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Mitochondrial DNA Stimulates TLR9-Dependent NET Formation in Primary Graft Dysfunction.

Mallavia B, Liu F, Lefrançais E, Cleary SJ, Kwaan N, Tian JJ, Magnen M, Sayah DM, Soong A, Chen J, Saggar R, Shino MY, Ross DJ, Derhovanessian A, Lynch Iii JP, Ardehali A, Weigt SS, Belperio JA, Hays SR, Golden JA, Leard LE, Shah RJ, Kleinhenz ME, Venado A, Kukreja J, Singer JP, Looney MR.

Am J Respir Cell Mol Biol. 2019 Oct 24. doi: 10.1165/rcmb.2019-0140OC. [Epub ahead of print]


Platelet Biogenesis in the Lung Circulation.

Lefrançais E, Looney MR.

Physiology (Bethesda). 2019 Nov 1;34(6):392-401. doi: 10.1152/physiol.00017.2019.


Modulating Pathogenesis with Mobile-CRISPRi.

Qu J, Prasad NK, Yu MA, Chen S, Lyden A, Herrera N, Silvis MR, Crawford E, Looney MR, Peters JM, Rosenberg OS.

J Bacteriol. 2019 Oct 21;201(22). pii: e00304-19. doi: 10.1128/JB.00304-19. Print 2019 Nov 15.


An update of the transfusion-related acute lung injury (TRALI) definition.

Vlaar APJ, Toy P, Fung M, Looney MR, Juffermans NP, Bux J, Bolton-Maggs P, Peters AL, Silliman CC, Kor DJ, Kleinman S.

Transfus Clin Biol. 2019 Nov;26(4):354-356. doi: 10.1016/j.tracli.2019.05.007. Epub 2019 Jun 12. No abstract available.


A consensus redefinition of transfusion-related acute lung injury.

Vlaar APJ, Toy P, Fung M, Looney MR, Juffermans NP, Bux J, Bolton-Maggs P, Peters AL, Silliman CC, Kor DJ, Kleinman S.

Transfusion. 2019 Jul;59(7):2465-2476. doi: 10.1111/trf.15311. Epub 2019 Apr 16.


Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma.

Lachowicz-Scroggins ME, Dunican EM, Charbit AR, Raymond W, Looney MR, Peters MC, Gordon ED, Woodruff PG, Lefrançais E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Fajt ML, Wenzel SE, Israel E, Levy BD, Fahy JV.

Am J Respir Crit Care Med. 2019 May 1;199(9):1076-1085. doi: 10.1164/rccm.201810-1869OC.


LPS-induced Lung Platelet Recruitment Occurs Independently from Neutrophils, PSGL-1, and P-Selectin.

Cleary SJ, Hobbs C, Amison RT, Arnold S, O'Shaughnessy BG, Lefrançais E, Mallavia B, Looney MR, Page CP, Pitchford SC.

Am J Respir Cell Mol Biol. 2019 Aug;61(2):232-243. doi: 10.1165/rcmb.2018-0182OC.


Live imaging of the pulmonary immune environment.

Looney MR, Headley MB.

Cell Immunol. 2018 Oct 9:103862. doi: 10.1016/j.cellimm.2018.09.007. [Epub ahead of print]


The incomparable platelet: holy alveoli!

Looney MR.

Blood. 2018 Sep 13;132(11):1088-1089. doi: 10.1182/blood-2018-06-856351. No abstract available.


Advances in Clinical and Basic Science of Coagulation: Illustrated abstracts of the 9th Chapel Hill Symposium on Hemostasis.

Bergmeier W, Antoniak S, Conway EM, Denis CV, George LA, Isermann B, Key NS, Krishnaswamy S, Lam WA, Lillicrap D, Liu J, Looney MR, López JA, Maas C, Peyvandi F, Ruf W, Sood AK, Versteeg HH, Wolberg AS, Wong PC, Wood JP, Weiler H.

Res Pract Thromb Haemost. 2018 Apr 12;2(3):407-428. doi: 10.1002/rth2.12095. eCollection 2018 Jul. Review.


Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury.

Lefrançais E, Mallavia B, Zhuo H, Calfee CS, Looney MR.

JCI Insight. 2018 Feb 8;3(3). pii: 98178. doi: 10.1172/jci.insight.98178. eCollection 2018 Feb 8.


Contemporary Risk Factors and Outcomes of Transfusion-Associated Circulatory Overload.

Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Michalkiewicz M, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL; National Heart, Lung, and Blood Institute (NHLBI) Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).

Crit Care Med. 2018 Apr;46(4):577-585. doi: 10.1097/CCM.0000000000002948.


Neutralizing Extracellular Histones in Acute Respiratory Distress Syndrome. A New Role for an Endogenous Pathway.

Lefrançais E, Looney MR.

Am J Respir Crit Care Med. 2017 Jul 15;196(2):122-124. doi: 10.1164/rccm.201701-0095ED. No abstract available.


The Lung is a Host Defense Niche for Immediate Neutrophil-Mediated Vascular Protection.

Yipp BG, Kim JH, Lima R, Zbytnuik LD, Petri B, Swanlund N, Ho M, Szeto VG, Tak T, Koenderman L, Pickkers P, Tool ATJ, Kuijpers TW, van den Berg TK, Looney MR, Krummel MF, Kubes P.

Sci Immunol. 2017 Apr 28;2(10). pii: eaam8929. doi: 10.1126/sciimmunol.aam8929.


Mirasol pathogen reduction technology treatment of human whole blood does not induce acute lung injury in mice.

Mallavia B, Kwaan N, Marschner S, Yonemura S, Looney MR.

PLoS One. 2017 Jun 1;12(6):e0178725. doi: 10.1371/journal.pone.0178725. eCollection 2017.


Differentiating pulmonary transfusion reactions using recipient and transfusion factors.

Roubinian NH, Looney MR, Keating S, Kor DJ, Lowell CA, Gajic O, Hubmayr R, Gropper M, Koenigsberg M, Wilson GA, A Matthay M, Toy P, Murphy EL; TRALI Study Group.

Transfusion. 2017 Jul;57(7):1684-1690. doi: 10.1111/trf.14118. Epub 2017 May 3.


Models of Lung Transplant Research: a consensus statement from the National Heart, Lung, and Blood Institute workshop.

Lama VN, Belperio JA, Christie JD, El-Chemaly S, Fishbein MC, Gelman AE, Hancock WW, Keshavjee S, Kreisel D, Laubach VE, Looney MR, McDyer JF, Mohanakumar T, Shilling RA, Panoskaltsis-Mortari A, Wilkes DS, Eu JP, Nicolls MR.

JCI Insight. 2017 May 4;2(9). pii: 93121. doi: 10.1172/jci.insight.93121. eCollection 2017 May 4. Review.


Whither the Pulmonary Ward Attending? Preserving Subspecialty Exposure in United States Internal Medicine Residency Training.

Santhosh L, Babik J, Looney MR, Hollander H.

Ann Am Thorac Soc. 2017 Apr;14(4):565-568. doi: 10.1513/AnnalsATS.201612-995OI.


The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors.

Lefrançais E, Ortiz-Muñoz G, Caudrillier A, Mallavia B, Liu F, Sayah DM, Thornton EE, Headley MB, David T, Coughlin SR, Krummel MF, Leavitt AD, Passegué E, Looney MR.

Nature. 2017 Apr 6;544(7648):105-109. doi: 10.1038/nature21706. Epub 2017 Mar 22.


Aspirin reduces lipopolysaccharide-induced pulmonary inflammation in human models of ARDS.

Hamid U, Krasnodembskaya A, Fitzgerald M, Shyamsundar M, Kissenpfennig A, Scott C, Lefrancais E, Looney MR, Verghis R, Scott J, Simpson AJ, McNamee J, McAuley DF, O'Kane CM.

Thorax. 2017 Nov;72(11):971-980. doi: 10.1136/thoraxjnl-2016-208571. Epub 2017 Jan 12.


Proposed revised nomenclature for transfusion-related acute lung injury.

Toy P, Kleinman SH, Looney MR.

Transfusion. 2017 Mar;57(3):709-713. doi: 10.1111/trf.13944. Epub 2016 Dec 26.


Incidence and clinical characteristics of transfusion-associated circulatory overload using an active surveillance algorithm.

Roubinian NH, Hendrickson JE, Triulzi DJ, Gottschall JL, Chowdhury D, Kor DJ, Looney MR, Matthay MA, Kleinman SH, Brambilla D, Murphy EL; NHLBI Recipient Epidemiology and Donor Evaluation Study-III (REDS-III).

Vox Sang. 2017 Jan;112(1):56-63. doi: 10.1111/vox.12466. Epub 2016 Dec 21.


Prevention or Treatment of Ards With Aspirin: A Review of Preclinical Models and Meta-Analysis of Clinical Studies.

Panka BA, de Grooth HJ, Spoelstra-de Man AM, Looney MR, Tuinman PR.

Shock. 2017 Jan;47(1):13-21. Review.


Directed transport of neutrophil-derived extracellular vesicles enables platelet-mediated innate immune response.

Rossaint J, Kühne K, Skupski J, Van Aken H, Looney MR, Hidalgo A, Zarbock A.

Nat Commun. 2016 Nov 15;7:13464. doi: 10.1038/ncomms13464.


CXCR4 identifies transitional bone marrow premonocytes that replenish the mature monocyte pool for peripheral responses.

Chong SZ, Evrard M, Devi S, Chen J, Lim JY, See P, Zhang Y, Adrover JM, Lee B, Tan L, Li JL, Liong KH, Phua C, Balachander A, Boey A, Liebl D, Tan SM, Chan JK, Balabanian K, Harris JE, Bianchini M, Weber C, Duchene J, Lum J, Poidinger M, Chen Q, Rénia L, Wang CI, Larbi A, Randolph GJ, Weninger W, Looney MR, Krummel MF, Biswas SK, Ginhoux F, Hidalgo A, Bachelerie F, Ng LG.

J Exp Med. 2016 Oct 17;213(11):2293-2314. Epub 2016 Oct 10.


Dyspnea and Pulmonary Hypertension with Diffuse Centrilobular Nodules.

Henry TS, Naeger DM, Looney MR, Elicker BM.

Ann Am Thorac Soc. 2016 Oct;13(10):1858-1860. No abstract available.


Telomere dysfunction in alveolar epithelial cells causes lung remodeling and fibrosis.

Naikawadi RP, Disayabutr S, Mallavia B, Donne ML, Green G, La JL, Rock JR, Looney MR, Wolters PJ.

JCI Insight. 2016 Sep 8;1(14):e86704. doi: 10.1172/jci.insight.86704.


Reply to concerns regarding dropping the term "possible TRALI".

Toy P, Kleinman SH, Looney MR.

Transfusion. 2016 Sep;56(9):2394-5. doi: 10.1111/trf.13734. No abstract available.


Visualization of immediate immune responses to pioneer metastatic cells in the lung.

Headley MB, Bins A, Nip A, Roberts EW, Looney MR, Gerard A, Krummel MF.

Nature. 2016 Mar 24;531(7595):513-7. doi: 10.1038/nature16985. Epub 2016 Mar 16.


Inhibiting Integrin αvβ5 Reduces Ischemia-Reperfusion Injury in an Orthotopic Lung Transplant Model in Mice.

Mallavia B, Liu F, Sheppard D, Looney MR.

Am J Transplant. 2016 Apr;16(4):1306-11. doi: 10.1111/ajt.13605. Epub 2016 Jan 22.


Transfusion of Human Platelets Treated with Mirasol Pathogen Reduction Technology Does Not Induce Acute Lung Injury in Mice.

Caudrillier A, Mallavia B, Rouse L, Marschner S, Looney MR.

PLoS One. 2015 Jul 15;10(7):e0133022. doi: 10.1371/journal.pone.0133022. eCollection 2015.


Selectin' for NETs.

Looney MR.

Blood. 2015 Jul 9;126(2):129-30. doi: 10.1182/blood-2015-05-646729. No abstract available.


Two-event Transfusion-related Acute Lung Injury Mouse Model.

Ortiz-Muñoz G, Looney MR.

Bio Protoc. 2015 Jun 20;5(12). pii: e1505. doi: 10.21769/BioProtoc.1505.


Reply: neutrophil extracellular traps in primary graft dysfunction after lung transplantation.

Sayah DM, Mallavia B, Looney MR.

Am J Respir Crit Care Med. 2015 May 1;191(9):1089. doi: 10.1164/rccm.201501-0177LE. No abstract available.


Mast cells present protrusions into blood vessels upon tracheal allergen challenge in mice.

Bose O, Baluk P, Looney MR, Cheng LE, McDonald DM, Caughey GH, Krummel MF.

PLoS One. 2015 Mar 19;10(3):e0118513. doi: 10.1371/journal.pone.0118513. eCollection 2015.


Cytokines and clinical predictors in distinguishing pulmonary transfusion reactions.

Roubinian NH, Looney MR, Kor DJ, Lowell CA, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson GA, Matthay MA, Toy P, Murphy EL; TRALI Study Group.

Transfusion. 2015 Aug;55(8):1838-46. doi: 10.1111/trf.13021. Epub 2015 Feb 23.


Non-invasive Intratracheal Instillation in Mice.

Ortiz-Muñoz G, Looney MR.

Bio Protoc. 2015;5(12). pii: e1504. Epub 2015 Jun 20.


Lineage-negative progenitors mobilize to regenerate lung epithelium after major injury.

Vaughan AE, Brumwell AN, Xi Y, Gotts JE, Brownfield DG, Treutlein B, Tan K, Tan V, Liu FC, Looney MR, Matthay MA, Rock JR, Chapman HA.

Nature. 2015 Jan 29;517(7536):621-5. doi: 10.1038/nature14112. Epub 2014 Dec 24.


Recipient clinical risk factors predominate in possible transfusion-related acute lung injury.

Toy P, Bacchetti P, Grimes B, Gajic O, Murphy EL, Winters JL, Gropper MA, Hubmayr RD, Matthay MA, Wilson G, Koenigsberg M, Lee DC, Hirschler NV, Lowell CA, Schuller RM, Gandhi MJ, Norris PJ, Mair DC, Sanchez Rosen R, Looney MR.

Transfusion. 2015 May;55(5):947-52. doi: 10.1111/trf.12954. Epub 2014 Dec 8.


Neutrophil extracellular traps are pathogenic in primary graft dysfunction after lung transplantation.

Sayah DM, Mallavia B, Liu F, Ortiz-Muñoz G, Caudrillier A, DerHovanessian A, Ross DJ, Lynch JP 3rd, Saggar R, Ardehali A; Lung Transplant Outcomes Group Investigators, Ware LB, Christie JD, Belperio JA, Looney MR.

Am J Respir Crit Care Med. 2015 Feb 15;191(4):455-63. doi: 10.1164/rccm.201406-1086OC.


Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice.

Ortiz-Muñoz G, Mallavia B, Bins A, Headley M, Krummel MF, Looney MR.

Blood. 2014 Oct 23;124(17):2625-34. doi: 10.1182/blood-2014-03-562876. Epub 2014 Aug 20.


Mast cells in a murine lung ischemia-reperfusion model of primary graft dysfunction.

Greenland JR, Xu X, Sayah DM, Liu FC, Jones KD, Looney MR, Caughey GH.

Respir Res. 2014 Aug 13;15:95. doi: 10.1186/s12931-014-0095-0.


The spatiotemporal cellular dynamics of lung immunity.

Lelkes E, Headley MB, Thornton EE, Looney MR, Krummel MF.

Trends Immunol. 2014 Aug;35(8):379-86. doi: 10.1016/ Epub 2014 Jun 26. Review.


Prospective study on the clinical course and outcomes in transfusion-related acute lung injury*.

Looney MR, Roubinian N, Gajic O, Gropper MA, Hubmayr RD, Lowell CA, Bacchetti P, Wilson G, Koenigsberg M, Lee DC, Wu P, Grimes B, Norris PJ, Murphy EL, Gandhi MJ, Winters JL, Mair DC, Schuller RM, Hirschler NV, Rosen RS, Matthay MA, Toy P; Transfusion-Related Acute Lung Injury Study Group.

Crit Care Med. 2014 Jul;42(7):1676-87. doi: 10.1097/CCM.0000000000000323.


Live imaging of the lung.

Looney MR, Bhattacharya J.

Annu Rev Physiol. 2014;76:431-45. doi: 10.1146/annurev-physiol-021113-170331. Epub 2013 Nov 13. Review.


Risk factors and outcomes in transfusion-associated circulatory overload.

Murphy EL, Kwaan N, Looney MR, Gajic O, Hubmayr RD, Gropper MA, Koenigsberg M, Wilson G, Matthay M, Bacchetti P, Toy P; TRALI Study Group.

Am J Med. 2013 Apr;126(4):357.e29-38. doi: 10.1016/j.amjmed.2012.08.019. Epub 2013 Jan 26.


Transfusion reactions: newer concepts on the pathophysiology, incidence, treatment, and prevention of transfusion-related acute lung injury.

Sayah DM, Looney MR, Toy P.

Crit Care Clin. 2012 Jul;28(3):363-72, v. doi: 10.1016/j.ccc.2012.04.001. Review.


Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury.

Caudrillier A, Kessenbrock K, Gilliss BM, Nguyen JX, Marques MB, Monestier M, Toy P, Werb Z, Looney MR.

J Clin Invest. 2012 Jul;122(7):2661-71. doi: 10.1172/JCI61303. Epub 2012 Jun 11.


Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung.

Thornton EE, Looney MR, Bose O, Sen D, Sheppard D, Locksley R, Huang X, Krummel MF.

J Exp Med. 2012 Jun 4;209(6):1183-99. doi: 10.1084/jem.20112667. Epub 2012 May 14.

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