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Comparison of null models for combination drug therapy reveals Hand model as biochemically most plausible.

Sinzger M, Vanhoefer J, Loos C, Hasenauer J.

Sci Rep. 2019 Feb 28;9(1):3002. doi: 10.1038/s41598-019-38907-x.


Benchmark Problems for Dynamic Modeling of Intracellular Processes.

Hass H, Loos C, Alvarez ER, Timmer J, Hasenauer J, Kreutz C.

Bioinformatics. 2019 Jan 8. doi: 10.1093/bioinformatics/btz020. [Epub ahead of print]


Scalable Inference of Ordinary Differential Equation Models of Biochemical Processes.

Fröhlich F, Loos C, Hasenauer J.

Methods Mol Biol. 2019;1883:385-422. doi: 10.1007/978-1-4939-8882-2_16.


Hierarchical optimization for the efficient parametrization of ODE models.

Loos C, Krause S, Hasenauer J.

Bioinformatics. 2018 Dec 15;34(24):4266-4273. doi: 10.1093/bioinformatics/bty514.


Response by Loos et al to Letter Regarding Article, "Long-Term Morphological Changes of Symptomatic Lacunar Infarcts and Surrounding White Matter on Structural Magnetic Resonance Imaging".

Loos CMJ, Staals J, Wardlaw JM.

Stroke. 2018 Jul;49(7):e269. doi: 10.1161/STROKEAHA.118.021876. Epub 2018 Jun 18. No abstract available.


A Hierarchical, Data-Driven Approach to Modeling Single-Cell Populations Predicts Latent Causes of Cell-To-Cell Variability.

Loos C, Moeller K, Fröhlich F, Hucho T, Hasenauer J.

Cell Syst. 2018 May 23;6(5):593-603.e13. doi: 10.1016/j.cels.2018.04.008. Epub 2018 May 2.


Long-Term Morphological Changes of Symptomatic Lacunar Infarcts and Surrounding White Matter on Structural Magnetic Resonance Imaging.

Loos CMJ, Makin SDJ, Staals J, Dennis MS, van Oostenbrugge RJ, Wardlaw JM.

Stroke. 2018 May;49(5):1183-1188. doi: 10.1161/STROKEAHA.117.020495. Epub 2018 Mar 22.


Cell model for the identification and characterization of prion-like components from Alzheimer brain tissue.

Markx D, Loos C, Claus S, Haupt C, Mawrin C, Fändrich M.

Biochem Biophys Res Commun. 2018 Mar 11;497(3):857-862. doi: 10.1016/j.bbrc.2018.02.137. Epub 2018 Feb 16.


Herpes Encephalitis: A Mortal Complication in a Patient Treated with Immunosuppressive Drugs because of Immune-Related Adverse Events after Ipilimumab Treatment.

van Montfort L, Loos CM, Anten M, Jansen RLH.

Case Rep Oncol. 2017 Dec 18;10(3):1112-1115. doi: 10.1159/000484553. eCollection 2017 Sep-Dec.


Are neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and/or mean platelet volume (MPV) clinically useful as predictive parameters for preeclampsia?

Mannaerts D, Heyvaert S, De Cordt C, Macken C, Loos C, Jacquemyn Y.

J Matern Fetal Neonatal Med. 2019 May;32(9):1412-1419. doi: 10.1080/14767058.2017.1410701. Epub 2017 Dec 11.


PESTO: Parameter EStimation TOolbox.

Stapor P, Weindl D, Ballnus B, Hug S, Loos C, Fiedler A, Krause S, Hroß S, Fröhlich F, Hasenauer J, Wren J.

Bioinformatics. 2018 Feb 15;34(4):705-707. doi: 10.1093/bioinformatics/btx676.


The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke.

Loos CM, McHutchison C, Cvoro V, Makin SD, Staals J, Chappell F, Dennis MS, van Oostenbrugge RJ, Wardlaw JM.

Int J Stroke. 2018 Jul;13(5):518-524. doi: 10.1177/1747493017730780. Epub 2017 Sep 14.


Acetyl-lupeolic acid inhibits Akt signaling and induces apoptosis in chemoresistant prostate cancer cells in vitro and in vivo.

Schmidt C, Loos C, Jin L, Schmiech M, Schmidt CQ, Gaafary ME, Syrovets T, Simmet T.

Oncotarget. 2017 Jul 8;8(33):55147-55161. doi: 10.18632/oncotarget.19101. eCollection 2017 Aug 15.


A chlorhexidine-releasing epoxy-based coating on titanium implants prevents Staphylococcus aureus experimental biomaterial-associated infection.

Riool M, Dirks AJ, Jaspers V, de Boer L, Loontjens TJ, van der Loos CM, Florquin S, Apachitei I, Rijk LN, Keul HA, Zaat SA.

Eur Cell Mater. 2017 Feb 14;33:143-157. doi: 10.22203/eCM.v033a11.


Robust parameter estimation for dynamical systems from outlier-corrupted data.

Maier C, Loos C, Hasenauer J.

Bioinformatics. 2017 Mar 1;33(5):718-725. doi: 10.1093/bioinformatics/btw703.


Hydrostatic Pressure Increases the Catalytic Activity of Amyloid Fibril Enzymes.

Luong TQ, Erwin N, Neumann M, Schmidt A, Loos C, Schmidt V, Fändrich M, Winter R.

Angew Chem Int Ed Engl. 2016 Sep 26;55(40):12412-6. doi: 10.1002/anie.201605715. Epub 2016 Aug 30.


Characteristics of Queensland physicians and the influence of rural exposure on practice location.

Runge CE, MacKenzie A, Loos C, Waller M, Gabbett M, Mills R, Eley D.

Intern Med J. 2016 Aug;46(8):981-5. doi: 10.1111/imj.13156.


Electron tomography reveals the fibril structure and lipid interactions in amyloid deposits.

Kollmer M, Meinhardt K, Haupt C, Liberta F, Wulff M, Linder J, Handl L, Heinrich L, Loos C, Schmidt M, Syrovets T, Simmet T, Westermark P, Westermark GT, Horn U, Schmidt V, Walther P, Fändrich M.

Proc Natl Acad Sci U S A. 2016 May 17;113(20):5604-9. doi: 10.1073/pnas.1523496113. Epub 2016 May 2.


Polymorphism of Amyloid Fibrils In Vivo.

Annamalai K, Gührs KH, Koehler R, Schmidt M, Michel H, Loos C, Gaffney PM, Sigurdson CJ, Hegenbart U, Schönland S, Fändrich M.

Angew Chem Int Ed Engl. 2016 Apr 4;55(15):4822-5. doi: 10.1002/anie.201511524. Epub 2016 Mar 8.


Carboxyl- and amino-functionalized polystyrene nanoparticles differentially affect the polarization profile of M1 and M2 macrophage subsets.

Fuchs AK, Syrovets T, Haas KA, Loos C, Musyanovych A, Mailänder V, Landfester K, Simmet T.

Biomaterials. 2016 Apr;85:78-87. doi: 10.1016/j.biomaterials.2016.01.064. Epub 2016 Jan 29.


Association between Perivascular Spaces and Progression of White Matter Hyperintensities in Lacunar Stroke Patients.

Loos CM, Klarenbeek P, van Oostenbrugge RJ, Staals J.

PLoS One. 2015 Sep 9;10(9):e0137323. doi: 10.1371/journal.pone.0137323. eCollection 2015.


Complexity and Diversity of the Mammalian Sialome Revealed by Nidovirus Virolectins.

Langereis MA, Bakkers MJ, Deng L, Padler-Karavani V, Vervoort SJ, Hulswit RJ, van Vliet AL, Gerwig GJ, de Poot SA, Boot W, van Ederen AM, Heesters BA, van der Loos CM, van Kuppeveld FJ, Yu H, Huizinga EG, Chen X, Varki A, Kamerling JP, de Groot RJ.

Cell Rep. 2015 Jun 30;11(12):1966-78. doi: 10.1016/j.celrep.2015.05.044. Epub 2015 Jun 18.


A rare variant in MCF2L identified using exclusion linkage in a pedigree with premature atherosclerosis.

Maiwald S, Motazacker MM, van Capelleveen JC, Sivapalaratnam S, van der Wal AC, van der Loos C, Kastelein JJ, Ouwehand WH, Hovingh GK, Trip MD, van Buul JD, Dallinga-Thie GM.

Eur J Hum Genet. 2016 Jan;24(1):86-91. doi: 10.1038/ejhg.2015.70. Epub 2015 Apr 22.


Functionalized polystyrene nanoparticles as a platform for studying bio-nano interactions.

Loos C, Syrovets T, Musyanovych A, Mailänder V, Landfester K, Nienhaus GU, Simmet T.

Beilstein J Nanotechnol. 2014 Dec 15;5:2403-12. doi: 10.3762/bjnano.5.250. eCollection 2014. Review.


Staphylococcus epidermidis originating from titanium implants infects surrounding tissue and immune cells.

Riool M, de Boer L, Jaspers V, van der Loos CM, van Wamel WJB, Wu G, Kwakman PHS, Zaat SAJ.

Acta Biomater. 2014 Dec;10(12):5202-5212. doi: 10.1016/j.actbio.2014.08.012. Epub 2014 Aug 18.


Impact of malpositioning on panoramic radiography in implant dentistry.

Riecke B, Friedrich RE, Schulze D, Loos C, Blessmann M, Heiland M, Wikner J.

Clin Oral Investig. 2015 May;19(4):781-90. doi: 10.1007/s00784-014-1295-1. Epub 2014 Jul 31.


Mutation in KERA identified by linkage analysis and targeted resequencing in a pedigree with premature atherosclerosis.

Maiwald S, Sivapalaratnam S, Motazacker MM, van Capelleveen JC, Bot I, de Jager SC, van Eck M, Jolley J, Kuiper J, Stephens J, Albers CA, Vosmeer CR, Kruize H, Geerke DP, van der Wal AC, van der Loos CM, Kastelein JJ, Trip MD, Ouwehand WH, Dallinga-Thie GM, Hovingh GK.

PLoS One. 2014 May 30;9(5):e98289. doi: 10.1371/journal.pone.0098289. eCollection 2014.


Antibody validation of immunohistochemistry for biomarker discovery: recommendations of a consortium of academic and pharmaceutical based histopathology researchers.

Howat WJ, Lewis A, Jones P, Kampf C, Pontén F, van der Loos CM, Gray N, Womack C, Warford A.

Methods. 2014 Nov;70(1):34-8. doi: 10.1016/j.ymeth.2014.01.018. Epub 2014 Feb 11.


Intraplaque hemorrhage in cardiac allograft vasculopathy.

Castellani C, Angelini A, de Boer OJ, van der Loos CM, Fedrigo M, Frigo AC, Meijer-Jorna LB, Li X, Ploegmakers HJ, Tona F, Feltrin G, Gerosa G, Valente M, Thiene G, van der Wal AC.

Am J Transplant. 2014 Jan;14(1):184-92. doi: 10.1111/ajt.12517. Epub 2013 Dec 4. Erratum in: Am J Transplant. 2014 Mar;14(3):739.


Amino-functionalized nanoparticles as inhibitors of mTOR and inducers of cell cycle arrest in leukemia cells.

Loos C, Syrovets T, Musyanovych A, Mailänder V, Landfester K, Simmet T.

Biomaterials. 2014 Feb;35(6):1944-53. doi: 10.1016/j.biomaterials.2013.11.056. Epub 2013 Dec 9.


Imbalance between pulmonary angiotensin-converting enzyme and angiotensin-converting enzyme 2 activity in acute respiratory distress syndrome.

Wösten-van Asperen RM, Bos AP, Bem RA, Dierdorp BS, Dekker T, van Goor H, Kamilic J, van der Loos CM, van den Berg E, Bruijn M, van Woensel JB, Lutter R.

Pediatr Crit Care Med. 2013 Nov;14(9):e438-41. doi: 10.1097/PCC.0b013e3182a55735.


Therapeutic expression of hairpins targeting apolipoprotein B100 induces phenotypic and transcriptome changes in murine liver.

Maczuga P, Verheij J, van der Loos C, van Logtenstein R, Hooijer G, Martier R, Borel F, Lubelski J, Koornneef A, Blits B, van Deventer S, Petry H, Konstantinova P.

Gene Ther. 2014 Jan;21(1):60-70. doi: 10.1038/gt.2013.58. Epub 2013 Oct 24.


The thrombomodulin lectin-like domain does not change host responses to tuberculosis.

Kager LM, de Vos AF, Roelofs JJ, van der Loos CM, de Boer OJ, van't Veer C, Conway EM, van der Poll T.

Thromb Haemost. 2014 Feb;111(2):345-53. doi: 10.1160/TH13-08-0719. Epub 2013 Oct 17.


Microvascular proliferations in arteriovenous malformations relate to high-flow characteristics, inflammation, and previous therapeutic embolization of the lesion.

Meijer-Jorna LB, van der Loos CM, de Boer OJ, Horrevoets AJG, Mekkes JR, van der Horst CMAM, van der Wal AC.

J Am Acad Dermatol. 2013 Apr;68(4):638-646. doi: 10.1016/j.jaad.2012.10.047. Epub 2012 Dec 23.


Neutrophils, neutrophil extracellular traps and interleukin-17 associate with the organisation of thrombi in acute myocardial infarction.

de Boer OJ, Li X, Teeling P, Mackaay C, Ploegmakers HJ, van der Loos CM, Daemen MJ, de Winter RJ, van der Wal AC.

Thromb Haemost. 2013 Feb;109(2):290-7. doi: 10.1160/TH12-06-0425. Epub 2012 Dec 13.


The appearance of a new white matter lesion adjacent to the old infarct in first-ever lacunar stroke patients: a two-year follow-up study with MRI.

Loos CM, van Oostenbrugge RJ, Staals J.

Cerebrovasc Dis. 2012;34(5-6):443-5. doi: 10.1159/000344003. Epub 2012 Dec 1. No abstract available.


Enhanced tumor growth after portal vein embolization in a rabbit tumor model.

Hoekstra LT, van Lienden KP, Verheij J, van der Loos CM, Heger M, van Gulik TM.

J Surg Res. 2013 Mar;180(1):89-96. doi: 10.1016/j.jss.2012.10.032. Epub 2012 Nov 6.


Distribution of macrophage polarization markers in human atherosclerosis.

Stöger JL, Gijbels MJ, van der Velden S, Manca M, van der Loos CM, Biessen EA, Daemen MJ, Lutgens E, de Winther MP.

Atherosclerosis. 2012 Dec;225(2):461-8. doi: 10.1016/j.atherosclerosis.2012.09.013. Epub 2012 Sep 26.


Memory CD4(+)CCR5(+) T cells are abundantly present in the gut of newborn infants to facilitate mother-to-child transmission of HIV-1.

Bunders MJ, van der Loos CM, Klarenbeek PL, van Hamme JL, Boer K, Wilde JC, de Vries N, van Lier RA, Kootstra N, Pals ST, Kuijpers TW.

Blood. 2012 Nov 22;120(22):4383-90. doi: 10.1182/blood-2012-06-437566. Epub 2012 Oct 1.


Accurate quantitation of Ki67-positive proliferating hepatocytes in rabbit liver by a multicolor immunohistochemical (IHC) approach analyzed with automated tissue and cell segmentation software.

van der Loos CM, de Boer OJ, Mackaaij C, Hoekstra LT, van Gulik TM, Verheij J.

J Histochem Cytochem. 2013 Jan;61(1):11-8. doi: 10.1369/0022155412461154. Epub 2012 Sep 1.


The TNF family member APRIL promotes colorectal tumorigenesis.

Lascano V, Zabalegui LF, Cameron K, Guadagnoli M, Jansen M, Burggraaf M, Versloot M, Rodermond H, van der Loos C, Carvalho-Pinto CE, Kalthoff H, Medema JP, Hahne M.

Cell Death Differ. 2012 Nov;19(11):1826-35. doi: 10.1038/cdd.2012.68. Epub 2012 Jun 15.


Cavitation of deep lacunar infarcts in patients with first-ever lacunar stroke: a 2-year follow-up study with MR.

Loos CM, Staals J, Wardlaw JM, van Oostenbrugge RJ.

Stroke. 2012 Aug;43(8):2245-7. doi: 10.1161/STROKEAHA.112.660076. Epub 2012 Jun 12.


Proliferation and maturation of microvessels in arteriovenous malformations--expression patterns of angiogenic and cell cycle-dependent factors.

Meijer-Jorna LB, van der Loos CM, Teeling P, de Boer OJ, Florquin S, van der Horst CM, van der Wal AC.

J Cutan Pathol. 2012 Jun;39(6):610-20. doi: 10.1111/j.1600-0560.2012.01913.x.


Congenital vascular malformations--cerebral lesions differ from extracranial lesions by their immune expression of the glucose transporter protein GLUT1.

Meijer-Jorna LB, Aronica E, van der Loos CM, Troost D, van der Wal AC.

Clin Neuropathol. 2012 May-Jun;31(3):135-41.


Mucosal immune cell numbers and visceral sensitivity in patients with irritable bowel syndrome: is there any relationship?

Braak B, Klooker TK, Wouters MM, Welting O, van der Loos CM, Stanisor OI, van Diest S, van den Wijngaard RM, Boeckxstaens GE.

Am J Gastroenterol. 2012 May;107(5):715-26. doi: 10.1038/ajg.2012.54. Epub 2012 Apr 10.


Microvascular endoglin (CD105) expression correlates with tissue markers for atherosclerotic plaque vulnerability in an ageing population with multivessel coronary artery disease.

Li X, van der Meer JJ, van der Loos CM, Ploegmakers HJ, de Boer OJ, de Winter RJ, van der Wal AC.

Histopathology. 2012 Jul;61(1):88-97. doi: 10.1111/j.1365-2559.2011.04166.x. Epub 2012 Mar 28.


Pulmonary epithelial apoptosis in fetal down syndrome: not higher than normal.

Bruijn M, von der Thüsen JH, van der Loos CM, de Krijger RR, van Loenhout RB, Bos AP, van Woensel JB.

Pediatr Dev Pathol. 2012 May-Jun;15(3):199-205. doi: 10.2350/11-08-1080-OA.1. Epub 2012 Feb 27.


Endothelial insulin receptor expression in human atherosclerotic plaques: linking micro- and macrovascular disease in diabetes?

Rensing KL, von der Thüsen JH, Weijers EM, Houttuijn Bloemendaal FM, van Lammeren GW, Vink A, van der Wal AC, van Hinsbergh VW, van der Loos CM, Stroes ES, Koolwijk P, Twickler TB.

Atherosclerosis. 2012 May;222(1):208-15. doi: 10.1016/j.atherosclerosis.2012.01.035. Epub 2012 Jan 28.


Increased numbers of CD5+ B lymphocytes with a regulatory phenotype in spondylarthritis.

Cantaert T, Doorenspleet ME, Francosalinas G, Paramarta JE, Klarenbeek PL, Tiersma Y, van der Loos CM, De Vries N, Tak PP, Baeten DL.

Arthritis Rheum. 2012 Jun;64(6):1859-68. doi: 10.1002/art.34364. Epub 2012 Jan 9.

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