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Expression of a Degradation-Resistant β-Catenin Mutant in Osteocytes Protects the Skeleton From Mechanodeprivation-Induced Bone Wasting.

Bullock WA, Hoggatt AM, Horan DJ, Lewis KJ, Yokota H, Hann S, Warman ML, Sebastian A, Loots GG, Pavalko FM, Robling AG.

J Bone Miner Res. 2019 Jun 7. doi: 10.1002/jbmr.3812. [Epub ahead of print]


The Sustained Induction of c-MYC Drives Nab-Paclitaxel Resistance in Primary Pancreatic Ductal Carcinoma Cells.

Parasido E, Avetian GS, Naeem A, Graham G, Pishvaian M, Glasgow E, Mudambi S, Lee Y, Ihemelandu C, Choudhry M, Peran I, Banerjee PP, Avantaggiati ML, Bryant K, Baldelli E, Pierobon M, Liotta L, Petricoin E, Fricke ST, Sebastian A, Cozzitorto J, Loots GG, Kumar D, Byers S, Londin E, DiFeo A, Narla G, Winter J, Brody JR, Rodriguez O, Albanese C.

Mol Cancer Res. 2019 Sep;17(9):1815-1827. doi: 10.1158/1541-7786.MCR-19-0191. Epub 2019 Jun 4.


Radiocarbon Tracers in Toxicology and Medicine: Recent Advances in Technology and Science.

Malfatti MA, Buchholz BA, Enright HA, Stewart BJ, Ognibene TJ, McCartt AD, Loots GG, Zimmermann M, Scharadin TM, Cimino GD, Jonas BA, Pan CX, Bench G, Henderson PT, Turteltaub KW.

Toxics. 2019 May 9;7(2). pii: E27. doi: 10.3390/toxics7020027. Review.


Sostdc1 Regulates NK Cell Maturation and Cytotoxicity.

Millan AJ, Elizaldi SR, Lee EM, Aceves JO, Murugesh D, Loots GG, Manilay JO.

J Immunol. 2019 Apr 15;202(8):2296-2306. doi: 10.4049/jimmunol.1801157. Epub 2019 Feb 27.


Regional Control of Hairless versus Hair-Bearing Skin by Dkk2.

Song Y, Boncompagni AC, Kim SS, Gochnauer HR, Zhang Y, Loots GG, Wu D, Li Y, Xu M, Millar SE.

Cell Rep. 2018 Dec 11;25(11):2981-2991.e3. doi: 10.1016/j.celrep.2018.11.017. Epub 2018 Nov 30.


Tracking Tumor Colonization in Xenograft Mouse Models Using Accelerator Mass Spectrometry.

Hum NR, Martin KA, Malfatti MA, Haack K, Buchholz BA, Loots GG.

Sci Rep. 2018 Oct 9;8(1):15013. doi: 10.1038/s41598-018-33368-0.


Comparative Transcriptomics Identifies Novel Genes and Pathways Involved in Post-Traumatic Osteoarthritis Development and Progression.

Sebastian A, Chang JC, Mendez ME, Murugesh DK, Hatsell S, Economides AN, Christiansen BA, Loots GG.

Int J Mol Sci. 2018 Sep 7;19(9). pii: E2657. doi: 10.3390/ijms19092657.


Vhl deficiency in osteocytes produces high bone mass and hematopoietic defects.

Loots GG, Robling AG, Chang JC, Murugesh DK, Bajwa J, Carlisle C, Manilay JO, Wong A, Yellowley CE, Genetos DC.

Bone. 2018 Nov;116:307-314. doi: 10.1016/j.bone.2018.08.022. Epub 2018 Aug 30.


Global gene expression analysis identifies Mef2c as a potential player in Wnt16-mediated transcriptional regulation.

Sebastian A, Hum NR, Morfin C, Murugesh DK, Loots GG.

Gene. 2018 Oct 30;675:312-321. doi: 10.1016/j.gene.2018.06.079. Epub 2018 Jul 5.


Sclerostin neutralization unleashes the osteoanabolic effects of Dkk1 inhibition.

Witcher PC, Miner SE, Horan DJ, Bullock WA, Lim KE, Kang KS, Adaniya AL, Ross RD, Loots GG, Robling AG.

JCI Insight. 2018 Jun 7;3(11). pii: 98673. doi: 10.1172/jci.insight.98673. eCollection 2018 Jun 7.


Conditional Deletion of Sost in MSC-Derived Lineages Identifies Specific Cell-Type Contributions to Bone Mass and B-Cell Development.

Yee CS, Manilay JO, Chang JC, Hum NR, Murugesh DK, Bajwa J, Mendez ME, Economides AE, Horan DJ, Robling AG, Loots GG.

J Bone Miner Res. 2018 Oct;33(10):1748-1759. doi: 10.1002/jbmr.3467. Epub 2018 Jun 29.


Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer's Patches.

Georgiev H, Ravens I, Papadogianni G, Halle S, Malissen B, Loots GG, Förster R, Bernhardt G.

Front Immunol. 2018 Apr 9;9:714. doi: 10.3389/fimmu.2018.00714. eCollection 2018.


SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury.

Chang JC, Christiansen BA, Murugesh DK, Sebastian A, Hum NR, Collette NM, Hatsell S, Economides AN, Blanchette CD, Loots GG.

J Bone Miner Res. 2018 Jun;33(6):1105-1113. doi: 10.1002/jbmr.3397. Epub 2018 Apr 2.


Wnt co-receptors Lrp5 and Lrp6 differentially mediate Wnt3a signaling in osteoblasts.

Sebastian A, Hum NR, Murugesh DK, Hatsell S, Economides AN, Loots GG.

PLoS One. 2017 Nov 27;12(11):e0188264. doi: 10.1371/journal.pone.0188264. eCollection 2017.


Genetics of Sost/SOST in sclerosteosis and van Buchem disease animal models.

Sebastian A, Loots GG.

Metabolism. 2018 Mar;80:38-47. doi: 10.1016/j.metabol.2017.10.005. Epub 2017 Oct 25. Review.


Maternal exposure to an environmentally relevant dose of triclocarban results in perinatal exposure and potential alterations in offspring development in the mouse model.

Enright HA, Falso MJS, Malfatti MA, Lao V, Kuhn EA, Hum N, Shi Y, Sales AP, Haack KW, Kulp KS, Buchholz BA, Loots GG, Bench G, Turteltaub KW.

PLoS One. 2017 Aug 9;12(8):e0181996. doi: 10.1371/journal.pone.0181996. eCollection 2017.


Wnt Signaling Pathway Inhibitor Sclerostin Inhibits Angiotensin II-Induced Aortic Aneurysm and Atherosclerosis.

Krishna SM, Seto SW, Jose RJ, Li J, Morton SK, Biros E, Wang Y, Nsengiyumva V, Lindeman JH, Loots GG, Rush CM, Craig JM, Golledge J.

Arterioscler Thromb Vasc Biol. 2017 Mar;37(3):553-566. doi: 10.1161/ATVBAHA.116.308723. Epub 2016 Dec 22.


Transcriptional control of Sost in bone.

Sebastian A, Loots GG.

Bone. 2017 Mar;96:76-84. doi: 10.1016/j.bone.2016.10.009. Epub 2016 Oct 19. Review.


Sost, independent of the non-coding enhancer ECR5, is required for bone mechanoadaptation.

Robling AG, Kang KS, Bullock WA, Foster WH, Murugesh D, Loots GG, Genetos DC.

Bone. 2016 Nov;92:180-188. doi: 10.1016/j.bone.2016.09.001. Epub 2016 Sep 4.


Sostdc1 deficiency accelerates fracture healing by promoting the expansion of periosteal mesenchymal stem cells.

Collette NM, Yee CS, Hum NR, Murugesh DK, Christiansen BA, Xie L, Economides AN, Manilay JO, Robling AG, Loots GG.

Bone. 2016 Jul;88:20-30. doi: 10.1016/j.bone.2016.04.005. Epub 2016 Apr 19.


Global molecular changes in a tibial compression induced ACL rupture model of post-traumatic osteoarthritis.

Chang JC, Sebastian A, Murugesh DK, Hatsell S, Economides AN, Christiansen BA, Loots GG.

J Orthop Res. 2017 Mar;35(3):474-485. doi: 10.1002/jor.23263. Epub 2016 May 10.


SOST Inhibits Prostate Cancer Invasion.

Hudson BD, Hum NR, Thomas CB, Kohlgruber A, Sebastian A, Collette NM, Coleman MA, Christiansen BA, Loots GG.

PLoS One. 2015 Nov 6;10(11):e0142058. doi: 10.1371/journal.pone.0142058. eCollection 2015.


Parathyroid hormone regulation of hypoxia-inducible factor signaling in osteoblastic cells.

Wong A, Loots GG, Yellowley CE, Dosé AC, Genetos DC.

Bone. 2015 Dec;81:97-103. doi: 10.1016/j.bone.2015.07.002. Epub 2015 Jul 4.


1α,25-dihydroxyvitamin D3 stimulates human SOST gene expression and sclerostin secretion.

Wijenayaka AR, Yang D, Prideaux M, Ito N, Kogawa M, Anderson PH, Morris HA, Solomon LB, Loots GG, Findlay DM, Atkins GJ.

Mol Cell Endocrinol. 2015 Sep 15;413:157-67. doi: 10.1016/j.mce.2015.06.021. Epub 2015 Jun 23.


Sclerostin antibody treatment improves fracture outcomes in a Type I diabetic mouse model.

Yee CS, Xie L, Hatsell S, Hum N, Murugesh D, Economides AN, Loots GG, Collette NM.

Bone. 2016 Jan;82:122-34. doi: 10.1016/j.bone.2015.04.048. Epub 2015 May 5.


Cancer-Osteoblast Interaction Reduces Sost Expression in Osteoblasts and Up-Regulates lncRNA MALAT1 in Prostate Cancer.

Sebastian A, Hum NR, Hudson BD, Loots GG.

Microarrays (Basel). 2015 Oct 29;4(4):503-19. doi: 10.3390/microarrays4040503.


Evaluation of nanolipoprotein particles (NLPs) as an in vivo delivery platform.

Fischer NO, Weilhammer DR, Dunkle A, Thomas C, Hwang M, Corzett M, Lychak C, Mayer W, Urbin S, Collette N, Chiun Chang J, Loots GG, Rasley A, Blanchette CD.

PLoS One. 2014 Mar 27;9(3):e93342. doi: 10.1371/journal.pone.0093342. eCollection 2014.


Nanocomposite scaffold for chondrocyte growth and cartilage tissue engineering: effects of carbon nanotube surface functionalization.

Chahine NO, Collette NM, Thomas CB, Genetos DC, Loots GG.

Tissue Eng Part A. 2014 Sep;20(17-18):2305-15. doi: 10.1089/ten.TEA.2013.0328. Epub 2014 May 20.


The use of nanolipoprotein particles to enhance the immunostimulatory properties of innate immune agonists against lethal influenza challenge.

Weilhammer DR, Blanchette CD, Fischer NO, Alam S, Loots GG, Corzett M, Thomas C, Lychak C, Dunkle AD, Ruitenberg JJ, Ghanekar SA, Sant AJ, Rasley A.

Biomaterials. 2013 Dec;34(38):10305-18. doi: 10.1016/j.biomaterials.2013.09.038. Epub 2013 Sep 27.


How genomics is changing our view of cancer.

Loots GG.

Brief Funct Genomics. 2013 Sep;12(5):389-90. doi: 10.1093/bfgp/elt035. No abstract available.


Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner.

Collette NM, Yee CS, Murugesh D, Sebastian A, Taher L, Gale NW, Economides AN, Harland RM, Loots GG.

Dev Biol. 2013 Nov 1;383(1):90-105. doi: 10.1016/j.ydbio.2013.08.015. Epub 2013 Aug 29.


Prostate cancer invasion and metastasis: insights from mining genomic data.

Hudson BD, Kulp KS, Loots GG.

Brief Funct Genomics. 2013 Sep;12(5):397-410. doi: 10.1093/bfgp/elt021. Epub 2013 Jul 22. Review.


Interrogating transcriptional regulatory sequences in Tol2-mediated Xenopus transgenics.

Loots GG, Bergmann A, Hum NR, Oldenburg CE, Wills AE, Hu N, Ovcharenko I, Harland RM.

PLoS One. 2013 Jul 16;8(7):e68548. doi: 10.1371/journal.pone.0068548. Print 2013.


Effect of age and cytoskeletal elements on the indentation-dependent mechanical properties of chondrocytes.

Chahine NO, Blanchette C, Thomas CB, Lu J, Haudenschild D, Loots GG.

PLoS One. 2013 Apr 16;8(4):e61651. doi: 10.1371/journal.pone.0061651. Print 2013.


Targeted deletion of Sost distal enhancer increases bone formation and bone mass.

Collette NM, Genetos DC, Economides AN, Xie L, Shahnazari M, Yao W, Lane NE, Harland RM, Loots GG.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14092-7. doi: 10.1073/pnas.1207188109. Epub 2012 Aug 10.


Long-term administration of AMD3100, an antagonist of SDF-1/CXCR4 signaling, alters fracture repair.

Toupadakis CA, Wong A, Genetos DC, Chung DJ, Murugesh D, Anderson MJ, Loots GG, Christiansen BA, Kapatkin AS, Yellowley CE.

J Orthop Res. 2012 Nov;30(11):1853-9. doi: 10.1002/jor.22145. Epub 2012 May 16.


Absence of sclerostin adversely affects B-cell survival.

Cain CJ, Rueda R, McLelland B, Collette NM, Loots GG, Manilay JO.

J Bone Miner Res. 2012 Jul;27(7):1451-61. doi: 10.1002/jbmr.1608.


Global gene expression analysis of murine limb development.

Taher L, Collette NM, Murugesh D, Maxwell E, Ovcharenko I, Loots GG.

PLoS One. 2011;6(12):e28358. doi: 10.1371/journal.pone.0028358. Epub 2011 Dec 9.


TGF-β regulates sclerostin expression via the ECR5 enhancer.

Loots GG, Keller H, Leupin O, Murugesh D, Collette NM, Genetos DC.

Bone. 2012 Mar;50(3):663-9. doi: 10.1016/j.bone.2011.11.016. Epub 2011 Dec 2.


Prostaglandin E2 signals through PTGER2 to regulate sclerostin expression.

Genetos DC, Yellowley CE, Loots GG.

PLoS One. 2011 Mar 16;6(3):e17772. doi: 10.1371/journal.pone.0017772.


Genetic evidence that SOST inhibits WNT signaling in the limb.

Collette NM, Genetos DC, Murugesh D, Harland RM, Loots GG.

Dev Biol. 2010 Jun 15;342(2):169-79. doi: 10.1016/j.ydbio.2010.03.021. Epub 2010 Mar 30.


Hypoxia decreases sclerostin expression and increases Wnt signaling in osteoblasts.

Genetos DC, Toupadakis CA, Raheja LF, Wong A, Papanicolaou SE, Fyhrie DP, Loots GG, Yellowley CE.

J Cell Biochem. 2010 May 15;110(2):457-67. doi: 10.1002/jcb.22559.


Human variation in short regions predisposed to deep evolutionary conservation.

Loots GG, Ovcharenko I.

Mol Biol Evol. 2010 Jun;27(6):1279-88. doi: 10.1093/molbev/msq011. Epub 2010 Jan 21.


Parathyroid hormone (PTH)-induced bone gain is blunted in SOST overexpressing and deficient mice.

Kramer I, Loots GG, Studer A, Keller H, Kneissel M.

J Bone Miner Res. 2010 Feb;25(2):178-89. doi: 10.1359/jbmr.090730.


Genomic identification of regulatory elements by evolutionary sequence comparison and functional analysis.

Loots GG.

Adv Genet. 2008;61:269-93. doi: 10.1016/S0065-2660(07)00010-7. Review.


Control of the SOST bone enhancer by PTH using MEF2 transcription factors.

Leupin O, Kramer I, Collette NM, Loots GG, Natt F, Kneissel M, Keller H.

J Bone Miner Res. 2007 Dec;22(12):1957-67.


Predicting tissue-specific enhancers in the human genome.

Pennacchio LA, Loots GG, Nobrega MA, Ovcharenko I.

Genome Res. 2007 Feb;17(2):201-11. Epub 2007 Jan 8.


Array2BIO: from microarray expression data to functional annotation of co-regulated genes.

Loots GG, Chain PS, Mabery S, Rasley A, Garcia E, Ovcharenko I.

BMC Bioinformatics. 2006 Jun 16;7:307.

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