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Items: 1 to 50 of 120

1.

Nerve Growth Factor Pathobiology During the Progression of Alzheimer's Disease.

Mufson EJ, Counts SE, Ginsberg SD, Mahady L, Perez SE, Massa SM, Longo FM, Ikonomovic MD.

Front Neurosci. 2019 Jul 1;13:533. doi: 10.3389/fnins.2019.00533. eCollection 2019. Review.

2.

Reduced cognitive deficits after FLASH irradiation of whole mouse brain are associated with less hippocampal dendritic spine loss and neuroinflammation.

Simmons DA, Lartey FM, Schüler E, Rafat M, King G, Kim A, Ko R, Semaan S, Gonzalez S, Jenkins M, Pradhan P, Shih Z, Wang J, von Eyben R, Graves EE, Maxim PG, Longo FM, Loo BW Jr.

Radiother Oncol. 2019 Oct;139:4-10. doi: 10.1016/j.radonc.2019.06.006. Epub 2019 Jun 25.

PMID:
31253467
3.

Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment.

Geraghty AC, Gibson EM, Ghanem RA, Greene JJ, Ocampo A, Goldstein AK, Ni L, Yang T, Marton RM, Paşca SP, Greenberg ME, Longo FM, Monje M.

Neuron. 2019 Jul 17;103(2):250-265.e8. doi: 10.1016/j.neuron.2019.04.032. Epub 2019 May 20.

PMID:
31122677
4.

Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinal vascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway.

Elshaer SL, Alwhaibi A, Mohamed R, Lemtalsi T, Coucha M, Longo FM, El-Remessy AB.

Diabetologia. 2019 Aug;62(8):1488-1500. doi: 10.1007/s00125-019-4885-2. Epub 2019 May 9.

PMID:
31073629
5.

Receptor dependence of BDNF actions in superficial dorsal horn: relation to central sensitization and actions of macrophage colony stimulating factor 1.

Boakye PA, Rancic V, Whitlock KH, Simmons D, Longo FM, Ballanyi K, Smith PA.

J Neurophysiol. 2019 Jun 1;121(6):2308-2322. doi: 10.1152/jn.00839.2018. Epub 2019 Apr 17.

PMID:
30995156
6.

Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling.

Wong HLX, Qin HY, Tsang SW, Zuo X, Che S, Chow CFW, Li X, Xiao HT, Zhao L, Huang T, Lin CY, Kwan HY, Yang T, Longo FM, Lyu A, Bian ZX.

Nat Commun. 2019 Apr 15;10(1):1745. doi: 10.1038/s41467-019-09744-3.

7.

Modulation of the p75 neurotrophin receptor suppresses age-related basal forebrain cholinergic neuron degeneration.

Xie Y, Meeker RB, Massa SM, Longo FM.

Sci Rep. 2019 Mar 27;9(1):5273. doi: 10.1038/s41598-019-41654-8.

8.

A Small Molecule TrkB Neurotrophin Receptor Partial Agonist as Possible Treatment for Experimental Nonarteritic Anterior Ischemic Optic Neuropathy.

Ali Shariati M, Kumar V, Yang T, Chakraborty C, Barres BA, Longo FM, Liao YJ.

Curr Eye Res. 2018 Dec;43(12):1489-1499. doi: 10.1080/02713683.2018.1508726. Epub 2018 Oct 1.

PMID:
30273053
9.

Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia.

Nguyen TV, Hayes M, Zbesko JC, Frye JB, Congrove NR, Belichenko NP, McKay BS, Longo FM, Doyle KP.

Acta Neuropathol Commun. 2018 Sep 24;6(1):100. doi: 10.1186/s40478-018-0603-4.

10.

Unsolicited Patient Complaints Identify Physicians with Evidence of Neurocognitive Disorders.

Cooper WO, Martinez W, Domenico HJ, Callahan ST, Kirkby BP, Finlayson AJR, Foster JJ, Johnson TM, Longo FM, Merrill DG, Jacobs ML, Pichert JW, Catron TF, Moore IN, Webb LE, Karrass J, Hickson GB.

Am J Geriatr Psychiatry. 2018 Sep;26(9):927-936. doi: 10.1016/j.jagp.2018.04.005. Epub 2018 May 8.

11.

TSPO-PET imaging using [18F]PBR06 is a potential translatable biomarker for treatment response in Huntington's disease: preclinical evidence with the p75NTR ligand LM11A-31.

Simmons DA, James ML, Belichenko NP, Semaan S, Condon C, Kuan J, Shuhendler AJ, Miao Z, Chin FT, Longo FM.

Hum Mol Genet. 2018 Aug 15;27(16):2893-2912. doi: 10.1093/hmg/ddy202.

12.

Partial TrkB receptor activation suppresses cortical epileptogenesis through actions on parvalbumin interneurons.

Gu F, Parada I, Yang T, Longo FM, Prince DA.

Neurobiol Dis. 2018 May;113:45-58. doi: 10.1016/j.nbd.2018.01.018. Epub 2018 Feb 2.

13.

Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts.

Zbesko JC, Nguyen TV, Yang T, Frye JB, Hussain O, Hayes M, Chung A, Day WA, Stepanovic K, Krumberger M, Mona J, Longo FM, Doyle KP.

Neurobiol Dis. 2018 Apr;112:63-78. doi: 10.1016/j.nbd.2018.01.007. Epub 2018 Jan 10.

14.

A small-molecule TrkB ligand restores hippocampal synaptic plasticity and object location memory in Rett syndrome mice.

Li W, Bellot-Saez A, Phillips ML, Yang T, Longo FM, Pozzo-Miller L.

Dis Model Mech. 2017 Jul 1;10(7):837-845. doi: 10.1242/dmm.029959.

15.

[18F]GE-180 PET Detects Reduced Microglia Activation After LM11A-31 Therapy in a Mouse Model of Alzheimer's Disease.

James ML, Belichenko NP, Shuhendler AJ, Hoehne A, Andrews LE, Condon C, Nguyen TV, Reiser V, Jones P, Trigg W, Rao J, Gambhir SS, Longo FM.

Theranostics. 2017 Mar 24;7(6):1422-1436. doi: 10.7150/thno.17666. eCollection 2017.

16.

Microglial complement receptor 3 regulates brain Aβ levels through secreted proteolytic activity.

Czirr E, Castello NA, Mosher KI, Castellano JM, Hinkson IV, Lucin KM, Baeza-Raja B, Ryu JK, Li L, Farina SN, Belichenko NP, Longo FM, Akassoglou K, Britschgi M, Cirrito JR, Wyss-Coray T.

J Exp Med. 2017 Apr 3;214(4):1081-1092. doi: 10.1084/jem.20162011. Epub 2017 Mar 15.

17.

A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.

Simmons DA, Belichenko NP, Ford EC, Semaan S, Monbureau M, Aiyaswamy S, Holman CM, Condon C, Shamloo M, Massa SM, Longo FM.

Hum Mol Genet. 2016 Nov 15;25(22):4920-4938. doi: 10.1093/hmg/ddw316.

18.

Neurotrophin Receptor Signaling as a Therapeutic Target for Huntington's Disease.

Simmons DA, Longo FM, Massa SM.

CNS Neurol Disord Drug Targets. 2017;16(3):291-302. doi: 10.2174/1871527315666161107093047. Review.

PMID:
27823570
19.

The Neurotrophic Factor Receptor p75 in the Rat Dorsolateral Striatum Drives Excessive Alcohol Drinking.

Darcq E, Morisot N, Phamluong K, Warnault V, Jeanblanc J, Longo FM, Massa SM, Ron D.

J Neurosci. 2016 Sep 28;36(39):10116-27. doi: 10.1523/JNEUROSCI.4597-14.2016. Epub 2016 Sep 28.

20.

A small molecule TrkB/TrkC neurotrophin receptor co-activator with distinctive effects on neuronal survival and process outgrowth.

Yang T, Massa SM, Tran KC, Simmons DA, Rajadas J, Zeng AY, Jang T, Carsanaro S, Longo FM.

Neuropharmacology. 2016 Nov;110(Pt A):343-361. doi: 10.1016/j.neuropharm.2016.06.015. Epub 2016 Jun 19.

21.

Novel p75 neurotrophin receptor ligand stabilizes neuronal calcium, preserves mitochondrial movement and protects against HIV associated neuropathogenesis.

Meeker RB, Poulton W, Clary G, Schriver M, Longo FM.

Exp Neurol. 2016 Jan;275 Pt 1:182-98. doi: 10.1016/j.expneurol.2015.09.012. Epub 2015 Sep 28.

22.

The BDNF Valine 68 to Methionine Polymorphism Increases Compulsive Alcohol Drinking in Mice That Is Reversed by Tropomyosin Receptor Kinase B Activation.

Warnault V, Darcq E, Morisot N, Phamluong K, Wilbrecht L, Massa SM, Longo FM, Ron D.

Biol Psychiatry. 2016 Mar 15;79(6):463-73. doi: 10.1016/j.biopsych.2015.06.007. Epub 2015 Jun 12.

23.
24.

B-lymphocyte-mediated delayed cognitive impairment following stroke.

Doyle KP, Quach LN, Solé M, Axtell RC, Nguyen TV, Soler-Llavina GJ, Jurado S, Han J, Steinman L, Longo FM, Schneider JA, Malenka RC, Buckwalter MS.

J Neurosci. 2015 Feb 4;35(5):2133-45. doi: 10.1523/JNEUROSCI.4098-14.2015.

25.

PET imaging of translocator protein (18 kDa) in a mouse model of Alzheimer's disease using N-(2,5-dimethoxybenzyl)-2-18F-fluoro-N-(2-phenoxyphenyl)acetamide.

James ML, Belichenko NP, Nguyen TV, Andrews LE, Ding Z, Liu H, Bodapati D, Arksey N, Shen B, Cheng Z, Wyss-Coray T, Gambhir SS, Longo FM, Chin FT.

J Nucl Med. 2015 Feb;56(2):311-6. doi: 10.2967/jnumed.114.141648. Epub 2015 Jan 22.

26.

Amelioration of cisplatin-induced experimental peripheral neuropathy by a small molecule targeting p75 NTR.

Friesland A, Weng Z, Duenas M, Massa SM, Longo FM, Lu Q.

Neurotoxicology. 2014 Dec;45:81-90. doi: 10.1016/j.neuro.2014.09.005. Epub 2014 Sep 30.

27.

Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury.

Xu B, Park D, Ohtake Y, Li H, Hayat U, Liu J, Selzer ME, Longo FM, Li S.

Neurobiol Dis. 2015 Jan;73:36-48. doi: 10.1016/j.nbd.2014.08.030. Epub 2014 Sep 8.

28.

A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.

Simmons DA, Knowles JK, Belichenko NP, Banerjee G, Finkle C, Massa SM, Longo FM.

PLoS One. 2014 Aug 25;9(8):e102136. doi: 10.1371/journal.pone.0102136. eCollection 2014.

29.

Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPP(L/S) transgenic mice.

Nguyen TV, Shen L, Vander Griend L, Quach LN, Belichenko NP, Saw N, Yang T, Shamloo M, Wyss-Coray T, Massa SM, Longo FM.

J Alzheimers Dis. 2014;42(2):459-83. doi: 10.3233/JAD-140036.

30.

Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus.

Grabenstatter HL, Carlsen J, Raol YH, Yang T, Hund D, Cruz Del Angel Y, White AM, Gonzalez MI, Longo FM, Russek SJ, Brooks-Kayal AR.

J Neurosci Res. 2014 Oct;92(10):1307-18. doi: 10.1002/jnr.23402. Epub 2014 May 7.

31.

Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.

Villeda SA, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, Smith LK, Bieri G, Lin K, Berdnik D, Wabl R, Udeochu J, Wheatley EG, Zou B, Simmons DA, Xie XS, Longo FM, Wyss-Coray T.

Nat Med. 2014 Jun;20(6):659-63. doi: 10.1038/nm.3569. Epub 2014 May 4.

32.

A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease.

Simmons DA, Belichenko NP, Yang T, Condon C, Monbureau M, Shamloo M, Jing D, Massa SM, Longo FM.

J Neurosci. 2013 Nov 27;33(48):18712-27. doi: 10.1523/JNEUROSCI.1310-13.2013. Erratum in: J Neurosci. 2014 Jan 29;34(5):2012.

33.

Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease.

Longo FM, Massa SM.

Nat Rev Drug Discov. 2013 Jul;12(7):507-25. Review.

PMID:
23977697
34.

A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain injury.

Shi J, Longo FM, Massa SM.

Stem Cells. 2013 Nov;31(11):2561-74. doi: 10.1002/stem.1516.

35.

Optimizing the use of CROs by academia and small companies.

Lane RF, Friedman LG, Keith C, Braithwaite SP, Frearson JA, Lowe DA, Longo FM, Refolo LM, Watterson DM, Tsaioun K, Shineman DW, Fillit HM.

Nat Rev Drug Discov. 2013 Jul;12(7):487-8. doi: 10.1038/nrd4057. No abstract available.

PMID:
23812255
36.

Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model.

Knowles JK, Simmons DA, Nguyen TV, Vander Griend L, Xie Y, Zhang H, Yang T, Pollak J, Chang T, Arancio O, Buckwalter MS, Wyss-Coray T, Massa SM, Longo FM.

Neurobiol Aging. 2013 Aug;34(8):2052-63. doi: 10.1016/j.neurobiolaging.2013.02.015. Epub 2013 Mar 29.

37.

Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury.

Tep C, Lim TH, Ko PO, Getahun S, Ryu JC, Goettl VM, Massa SM, Basso M, Longo FM, Yoon SO.

J Neurosci. 2013 Jan 9;33(2):397-410. doi: 10.1523/JNEUROSCI.0399-12.2013. Erratum in: J Neurosci. 2014 Jan 29;34(5):2012.

38.

Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function.

Faizi M, Bader PL, Saw N, Nguyen TV, Beraki S, Wyss-Coray T, Longo FM, Shamloo M.

Brain Behav. 2012 Mar;2(2):142-54. doi: 10.1002/brb3.41.

39.

Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic stroke.

Han J, Pollak J, Yang T, Siddiqui MR, Doyle KP, Taravosh-Lahn K, Cekanaviciute E, Han A, Goodman JZ, Jones B, Jing D, Massa SM, Longo FM, Buckwalter MS.

Stroke. 2012 Jul;43(7):1918-24. doi: 10.1161/STROKEAHA.111.641878. Epub 2012 Apr 24.

40.

A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome.

Schmid DA, Yang T, Ogier M, Adams I, Mirakhur Y, Wang Q, Massa SM, Longo FM, Katz DM.

J Neurosci. 2012 Feb 1;32(5):1803-10. doi: 10.1523/JNEUROSCI.0865-11.2012. Erratum in: J Neurosci. 2014 Jan 29;34(5):2012.

41.

Suppression of immunodeficiency virus-associated neural damage by the p75 neurotrophin receptor ligand, LM11A-31, in an in vitro feline model.

Meeker RB, Poulton W, Feng WH, Hudson L, Longo FM.

J Neuroimmune Pharmacol. 2012 Jun;7(2):388-400. doi: 10.1007/s11481-011-9325-0. Epub 2011 Dec 10.

42.

Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors.

Fisher D, Xing B, Dill J, Li H, Hoang HH, Zhao Z, Yang XL, Bachoo R, Cannon S, Longo FM, Sheng M, Silver J, Li S.

J Neurosci. 2011 Oct 5;31(40):14051-66. doi: 10.1523/JNEUROSCI.1737-11.2011.

43.
44.

Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents.

Massa SM, Yang T, Xie Y, Shi J, Bilgen M, Joyce JN, Nehama D, Rajadas J, Longo FM.

J Clin Invest. 2010 May;120(5):1774-85. doi: 10.1172/JCI41356. Epub 2010 Apr 19.

45.

The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo.

Knowles JK, Rajadas J, Nguyen TV, Yang T, LeMieux MC, Vander Griend L, Ishikawa C, Massa SM, Wyss-Coray T, Longo FM.

J Neurosci. 2009 Aug 26;29(34):10627-37. doi: 10.1523/JNEUROSCI.0620-09.2009.

46.

Signaling through Rho GTPase pathway as viable drug target.

Lu Q, Longo FM, Zhou H, Massa SM, Chen YH.

Curr Med Chem. 2009;16(11):1355-65.

47.

Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment.

Yang T, Knowles JK, Lu Q, Zhang H, Arancio O, Moore LA, Chang T, Wang Q, Andreasson K, Rajadas J, Fuller GG, Xie Y, Massa SM, Longo FM.

PLoS One. 2008;3(11):e3604. doi: 10.1371/journal.pone.0003604. Epub 2008 Nov 3.

48.

A common motif targets huntingtin and the androgen receptor to the proteasome.

Chandra S, Shao J, Li JX, Li M, Longo FM, Diamond MI.

J Biol Chem. 2008 Aug 29;283(35):23950-5. doi: 10.1074/jbc.M800467200. Epub 2008 Jun 27.

49.

Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants.

James SE, Burden H, Burgess R, Xie Y, Yang T, Massa SM, Longo FM, Lu Q.

Neurotoxicology. 2008 Jul;29(4):605-12. doi: 10.1016/j.neuro.2008.04.008. Epub 2008 Apr 26.

50.

Small molecule modulation of p75 neurotrophin receptor functions.

Longo FM, Massa SM.

CNS Neurol Disord Drug Targets. 2008 Feb;7(1):63-70. Review.

PMID:
18289033

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