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Items: 36

1.

A Direct C11 Alkylation Strategy on the Saxitoxin Core: A Synthesis of (+)-11-Saxitoxinethanoic Acid.

Paladugu SR, James CK, Looper RE.

Org Lett. 2019 Oct 4;21(19):7999-8002. doi: 10.1021/acs.orglett.9b02986. Epub 2019 Sep 25.

PMID:
31553620
2.

Growth substrate may influence biofilm susceptibility to antibiotics.

Williams DL, Smith SR, Peterson BR, Allyn G, Cadenas L, Epperson RT, Looper RE.

PLoS One. 2019 Mar 14;14(3):e0206774. doi: 10.1371/journal.pone.0206774. eCollection 2019.

3.

In vitro testing of a first-in-class tri-alkylnorspermidine-biaryl antibiotic in an anti-biofilm silicone coating.

Ashton NN, Allyn G, Porter ST, Haussener TJ, Sebahar PR, Looper RE, Williams DL.

Acta Biomater. 2019 Jul 15;93:25-35. doi: 10.1016/j.actbio.2019.02.010. Epub 2019 Feb 12.

PMID:
30769135
4.

In vivo analysis of a first-in-class tri-alkyl norspermidine-biaryl antibiotic in an active release coating to reduce the risk of implant-related infection.

Williams DL, Epperson RT, Ashton NN, Taylor NB, Kawaguchi B, Olsen RE, Haussener TJ, Sebahar PR, Allyn G, Looper RE.

Acta Biomater. 2019 Jul 15;93:36-49. doi: 10.1016/j.actbio.2019.01.055. Epub 2019 Jan 31.

PMID:
30710710
5.

A Cancer-Selective Zinc Ionophore Inspired by the Natural Product Naamidine A.

Vaden RM, Guillen KP, Salvant JM, Santiago CB, Gibbons JB, Pathi SS, Arunachalam S, Sigman MS, Looper RE, Welm BE.

ACS Chem Biol. 2019 Jan 18;14(1):106-117. doi: 10.1021/acschembio.8b00977. Epub 2019 Jan 8.

PMID:
30571086
6.

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma.

McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG Jr.

Cell. 2018 Sep 20;175(1):101-116.e25. doi: 10.1016/j.cell.2018.08.038. Epub 2018 Sep 13.

7.

Synthetic Ingenols Maximize Protein Kinase C-Induced HIV-1 Latency Reversal.

Spivak AM, Nell RA, Petersen M, Martins L, Sebahar P, Looper RE, Planelles V.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01361-18. doi: 10.1128/AAC.01361-18. Print 2018 Nov.

8.

Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases.

Laukka T, Myllykoski M, Looper RE, Koivunen P.

J Mol Biol. 2018 Sep 14;430(18 Pt B):3081-3092. doi: 10.1016/j.jmb.2018.06.048. Epub 2018 Jul 5.

PMID:
29981745
9.

Mutant IDH1 Promotes Glioma Formation In Vivo.

Philip B, Yu DX, Silvis MR, Shin CH, Robinson JP, Robinson GL, Welker AE, Angel SN, Tripp SR, Sonnen JA, VanBrocklin MW, Gibbons RJ, Looper RE, Colman H, Holmen SL.

Cell Rep. 2018 May 1;23(5):1553-1564. doi: 10.1016/j.celrep.2018.03.133.

10.

Exploring hydroamination-cycloaddition-fragmentation sequences to access polycyclicguanidines and vinyl-2-aminoimidazoles.

Kwon KH, Edwards AV, Yang M, Looper RE.

Tetrahedron. 2017 Oct 19;73(42):6067-6079. doi: 10.1016/j.tet.2017.08.052.

11.

Blueberry Metabolites Attenuate Lipotoxicity-Induced Endothelial Dysfunction.

Bharat D, Cavalcanti RRM, Petersen C, Begaye N, Cutler BR, Costa MMA, Ramos RKLG, Ferreira MR, Li Y, Bharath LP, Toolson E, Sebahar P, Looper RE, Jalili T, Rajasekaran NS, Jia Z, Symons JD, Anandh Babu PV.

Mol Nutr Food Res. 2018 Jan;62(2). doi: 10.1002/mnfr.201700601. Epub 2017 Dec 14.

PMID:
29024402
12.

Regioselective Base-Mediated Cyclizations of Mono-N-acylpropargylguanidines.

Salvant JM, Edwards AV, Kurek DZ, Looper RE.

J Org Chem. 2017 Jul 7;82(13):6958-6967. doi: 10.1021/acs.joc.7b00639. Epub 2017 Jun 15.

13.

Preparation of a 1,2-isoxazolidine synthon for the synthesis of zetekitoxin AB.

Paladugu SR, Looper RE.

Tetrahedron Lett. 2015 Nov 18;56(46):6332-6334.

14.

Synthesis of Naamidine A and Selective Access to N(2)-Acyl-2-aminoimidazole Analogues.

Gibbons JB, Salvant JM, Vaden RM, Kwon KH, Welm BE, Looper RE.

J Org Chem. 2015 Oct 16;80(20):10076-85. doi: 10.1021/acs.joc.5b01703. Epub 2015 Sep 24.

15.

Preparation of Mono-Cbz Protected Guanidines.

Kwon K, Haussener TJ, Looper RE.

Organic Synth. 2015;92:91-102. No abstract available.

16.

Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate.

Fan J, Teng X, Liu L, Mattaini KR, Looper RE, Vander Heiden MG, Rabinowitz JD.

ACS Chem Biol. 2015 Feb 20;10(2):510-6. doi: 10.1021/cb500683c. Epub 2014 Nov 18.

17.

Synthesis of bicyclic guanidines via cascade hydroamination/Michael additions of mono-N-acryloylpropargylguanidines.

Kwon KH, Serrano CM, Koch M, Barrows LR, Looper RE.

Org Lett. 2014 Dec 5;16(23):6048-51. doi: 10.1021/ol502691w. Epub 2014 Nov 13.

18.

Dioxin exposure blocks lactation through a direct effect on mammary epithelial cells mediated by the aryl hydrocarbon receptor repressor.

Basham KJ, Leonard CJ, Kieffer C, Shelton DN, McDowell ME, Bhonde VR, Looper RE, Welm BE.

Toxicol Sci. 2015 Jan;143(1):36-45. doi: 10.1093/toxsci/kfu203. Epub 2014 Sep 29.

19.

Bis-aryloxadiazoles as effective activators of the aryl hydrocarbon receptor.

Basham KJ, Bhonde VR, Kieffer C, Mack JB, Hess M, Welm BE, Looper RE.

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2473-6. doi: 10.1016/j.bmcl.2014.04.013. Epub 2014 Apr 13.

20.

Development of a screen to identify selective small molecules active against patient-derived metastatic and chemoresistant breast cancer cells.

Gligorich KM, Vaden RM, Shelton DN, Wang G, Matsen CB, Looper RE, Sigman MS, Welm BE.

Breast Cancer Res. 2013;15(4):R58.

21.

Cationic dirhodium carboxylate-catalyzed synthesis of dihydropyrimidones from propargyl ureas.

Yang M, Odelberg SJ, Tong Z, Li DY, Looper RE.

Tetrahedron. 2013 Jul 8;69(27-28):5744-5750.

22.

(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible.

Losman JA, Looper RE, Koivunen P, Lee S, Schneider RK, McMahon C, Cowley GS, Root DE, Ebert BL, Kaelin WG Jr.

Science. 2013 Mar 29;339(6127):1621-5. doi: 10.1126/science.1231677. Epub 2013 Feb 7.

23.

Chemical genetic screen reveals a role for desmosomal adhesion in mammary branching morphogenesis.

Basham KJ, Kieffer C, Shelton DN, Leonard CJ, Bhonde VR, Vankayalapati H, Milash B, Bearss DJ, Looper RE, Welm BE.

J Biol Chem. 2013 Jan 25;288(4):2261-70. doi: 10.1074/jbc.M112.411033. Epub 2012 Dec 3.

24.

Synthesis of the reported structures for kealiinines B and C.

Gibbons JB, Gligorich KM, Welm BE, Looper RE.

Org Lett. 2012 Sep 21;14(18):4734-7. Epub 2012 Sep 11.

25.

Access to the pactamycin core via an epoxide opening cascade.

Haussener TJ, Looper RE.

Org Lett. 2012 Jul 20;14(14):3632-5. doi: 10.1021/ol301461e. Epub 2012 Jul 3.

PMID:
22758908
26.

A stereocontrolled synthesis of (+)-saxitoxin.

Bhonde VR, Looper RE.

J Am Chem Soc. 2011 Dec 21;133(50):20172-4. doi: 10.1021/ja2098063. Epub 2011 Nov 23.

27.

Synthesis of cytimidine through a one-pot copper-mediated amidation cascade.

Serrano CM, Looper RE.

Org Lett. 2011 Oct 7;13(19):5000-3. doi: 10.1021/ol2018196. Epub 2011 Sep 13.

PMID:
21913679
28.

Chlorotrimethylsilane activation of acylcyanamides for the synthesis of mono-N-acylguanidines.

Looper RE, Haussener TJ, Mack JB.

J Org Chem. 2011 Aug 19;76(16):6967-71. doi: 10.1021/jo201264j. Epub 2011 Jul 19.

29.

Regioselective rhodium(II)-catalyzed hydroaminations of propargylguanidines.

Gainer MJ, Bennett NR, Takahashi Y, Looper RE.

Angew Chem Int Ed Engl. 2011 Jan 17;50(3):684-7. doi: 10.1002/anie.201006087. Epub 2010 Dec 9. No abstract available.

30.

Synthesis of 2-thio- and 2-oxoimidazoles via cascade addition-cycloisomerization reactions of propargylcyanamides.

Giles RL, Nkansah RA, Looper RE.

J Org Chem. 2010 Jan 1;75(1):261-4. doi: 10.1021/jo902326d.

PMID:
19954194
31.

Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity.

Kaadige MR, Looper RE, Kamalanaadhan S, Ayer DE.

Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14878-83. doi: 10.1073/pnas.0901221106. Epub 2009 Aug 17.

32.

Addition-hydroamination reactions of propargyl cyanamides: rapid access to highly substituted 2-aminoimidazoles.

Giles RL, Sullivan JD, Steiner AM, Looper RE.

Angew Chem Int Ed Engl. 2009;48(17):3116-20. doi: 10.1002/anie.200900160.

PMID:
19322858
33.

Macrocycloadditions leading to conformationally restricted small molecules.

Looper RE, Pizzirani D, Schreiber SL.

Org Lett. 2006 May 11;8(10):2063-6. Erratum in: Org Lett. 2009 Aug 6;11(15):3522.

PMID:
16671782
34.

Synthesis of the putative structure of 7-deoxycylindrospermopsin: C7 oxygenation is not required for the inhibition of protein synthesis.

Looper RE, Runnegar MT, Williams RM.

Angew Chem Int Ed Engl. 2005 Jun 20;44(25):3879-81. No abstract available.

PMID:
15900531
35.

A concise asymmetric synthesis of the marine hepatotoxin 7-epicylindrospermopsin.

Looper RE, Williams RM.

Angew Chem Int Ed Engl. 2004 May 24;43(22):2930-3. No abstract available.

PMID:
15170307
36.

Synthesis of aromatic bisabolene natural products via palladium-catalyzed cross-couplings of organozinc reagents.

Vyvyan JR, Loitz C, Looper RE, Mattingly CS, Peterson EA, Staben ST.

J Org Chem. 2004 Apr 2;69(7):2461-8.

PMID:
15049646

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