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Items: 1 to 50 of 276

1.

NR5A1 gene variants repress the ovarian-specific WNT signalling pathway in 46,XX Disorders of sex development patients.

Knarston IM, Robevska G, van den Bergen JA, Eggers S, Croft B, Yates J, Hersmus R, Looijenga LHJ, Cameron FJ, Monhike K, Ayers KL, Sinclair AH.

Hum Mutat. 2018 Oct 23. doi: 10.1002/humu.23672. [Epub ahead of print]

PMID:
30350900
2.

Management of Gonads in Adults with Androgen Insensitivity: An International Survey.

Tack LJW, Maris E, Looijenga LHJ, Hannema SE, Audi L, Köhler B, Holterhus PM, Riedl S, Wisniewski A, Flück CE, Davies JH, T Apos Sjoen G, Lucas-Herald AK, Evliyaoglu O, Krone N, Iotova V, Marginean O, Balsamo A, Verkauskas G, Weintrob N, Ellaithi M, Nordenström A, Verrijn Stuart A, Kluivers KB, Wolffenbuttel KP, Ahmed SF, Cools M.

Horm Res Paediatr. 2018 Oct 18:1-11. doi: 10.1159/000493645. [Epub ahead of print]

PMID:
30336477
3.

Testicular cancer.

Cheng L, Albers P, Berney DM, Feldman DR, Daugaard G, Gilligan T, Looijenga LHJ.

Nat Rev Dis Primers. 2018 Oct 5;4(1):29. doi: 10.1038/s41572-018-0029-0. Review.

PMID:
30291251
4.

c-MET receptor as potential biomarker and target molecule for malignant testicular germ cell tumors.

Scheri KC, Leonetti E, Laino L, Gigantino V, Gesualdi L, Grammatico P, Bizzari M, Franco R, Oosterhuis JW, Stoop H, Looijenga LHJ, Ricci G, Catizone A.

Oncotarget. 2018 Aug 7;9(61):31842-31860. doi: 10.18632/oncotarget.25867. eCollection 2018 Aug 7.

5.

Improved Progression Prediction in Barrett's Esophagus With Low-grade Dysplasia Using Specific Histologic Criteria.

Ten Kate FJC, Nieboer D, Ten Kate FJW, Doukas M, Bruno MJ, Spaander MCW, Looijenga LHJ, Biermann K; ProBar study group and Palga Group.

Am J Surg Pathol. 2018 Jul;42(7):918-926. doi: 10.1097/PAS.0000000000001066.

PMID:
29697438
6.

Serum microRNA profiles in athyroid patients on and off levothyroxine therapy.

Massolt ET, Chaker L, Visser TJ, Gillis AJM, Dorssers LCJ, Beukhof CM, Kam BLR, Franssen GJ, Brigante G, van Ginhoven TM, Visser WE, Looijenga LHJ, Peeters RP.

PLoS One. 2018 Apr 12;13(4):e0194259. doi: 10.1371/journal.pone.0194259. eCollection 2018.

7.

EGF Receptor and mTORC1 Are Novel Therapeutic Targets in Nonseminomatous Germ Cell Tumors.

Chen KS, Fustino NJ, Shukla AA, Stroup EK, Budhipramono A, Ateek C, Stuart SH, Yamaguchi K, Kapur P, Frazier AL, Lum L, Looijenga LHJ, Laetsch TW, Rakheja D, Amatruda JF.

Mol Cancer Ther. 2018 May;17(5):1079-1089. doi: 10.1158/1535-7163.MCT-17-0137. Epub 2018 Feb 26.

PMID:
29483210
8.

Serum miRNA Predicts Viable Disease after Chemotherapy in Patients with Testicular Nonseminoma Germ Cell Tumor.

Leão R, van Agthoven T, Figueiredo A, Jewett MAS, Fadaak K, Sweet J, Ahmad AE, Anson-Cartwright L, Chung P, Hansen A, Warde P, Castelo-Branco P, O'Malley M, Bedard PL, Looijenga LHJ, Hamilton RJ.

J Urol. 2018 Jul;200(1):126-135. doi: 10.1016/j.juro.2018.02.068. Epub 2018 Feb 21.

PMID:
29474847
9.

SNPitty: An Intuitive Web Application for Interactive B-Allele Frequency and Copy Number Visualization of Next-Generation Sequencing Data.

van Riet J, Krol NMG, Atmodimedjo PN, Brosens E, van IJcken WFJ, Jansen MPHM, Martens JWM, Looijenga LH, Jenster G, Dubbink HJ, Dinjens WNM, van de Werken HJG.

J Mol Diagn. 2018 Mar;20(2):166-176. doi: 10.1016/j.jmoldx.2017.11.011. Epub 2018 Jan 2.

PMID:
29305224
10.

Pattern of p53 protein expression is predictive for survival in chemoradiotherapy-naive esophageal adenocarcinoma.

Ten Kate FJC, Suzuki L, Dorssers LCJ, Dinjens WNM, Jones DTW, Nieboer D, Doukas M, Van Lanschot JJB, Wijnhoven BPL, Looijenga LHJ, Biermann K.

Oncotarget. 2017 Oct 24;8(61):104123-104135. doi: 10.18632/oncotarget.22021. eCollection 2017 Nov 28.

11.

Biallelic and monoallelic ESR2 variants associated with 46,XY disorders of sex development.

Baetens D, Güran T, Mendonca BB, Gomes NL, De Cauwer L, Peelman F, Verdin H, Vuylsteke M, Van der Linden M; ESR2 STUDY GROUP, Atay Z, Bereket A, de Krijger RR, Preter K, Domenice S, Turan S, Stoop H, Looijenga LH, De Bosscher K, Cools M, De Baere E.

Genet Med. 2018 Jul;20(7):717-727. doi: 10.1038/gim.2017.163. Epub 2017 Oct 26.

PMID:
29261182
12.

A Rare Case of Embryonal Carcinoma in a Patient with Turner Syndrome without Y Chromosomal Material but Mutations in KIT, AKT1, and ZNF358 Demonstrated Using Exome Sequencing.

Gravholt CH, Dollerup OL, Duval L, Mejlgaard E, Stribolt K, Vang S, Laursen BE, Knudsen M, Thorsen K, Hersmus R, Looijenga LHJ, Stochholm K.

Sex Dev. 2017;11(5-6):262-268. doi: 10.1159/000484398. Epub 2017 Dec 2.

PMID:
29197878
13.

Histological Assessment of Gonads in DSD: Relevance for Clinical Management.

Spoor JA, Oosterhuis JW, Hersmus R, Biermann K, Wolffenbuttel KP, Cools M, Kazmi Z, Ahmed SF, Looijenga LHJ.

Sex Dev. 2018;12(1-3):106-122. doi: 10.1159/000481757. Epub 2017 Nov 3.

PMID:
29131109
14.

Malignant testicular germ cell tumors in postpubertal individuals with androgen insensitivity: prevalence, pathology and relevance of single nucleotide polymorphism-based susceptibility profiling.

Cools M, Wolffenbuttel KP, Hersmus R, Mendonca BB, Kaprová J, Drop SLS, Stoop H, Gillis AJM, Oosterhuis JW, Costa EMF, Domenice S, Nishi MY, Wunsch L, Quigley CA, T'Sjoen G, Looijenga LHJ.

Hum Reprod. 2017 Dec 1;32(12):2561-2573. doi: 10.1093/humrep/dex300.

PMID:
29121256
15.

Use of immunohistochemical biomarkers as independent predictor of neoplastic progression in Barrett's oesophagus surveillance: A systematic review and meta-analysis.

Janmaat VT, van Olphen SH, Biermann KE, Looijenga LHJ, Bruno MB, Spaander MCW.

PLoS One. 2017 Oct 23;12(10):e0186305. doi: 10.1371/journal.pone.0186305. eCollection 2017. Review.

16.

Multiparameter Investigation of a 46,XX/46,XY Tetragametic Chimeric Phenotypical Male Patient with Bilateral Scrotal Ovotestes and Ovulatory Activity.

van Bever Y, Wolffenbuttel KP, Brüggenwirth HT, Blom E, de Klein A, Eussen BHJ, van der Windt F, Hannema SE, Dessens AB, Dorssers LCJ, Biermann K, Hersmus R, de Rijke YB, Looijenga LHJ.

Sex Dev. 2018;12(1-3):145-154. doi: 10.1159/000479946. Epub 2017 Sep 20.

17.

Adrenal Cushing's syndrome during pregnancy.

Andreescu CE, Alwani RA, Hofland J, Looijenga LHJ, de Herder WW, Hofland LJ, Feelders RA.

Eur J Endocrinol. 2017 Nov;177(5):K13-K20. doi: 10.1530/EJE-17-0263. Epub 2017 Aug 17.

PMID:
28819015
18.

VASA mRNA (DDX4) detection is more specific than immunohistochemistry using poly- or monoclonal antibodies for germ cells in the male urogenital tract.

Boellaard WPA, Stoop H, Gillis AJM, Oosterhuis JW, Looijenga LHJ.

Medicine (Baltimore). 2017 Jul;96(30):e7489. doi: 10.1097/MD.0000000000007489.

19.

Loss of SRY-box2 (SOX2) expression and its impact on survival of patients with oesophageal adenocarcinoma.

Ten Kate FJC, van Olphen SH, Bruno MJ, Wijnhoven BPL, van Lanschot JJB, Looijenga LHJ, Fitzgerald RC, Biermann K.

Br J Surg. 2017 Sep;104(10):1327-1337. doi: 10.1002/bjs.10553. Epub 2017 Jul 10.

20.

DOC1-Dependent Recruitment of NURD Reveals Antagonism with SWI/SNF during Epithelial-Mesenchymal Transition in Oral Cancer Cells.

Mohd-Sarip A, Teeuwssen M, Bot AG, De Herdt MJ, Willems SM, Baatenburg de Jong RJ, Looijenga LHJ, Zatreanu D, Bezstarosti K, van Riet J, Oole E, van Ijcken WFJ, van de Werken HJG, Demmers JA, Fodde R, Verrijzer CP.

Cell Rep. 2017 Jul 5;20(1):61-75. doi: 10.1016/j.celrep.2017.06.020.

21.

microRNA-371a-3p as informative biomarker for the follow-up of testicular germ cell cancer patients.

van Agthoven T, Eijkenboom WMH, Looijenga LHJ.

Cell Oncol (Dordr). 2017 Aug;40(4):379-388. doi: 10.1007/s13402-017-0333-9. Epub 2017 Jun 13.

22.

Whole-genome sequencing of spermatocytic tumors provides insights into the mutational processes operating in the male germline.

Giannoulatou E, Maher GJ, Ding Z, Gillis AJM, Dorssers LCJ, Hoischen A, Rajpert-De Meyts E; WGS500 Consortium, McVean G, Wilkie AOM, Looijenga LHJ, Goriely A.

PLoS One. 2017 May 22;12(5):e0178169. doi: 10.1371/journal.pone.0178169. eCollection 2017.

23.

A MicroRNA Panel in Pancreatic Cyst Fluid for the Risk Stratification of Pancreatic Cysts in a Prospective Cohort.

Utomo WK, Looijenga LH, Bruno MJ, Hansen BE, Gillis A, Biermann K, Peppelenbosch MP, Fuhler GM, Braat H.

Mol Ther Nucleic Acids. 2016;5:e350. doi: 10.1038/mtna.2016.61.

24.

P53 and SOX2 Protein Expression Predicts Esophageal Adenocarcinoma in Response to Neoadjuvant Chemoradiotherapy.

van Olphen SH, Biermann K, Shapiro J, Wijnhoven BP, Toxopeus EL, van der Gaast A, Stoop HA, van Lanschot JJ, Spaander MC, Bruno MJ, Looijenga LH.

Ann Surg. 2017 Feb;265(2):347-355. doi: 10.1097/SLA.0000000000001625.

PMID:
28059963
25.

Value of cyclin A immunohistochemistry for cancer risk stratification in Barrett esophagus surveillance: A multicenter case-control study.

van Olphen SH, Ten Kate FJ, Doukas M, Kastelein F, Steyerberg EW, Stoop HA, Spaander MC, Looijenga LH, Bruno MJ, Biermann K; ProBar-Study Group.

Medicine (Baltimore). 2016 Nov;95(47):e5402.

26.

Imprints and DPPA3 are bypassed during pluripotency- and differentiation-coupled methylation reprogramming in testicular germ cell tumors.

Killian JK, Dorssers LC, Trabert B, Gillis AJ, Cook MB, Wang Y, Waterfall JJ, Stevenson H, Smith WI Jr, Noyes N, Retnakumar P, Stoop JH, Oosterhuis JW, Meltzer PS, McGlynn KA, Looijenga LH.

Genome Res. 2016 Nov;26(11):1490-1504. Epub 2016 Oct 20.

27.

Gonadal dysgenesis in disorders of sex development: Diagnosis and surgical management.

Wolffenbuttel KP, Hersmus R, Stoop H, Biermann K, Hoebeke P, Cools M, Looijenga LH.

J Pediatr Urol. 2016 Dec;12(6):411-416. doi: 10.1016/j.jpurol.2016.08.015. Epub 2016 Oct 8. Review.

PMID:
27769830
28.

The biology of germ cell tumors in disorders of sex development.

Hersmus R, van Bever Y, Wolffenbuttel KP, Biermann K, Cools M, Looijenga LH.

Clin Genet. 2017 Feb;91(2):292-301. doi: 10.1111/cge.12882. Epub 2016 Nov 24. Review.

PMID:
27716895
29.

NR5A1 is a novel disease gene for 46,XX testicular and ovotesticular disorders of sex development.

Baetens D, Stoop H, Peelman F, Todeschini AL, Rosseel T, Coppieters F, Veitia RA, Looijenga LH, De Baere E, Cools M.

Genet Med. 2017 Apr;19(4):367-376. doi: 10.1038/gim.2016.118. Epub 2016 Aug 4.

30.

Accurate primary germ cell cancer diagnosis using serum based microRNA detection (ampTSmiR test).

van Agthoven T, Looijenga LHJ.

Oncotarget. 2016 Jul 27;8(35):58037-58049. doi: 10.18632/oncotarget.10867. eCollection 2017 Aug 29.

31.

MET expression during prostate cancer progression.

Verhoef EI, Kolijn K, De Herdt MJ, van der Steen B, Hoogland AM, Sleddens HF, Looijenga LH, van Leenders GJ.

Oncotarget. 2016 May 24;7(21):31029-36. doi: 10.18632/oncotarget.8829.

32.

Hormonal evaluation in relation to phenotype and genotype in 286 patients with a disorder of sex development from Indonesia.

Juniarto AZ, van der Zwan YG, Santosa A, Ariani MD, Eggers S, Hersmus R, Themmen AP, Bruggenwirth HT, Wolffenbuttel KP, Sinclair A, White SJ, Looijenga LH, de Jong FH, Faradz SM, Drop SL.

Clin Endocrinol (Oxf). 2016 Aug;85(2):247-57. doi: 10.1111/cen.13051. Epub 2016 Apr 4.

PMID:
26935236
33.

Germ cell neoplasia in situ (GCNIS): evolution of the current nomenclature for testicular pre-invasive germ cell malignancy.

Berney DM, Looijenga LH, Idrees M, Oosterhuis JW, Rajpert-De Meyts E, Ulbright TM, Skakkebaek NE.

Histopathology. 2016 Jul;69(1):7-10. doi: 10.1111/his.12958. Epub 2016 Apr 12. Review.

PMID:
26918959
34.

Absent and abundant MET immunoreactivity is associated with poor prognosis of patients with oral and oropharyngeal squamous cell carcinoma.

De Herdt MJ, Willems SM, van der Steen B, Noorlag R, Verhoef EI, van Leenders GJ, van Es RJ, KoljenoviÄ S, Baatenburg de Jong RJ, Looijenga LH.

Oncotarget. 2016 Mar 15;7(11):13167-81. doi: 10.18632/oncotarget.7534.

35.

Global Disorders of Sex Development Update since 2006: Perceptions, Approach and Care.

Lee PA, Nordenström A, Houk CP, Ahmed SF, Auchus R, Baratz A, Baratz Dalke K, Liao LM, Lin-Su K, Looijenga LH 3rd, Mazur T, Meyer-Bahlburg HF, Mouriquand P, Quigley CA, Sandberg DE, Vilain E, Witchel S; Global DSD Update Consortium.

Horm Res Paediatr. 2016;85(3):158-80. doi: 10.1159/000442975. Epub 2016 Jan 28. Review. Erratum in: Horm Res Paediatr. 2016;85(3):180. Koopman, Peter [added].

36.

A pipeline to quantify serum and cerebrospinal fluid microRNAs for diagnosis and detection of relapse in paediatric malignant germ-cell tumours.

Murray MJ, Bell E, Raby KL, Rijlaarsdam MA, Gillis AJ, Looijenga LH, Brown H, Destenaves B, Nicholson JC, Coleman N.

Br J Cancer. 2016 Jan 19;114(2):151-62. doi: 10.1038/bjc.2015.429. Epub 2015 Dec 15.

37.

Cripto: Expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors.

Spiller CM, Gillis AJ, Burnet G, Stoop H, Koopman P, Bowles J, Looijenga LH.

Mol Oncol. 2016 Apr;10(4):526-37. doi: 10.1016/j.molonc.2015.11.003. Epub 2015 Nov 18.

38.

SOX2 as a novel marker to predict neoplastic progression in Barrett's esophagus.

van Olphen S, Biermann K, Spaander MC, Kastelein F, Steyerberg EW, Stoop HA, Bruno MJ, Looijenga LH.

Am J Gastroenterol. 2015 Oct;110(10):1420-8. doi: 10.1038/ajg.2015.260. Epub 2015 Sep 1.

PMID:
26323187
39.

Breast Cancer Anti-Estrogen Resistance 4 (BCAR4) Drives Proliferation of IPH-926 lobular Carcinoma Cells.

van Agthoven T, Dorssers LC, Lehmann U, Kreipe H, Looijenga LH, Christgen M.

PLoS One. 2015 Aug 28;10(8):e0136845. doi: 10.1371/journal.pone.0136845. eCollection 2015.

40.

Widespread somatic L1 retrotransposition occurs early during gastrointestinal cancer evolution.

Ewing AD, Gacita A, Wood LD, Ma F, Xing D, Kim MS, Manda SS, Abril G, Pereira G, Makohon-Moore A, Looijenga LH, Gillis AJ, Hruban RH, Anders RA, Romans KE, Pandey A, Iacobuzio-Donahue CA, Vogelstein B, Kinzler KW, Kazazian HH Jr, Solyom S.

Genome Res. 2015 Oct;25(10):1536-45. doi: 10.1101/gr.196238.115. Epub 2015 Aug 10.

41.

Genome wide DNA methylation profiles provide clues to the origin and pathogenesis of germ cell tumors.

Rijlaarsdam MA, Tax DM, Gillis AJ, Dorssers LC, Koestler DC, de Ridder J, Looijenga LH.

PLoS One. 2015 Apr 10;10(4):e0122146. doi: 10.1371/journal.pone.0122146. eCollection 2015. Erratum in: PLoS One. 2015;10(7):e0132981.

42.

Etiology and early pathogenesis of malignant testicular germ cell tumors: towards possibilities for preinvasive diagnosis.

Elzinga-Tinke JE, Dohle GR, Looijenga LH.

Asian J Androl. 2015 May-Jun;17(3):381-93. doi: 10.4103/1008-682X.148079. Review.

43.

Pediatric germ cell tumors presenting beyond childhood?

Oosterhuis JW, Stoop JA, Rijlaarsdam MA, Biermann K, Smit VT, Hersmus R, Looijenga LH.

Andrology. 2015 Jan;3(1):70-7. doi: 10.1111/andr.305. Epub 2014 Nov 27.

44.

Identification of known and novel germ cell cancer-specific (embryonic) miRs in serum by high-throughput profiling.

Rijlaarsdam MA, van Agthoven T, Gillis AJ, Patel S, Hayashibara K, Lee KY, Looijenga LH.

Andrology. 2015 Jan;3(1):85-91. doi: 10.1111/andr.298. Epub 2014 Nov 7.

45.

Managing the risk of germ cell tumourigenesis in disorders of sex development patients.

Cools M, Looijenga LH, Wolffenbuttel KP, T'Sjoen G.

Endocr Dev. 2014;27:185-96. doi: 10.1159/000363642. Epub 2014 Sep 9. Review.

PMID:
25247655
46.

Advances in molecular markers of germ cell cancer in patients with disorders of sex development.

van der Zwan YG, Cools M, Looijenga LH.

Endocr Dev. 2014;27:172-84. doi: 10.1159/000363641. Epub 2014 Sep 9. Review.

PMID:
25247654
47.

Gonadal maldevelopment as risk factor for germ cell cancer: towards a clinical decision model.

van der Zwan YG, Biermann K, Wolffenbuttel KP, Cools M, Looijenga LH.

Eur Urol. 2015 Apr;67(4):692-701. doi: 10.1016/j.eururo.2014.07.011. Epub 2014 Sep 18. Review.

PMID:
25240975
48.

Testes in infants with Prader-Willi syndrome: human chorionic gonadotropin treatment, surgery and histology.

Bakker NE, Wolffenbuttel KP, Looijenga LH, Hokken-Koelega AC.

J Urol. 2015 Jan;193(1):291-8. doi: 10.1016/j.juro.2014.07.113. Epub 2014 Aug 7.

PMID:
25109686
49.

Aberrant SOX2 expression in colorectal cancers does not correlate with mucinous differentiation and gastric mucin MUC5AC expression.

Raghoebir L, Biermann K, Kempen MB, Dubbink HJ, Dinjens WN, Hersmus R, Looijenga LH, Bruno MJ, Tibboel D, Rottier RJ, Smits R.

Virchows Arch. 2014 Oct;465(4):395-400. doi: 10.1007/s00428-014-1638-y. Epub 2014 Aug 10.

PMID:
25108707
50.

Whole exome sequencing combined with linkage analysis identifies a novel 3 bp deletion in NR5A1.

Eggers S, Smith KR, Bahlo M, Looijenga LH, Drop SL, Juniarto ZA, Harley VR, Koopman P, Faradz SM, Sinclair AH.

Eur J Hum Genet. 2015 Apr;23(4):486-93. doi: 10.1038/ejhg.2014.130. Epub 2014 Aug 6.

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