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Two Pathways of p27Kip1 Degradation Are Required for Murine Lymphoma Driven by Myc and EBV Latent Membrane Protein 2A.

Sora RP, Ikeda M, Longnecker R.

MBio. 2019 Apr 16;10(2). pii: e00548-19. doi: 10.1128/mBio.00548-19.


Ephrin Receptor A4 is a New Kaposi's Sarcoma-Associated Herpesvirus Virus Entry Receptor.

Chen J, Zhang X, Schaller S, Jardetzky TS, Longnecker R.

MBio. 2019 Feb 19;10(1). pii: e02892-18. doi: 10.1128/mBio.02892-18.


Natural Selection of Glycoprotein B Mutations That Rescue the Small-Plaque Phenotype of a Fusion-Impaired Herpes Simplex Virus Mutant.

Fan Q, Kopp SJ, Byskosh NC, Connolly SA, Longnecker R.

MBio. 2018 Oct 16;9(5). pii: e01948-18. doi: 10.1128/mBio.01948-18.


Spleen Tyrosine Kinase Inhibitor TAK-659 Prevents Splenomegaly and Tumor Development in a Murine Model of Epstein-Barr Virus-Associated Lymphoma.

Cen O, Kannan K, Huck Sappal J, Yu J, Zhang M, Arikan M, Ucur A, Ustek D, Cen Y, Gordon L, Longnecker R.

mSphere. 2018 Aug 22;3(4). pii: e00378-18. doi: 10.1128/mSphereDirect.00378-18.


Ephrin receptor A2 is a functional entry receptor for Epstein-Barr virus.

Chen J, Sathiyamoorthy K, Zhang X, Schaller S, Perez White BE, Jardetzky TS, Longnecker R.

Nat Microbiol. 2018 Feb;3(2):172-180. doi: 10.1038/s41564-017-0081-7. Epub 2018 Jan 1.


EBV latent membrane protein 2A orchestrates p27kip1 degradation via Cks1 to accelerate MYC-driven lymphoma in mice.

Fish K, Sora RP, Schaller SJ, Longnecker R, Ikeda M.

Blood. 2017 Dec 7;130(23):2516-2526. doi: 10.1182/blood-2017-07-796821. Epub 2017 Oct 26.


Epstein-Barr Virus Fusion with Epithelial Cells Triggered by gB Is Restricted by a gL Glycosylation Site.

Möhl BS, Chen J, Park SJ, Jardetzky TS, Longnecker R.

J Virol. 2017 Nov 14;91(23). pii: e01255-17. doi: 10.1128/JVI.01255-17. Print 2017 Dec 1.


Inhibition of EBV-mediated membrane fusion by anti-gHgL antibodies.

Sathiyamoorthy K, Jiang J, Möhl BS, Chen J, Zhou ZH, Longnecker R, Jardetzky TS.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8703-E8710. doi: 10.1073/pnas.1704661114. Epub 2017 Sep 22.


Rational Targeting of Cellular Cholesterol in Diffuse Large B-Cell Lymphoma (DLBCL) Enabled by Functional Lipoprotein Nanoparticles: A Therapeutic Strategy Dependent on Cell of Origin.

Rink JS, Yang S, Cen O, Taxter T, McMahon KM, Misener S, Behdad A, Longnecker R, Gordon LI, Thaxton CS.

Mol Pharm. 2017 Nov 6;14(11):4042-4051. doi: 10.1021/acs.molpharmaceut.7b00710. Epub 2017 Oct 3.


The COMPLEXity in herpesvirus entry.

Sathiyamoorthy K, Chen J, Longnecker R, Jardetzky TS.

Curr Opin Virol. 2017 Jun;24:97-104. doi: 10.1016/j.coviro.2017.04.006. Epub 2017 May 21. Review.


Structure-Based Mutations in the Herpes Simplex Virus 1 Glycoprotein B Ectodomain Arm Impart a Slow-Entry Phenotype.

Fan Q, Kopp SJ, Connolly SA, Longnecker R.

MBio. 2017 May 16;8(3). pii: e00614-17. doi: 10.1128/mBio.00614-17.


EBV germinates lymphoma from the germinal center in a battle with T and NK cells.

Fish K, Longnecker R.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):4571-4573. doi: 10.1073/pnas.1704102114. Epub 2017 Apr 25. No abstract available.


Herpesvirus Entry Mediator and Ocular Herpesvirus Infection: More than Meets the Eye.

Edwards RG, Longnecker R.

J Virol. 2017 Jun 9;91(13). pii: e00115-17. doi: 10.1128/JVI.00115-17. Print 2017 Jul 1. Review.


The Type I Interferon Response and Age-Dependent Susceptibility to Herpes Simplex Virus Infection.

Giraldo D, Wilcox DR, Longnecker R.

DNA Cell Biol. 2017 May;36(5):329-334. doi: 10.1089/dna.2017.3668. Epub 2017 Mar 9. Review.


Mapping sites of herpes simplex virus type 1 glycoprotein D that permit insertions and impact gD and gB receptors usage.

Fan Q, Kopp S, Connolly SA, Muller WJ, Longnecker R.

Sci Rep. 2017 Mar 3;7:43712. doi: 10.1038/srep43712.


Murine Corneal Inflammation and Nerve Damage After Infection With HSV-1 Are Promoted by HVEM and Ameliorated by Immune-Modifying Nanoparticle Therapy.

Edwards RG, Kopp SJ, Ifergan I, Shui JW, Kronenberg M, Miller SD, Longnecker R.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):282-291. doi: 10.1167/iovs.16-20668.


Structural basis for Epstein-Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins.

Sathiyamoorthy K, Hu YX, Möhl BS, Chen J, Longnecker R, Jardetzky TS.

Nat Commun. 2016 Dec 8;7:13557. doi: 10.1038/ncomms13557.


Structural and Mechanistic Insights into the Tropism of Epstein-Barr Virus.

Möhl BS, Chen J, Sathiyamoorthy K, Jardetzky TS, Longnecker R.

Mol Cells. 2016 Apr 30;39(4):286-91. doi: 10.14348/molcells.2016.0066. Epub 2016 Apr 6. Review.


The Type I Interferon Response Determines Differences in Choroid Plexus Susceptibility between Newborns and Adults in Herpes Simplex Virus Encephalitis.

Wilcox DR, Folmsbee SS, Muller WJ, Longnecker R.

MBio. 2016 Apr 12;7(2):e00437-16. doi: 10.1128/mBio.00437-16.


A combination of an anti-SLAMF6 antibody and ibrutinib efficiently abrogates expansion of chronic lymphocytic leukemia cells.

Yigit B, Halibozek PJ, Chen SS, O'Keeffe MS, Arnason J, Avigan D, Gattei V, Bhan A, Cen O, Longnecker R, Chiorazzi N, Wang N, Engel P, Terhorst C.

Oncotarget. 2016 May 3;7(18):26346-60. doi: 10.18632/oncotarget.8378.


The Herpes Simplex Virus Neurovirulence Factor γ34.5: Revealing Virus-Host Interactions.

Wilcox DR, Longnecker R.

PLoS Pathog. 2016 Mar 10;12(3):e1005449. doi: 10.1371/journal.ppat.1005449. eCollection 2016 Mar. No abstract available.


Comparative Mutagenesis of Pseudorabies Virus and Epstein-Barr Virus gH Identifies a Structural Determinant within Domain III of gH Required for Surface Expression and Entry Function.

Möhl BS, Schröter C, Klupp BG, Fuchs W, Mettenleiter TC, Jardetzky TS, Longnecker R.

J Virol. 2015 Dec 9;90(5):2285-93. doi: 10.1128/JVI.03032-15.


HSV targeting of the host phosphatase PP1α is required for disseminated disease in the neonate and contributes to pathogenesis in the brain.

Wilcox DR, Muller WJ, Longnecker R.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E6937-44. doi: 10.1073/pnas.1513045112. Epub 2015 Nov 30.


Herpesvirus entry mediator on radiation-resistant cell lineages promotes ocular herpes simplex virus 1 pathogenesis in an entry-independent manner.

Edwards RG, Kopp SJ, Karaba AH, Wilcox DR, Longnecker R.

MBio. 2015 Oct 20;6(5):e01532-15. doi: 10.1128/mBio.01532-15.


Latent Membrane Protein 2 (LMP2).

Cen O, Longnecker R.

Curr Top Microbiol Immunol. 2015;391:151-80. doi: 10.1007/978-3-319-22834-1_5. Review.


Icacinlactone H and Icacintrichantholide from the Tuber of Icacina trichantha.

Zhao M, Onakpa MM, Santarsiero BD, Huang XJ, Zhang XQ, Chen J, Cheng JJ, Longnecker R, Che CT.

Org Lett. 2015 Aug 7;17(15):3834-7. doi: 10.1021/acs.orglett.5b01806. Epub 2015 Jul 17.


A Functional Interaction between Herpes Simplex Virus 1 Glycoprotein gH/gL Domains I and II and gD Is Defined by Using Alphaherpesvirus gH and gL Chimeras.

Fan Q, Longnecker R, Connolly SA.

J Virol. 2015 Jul;89(14):7159-69. doi: 10.1128/JVI.00740-15. Epub 2015 Apr 29.


Differential reliance on autophagy for protection from HSV encephalitis between newborns and adults.

Wilcox DR, Wadhwani NR, Longnecker R, Muller WJ.

PLoS Pathog. 2015 Jan 8;11(1):e1004580. doi: 10.1371/journal.ppat.1004580. eCollection 2015 Jan.


Membrane anchoring of Epstein-Barr virus gp42 inhibits fusion with B cells even with increased flexibility allowed by engineered spacers.

Rowe CL, Chen J, Jardetzky TS, Longnecker R.

MBio. 2015 Jan 6;6(1). pii: e02285-14. doi: 10.1128/mBio.02285-14.


The conserved disulfide bond within domain II of Epstein-Barr virus gH has divergent roles in membrane fusion with epithelial cells and B cells.

Möhl BS, Sathiyamoorthy K, Jardetzky TS, Longnecker R.

J Virol. 2014 Dec;88(23):13570-9. doi: 10.1128/JVI.02272-14. Epub 2014 Sep 17.


Assembly and architecture of the EBV B cell entry triggering complex.

Sathiyamoorthy K, Jiang J, Hu YX, Rowe CL, Möhl BS, Chen J, Jiang W, Mellins ED, Longnecker R, Zhou ZH, Jardetzky TS.

PLoS Pathog. 2014 Aug 21;10(8):e1004309. doi: 10.1371/journal.ppat.1004309. eCollection 2014 Aug.


The Epstein-Barr virus (EBV) glycoprotein B cytoplasmic C-terminal tail domain regulates the energy requirement for EBV-induced membrane fusion.

Chen J, Zhang X, Jardetzky TS, Longnecker R.

J Virol. 2014 Oct;88(20):11686-95. doi: 10.1128/JVI.01349-14. Epub 2014 Aug 6.


Epstein-Barr virus latent membrane protein 2A enhances MYC-driven cell cycle progression in a mouse model of B lymphoma.

Fish K, Chen J, Longnecker R.

Blood. 2014 Jan 23;123(4):530-40. doi: 10.1182/blood-2013-07-517649. Epub 2013 Oct 30.


Oral cavity tumors in younger patients show a poor prognosis and do not contain viral RNA.

Brägelmann J, Dagogo-Jack I, El Dinali M, Stricker T, Brown CD, Zuo Z, Khattri A, Keck M, McNerney ME, Longnecker R, Bieging K, Kocherginsky M, Alexander K, Salgia R, Lingen MW, Vokes EE, White KP, Cohen EE, Seiwert TY.

Oral Oncol. 2013 Jun;49(6):525-33. doi: 10.1016/j.oraloncology.2013.02.003. Epub 2013 Mar 13.


Drosophila Schneider 2 (S2) cells: a novel tool for studying HSV-induced membrane fusion.

Fan Q, Bohannon KP, Longnecker R.

Virology. 2013 Mar 15;437(2):100-9. doi: 10.1016/j.virol.2013.01.004. Epub 2013 Feb 9.


Modulation of Epstein-Barr virus glycoprotein B (gB) fusion activity by the gB cytoplasmic tail domain.

Garcia NJ, Chen J, Longnecker R.

MBio. 2013 Jan 22;4(1):e00571-12. doi: 10.1128/mBio.00571-12.


The large groove found in the gH/gL structure is an important functional domain for Epstein-Barr virus fusion.

Chen J, Jardetzky TS, Longnecker R.

J Virol. 2013 Apr;87(7):3620-7. doi: 10.1128/JVI.03245-12. Epub 2013 Jan 16.


A soluble form of Epstein-Barr virus gH/gL inhibits EBV-induced membrane fusion and does not function in fusion.

Rowe CL, Connolly SA, Chen J, Jardetzky TS, Longnecker R.

Virology. 2013 Feb 5;436(1):118-26. doi: 10.1016/j.virol.2012.10.039. Epub 2012 Nov 29.


Herpesvirus entry mediator is a serotype specific determinant of pathogenesis in ocular herpes.

Karaba AH, Kopp SJ, Longnecker R.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20649-54. doi: 10.1073/pnas.1216967109. Epub 2012 Nov 26.


Multipronged attenuation of macrophage-colony stimulating factor signaling by Epstein-Barr virus BARF1.

Shim AH, Chang RA, Chen X, Longnecker R, He X.

Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):12962-7. doi: 10.1073/pnas.1205309109. Epub 2012 Jul 23.


Is nectin-1 the "master" receptor for deadly herpes B virus infection?

Fan Q, Longnecker R.

Virulence. 2012 Jul 1;3(4):405. doi: 10.4161/viru.20587. Epub 2012 Jun 22. No abstract available.


Dasatinib therapy results in decreased B cell proliferation, splenomegaly, and tumor growth in a murine model of lymphoma expressing Myc and Epstein-Barr virus LMP2A.

Dargart JL, Fish K, Gordon LI, Longnecker R, Cen O.

Antiviral Res. 2012 Jul;95(1):49-56. doi: 10.1016/j.antiviral.2012.05.003. Epub 2012 May 16.


Off-targeting oft-targeted CD20 in cHL.

Gordon LI, Longnecker R.

Blood. 2012 May 3;119(18):4095-6. doi: 10.1182/blood-2012-03-413146.


Epstein-Barr virus LMP2A reduces hyperactivation induced by LMP1 to restore normal B cell phenotype in transgenic mice.

Vrazo AC, Chauchard M, Raab-Traub N, Longnecker R.

PLoS Pathog. 2012;8(4):e1002662. doi: 10.1371/journal.ppat.1002662. Epub 2012 Apr 19.

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