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Items: 9


Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-induced Liver Injury.

Longo DM, Woodhead JL, Walker P, Herédi-Szabó K, Mogyorósi K, Wolenski FS, Dragan YP, Mosedale M, Siler SQ, Watkins PB, Howell BA.

Toxicol Sci. 2018 Oct 5. doi: 10.1093/toxsci/kfy253. [Epub ahead of print]


Refining Liver Safety Risk Assessment: Application of Mechanistic Modeling and Serum Biomarkers to Cimaglermin Alfa (GGF2) Clinical Trials.

Longo DM, Generaux GT, Howell BA, Siler SQ, Antoine DJ, Button D, Caggiano A, Eisen A, Iaci J, Stanulis R, Parry T, Mosedale M, Watkins PB.

Clin Pharmacol Ther. 2017 Dec;102(6):961-969. doi: 10.1002/cpt.711. Epub 2017 May 27.


Elucidating Differences in the Hepatotoxic Potential of Tolcapone and Entacapone With DILIsym(®), a Mechanistic Model of Drug-Induced Liver Injury.

Longo DM, Yang Y, Watkins PB, Howell BA, Siler SQ.

CPT Pharmacometrics Syst Pharmacol. 2016 Jan;5(1):31-9. doi: 10.1002/psp4.12053. Epub 2016 Jan 13.


High-dimensional analysis of the aging immune system: verification of age-associated differences in immune signaling responses in healthy donors.

Longo DM, Louie B, Ptacek J, Friedland G, Evensen E, Putta S, Atallah M, Spellmeyer D, Wang E, Pos Z, Marincola FM, Schaeffer A, Lukac S, Railkar R, Beals CR, Cesano A, Carayannopoulos LN, Hawtin RE.

J Transl Med. 2014 Jun 21;12:178. doi: 10.1186/1479-5876-12-178.


Dual delayed feedback provides sensitivity and robustness to the NF-κB signaling module.

Longo DM, Selimkhanov J, Kearns JD, Hasty J, Hoffmann A, Tsimring LS.

PLoS Comput Biol. 2013;9(6):e1003112. doi: 10.1371/journal.pcbi.1003112. Epub 2013 Jun 27.


Racial differences in B cell receptor signaling pathway activation.

Longo DM, Louie B, Mathi K, Pos Z, Wang E, Hawtin RE, Marincola FM, Cesano A.

J Transl Med. 2012 Jun 6;10:113. doi: 10.1186/1479-5876-10-113.


Single-cell network profiling of peripheral blood mononuclear cells from healthy donors reveals age- and race-associated differences in immune signaling pathway activation.

Longo DM, Louie B, Putta S, Evensen E, Ptacek J, Cordeiro J, Wang E, Pos Z, Hawtin RE, Marincola FM, Cesano A.

J Immunol. 2012 Feb 15;188(4):1717-25. doi: 10.4049/jimmunol.1102514. Epub 2012 Jan 13.


Inter-donor variation in cell subset specific immune signaling responses in healthy individuals.

Longo DM, Louie B, Wang E, Pos Z, Marincola FM, Hawtin RE, Cesano A.

Am J Clin Exp Immunol. 2012 Apr 24;1(1):1-11. Print 2012.


Coherent activation of a synthetic mammalian gene network.

Longo DM, Hoffmann A, Tsimring LS, Hasty J.

Syst Synth Biol. 2010 Mar;4(1):15-23. doi: 10.1007/s11693-009-9044-5. Epub 2009 Sep 11.

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