within Lung Compartments in COPD.

Sales DS, Ito JT, Zanchetta IA, Annoni R, Aun MV, Ferraz LFS, Cervilha DAB, Negri E, Mauad T, Martins MA, Lopes FDTQS.

COPD. 2017 Oct;14(5):533-542. doi: 10.1080/15412555.2017.1346069. Epub 2017 Jul 26.


Time-course effects of aerobic physical training in the prevention of cigarette smoke-induced COPD.

Toledo-Arruda AC, Vieira RP, Guarnier FA, Suehiro CL, Caleman-Neto A, Olivo CR, Arantes PMM, Almeida FM, Lopes FDTQS, Ramos EMC, Cecchini R, Lin CJ, Martins MA.

J Appl Physiol (1985). 2017 Sep 1;123(3):674-683. doi: 10.1152/japplphysiol.00819.2016. Epub 2017 Jul 20.


A murine model of elastase- and cigarette smoke-induced emphysema.

Rodrigues R, Olivo CR, Lourenço JD, Riane A, Cervilha DAB, Ito JT, Martins MA, Lopes FDTQDS.

J Bras Pneumol. 2017 Mar-Apr;43(2):95-100. doi: 10.1590/S1806-37562016000000179. English, Portuguese.


Plant Proteinase Inhibitor BbCI Modulates Lung Inflammatory Responses and Mechanic and Remodeling Alterations Induced by Elastase in Mice.

Almeida-Reis R, Theodoro-Junior OA, Oliveira BTM, Oliva LV, Toledo-Arruda AC, Bonturi CR, Brito MV, Lopes FDTQS, Prado CM, Florencio AC, Martins MA, Owen CA, Leick EA, Oliva MLV, Tibério IFLC.

Biomed Res Int. 2017;2017:8287125. doi: 10.1155/2017/8287125. Epub 2017 Mar 30.


Structurally Related Monoterpenes p-Cymene, Carvacrol and Thymol Isolated from Essential Oil from Leaves of Lippia sidoides Cham. (Verbenaceae) Protect Mice against Elastase-Induced Emphysema.

Games E, Guerreiro M, Santana FR, Pinheiro NM, de Oliveira EA, Lopes FD, Olivo CR, Tibério IF, Martins MA, Lago JH, Prado CM.

Molecules. 2016 Oct 20;21(10). pii: E1390.


Evidences of Herbal Medicine-Derived Natural Products Effects in Inflammatory Lung Diseases.

Santana FP, Pinheiro NM, Mernak MI, Righetti RF, Martins MA, Lago JH, Lopes FD, Tibério IF, Prado CM.

Mediators Inflamm. 2016;2016:2348968. doi: 10.1155/2016/2348968. Epub 2016 Jun 29. Review.


Erratum: A flavanone from Baccharis retusa (Asteraceae) prevents elastase-induced emphysema in mice by regulating NF-κB, oxidative stress and metalloproteinases.

Taguchi L, Pinheiro NM, Olivo CR, Choqueta-Toledo A, Grecco SS, Lopes FD, Caperuto LC, Martins MA, Tiberio IF, Câmara NO, Lago JH, Prado CM.

Respir Res. 2015 Sep 17;16:113. doi: 10.1186/s12931-015-0258-7. No abstract available.


Creatine supplementation attenuates pulmonary and systemic effects of lung ischemia and reperfusion injury.

Almeida FM, Oliveira-Junior MC, Souza RA, Petroni RC, Soto SF, Soriano FG, Carvalho PT, Albertini R, Damaceno-Rodrigues NR, Lopes FD, Castro-Faria-Neto HC, Martins MA, Dolhnikoff M, Pazetti R, Vieira RP.

J Heart Lung Transplant. 2016 Feb;35(2):242-50. doi: 10.1016/j.healun.2015.06.012. Epub 2015 Jul 4.


A flavanone from Baccharis retusa (Asteraceae) prevents elastase-induced emphysema in mice by regulating NF-κB, oxidative stress and metalloproteinases.

Taguchi L, Pinheiro NM, Olivo CR, Choqueta-Toledo A, Grecco SS, Lopes FD, Caperuto LC, Martins MA, Tiberio IF, Câmara NO, Lago JH, Prado CM.

Respir Res. 2015 Jun 30;16:79. doi: 10.1186/s12931-015-0233-3. Erratum in: Respir Res. 2015;16:113.


Collagenase mRNA Overexpression and Decreased Extracellular Matrix Components Are Early Events in the Pathogenesis of Emphysema.

Robertoni FS, Olivo CR, Lourenço JD, Gonçalves NG, Velosa AP, Lin CJ, Fló CM, Saraiva-Romanholo BM, Sasaki SD, Martins MA, Teodoro WR, Lopes FD.

PLoS One. 2015 Jun 8;10(6):e0129590. doi: 10.1371/journal.pone.0129590. eCollection 2015.


Aerobic exercise attenuates pulmonary inflammation induced by Streptococcus pneumoniae.

Olivo CR, Miyaji EN, Oliveira ML, Almeida FM, Lourenço JD, Abreu RM, Arantes PM, Lopes FD, Martins MA.

J Appl Physiol (1985). 2014 Nov 1;117(9):998-1007. doi: 10.1152/japplphysiol.00290.2014. Epub 2014 Sep 4.


A treatment with a protease inhibitor recombinant from the cattle tick (Rhipicephalus Boophilus microplus) ameliorates emphysema in mice.

Lourenço JD, Neves LP, Olivo CR, Duran A, Almeida FM, Arantes PM, Prado CM, Leick EA, Tanaka AS, Martins MA, Sasaki SD, Lopes FD.

PLoS One. 2014 Jun 2;9(6):e98216. doi: 10.1371/journal.pone.0098216. eCollection 2014.


A new experimental model of cigarette smoke-induced emphysema in Wistar rats.

Kozma Rde L, Alves EM, Barbosa-de-Oliveira VA, Lopes FD, Guardia RC, Buzo HV, Faria CA, Yamashita C, Cavazzana Júnior M, Frei F, Ribeiro-Paes MJ, Ribeiro-Paes JT.

J Bras Pneumol. 2014 Jan-Feb;40(1):46-54. doi: 10.1590/S1806-37132014000100007. English, Portuguese.


Antileukotriene reverts the early effects of inflammatory response of distal parenchyma in experimental chronic allergic inflammation.

Gobbato NB, de Souza FC, Fumagalli SB, Lopes FD, Prado CM, Martins MA, Tibério Ide F, Leick EA.

Biomed Res Int. 2013;2013:523761. doi: 10.1155/2013/523761. Epub 2013 Sep 15.


Anacardic acids from cashew nuts ameliorate lung damage induced by exposure to diesel exhaust particles in mice.

Carvalho AL, Annoni R, Torres LH, Durão AC, Shimada AL, Almeida FM, Hebeda CB, Lopes FD, Dolhnikoff M, Martins MA, Silva LF, Farsky SH, Saldiva PH, Ulrich CM, Owen RW, Marcourakis T, Trevisan MT, Mauad T.

Evid Based Complement Alternat Med. 2013;2013:549879. doi: 10.1155/2013/549879. Epub 2013 Feb 27.


Risk of recurrent venous thrombosis related to past provoking risk situations: follow-up of a cohort study.

Ribeiro DD, Lijfering WM, Barreto SM, Lopes FD, Pires Gde S, Rosendaal FR, Rezende SM.

Blood Coagul Fibrinolysis. 2013 Jul;24(5):562-6. doi: 10.1097/MBC.0b013e32835fad32.


A comparative study of extracellular matrix remodeling in two murine models of emphysema.

Lopes FD, Toledo AC, Olivo CR, Prado CM, Leick EA, Medeiros MC, Santos AB, Garippo A, Martins MA, Mauad T.

Histol Histopathol. 2013 Feb;28(2):269-76. doi: 10.14670/HH-28.269.


Protective effects of aerobic exercise on acute lung injury induced by LPS in mice.

Reis Gonçalves CT, Reis Gonçalves CG, de Almeida FM, Lopes FD, dos Santos Durão AC, dos Santos FA, da Silva LF, Marcourakis T, Castro-Faria-Neto HC, Vieira RP, Dolhnikoff M.

Crit Care. 2012 Oct 18;16(5):R199. doi: 10.1186/cc11807.


The influence of prothrombotic laboratory abnormalities on the risk of recurrent venous thrombosis.

Ribeiro DD, Lijfering WM, Barreto SM, Lopes FD, Pires Gde S, Rosendaal FR, Rezende SM.

Thromb Res. 2012 Dec;130(6):974-6. doi: 10.1016/j.thromres.2012.09.007. Epub 2012 Oct 10. No abstract available.


Anti-inflammatory effects of aerobic exercise in mice exposed to air pollution.

Vieira RP, Toledo AC, Silva LB, Almeida FM, Damaceno-Rodrigues NR, Caldini EG, Santos AB, Rivero DH, Hizume DC, Lopes FD, Olivo CR, Castro-Faria-Neto HC, Martins MA, Saldiva PH, Dolhnikoff M.

Med Sci Sports Exerc. 2012 Jul;44(7):1227-34. doi: 10.1249/MSS.0b013e31824b2877.


N-acetylcysteine prevents pulmonary edema and acute kidney injury in rats with sepsis submitted to mechanical ventilation.

Campos R, Shimizu MH, Volpini RA, de Bragança AC, Andrade L, Lopes FD, Olivo C, Canale D, Seguro AC.

Am J Physiol Lung Cell Mol Physiol. 2012 Apr 1;302(7):L640-50. doi: 10.1152/ajplung.00097.2011. Epub 2012 Jan 20.


Respiratory mechanics do not always mirror pulmonary histological changes in emphysema.

Anciães AM, Olivo CR, Prado CM, Kagohara KH, Pinto Tda S, Moriya HT, Mauad T, Martins Mde A, Lopes FD.

Clinics (Sao Paulo). 2011;66(10):1797-803.


Insulin modulates inflammatory and repair responses to elastase-induced emphysema in diabetic rats.

Di Petta A, Greco KV, Castro EO, Lopes FD, Martins MA, Capelozzi VL, Moreira LF, Sannomiya P.

Int J Exp Pathol. 2011 Dec;92(6):392-9. doi: 10.1111/j.1365-2613.2011.00787.x. Epub 2011 Sep 22.


Aerobic exercise attenuates pulmonary injury induced by exposure to cigarette smoke.

Toledo AC, Magalhaes RM, Hizume DC, Vieira RP, Biselli PJ, Moriya HT, Mauad T, Lopes FD, Martins MA.

Eur Respir J. 2012 Feb;39(2):254-64. doi: 10.1183/09031936.00003411. Epub 2011 Jun 23.


Short-term exposure of mice to cigarette smoke and/or residual oil fly ash produces proximal airspace enlargements and airway epithelium remodeling.

Biselli PJ, Lopes FD, Moriya HT, Rivero DH, Toledo AC, Saldiva PH, Mauad T, Martins MA.

Braz J Med Biol Res. 2011 May;44(5):460-8. doi: 10.1590/S0100-879X2011007500040. Epub 2011 Apr 1.


Aerobic training reverses airway inflammation and remodelling in an asthma murine model.

Silva RA, Vieira RP, Duarte AC, Lopes FD, Perini A, Mauad T, Martins MA, Carvalho CR.

Eur Respir J. 2010 May;35(5):994-1002. doi: 10.1183/09031936.00049509. Epub 2009 Nov 6.


Eosinophilic pneumonitis induced by aerosol-administered diesel oil and pyrethrum to mice.

Garcia ML, Santos UP, Perini A, Acencio MM, Lopes FD, Bueno HM, Saldiva PH, Martins MA.

Rev Panam Salud Publica. 2009 Jun;25(6):518-23.


Exposure to ambient levels of particles emitted by traffic worsens emphysema in mice.

Lopes FD, Pinto TS, Arantes-Costa FM, Moriya HT, Biselli PJ, Ferraz LF, Lichtenfels AJ, Saldiva PH, Mauad T, Martins MA.

Environ Res. 2009 Jul;109(5):544-51. doi: 10.1016/j.envres.2009.03.002. Epub 2009 Apr 10.


Effects of residual oil fly ash (ROFA) in mice with chronic allergic pulmonary inflammation.

Arantes-Costa FM, Lopes FD, Toledo AC, Magliarelli-Filho PA, Moriya HT, Carvalho-Oliveira R, Mauad T, Saldiva PH, Martins MA.

Toxicol Pathol. 2008 Jul;36(5):680-6. doi: 10.1177/0192623308317427. Epub 2008 May 13.


Effects of exercise training on papain-induced pulmonary emphysema in Wistar rats.

Fló C, Lopes FD, Kasahara DI, Silva AC, Jesus RC, Rivero DH, Saldiva PH, Martins MA, Jacob-Filho W.

J Appl Physiol (1985). 2006 Jan;100(1):281-5. Epub 2005 Sep 1.


Effect of salbutamol on pulmonary responsiveness in chronic pulmonary allergic inflammation in guinea pigs.

Kasahara DI, Perini A, Lopes FD, Arantes-Costa FM, Martins MA, Nunes MP.

Braz J Med Biol Res. 2005 May;38(5):723-30. Epub 2005 May 25.


Pulmonary responses to tracheal or esophageal acidification in guinea pigs with airway inflammation.

Lopes FD, Alvarenga GS, Quiles R, Dorna MB, Vieira JE, Dolhnikoff M, Martins MA.

J Appl Physiol (1985). 2002 Sep;93(3):842-7.

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