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The Impact of Sourdough Fermentation on Non-Nutritive Compounds and Antioxidant Activities of Flours from Different Phaseolus Vulgaris L. Genotypes.

Gabriele M, Sparvoli F, Bollini R, Lubrano V, Longo V, Pucci L.

J Food Sci. 2019 Jun 19. doi: 10.1111/1750-3841.14672. [Epub ahead of print]


Molecular Characterization of a Long-Term Survivor Double Metastatic Non-Small Cell Lung Cancer and Pancreatic Ductal Adenocarcinoma Treated with Gefitinib in Combination with Gemcitabine Plus Nab-Paclitaxel and mFOLFOX6 as First and Second Line Therapy.

Brunetti O, Badalamenti G, De Summa S, Calabrese A, Argentiero A, Fucci L, Longo V, Galetta D, Perrotti PMS, Pinto R, Petriella D, Danza K, Tommasi S, Leonetti F, Silvestris N.

Cancers (Basel). 2019 May 29;11(6). pii: E749. doi: 10.3390/cancers11060749.


Phytochemical and Biological Activities in Limonium Species Collected in Different Biotopes of Tunisia.

Souid A, Bellani L, Gabriele M, Pucci L, Smaoui A, Abdelly C, Hamed KB, Longo V.

Chem Biodivers. 2019 May 26. doi: 10.1002/cbdv.201900216. [Epub ahead of print]


Strategies to Improve Cancer Immune Checkpoint Inhibitors Efficacy, Other Than Abscopal Effect: A Systematic Review.

Longo V, Brunetti O, Azzariti A, Galetta D, Nardulli P, Leonetti F, Silvestris N.

Cancers (Basel). 2019 Apr 15;11(4). pii: E539. doi: 10.3390/cancers11040539. Review.


FDA-approved ferumoxytol displays anti-leukaemia efficacy against cells with low ferroportin levels.

Trujillo-Alonso V, Pratt EC, Zong H, Lara-Martinez A, Kaittanis C, Rabie MO, Longo V, Becker MW, Roboz GJ, Grimm J, Guzman ML.

Nat Nanotechnol. 2019 Jun;14(6):616-622. doi: 10.1038/s41565-019-0406-1. Epub 2019 Mar 25.


Dietary Restrictions and Nutrition in the Prevention and Treatment of Cardiovascular Disease.

Brandhorst S, Longo VD.

Circ Res. 2019 Mar 15;124(6):952-965. doi: 10.1161/CIRCRESAHA.118.313352.


Fasting-Mimicking Diet Modulates Microbiota and Promotes Intestinal Regeneration to Reduce Inflammatory Bowel Disease Pathology.

Rangan P, Choi I, Wei M, Navarrete G, Guen E, Brandhorst S, Enyati N, Pasia G, Maesincee D, Ocon V, Abdulridha M, Longo VD.

Cell Rep. 2019 Mar 5;26(10):2704-2719.e6. doi: 10.1016/j.celrep.2019.02.019.


Inflammatory cells infiltrate and angiogenesis in locally advanced and metastatic cholangiocarcinoma.

Tamma R, Annese T, Ruggieri S, Brunetti O, Longo V, Cascardi E, Mastropasqua MG, Maiorano E, Silvestris N, Ribatti D.

Eur J Clin Invest. 2019 May;49(5):e13087. doi: 10.1111/eci.13087. Epub 2019 Mar 3.


BRMS1 expression in resected lung adenocarcinoma.

Galetta D, Pizzutilo P, Longo V.

Transl Lung Cancer Res. 2018 Dec;7(Suppl 4):S364-S366. doi: 10.21037/tlcr.2018.09.20. No abstract available.


Altered Nup153 Expression Impairs the Function of Cultured Hippocampal Neural Stem Cells Isolated from a Mouse Model of Alzheimer's Disease.

Leone L, Colussi C, Gironi K, Longo V, Fusco S, Li Puma DD, D'Ascenzo M, Grassi C.

Mol Neurobiol. 2019 Jan 28. doi: 10.1007/s12035-018-1466-1. [Epub ahead of print]


Reply to 'Fasting in oncology: a word of caution'.

Nencioni A, Caffa I, Cortellino S, Longo VD.

Nat Rev Cancer. 2019 Mar;19(3):178. doi: 10.1038/s41568-018-0100-x. No abstract available.


Indoor air quality in schools of a highly polluted south Mediterranean area.

Ruggieri S, Longo V, Perrino C, Canepari S, Drago G, L'Abbate L, Balzan M, Cuttitta G, Scaccianoce G, Minardi R, Viegi G, Cibella F; RESPIRA Project Group.

Indoor Air. 2019 Mar;29(2):276-290. doi: 10.1111/ina.12529. Epub 2019 Jan 19.


In vitro exposure to 2,2',4,4'-tetrabromodiphenyl ether (PBDE-47) impairs innate inflammatory response.

Longo V, Longo A, Di Sano C, Cigna D, Cibella F, Di Felice G, Colombo P.

Chemosphere. 2019 Mar;219:845-854. doi: 10.1016/j.chemosphere.2018.12.082. Epub 2018 Dec 11.


Programmed longevity, youthspan, and juventology.

Longo VD.

Aging Cell. 2019 Feb;18(1):e12843. doi: 10.1111/acel.12843. Epub 2018 Oct 17.


Fasting and cancer: molecular mechanisms and clinical application.

Nencioni A, Caffa I, Cortellino S, Longo VD.

Nat Rev Cancer. 2018 Nov;18(11):707-719. doi: 10.1038/s41568-018-0061-0. Review.


Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans.

Yen K, Wan J, Mehta HH, Miller B, Christensen A, Levine ME, Salomon MP, Brandhorst S, Xiao J, Kim SJ, Navarrete G, Campo D, Harry GJ, Longo V, Pike CJ, Mack WJ, Hodis HN, Crimmins EM, Cohen P.

Sci Rep. 2018 Sep 21;8(1):14212. doi: 10.1038/s41598-018-32616-7.


Self-evaluation of duration of adjuvant chemotherapy side effects in breast cancer patients: A prospective study.

Galizia D, Milani A, Geuna E, Martinello R, Cagnazzo C, Foresto M, Longo V, Berchialla P, Solinas G, Calori A, Grasso B, Volpone C, Bertola G, Parola G, Tealdi G, Giuliano PL, Ballari AM, Aglietta M, Montemurro F.

Cancer Med. 2018 Sep;7(9):4339-4344. doi: 10.1002/cam4.1687. Epub 2018 Jul 20.


Periodic fasting starves cisplatin-resistant cancers to death.

Guidi N, Longo VD.

EMBO J. 2018 Jul 13;37(14). pii: e99815. doi: 10.15252/embj.201899815. Epub 2018 Jun 6. No abstract available.


Nutraceutical potential of hemp (Cannabis sativa L.) seeds and sprouts.

Frassinetti S, Moccia E, Caltavuturo L, Gabriele M, Longo V, Bellani L, Giorgi G, Giorgetti L.

Food Chem. 2018 Oct 1;262:56-66. doi: 10.1016/j.foodchem.2018.04.078. Epub 2018 Apr 22.


ImmunoPET Imaging of Endogenous and Transfected Prolactin Receptor Tumor Xenografts.

Cheal SM, Ruan S, Veach DR, Longo VA, Punzalan BJ, Wu J, Fung EK, Kelly MP, Kirshner JR, Giurleo JT, Ehrlich G, Han AQ, Thurston G, Olson WC, Zanzonico PB, Larson SM, Carrasquillo JA.

Mol Pharm. 2018 Jun 4;15(6):2133-2141. doi: 10.1021/acs.molpharmaceut.7b01133. Epub 2018 Apr 30.


Relationship between domestic smoking and metals and rare earth elements concentration in indoor PM2.5.

Drago G, Perrino C, Canepari S, Ruggieri S, L'Abbate L, Longo V, Colombo P, Frasca D, Balzan M, Cuttitta G, Scaccianoce G, Piva G, Bucchieri S, Melis M, Viegi G, Cibella F; RESPIRA Collaborative Project Group; Indoor and Outdoor Air Quality and Respiratory Health in Malta and Sicily - RESPIRA Study Group:, Balzan M, Bilocca D, Borg C, Montefort S, Zammit C, Bucchieri S, Cibella F, Colombo P, Cuttitta G, Drago G, Ferrante G, L'Abbate L, Grutta S, Longo V, Melis MR, Ruggieri S, Viegi G, Minardi R, Piva G, Ristagno R, Rizzo G, Scaccianoce G.

Environ Res. 2018 Aug;165:71-80. doi: 10.1016/j.envres.2018.03.026. Epub 2018 Apr 16.


Biological therapy downregulates the heterodimer S100A8/A9 (calprotectin) expression in psoriatic patients.

D'Amico F, Granata M, Skarmoutsou E, Trovato C, Lovero G, Gangemi P, Longo V, Pettinato M, Mazzarino MC.

Inflamm Res. 2018 Jul;67(7):609-616. doi: 10.1007/s00011-018-1147-6. Epub 2018 Mar 31.


Mast cells and angiogenesis in pancreatic ductal adenocarcinoma.

Longo V, Tamma R, Brunetti O, Pisconti S, Argentiero A, Silvestris N, Ribatti D.

Clin Exp Med. 2018 Aug;18(3):319-323. doi: 10.1007/s10238-018-0493-6. Epub 2018 Feb 28. Review.


Skeletal and Dental Effectiveness of Treatment of Class II Malocclusion With Headgear: A Systematic Review and Meta-analysis.

Nucera R, Militi A, Lo Giudice A, Longo V, Fastuca R, Caprioglio A, Cordasco G, Papadopoulos MA.

J Evid Based Dent Pract. 2018 Mar;18(1):41-58. doi: 10.1016/j.jebdp.2017.07.008. Epub 2017 Aug 4. Review.


Starvation, Stress Resistance, and Cancer.

Buono R, Longo VD.

Trends Endocrinol Metab. 2018 Apr;29(4):271-280. doi: 10.1016/j.tem.2018.01.008. Epub 2018 Feb 17. Review.


Presence and inter-individual variability of carboxylesterases (CES1 and CES2) in human lung.

Gabriele M, Puccini P, Lucchi M, Vizziello A, Gervasi PG, Longo V.

Biochem Pharmacol. 2018 Apr;150:64-71. doi: 10.1016/j.bcp.2018.01.028. Epub 2018 Feb 3.


Metastatic HPV-related oropharyngeal carcinoma cured with chemoradiotherapy: importance of pretherapy biomolecular assessment.

Perri F, Longo F, Della Vittoria Scarpati G, Pisconti S, Longo V, Addeo R, Carducci F, Buonerba C, Fulciniti F, Solla R.

Clin Case Rep. 2017 Nov 24;6(1):56-62. doi: 10.1002/ccr3.1107. eCollection 2018 Jan.


Effects of low sulfur dioxide concentrations on bioactive compounds and antioxidant properties of Aglianico red wine.

Gabriele M, Gerardi C, Lucejko JJ, Longo V, Pucci L, Domenici V.

Food Chem. 2018 Apr 15;245:1105-1112. doi: 10.1016/j.foodchem.2017.11.060. Epub 2017 Nov 16.


Physiological and antioxidant responses of the sabkha biotope halophyte Limonium delicatulum to seasonal changes in environmental conditions.

Souid A, Bellani L, Magné C, Zorrig W, Smaoui A, Abdelly C, Longo V, Ben Hamed K.

Plant Physiol Biochem. 2018 Feb;123:180-191. doi: 10.1016/j.plaphy.2017.12.008. Epub 2017 Dec 6.


Angiogenesis in adenosquamous cancer of pancreas.

Silvestris N, Danza K, Longo V, Brunetti O, Fucci L, Argentiero A, Calabrese A, Cataldo I, Tamma R, Ribatti D, Tommasi S.

Oncotarget. 2017 Sep 27;8(56):95773-95779. doi: 10.18632/oncotarget.21319. eCollection 2017 Nov 10.


Management of patients with end-stage renal disease undergoing chemotherapy: recommendations of the Associazione Italiana di Oncologia Medica (AIOM) and the Società Italiana di Nefrologia (SIN).

Pedrazzoli P, Silvestris N, Santoro A, Secondino S, Brunetti O, Longo V, Mancini E, Mariucci S, Rampino T, Delfanti S, Brugnatelli S, Cinieri S.

ESMO Open. 2017 Jul 19;2(3):e000167. doi: 10.1136/esmoopen-2017-000167. eCollection 2017.


Interview with Professor Valter Longo.

Longo V.

FEMS Yeast Res. 2017 Nov 23. doi: 10.1093/femsyr/fox052. [Epub ahead of print] No abstract available.


Polyphenolic characterisation of plant mixture (Lisosan® Reduction) and its hypocholesterolaemic effect in high fat diet-fed mice.

Russo R, Pucci L, Giorgetti L, Árvay J, Vizzarri F, Longo V, Pozzo L.

Nat Prod Res. 2019 Mar;33(5):651-658. doi: 10.1080/14786419.2017.1402328. Epub 2017 Nov 15.


Chromatographic analysis of VOC patterns in exhaled breath from smokers and nonsmokers.

Capone S, Tufariello M, Forleo A, Longo V, Giampetruzzi L, Radogna AV, Casino F, Siciliano P.

Biomed Chromatogr. 2018 Apr;32(4). doi: 10.1002/bmc.4132. Epub 2017 Dec 12.


The Effectiveness of Eye Movement Desensitization and Reprocessing Integrative Group Protocol with Adolescent Survivors of the Central Italy Earthquake.

Maslovaric G, Zaccagnino M, Mezzaluna C, Perilli S, Trivellato D, Longo V, Civilotti C.

Front Psychol. 2017 Oct 23;8:1826. doi: 10.3389/fpsyg.2017.01826. eCollection 2017.


Screening and identification of major phytochemical compounds in seeds, sprouts and leaves of Tuscan black kale Brassica oleracea (L.) ssp acephala (DC) var. sabellica L.

Giorgetti L, Giorgi G, Cherubini E, Gervasi PG, Della Croce CM, Longo V, Bellani L.

Nat Prod Res. 2018 Jul;32(14):1617-1626. doi: 10.1080/14786419.2017.1392953. Epub 2017 Oct 23.


Sensitization to dust mite defines different phenotypes of asthma: A multicenter study.

Ruggieri S, Drago G, Longo V, Colombo P, Balzan M, Bilocca D, Zammit C, Montefort S, Scaccianoce G, Cuttitta G, Viegi G, Cibella F; RESPIRA Project Group.

Pediatr Allergy Immunol. 2017 Nov;28(7):675-682. doi: 10.1111/pai.12768. Epub 2017 Sep 7.


The combined effect of Sango sprout juice and caloric restriction on metabolic disorders and gut microbiota composition in an obesity model.

Vivarelli F, Canistro D, Babot Marquillas C, Cirillo S, De Nicola GR, Iori R, Biagi G, Pinna C, Gentilini F, Pozzo L, Longo V, Paolini M.

Int J Food Sci Nutr. 2018 Mar;69(2):192-204. doi: 10.1080/09637486.2017.1350940. Epub 2017 Aug 3.


Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.

Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo VD, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JR.

Cell Metab. 2017 Jun 6;25(6):1320-1333.e5. doi: 10.1016/j.cmet.2017.05.003.


A fermented bean flour extract downregulates LOX-1, CHOP and ICAM-1 in HMEC-1 stimulated by ox-LDL.

Gabriele M, Pucci L, La Marca M, Lucchesi D, Della Croce CM, Longo V, Lubrano V.

Cell Mol Biol Lett. 2016 Aug 12;21:10. doi: 10.1186/s11658-016-0015-z. eCollection 2016.


Metabolic Alterations at the Crossroad of Aging and Oncogenesis.

Raffaghello L, Longo V.

Int Rev Cell Mol Biol. 2017;332:1-42. doi: 10.1016/bs.ircmb.2017.01.003. Epub 2017 Feb 28. Review.


E-cigarettes induce toxicological effects that can raise the cancer risk.

Canistro D, Vivarelli F, Cirillo S, Babot Marquillas C, Buschini A, Lazzaretti M, Marchi L, Cardenia V, Rodriguez-Estrada MT, Lodovici M, Cipriani C, Lorenzini A, Croco E, Marchionni S, Franchi P, Lucarini M, Longo V, Della Croce CM, Vornoli A, Colacci A, Vaccari M, Sapone A, Paolini M.

Sci Rep. 2017 May 17;7(1):2028. doi: 10.1038/s41598-017-02317-8.


Correction: Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy.

Di Biase S, Shim HS, Kim KH, Vinciguerra M, Rappa F, Wei M, Brandhorst S, Cappello F, Mirzaei H, Lee C, Longo VD.

PLoS Biol. 2017 May 1;15(5):e1002603. doi: 10.1371/journal.pbio.1002603. eCollection 2017 May.


Immunotherapeutic approaches for hepatocellular carcinoma.

Longo V, Gnoni A, Casadei Gardini A, Pisconti S, Licchetta A, Scartozzi M, Memeo R, Palmieri VO, Aprile G, Santini D, Nardulli P, Silvestris N, Brunetti O.

Oncotarget. 2017 May 16;8(20):33897-33910. doi: 10.18632/oncotarget.15406. Review.


A Fermented Whole Grain Prevents Lipopolysaccharides-Induced Dysfunction in Human Endothelial Progenitor Cells.

Giusti L, Gabriele M, Penno G, Garofolo M, Longo V, Del Prato S, Lucchesi D, Pucci L.

Oxid Med Cell Longev. 2017;2017:1026268. doi: 10.1155/2017/1026268. Epub 2017 Mar 13.


Fasting regulates EGR1 and protects from glucose- and dexamethasone-dependent sensitization to chemotherapy.

Di Biase S, Shim HS, Kim KH, Vinciguerra M, Rappa F, Wei M, Brandhorst S, Cappello F, Mirzaei H, Lee C, Longo VD.

PLoS Biol. 2017 Mar 30;15(3):e2001951. doi: 10.1371/journal.pbio.2001951. eCollection 2017 Mar. Erratum in: PLoS Biol. 2017 May 1;15(5):e1002603.


Nanoincorporation of bioactive compounds from red grape pomaces: In vitro and ex vivo evaluation of antioxidant activity.

Manconi M, Marongiu F, Manca ML, Caddeo C, Sarais G, Cencetti C, Pucci L, Longo V, Bacchetta G, Fadda AM.

Int J Pharm. 2017 May 15;523(1):159-166. doi: 10.1016/j.ijpharm.2017.03.037. Epub 2017 Mar 20.


Euglena gracilis paramylon activates human lymphocytes by upregulating pro-inflammatory factors.

Russo R, Barsanti L, Evangelista V, Frassanito AM, Longo V, Pucci L, Penno G, Gualtieri P.

Food Sci Nutr. 2016 May 20;5(2):205-214. doi: 10.1002/fsn3.383. eCollection 2017 Mar.


Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes.

Cheng CW, Villani V, Buono R, Wei M, Kumar S, Yilmaz OH, Cohen P, Sneddon JB, Perin L, Longo VD.

Cell. 2017 Feb 23;168(5):775-788.e12. doi: 10.1016/j.cell.2017.01.040.


Protective effects of short-term dietary restriction in surgical stress and chemotherapy.

Brandhorst S, Harputlugil E, Mitchell JR, Longo VD.

Ageing Res Rev. 2017 Oct;39:68-77. doi: 10.1016/j.arr.2017.02.001. Epub 2017 Feb 20. Review.

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