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Items: 1 to 50 of 119

1.

Periodic fasting starves cisplatin-resistant cancers to death.

Guidi N, Longo VD.

EMBO J. 2018 Jul 13;37(14). pii: e99815. doi: 10.15252/embj.201899815. Epub 2018 Jun 6. No abstract available.

PMID:
29875131
2.

Starvation, Stress Resistance, and Cancer.

Buono R, Longo VD.

Trends Endocrinol Metab. 2018 Apr;29(4):271-280. doi: 10.1016/j.tem.2018.01.008. Epub 2018 Feb 17. Review.

PMID:
29463451
3.

Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.

Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo VD, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JR.

Cell Metab. 2017 Jun 6;25(6):1320-1333.e5. doi: 10.1016/j.cmet.2017.05.003.

4.

Correction: Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy.

Di Biase S, Shim HS, Kim KH, Vinciguerra M, Rappa F, Wei M, Brandhorst S, Cappello F, Mirzaei H, Lee C, Longo VD.

PLoS Biol. 2017 May 1;15(5):e1002603. doi: 10.1371/journal.pbio.1002603. eCollection 2017 May.

5.

Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy.

Di Biase S, Shim HS, Kim KH, Vinciguerra M, Rappa F, Wei M, Brandhorst S, Cappello F, Mirzaei H, Lee C, Longo VD.

PLoS Biol. 2017 Mar 30;15(3):e2001951. doi: 10.1371/journal.pbio.2001951. eCollection 2017 Mar. Erratum in: PLoS Biol. 2017 May 1;15(5):e1002603.

6.

Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes.

Cheng CW, Villani V, Buono R, Wei M, Kumar S, Yilmaz OH, Cohen P, Sneddon JB, Perin L, Longo VD.

Cell. 2017 Feb 23;168(5):775-788.e12. doi: 10.1016/j.cell.2017.01.040.

7.

Protective effects of short-term dietary restriction in surgical stress and chemotherapy.

Brandhorst S, Harputlugil E, Mitchell JR, Longo VD.

Ageing Res Rev. 2017 Oct;39:68-77. doi: 10.1016/j.arr.2017.02.001. Epub 2017 Feb 20. Review.

8.

Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease.

Wei M, Brandhorst S, Shelehchi M, Mirzaei H, Cheng CW, Budniak J, Groshen S, Mack WJ, Guen E, Di Biase S, Cohen P, Morgan TE, Dorff T, Hong K, Michalsen A, Laviano A, Longo VD.

Sci Transl Med. 2017 Feb 15;9(377). pii: eaai8700. doi: 10.1126/scitranslmed.aai8700.

PMID:
28202779
9.

Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice.

Lee AS, Brandhorst S, Rangel DF, Navarrete G, Cohen P, Longo VD, Chen J, Groshen S, Morgan TE, Dubeau L.

Sci Rep. 2017 Feb 1;7:40919. doi: 10.1038/srep40919.

10.

Nutrition and fasting mimicking diets in the prevention and treatment of autoimmune diseases and immunosenescence.

Choi IY, Lee C, Longo VD.

Mol Cell Endocrinol. 2017 Nov 5;455:4-12. doi: 10.1016/j.mce.2017.01.042. Epub 2017 Jan 28. Review.

11.

Brain Structure and Function Associated with Younger Adults in Growth Hormone Receptor-Deficient Humans.

Nashiro K, Guevara-Aguirre J, Braskie MN, Hafzalla GW, Velasco R, Balasubramanian P, Wei M, Thompson PM, Mather M, Nelson MD, Guevara A, Teran E, Longo VD.

J Neurosci. 2017 Feb 15;37(7):1696-1707. doi: 10.1523/JNEUROSCI.1929-16.2016. Epub 2017 Jan 10.

12.

Enhancing Stem Cell Transplantation with "Nutri-technology".

Longo VD, Cortellino S.

Cell Stem Cell. 2016 Dec 1;19(6):681-682. doi: 10.1016/j.stem.2016.11.015.

13.

Impact of intermittent fasting on health and disease processes.

Mattson MP, Longo VD, Harvie M.

Ageing Res Rev. 2017 Oct;39:46-58. doi: 10.1016/j.arr.2016.10.005. Epub 2016 Oct 31. Review.

PMID:
27810402
14.

Fasting and Caloric Restriction in Cancer Prevention and Treatment.

Brandhorst S, Longo VD.

Recent Results Cancer Res. 2016;207:241-66. doi: 10.1007/978-3-319-42118-6_12. Review.

PMID:
27557543
15.

Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality.

Song M, Fung TT, Hu FB, Willett WC, Longo VD, Chan AT, Giovannucci EL.

JAMA Intern Med. 2016 Oct 1;176(10):1453-1463. doi: 10.1001/jamainternmed.2016.4182. Erratum in: JAMA Intern Med. 2016 Nov 1;176(11):1728.

16.

Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity.

Di Biase S, Lee C, Brandhorst S, Manes B, Buono R, Cheng CW, Cacciottolo M, Martin-Montalvo A, de Cabo R, Wei M, Morgan TE, Longo VD.

Cancer Cell. 2016 Jul 11;30(1):136-146. doi: 10.1016/j.ccell.2016.06.005.

17.

Fasting-induced differential stress sensitization in cancer treatment.

Di Biase S, Longo VD.

Mol Cell Oncol. 2015 Dec 10;3(3):e1117701. doi: 10.1080/23723556.2015.1117701. eCollection 2016 May.

18.

Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan.

Longo VD, Panda S.

Cell Metab. 2016 Jun 14;23(6):1048-1059. doi: 10.1016/j.cmet.2016.06.001. Review.

19.

A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms.

Choi IY, Piccio L, Childress P, Bollman B, Ghosh A, Brandhorst S, Suarez J, Michalsen A, Cross AH, Morgan TE, Wei M, Paul F, Bock M, Longo VD.

Cell Rep. 2016 Jun 7;15(10):2136-2146. doi: 10.1016/j.celrep.2016.05.009. Epub 2016 May 26.

20.

Dietary Interventions, Cardiovascular Aging, and Disease: Animal Models and Human Studies.

Mirzaei H, Di Biase S, Longo VD.

Circ Res. 2016 May 13;118(10):1612-25. doi: 10.1161/CIRCRESAHA.116.307473. Review.

PMID:
27174953
21.

Growth factors, aging and age-related diseases.

Balasubramanian P, Longo VD.

Growth Horm IGF Res. 2016 Jun;28:66-8. doi: 10.1016/j.ghir.2016.01.001. Epub 2016 Jan 7.

22.

Fasting plus tyrosine kinase inhibitors in cancer.

Caffa I, Longo VD, Nencioni A.

Aging (Albany NY). 2015 Dec;7(12):1026-7. No abstract available.

23.

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin ARMR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker WK, Dhawan P, Diehl AME, Dong JT, Dou QP, Drew JE, Elkord E, El-Rayes B, Feitelson MA, Felsher DW, Ferguson LR, Fimognari C, Firestone GL, Frezza C, Fujii H, Fuster MM, Generali D, Georgakilas AG, Gieseler F, Gilbertson M, Green MF, Grue B, Guha G, Halicka D, Helferich WG, Heneberg P, Hentosh P, Hirschey MD, Hofseth LJ, Holcombe RF, Honoki K, Hsu HY, Huang GS, Jensen LD, Jiang WG, Jones LW, Karpowicz PA, Keith WN, Kerkar SP, Khan GN, Khatami M, Ko YH, Kucuk O, Kulathinal RJ, Kumar NB, Kwon BS, Le A, Lea MA, Lee HY, Lichtor T, Lin LT, Locasale JW, Lokeshwar BL, Longo VD, Lyssiotis CA, MacKenzie KL, Malhotra M, Marino M, Martinez-Chantar ML, Matheu A, Maxwell C, McDonnell E, Meeker AK, Mehrmohamadi M, Mehta K, Michelotti GA, Mohammad RM, Mohammed SI, Morre DJ, Muralidhar V, Muqbil I, Murphy MP, Nagaraju GP, Nahta R, Niccolai E, Nowsheen S, Panis C, Pantano F, Parslow VR, Pawelec G, Pedersen PL, Poore B, Poudyal D, Prakash S, Prince M, Raffaghello L, Rathmell JC, Rathmell WK, Ray SK, Reichrath J, Rezazadeh S, Ribatti D, Ricciardiello L, Robey RB, Rodier F, Rupasinghe HPV, Russo GL, Ryan EP, Samadi AK, Sanchez-Garcia I, Sanders AJ, Santini D, Sarkar M, Sasada T, Saxena NK, Shackelford RE, Shantha Kumara HMC, Sharma D, Shin DM, Sidransky D, Siegelin MD, Signori E, Singh N, Sivanand S, Sliva D, Smythe C, Spagnuolo C, Stafforini DM, Stagg J, Subbarayan PR, Sundin T, Talib WH, Thompson SK, Tran PT, Ungefroren H, Vander Heiden MG, Venkateswaran V, Vinay DS, Vlachostergios PJ, Wang Z, Wellen KE, Whelan RL, Yang ES, Yang H, Yang X, Yaswen P, Yedjou C, Yin X, Zhu J, Zollo M.

Semin Cancer Biol. 2015 Dec;35 Suppl:S276-S304. doi: 10.1016/j.semcancer.2015.09.007. Review.

24.

The conserved role of protein restriction in aging and disease.

Mirzaei H, Raynes R, Longo VD.

Curr Opin Clin Nutr Metab Care. 2016 Jan;19(1):74-9. doi: 10.1097/MCO.0000000000000239. Review.

25.

Dysregulated metabolism contributes to oncogenesis.

Hirschey MD, DeBerardinis RJ, Diehl AME, Drew JE, Frezza C, Green MF, Jones LW, Ko YH, Le A, Lea MA, Locasale JW, Longo VD, Lyssiotis CA, McDonnell E, Mehrmohamadi M, Michelotti G, Muralidhar V, Murphy MP, Pedersen PL, Poore B, Raffaghello L, Rathmell JC, Sivanand S, Vander Heiden MG, Wellen KE; Target Validation Team.

Semin Cancer Biol. 2015 Dec;35 Suppl:S129-S150. doi: 10.1016/j.semcancer.2015.10.002. Epub 2015 Oct 8. Review.

26.

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.

Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD.

Cell Metab. 2015 Jul 7;22(1):86-99. doi: 10.1016/j.cmet.2015.05.012. Epub 2015 Jun 18.

27.

GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity.

Guevara-Aguirre J, Rosenbloom AL, Balasubramanian P, Teran E, Guevara-Aguirre M, Guevara C, Procel P, Alfaras I, De Cabo R, Di Biase S, Narvaez L, Saavedra J, Longo VD.

J Clin Endocrinol Metab. 2015 Jul;100(7):2589-96. doi: 10.1210/jc.2015-1678. Epub 2015 May 18.

28.

Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition.

Caffa I, D'Agostino V, Damonte P, Soncini D, Cea M, Monacelli F, Odetti P, Ballestrero A, Provenzani A, Longo VD, Nencioni A.

Oncotarget. 2015 May 20;6(14):11820-32.

29.

Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models.

Bianchi G, Martella R, Ravera S, Marini C, Capitanio S, Orengo A, Emionite L, Lavarello C, Amaro A, Petretto A, Pfeffer U, Sambuceti G, Pistoia V, Raffaghello L, Longo VD.

Oncotarget. 2015 May 20;6(14):11806-19.

30.

Interventions to Slow Aging in Humans: Are We Ready?

Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L.

Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22. Review.

31.

Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells.

Shim HS, Wei M, Brandhorst S, Longo VD.

Cancer Res. 2015 Mar 15;75(6):1056-67. doi: 10.1158/0008-5472.CAN-14-2249. Epub 2015 Jan 22.

32.

A protein restriction-dependent sulfur code for longevity.

Shim HS, Longo VD.

Cell. 2015 Jan 15;160(1-2):15-7. doi: 10.1016/j.cell.2014.12.027.

33.

Meal frequency and timing in health and disease.

Mattson MP, Allison DB, Fontana L, Harvie M, Longo VD, Malaisse WJ, Mosley M, Notterpek L, Ravussin E, Scheer FA, Seyfried TN, Varady KA, Panda S.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16647-53. doi: 10.1073/pnas.1413965111. Epub 2014 Nov 17.

34.

Protein and amino acid restriction, aging and disease: from yeast to humans.

Mirzaei H, Suarez JA, Longo VD.

Trends Endocrinol Metab. 2014 Nov;25(11):558-66. doi: 10.1016/j.tem.2014.07.002. Epub 2014 Aug 19. Review.

35.

Medical research: treat ageing.

Fontana L, Kennedy BK, Longo VD, Seals D, Melov S.

Nature. 2014 Jul 24;511(7510):405-7. doi: 10.1038/511405a. No abstract available.

PMID:
25056047
36.

Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression.

Cheng CW, Adams GB, Perin L, Wei M, Zhou X, Lam BS, Da Sacco S, Mirisola M, Quinn DI, Dorff TB, Kopchick JJ, Longo VD.

Cell Stem Cell. 2014 Jun 5;14(6):810-23. doi: 10.1016/j.stem.2014.04.014. Erratum in: Cell Stem Cell. 2016 Feb 4;18(2):291-2.

37.

Acetyl-CoA synthetase is a conserved regulator of autophagy and life span.

Mirzaei H, Longo VD.

Cell Metab. 2014 Apr 1;19(4):555-7. doi: 10.1016/j.cmet.2014.03.021.

38.

Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity.

Hu J, Wei M, Mirzaei H, Madia F, Mirisola M, Amparo C, Chagoury S, Kennedy B, Longo VD.

Aging Cell. 2014 Jun;13(3):457-67. doi: 10.1111/acel.12202. Epub 2014 Mar 20.

39.

Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.

Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo VD.

Cell Metab. 2014 Mar 4;19(3):407-17. doi: 10.1016/j.cmet.2014.02.006.

40.

Serine- and threonine/valine-dependent activation of PDK and Tor orthologs converge on Sch9 to promote aging.

Mirisola MG, Taormina G, Fabrizio P, Wei M, Hu J, Longo VD.

PLoS Genet. 2014 Feb 6;10(2):e1004113. doi: 10.1371/journal.pgen.1004113. eCollection 2014 Feb.

41.

Fasting: molecular mechanisms and clinical applications.

Longo VD, Mattson MP.

Cell Metab. 2014 Feb 4;19(2):181-92. doi: 10.1016/j.cmet.2013.12.008. Epub 2014 Jan 16. Review.

42.

Dietary protein restriction inhibits tumor growth in human xenograft models.

Fontana L, Adelaiye RM, Rastelli AL, Miles KM, Ciamporcero E, Longo VD, Nguyen H, Vessella R, Pili R.

Oncotarget. 2013 Dec;4(12):2451-61.

43.

Autophagy in blood cancers: biological role and therapeutic implications.

Nencioni A, Cea M, Montecucco F, Longo VD, Patrone F, Carella AM, Holyoake TL, Helgason GV.

Haematologica. 2013 Sep;98(9):1335-43. doi: 10.3324/haematol.2012.079061. Review.

44.

SIRT1 but not its increased expression is essential for lifespan extension in caloric-restricted mice.

Mercken EM, Hu J, Krzysik-Walker S, Wei M, Li Y, McBurney MW, de Cabo R, Longo VD.

Aging Cell. 2014 Feb;13(1):193-6. doi: 10.1111/acel.12151. Epub 2013 Nov 19.

45.

A radical signal activates the epigenetic regulation of longevity.

Mirisola MG, Longo VD.

Cell Metab. 2013 Jun 4;17(6):812-3. doi: 10.1016/j.cmet.2013.05.015.

46.

Short-term calorie and protein restriction provide partial protection from chemotoxicity but do not delay glioma progression.

Brandhorst S, Wei M, Hwang S, Morgan TE, Longo VD.

Exp Gerontol. 2013 Oct;48(10):1120-8. doi: 10.1016/j.exger.2013.02.016. Epub 2013 Feb 21.

47.

Protein restriction cycles reduce IGF-1 and phosphorylated Tau, and improve behavioral performance in an Alzheimer's disease mouse model.

Parrella E, Maxim T, Maialetti F, Zhang L, Wan J, Wei M, Cohen P, Fontana L, Longo VD.

Aging Cell. 2013 Apr;12(2):257-68. doi: 10.1111/acel.12049. Epub 2013 Mar 11.

48.

Assessing chronological aging in Saccharomyces cerevisiae.

Hu J, Wei M, Mirisola MG, Longo VD.

Methods Mol Biol. 2013;965:463-72. doi: 10.1007/978-1-62703-239-1_30.

49.

Assessing chronological aging in bacteria.

Gonidakis S, Longo VD.

Methods Mol Biol. 2013;965:421-37. doi: 10.1007/978-1-62703-239-1_28.

50.

Aging, nutrient signaling, hematopoietic senescence, and cancer.

Balasubramanian P, Longo VD.

Crit Rev Oncog. 2013;18(6):559-71. Review.

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