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The peptide hormone adropin regulates signal transduction pathways controlling hepatic glucose metabolism in a mouse model of diet-induced obesity.

Gao S, Ghoshal S, Zhang L, Stevens JR, McCommis KS, Finck BN, Lopaschuk GD, Butler AA.

J Biol Chem. 2019 Sep 6;294(36):13366-13377. doi: 10.1074/jbc.RA119.008967. Epub 2019 Jul 19.


Malonyl CoA Decarboxylase Inhibition Improves Cardiac Function Post-Myocardial Infarction.

Wang W, Zhang L, Battiprolu PK, Fukushima A, Nguyen K, Milner K, Gupta A, Altamimi T, Byrne N, Mori J, Alrob OA, Wagg C, Fillmore N, Wang SH, Liu DM, Fu A, Lu JY, Chaves M, Motani A, Ussher JR, Reagan JD, Dyck JRB, Lopaschuk GD.

JACC Basic Transl Sci. 2019 Jun 24;4(3):385-400. doi: 10.1016/j.jacbts.2019.02.003. eCollection 2019 Jun.


Impaired branched chain amino acid oxidation contributes to cardiac insulin resistance in heart failure.

Uddin GM, Zhang L, Shah S, Fukushima A, Wagg CS, Gopal K, Al Batran R, Pherwani S, Ho KL, Boisvenue J, Karwi QG, Altamimi T, Wishart DS, Dyck JRB, Ussher JR, Oudit GY, Lopaschuk GD.

Cardiovasc Diabetol. 2019 Jul 5;18(1):86. doi: 10.1186/s12933-019-0892-3.


Allosteric, transcriptional and post-translational control of mitochondrial energy metabolism.

Karwi QG, Jörg AR, Lopaschuk GD.

Biochem J. 2019 Jun 19;476(12):1695-1712. doi: 10.1042/BCJ20180617. Review.


Adropin regulates cardiac energy metabolism and improves cardiac function and efficiency.

Altamimi TR, Gao S, Karwi QG, Fukushima A, Rawat S, Wagg CS, Zhang L, Lopaschuk GD.

Metabolism. 2019 Sep;98:37-48. doi: 10.1016/j.metabol.2019.06.005. Epub 2019 Jun 14.


Beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3xTg mouse model of Alzheimer's disease.

Esfandiarei M, Hoxha B, Talley NA, Anderson MR, Alkhouli MF, Squire MA, Eckman DM, Babu JR, Lopaschuk GD, Broderick TL.

Drug Des Devel Ther. 2019 Apr 17;13:1197-1211. doi: 10.2147/DDDT.S196119. eCollection 2019.


Weight loss enhances cardiac energy metabolism and function in heart failure associated with obesity.

Karwi QG, Zhang L, Altamimi TR, Wagg CS, Patel V, Uddin GM, Joerg AR, Padwal RS, Johnstone DE, Sharma A, Oudit GY, Lopaschuk GD.

Diabetes Obes Metab. 2019 Aug;21(8):1944-1955. doi: 10.1111/dom.13762. Epub 2019 Jun 4.


Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency.

Ho KL, Zhang L, Wagg C, Al Batran R, Gopal K, Levasseur J, Leone T, Dyck JRB, Ussher JR, Muoio DM, Kelly DP, Lopaschuk GD.

Cardiovasc Res. 2019 Sep 1;115(11):1606-1616. doi: 10.1093/cvr/cvz045.


Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction.

Karwi QG, Zhang L, Wagg CS, Wang W, Ghandi M, Thai D, Yan H, Ussher JR, Oudit GY, Lopaschuk GD.

Cardiovasc Diabetol. 2019 Jan 9;18(1):1. doi: 10.1186/s12933-019-0806-4.


Cardiac-specific deficiency of the mitochondrial calcium uniporter augments fatty acid oxidation and functional reserve.

Altamimi TR, Karwi QG, Uddin GM, Fukushima A, Kwong JQ, Molkentin JD, Lopaschuk GD.

J Mol Cell Cardiol. 2019 Feb;127:223-231. doi: 10.1016/j.yjmcc.2018.12.019. Epub 2019 Jan 4.


Empagliflozin Increases Cardiac Energy Production in Diabetes: Novel Translational Insights Into the Heart Failure Benefits of SGLT2 Inhibitors.

Verma S, Rawat S, Ho KL, Wagg CS, Zhang L, Teoh H, Dyck JE, Uddin GM, Oudit GY, Mayoux E, Lehrke M, Marx N, Lopaschuk GD.

JACC Basic Transl Sci. 2018 Aug 26;3(5):575-587. doi: 10.1016/j.jacbts.2018.07.006. eCollection 2018 Oct.


Disparate Remodeling of the Extracellular Matrix and Proteoglycans in Failing Pediatric Versus Adult Hearts.

Jana S, Zhang H, Lopaschuk GD, Freed DH, Sergi C, Kantor PF, Oudit GY, Kassiri Z.

J Am Heart Assoc. 2018 Oct 2;7(19):e010427. doi: 10.1161/JAHA.118.010427.


A novel role of endothelial autophagy as a regulator of myocardial fatty acid oxidation.

Altamimi TR, Chowdhury B, Singh KK, Zhang L, Mahmood MU, Pan Y, Quan A, Teoh H, Verma S, Lopaschuk GD.

J Thorac Cardiovasc Surg. 2019 Jan;157(1):185-193. doi: 10.1016/j.jtcvs.2018.07.047. Epub 2018 Aug 2.


Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction.

Fillmore N, Levasseur JL, Fukushima A, Wagg CS, Wang W, Dyck JRB, Lopaschuk GD.

Mol Med. 2018 Mar 15;24(1):3. doi: 10.1186/s10020-018-0005-x.


Metabolic effects of cardiovascular drugs.

Fragasso G, Margonato A, Spoladore R, Lopaschuk GD.

Trends Cardiovasc Med. 2019 Apr;29(3):176-187. doi: 10.1016/j.tcm.2018.08.001. Epub 2018 Aug 7. Review.


Cardiac branched-chain amino acid oxidation is reduced during insulin resistance in the heart.

Fillmore N, Wagg CS, Zhang L, Fukushima A, Lopaschuk GD.

Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E1046-E1052. doi: 10.1152/ajpendo.00097.2018. Epub 2018 Aug 14.


Loss of Metabolic Flexibility in the Failing Heart.

Karwi QG, Uddin GM, Ho KL, Lopaschuk GD.

Front Cardiovasc Med. 2018 Jun 6;5:68. doi: 10.3389/fcvm.2018.00068. eCollection 2018. Review.


Acetylation contributes to hypertrophy-caused maturational delay of cardiac energy metabolism.

Fukushima A, Zhang L, Huqi A, Lam VH, Rawat S, Altamimi T, Wagg CS, Dhaliwal KK, Hornberger LK, Kantor PF, Rebeyka IM, Lopaschuk GD.

JCI Insight. 2018 May 17;3(10). pii: 99239. doi: 10.1172/jci.insight.99239. eCollection 2018 May 17.


Maternal high fat diet induces early cardiac hypertrophy and alters cardiac metabolism in Sprague Dawley rat offspring.

De Jong KA, Barrand S, Wood-Bradley RJ, de Almeida DL, Czeczor JK, Lopaschuk GD, Armitage JA, McGee SL.

Nutr Metab Cardiovasc Dis. 2018 Jun;28(6):600-609. doi: 10.1016/j.numecd.2018.02.019. Epub 2018 Mar 13.


Increased cardiac fatty acid oxidation in a mouse model with decreased malonyl-CoA sensitivity of CPT1B.

van Weeghel M, Abdurrachim D, Nederlof R, Argmann CA, Houtkooper RH, Hagen J, Nabben M, Denis S, Ciapaite J, Kolwicz SC Jr, Lopaschuk GD, Auwerx J, Nicolay K, Des Rosiers C, Wanders RJ, Zuurbier CJ, Prompers JJ, Houten SM.

Cardiovasc Res. 2018 Aug 1;114(10):1324-1334. doi: 10.1093/cvr/cvy089.


Treading slowly through hypoxic waters: dichloroacetate to the rescue!

Uddin GM, Ho KL, Lopaschuk GD.

J Physiol. 2018 Aug;596(15):2957-2958. doi: 10.1113/JP275898. Epub 2018 Mar 23. No abstract available.


Cytosolic carnitine acetyltransferase as a source of cytosolic acetyl-CoA: a possible mechanism for regulation of cardiac energy metabolism.

Altamimi TR, Thomas PD, Darwesh AM, Fillmore N, Mahmoud MU, Zhang L, Gupta A, Al Batran R, Seubert JM, Lopaschuk GD.

Biochem J. 2018 Mar 9;475(5):959-976. doi: 10.1042/BCJ20170823.


Decreased Maternal Cardiac Glucose Oxidation: Taking One for the Fetus.

Ussher JR, Lopaschuk GD.

Circ Res. 2017 Dec 8;121(12):1299-1301. doi: 10.1161/CIRCRESAHA.117.312098. No abstract available.


Corrigendum: Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling.

Rines AK, Chang HC, Wu R, Sato T, Khechaduri A, Kouzu H, Shapiro J, Shang M, Burke MA, Abdelwahid E, Jiang X, Chen C, Rawlings TA, Lopaschuk GD, Schumacker PT, Abel ED, Ardehali H.

Nat Commun. 2017 Aug 30;8:16155. doi: 10.1038/ncomms16155.


Nrg4 promotes fuel oxidation and a healthy adipokine profile to ameliorate diet-induced metabolic disorders.

Chen Z, Wang GX, Ma SL, Jung DY, Ha H, Altamimi T, Zhao XY, Guo L, Zhang P, Hu CR, Cheng JX, Lopaschuk GD, Kim JK, Lin JD.

Mol Metab. 2017 Jun 21;6(8):863-872. doi: 10.1016/j.molmet.2017.03.016. eCollection 2017 Aug.


Why publish in the American Journal of Physiology-Heart and Circulatory Physiology?

Zucker IH, Lindsey ML, Delmar M, De Windt LJ, Des Rosiers C, Diz DI, Hester RL, Jones SP, Kanagy NL, Kitakaze M, Liao R, Lopaschuk GD, Patel KP, Recchia FA, Sadoshima J, Shah AM, Ungvari Z, Benjamin IJ, Blaustein MP, Charkoudian N, Efimov IR, Gutterman D, Kass DA, Liao Y, O'Leary DS, Ripplinger CM, Wolin MS.

Am J Physiol Heart Circ Physiol. 2017 Aug 1;313(2):H221-H223. doi: 10.1152/ajpheart.00329.2017. Epub 2017 Jun 16. No abstract available.


Complex Energy Metabolic Changes in Heart Failure With Preserved Ejection Fraction and Heart Failure With Reduced Ejection Fraction.

De Jong KA, Lopaschuk GD.

Can J Cardiol. 2017 Jul;33(7):860-871. doi: 10.1016/j.cjca.2017.03.009. Epub 2017 Mar 19. Review.


Erratum to: Obesity and type 2 diabetes have additive effects on left ventricular remodelling in normotensive patients-a cross sectional study.

De Jong KA, Czeczor JK, Sithara S, McEwen K, Lopaschuk GD, Appelbe A, Cukier K, Kotowicz M, McGee SL.

Cardiovasc Diabetol. 2017 Apr 20;16(1):53. doi: 10.1186/s12933-017-0535-5. No abstract available.


Metabolic Modulators in Heart Disease: Past, Present, and Future.

Lopaschuk GD.

Can J Cardiol. 2017 Jul;33(7):838-849. doi: 10.1016/j.cjca.2016.12.013. Epub 2016 Dec 21. Review.


Obesity and type 2 diabetes have additive effects on left ventricular remodelling in normotensive patients-a cross sectional study.

De Jong KA, Czeczor JK, Sithara S, McEwen K, Lopaschuk GD, Appelbe A, Cukier K, Kotowicz M, McGee SL.

Cardiovasc Diabetol. 2017 Feb 8;16(1):21. doi: 10.1186/s12933-017-0504-z. Erratum in: Cardiovasc Diabetol. 2017 Apr 20;16(1):53.


Snf1-related kinase improves cardiac mitochondrial efficiency and decreases mitochondrial uncoupling.

Rines AK, Chang HC, Wu R, Sato T, Khechaduri A, Kouzu H, Shapiro J, Shang M, Burke MA, Abdelwahid E, Jiang X, Chen C, Rawlings TA, Lopaschuk GD, Schumacker PT, Abel ED, Ardehali H.

Nat Commun. 2017 Jan 24;8:14095. doi: 10.1038/ncomms14095. Erratum in: Nat Commun. 2017 Aug 30;8:16155.


Evolving Concepts of Myocardial Energy Metabolism: More Than Just Fats and Carbohydrates.

Lopaschuk GD, Ussher JR.

Circ Res. 2016 Nov 11;119(11):1173-1176. doi: 10.1161/CIRCRESAHA.116.310078. Review. No abstract available.


Fatty Acid Oxidation and Its Relation with Insulin Resistance and Associated Disorders.

Lopaschuk GD.

Ann Nutr Metab. 2016;68 Suppl 3:15-20. Epub 2016 Dec 9. Review.


Empagliflozin's Fuel Hypothesis: Not so Soon.

Lopaschuk GD, Verma S.

Cell Metab. 2016 Aug 9;24(2):200-2. doi: 10.1016/j.cmet.2016.07.018.


Acetylation control of cardiac fatty acid β-oxidation and energy metabolism in obesity, diabetes, and heart failure.

Fukushima A, Lopaschuk GD.

Biochim Biophys Acta. 2016 Dec;1862(12):2211-2220. doi: 10.1016/j.bbadis.2016.07.020. Epub 2016 Jul 29. Review.


Inhibition of the Unfolded Protein Response Mechanism Prevents Cardiac Fibrosis.

Groenendyk J, Lee D, Jung J, Dyck JR, Lopaschuk GD, Agellon LB, Michalak M.

PLoS One. 2016 Jul 21;11(7):e0159682. doi: 10.1371/journal.pone.0159682. eCollection 2016.


Inhibition of Soluble Epoxide Hydrolase Limits Mitochondrial Damage and Preserves Function Following Ischemic Injury.

Akhnokh MK, Yang FH, Samokhvalov V, Jamieson KL, Cho WJ, Wagg C, Takawale A, Wang X, Lopaschuk GD, Hammock BD, Kassiri Z, Seubert JM.

Front Pharmacol. 2016 Jun 7;7:133. doi: 10.3389/fphar.2016.00133. eCollection 2016.


Acetylation and succinylation contribute to maturational alterations in energy metabolism in the newborn heart.

Fukushima A, Alrob OA, Zhang L, Wagg CS, Altamimi T, Rawat S, Rebeyka IM, Kantor PF, Lopaschuk GD.

Am J Physiol Heart Circ Physiol. 2016 Aug 1;311(2):H347-63. doi: 10.1152/ajpheart.00900.2015. Epub 2016 Jun 3.


Preface to the BBA special issue "heart lipid metabolism".

Lopaschuk GD.

Biochim Biophys Acta. 2016 Oct;1861(10):1423-4. doi: 10.1016/j.bbalip.2016.05.007. Epub 2016 May 18. No abstract available.


Genetic and Pharmacological Inhibition of Malonyl CoA Decarboxylase Does Not Exacerbate Age-Related Insulin Resistance in Mice.

Ussher JR, Fillmore N, Keung W, Zhang L, Mori J, Sidhu VK, Fukushima A, Gopal K, Lopaschuk DG, Wagg CS, Jaswal JS, Dyck JR, Lopaschuk GD.

Diabetes. 2016 Jul;65(7):1883-91. doi: 10.2337/db15-1145. Epub 2016 May 13.


Reply to Katlandur, Ozbek, and Keser.

Carvalho E, Lopaschuk GD, Børsheim E, Burgeiro A.

Am J Physiol Endocrinol Metab. 2016 May 15;310(10):E863. doi: 10.1152/ajpendo.00113.2016. No abstract available.


Assessing Cardiac Metabolism: A Scientific Statement From the American Heart Association.

Taegtmeyer H, Young ME, Lopaschuk GD, Abel ED, Brunengraber H, Darley-Usmar V, Des Rosiers C, Gerszten R, Glatz JF, Griffin JL, Gropler RJ, Holzhuetter HG, Kizer JR, Lewandowski ED, Malloy CR, Neubauer S, Peterson LR, Portman MA, Recchia FA, Van Eyk JE, Wang TJ; American Heart Association Council on Basic Cardiovascular Sciences.

Circ Res. 2016 May 13;118(10):1659-701. doi: 10.1161/RES.0000000000000097. Epub 2016 Mar 24. Review. Erratum in: Circ Res. 2016 May 13;118(10):e35.


Cardiac fatty acid oxidation in heart failure associated with obesity and diabetes.

Fukushima A, Lopaschuk GD.

Biochim Biophys Acta. 2016 Oct;1861(10):1525-34. doi: 10.1016/j.bbalip.2016.03.020. Epub 2016 Mar 18. Review.


Rationale and benefits of trimetazidine by acting on cardiac metabolism in heart failure.

Lopatin YM, Rosano GM, Fragasso G, Lopaschuk GD, Seferovic PM, Gowdak LH, Vinereanu D, Hamid MA, Jourdain P, Ponikowski P.

Int J Cardiol. 2016 Jan 15;203:909-15. doi: 10.1016/j.ijcard.2015.11.060. Epub 2015 Nov 7. Review.


Feeding the fibrillating heart: Dichloroacetate improves cardiac contractile dysfunction following VF.

Azam MA, Wagg CS, Massé S, Farid T, Lai PF, Kusha M, Asta J, Jaimes R 3rd, Kuzmiak-Glancy S, Kay MW, Lopaschuk GD, Nanthakumar K.

Am J Physiol Heart Circ Physiol. 2015 Nov;309(9):H1543-53. doi: 10.1152/ajpheart.00404.2015. Epub 2015 Sep 4.


ACE2 Deficiency Worsens Epicardial Adipose Tissue Inflammation and Cardiac Dysfunction in Response to Diet-Induced Obesity.

Patel VB, Mori J, McLean BA, Basu R, Das SK, Ramprasath T, Parajuli N, Penninger JM, Grant MB, Lopaschuk GD, Oudit GY.

Diabetes. 2016 Jan;65(1):85-95. doi: 10.2337/db15-0399. Epub 2015 Jul 29.


Myocardial Energy Substrate Metabolism in Heart Failure : from Pathways to Therapeutic Targets.

Fukushima A, Milner K, Gupta A, Lopaschuk GD.

Curr Pharm Des. 2015;21(25):3654-64. Review.


Tolerance to ischaemic injury in remodelled mouse hearts: less ischaemic glycogenolysis and preserved metabolic efficiency.

Masoud WG, Abo Al-Rob O, Yang Y, Lopaschuk GD, Clanachan AS.

Cardiovasc Res. 2015 Sep 1;107(4):499-508. doi: 10.1093/cvr/cvv195. Epub 2015 Jul 6.


Cardiac energy metabolic alterations in pressure overload-induced left and right heart failure (2013 Grover Conference Series).

Sankaralingam S, Lopaschuk GD.

Pulm Circ. 2015 Mar;5(1):15-28. doi: 10.1086/679608. Review.


Activating PPARα prevents post-ischemic contractile dysfunction in hypertrophied neonatal hearts.

Lam VH, Zhang L, Huqi A, Fukushima A, Tanner BA, Onay-Besikci A, Keung W, Kantor PF, Jaswal JS, Rebeyka IM, Lopaschuk GD.

Circ Res. 2015 Jun 19;117(1):41-51. doi: 10.1161/CIRCRESAHA.117.306585. Epub 2015 May 14.


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