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Items: 1 to 50 of 101

1.

Physiology of renal glucose handling via SGLT1, SGLT2 and GLUT2.

Ghezzi C, Loo DDF, Wright EM.

Diabetologia. 2018 Oct;61(10):2087-2097. doi: 10.1007/s00125-018-4656-5. Epub 2018 Aug 22. Review.

2.

Active site voltage clamp fluorometry of the sodium glucose cotransporter hSGLT1.

Gorraitz E, Hirayama BA, Paz A, Wright EM, Loo DDF.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9980-E9988. doi: 10.1073/pnas.1713899114. Epub 2017 Oct 30.

3.

Novel and Unexpected Functions of SGLTs.

Wright EM, Ghezzi C, Loo DDF.

Physiology (Bethesda). 2017 Nov;32(6):435-443. doi: 10.1152/physiol.00021.2017. Review.

4.

Structural and functional significance of water permeation through cotransporters.

Zeuthen T, Gorraitz E, Her K, Wright EM, Loo DD.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):E6887-E6894. Epub 2016 Oct 18.

5.

Stochastic steps in secondary active sugar transport.

Adelman JL, Ghezzi C, Bisignano P, Loo DD, Choe S, Abramson J, Rosenberg JM, Wright EM, Grabe M.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3960-6. doi: 10.1073/pnas.1525378113. Epub 2016 Jun 20.

6.

Functional characterization of the human facilitative glucose transporter 12 (GLUT12) by electrophysiological methods.

Pujol-Giménez J, Pérez A, Reyes AM, Loo DD, Lostao MP.

Am J Physiol Cell Physiol. 2015 Jun 15;308(12):C1008-22. doi: 10.1152/ajpcell.00343.2014. Epub 2015 Apr 8.

7.

SGLT2 inhibitors act from the extracellular surface of the cell membrane.

Ghezzi C, Hirayama BA, Gorraitz E, Loo DD, Liang Y, Wright EM.

Physiol Rep. 2014 Jun 27;2(6). pii: e12058. doi: 10.14814/phy2.12058. Print 2014 Jun 1.

8.

Fingerprints of hSGLT5 sugar and cation selectivity.

Ghezzi C, Gorraitz E, Hirayama BA, Loo DD, Grempler R, Mayoux E, Wright EM.

Am J Physiol Cell Physiol. 2014 May 1;306(9):C864-70. doi: 10.1152/ajpcell.00027.2014. Epub 2014 Feb 26.

9.

Functional identification and characterization of sodium binding sites in Na symporters.

Loo DD, Jiang X, Gorraitz E, Hirayama BA, Wright EM.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4557-66. doi: 10.1073/pnas.1319218110. Epub 2013 Nov 4.

10.

The importance of being aromatic: π interactions in sodium symporters.

Jiang X, Loo DD, Hirayama BA, Wright EM.

Biochemistry. 2012 Nov 27;51(47):9480-7. doi: 10.1021/bi301329w. Epub 2012 Nov 12.

11.

Bridging the gap between structure and kinetics of human SGLT1.

Sala-Rabanal M, Hirayama BA, Loo DD, Chaptal V, Abramson J, Wright EM.

Am J Physiol Cell Physiol. 2012 May 1;302(9):C1293-305. doi: 10.1152/ajpcell.00397.2011. Epub 2011 Dec 7.

12.

Structural selectivity of human SGLT inhibitors.

Hummel CS, Lu C, Liu J, Ghezzi C, Hirayama BA, Loo DD, Kepe V, Barrio JR, Wright EM.

Am J Physiol Cell Physiol. 2012 Jan 15;302(2):C373-82. doi: 10.1152/ajpcell.00328.2011. Epub 2011 Sep 21.

13.

Biology of human sodium glucose transporters.

Wright EM, Loo DD, Hirayama BA.

Physiol Rev. 2011 Apr;91(2):733-94. doi: 10.1152/physrev.00055.2009. Review.

14.

Glucose transport by human renal Na+/D-glucose cotransporters SGLT1 and SGLT2.

Hummel CS, Lu C, Loo DD, Hirayama BA, Voss AA, Wright EM.

Am J Physiol Cell Physiol. 2011 Jan;300(1):C14-21. doi: 10.1152/ajpcell.00388.2010. Epub 2010 Oct 27. Erratum in: Am J Physiol Cell Physiol. 2011 Mar;300(3):C721.

15.

Elucidating conformational changes in the gamma-aminobutyric acid transporter-1.

Meinild AK, Loo DD, Skovstrup S, Gether U, MacAulay N.

J Biol Chem. 2009 Jun 12;284(24):16226-35. doi: 10.1074/jbc.M109.003137. Epub 2009 Apr 10.

16.

How drugs interact with transporters: SGLT1 as a model.

Loo DD, Hirayama BA, Sala-Rabanal M, Wright EM.

J Membr Biol. 2008 May;223(2):87-106. doi: 10.1007/s00232-008-9116-6. Epub 2008 Jul 1.

PMID:
18592293
17.

Molecular mechanism of dipeptide and drug transport by the human renal H+/oligopeptide cotransporter hPEPT2.

Sala-Rabanal M, Loo DD, Hirayama BA, Wright EM.

Am J Physiol Renal Physiol. 2008 Jun;294(6):F1422-32. doi: 10.1152/ajprenal.00030.2008. Epub 2008 Mar 26.

18.

Sodium-dependent reorganization of the sugar-binding site of SGLT1.

Hirayama BA, Loo DD, Díez-Sampedro A, Leung DW, Meinild AK, Lai-Bing M, Turk E, Wright EM.

Biochemistry. 2007 Nov 20;46(46):13391-406. Epub 2007 Oct 26.

PMID:
17960916
19.

Conformational dynamics of hSGLT1 during Na+/glucose cotransport.

Loo DD, Hirayama BA, Karakossian MH, Meinild AK, Wright EM.

J Gen Physiol. 2006 Dec;128(6):701-20.

20.

Imino sugars are potent agonists of the human glucose sensor SGLT3.

Voss AA, Díez-Sampedro A, Hirayama BA, Loo DD, Wright EM.

Mol Pharmacol. 2007 Feb;71(2):628-34. Epub 2006 Nov 16.

PMID:
17110502
21.

Molecular interactions between dipeptides, drugs and the human intestinal H+ -oligopeptide cotransporter hPEPT1.

Sala-Rabanal M, Loo DD, Hirayama BA, Turk E, Wright EM.

J Physiol. 2006 Jul 1;574(Pt 1):149-66. Epub 2006 Apr 20.

22.

Kinetics of the reverse mode of the Na+/glucose cotransporter.

Eskandari S, Wright EM, Loo DD.

J Membr Biol. 2005 Mar;204(1):23-32.

23.

Novel properties of a mouse gamma-aminobutyric acid transporter (GAT4).

Karakossian MH, Spencer SR, Gomez AQ, Padilla OR, Sacher A, Loo DD, Nelson N, Eskandari S.

J Membr Biol. 2005 Jan;203(2):65-82.

24.

Perturbation analysis of the voltage-sensitive conformational changes of the Na+/glucose cotransporter.

Loo DD, Hirayama BA, Cha A, Bezanilla F, Wright EM.

J Gen Physiol. 2005 Jan;125(1):13-36. Epub 2004 Dec 13. Erratum in: J Gen Physiol. 2005 Mar;125(3):345.

25.

Surprising versatility of Na+-glucose cotransporters: SLC5.

Wright EM, Loo DD, Hirayama BA, Turk E.

Physiology (Bethesda). 2004 Dec;19:370-6. Review.

26.

Coupled sodium/glucose cotransport by SGLT1 requires a negative charge at position 454.

Díez-Sampedro A, Loo DD, Wright EM, Zampighi GA, Hirayama BA.

Biochemistry. 2004 Oct 19;43(41):13175-84.

PMID:
15476411
27.

Electrophysiological properties of the mouse Na+/Cl(-)-dependent taurine transporter (mTauT-1): steady-state kinetics: stoichiometry of taurine transport.

Sarkar HK, Wright EM, Boorer KJ, Loo DD.

Adv Exp Med Biol. 2003;526:197-204. No abstract available.

PMID:
12908601
28.

The anticonvulsant valproate increases the turnover rate of gamma-aminobutyric acid transporters.

Whitlow RD, Sacher A, Loo DD, Nelson N, Eskandari S.

J Biol Chem. 2003 May 16;278(20):17716-26. Epub 2003 Feb 20.

29.

Presteady-state and steady-state kinetics and turnover rate of the mouse gamma-aminobutyric acid transporter (mGAT3).

Sacher A, Nelson N, Ogi JT, Wright EM, Loo DD, Eskandari S.

J Membr Biol. 2002 Nov 1;190(1):57-73.

PMID:
12422272
30.

Low and high affinity amino acid H+-cotransporters for cellular import of neutral and charged amino acids.

Fischer WN, Loo DD, Koch W, Ludewig U, Boorer KJ, Tegeder M, Rentsch D, Wright EM, Frommer WB.

Plant J. 2002 Mar;29(6):717-31.

31.

Characterization of cyclic AMP-regulated chloride conductance in the pigmented rabbit conjunctival epithelial cells.

Shiue MH, Gukasyan HJ, Kim KJ, Loo DD, Lee VH.

Can J Physiol Pharmacol. 2002 Jun;80(6):533-40.

PMID:
12117302
32.

Water pumps.

Loo DD, Wright EM, Zeuthen T.

J Physiol. 2002 Jul 1;542(Pt 1):53-60. Review.

33.

Inhibition of gap junction hemichannels by chloride channel blockers.

Eskandari S, Zampighi GA, Leung DW, Wright EM, Loo DD.

J Membr Biol. 2002 Jan 15;185(2):93-102. Epub 2002 Feb 5.

PMID:
11891568
34.

Fluorescence studies of ligand-induced conformational changes of the Na(+)/glucose cotransporter.

Meinild AK, Hirayama BA, Wright EM, Loo DD.

Biochemistry. 2002 Jan 29;41(4):1250-8.

PMID:
11802724
35.

Evidence for the involvement of Ala 166 in coupling Na(+) to sugar transport through the human Na(+)/glucose cotransporter.

Meinild AK, Loo DD, Hirayama BA, Gallardo E, Wright EM.

Biochemistry. 2001 Oct 2;40(39):11897-904.

PMID:
11570890
36.

Commentary on "Epithelial Fluid Transport--A Century of Investigation"

Loo DD, Wright EM, Meinild AK, Klaerke DA, Zeuthen T.

News Physiol Sci. 1999 Jun;14:98-100. No abstract available.

PMID:
11390830
37.

Isotonic transport by the Na+-glucose cotransporter SGLT1 from humans and rabbit.

Zeuthen T, Meinild AK, Loo DD, Wright EM, Klaerke DA.

J Physiol. 2001 Mar 15;531(Pt 3):631-44.

38.

Coupling between Na+, sugar, and water transport across the intestine.

Wright EM, Loo DD.

Ann N Y Acad Sci. 2000;915:54-66. Review.

PMID:
11193601
39.

Urea transport by cotransporters.

Leung DW, Loo DD, Hirayama BA, Zeuthen T, Wright EM.

J Physiol. 2000 Oct 15;528 Pt 2:251-7.

40.
41.

Role of Cl- in electrogenic Na+-coupled cotransporters GAT1 and SGLT1.

Loo DD, Eskandari S, Boorer KJ, Sarkar HK, Wright EM.

J Biol Chem. 2000 Dec 1;275(48):37414-22.

42.

Electrophysiological analysis of the substrate selectivity of a sodium-coupled nucleoside transporter (rCNT1) expressed in Xenopus laevis oocytes.

Dresser MJ, Gerstin KM, Gray AT, Loo DD, Giacomini KM.

Drug Metab Dispos. 2000 Sep;28(9):1135-40.

PMID:
10950861
43.

Water transport by the renal Na(+)-dicarboxylate cotransporter.

Meinild AK, Loo DD, Pajor AM, Zeuthen T, Wright EM.

Am J Physiol Renal Physiol. 2000 May;278(5):F777-83.

44.

Passive water and ion transport by cotransporters.

Loo DD, Hirayama BA, Meinild AK, Chandy G, Zeuthen T, Wright EM.

J Physiol. 1999 Jul 1;518(Pt 1):195-202.

45.

Stoichiometry and Na+ binding cooperativity of rat and flounder renal type II Na+-Pi cotransporters.

Forster IC, Loo DD, Eskandari S.

Am J Physiol. 1999 Apr;276(4):F644-9. doi: 10.1152/ajprenal.1999.276.4.F644.

PMID:
10198426
46.

Functional and morphological correlates of connexin50 expressed in Xenopus laevis oocytes.

Zampighi GA, Loo DD, Kreman M, Eskandari S, Wright EM.

J Gen Physiol. 1999 Apr;113(4):507-24.

47.

Structure and function of the Na+/glucose cotransporter.

Wright EM, Loo DD, Panayotova-Heiermann M, Hirayama BA, Turk E, Eskandari S, Lam JT.

Acta Physiol Scand Suppl. 1998 Aug;643:257-64. Review.

PMID:
9789568
48.

Neutralization of conservative charged transmembrane residues in the Na+/glucose cotransporter SGLT1.

Panayotova-Heiermann M, Loo DD, Lam JT, Wright EM.

Biochemistry. 1998 Jul 21;37(29):10522-8.

PMID:
9671524
49.

Sodium and lithium interactions with the Na+/Dicarboxylate cotransporter.

Pajor AM, Hirayama BA, Loo DD.

J Biol Chem. 1998 Jul 24;273(30):18923-9.

50.

Conformational changes couple Na+ and glucose transport.

Loo DD, Hirayama BA, Gallardo EM, Lam JT, Turk E, Wright EM.

Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7789-94.

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