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DDR2 controls breast tumor stiffness and metastasis by regulating integrin mediated mechanotransduction in CAFs.

Bayer SV, Grither WR, Brenot A, Hwang PY, Barcus CE, Ernst M, Pence P, Walter C, Pathak A, Longmore GD.

Elife. 2019 May 30;8. pii: e45508. doi: 10.7554/eLife.45508.


Correction: Mechanical signals regulate and activate SNAIL1 protein to control the fibrogenic response of cancer-associated fibroblasts (doi:10.1242/jcs.180539).

Zhang K, Grither WR, Van Hove S, Biswas H, Ponik SM, Eliceiri KW, Keely PJ, Longmore GD.

J Cell Sci. 2019 May 2;132(9). pii: jcs232348. doi: 10.1242/jcs.232348. No abstract available.


Randomly Distributed K14+ Breast Tumor Cells Polarize to the Leading Edge and Guide Collective Migration in Response to Chemical and Mechanical Environmental Cues.

Hwang PY, Brenot A, King AC, Longmore GD, George SC.

Cancer Res. 2019 Apr 15;79(8):1899-1912. doi: 10.1158/0008-5472.CAN-18-2828. Epub 2019 Mar 12.


LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer.

Nozaki M, Yabuta N, Fukuzawa M, Mukai S, Okamoto A, Sasakura T, Fukushima K, Naito Y, Longmore GD, Nojima H.

Oncotarget. 2019 Feb 1;10(10):1014-1030. doi: 10.18632/oncotarget.26583. eCollection 2019 Feb 1.


Inhibition of tumor-microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain.

Grither WR, Longmore GD.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7786-E7794. doi: 10.1073/pnas.1805020115. Epub 2018 Jul 30.


SNAIL1 action in tumor cells influences macrophage polarization and metastasis in breast cancer through altered GM-CSF secretion.

Brenot A, Knolhoff BL, DeNardo DG, Longmore GD.

Oncogenesis. 2018 Mar 29;7(3):32. doi: 10.1038/s41389-018-0042-x.


TWIST1 induces expression of discoidin domain receptor 2 to promote ovarian cancer metastasis.

Grither WR, Divine LM, Meller EH, Wilke DJ, Desai RA, Loza AJ, Zhao P, Lohrey A, Longmore GD, Fuh KC.

Oncogene. 2018 Mar;37(13):1714-1729. doi: 10.1038/s41388-017-0043-9. Epub 2018 Jan 19.


Cancer-associated fibroblasts support vascular growth through mechanical force.

Sewell-Loftin MK, Bayer SVH, Crist E, Hughes T, Joison SM, Longmore GD, George SC.

Sci Rep. 2017 Oct 3;7(1):12574. doi: 10.1038/s41598-017-13006-x.


Past matrix stiffness primes epithelial cells and regulates their future collective migration through a mechanical memory.

Nasrollahi S, Walter C, Loza AJ, Schimizzi GV, Longmore GD, Pathak A.

Biomaterials. 2017 Nov;146:146-155. doi: 10.1016/j.biomaterials.2017.09.012. Epub 2017 Sep 8.


Upholding a role for EMT in breast cancer metastasis.

Ye X, Brabletz T, Kang Y, Longmore GD, Nieto MA, Stanger BZ, Yang J, Weinberg RA.

Nature. 2017 Jul 5;547(7661):E1-E3. doi: 10.1038/nature22816. No abstract available.


Cell density and actomyosin contractility control the organization of migrating collectives within an epithelium.

Loza AJ, Koride S, Schimizzi GV, Li B, Sun SX, Longmore GD.

Mol Biol Cell. 2016 Nov 7;27(22):3459-3470. Epub 2016 Sep 7.


Action of SNAIL1 in Cardiac Myofibroblasts Is Important for Cardiac Fibrosis following Hypoxic Injury.

Biswas H, Longmore GD.

PLoS One. 2016 Oct 5;11(10):e0162636. doi: 10.1371/journal.pone.0162636. eCollection 2016.


AJUBA LIM Proteins Limit Hippo Activity in Proliferating Cells by Sequestering the Hippo Core Kinase Complex in the Cytosol.

Jagannathan R, Schimizzi GV, Zhang K, Loza AJ, Yabuta N, Nojima H, Longmore GD.

Mol Cell Biol. 2016 Sep 26;36(20):2526-42. doi: 10.1128/MCB.00136-16. Print 2016 Oct 15.


Disruption of the Cdc42/Par6/aPKC or Dlg/Scrib/Lgl Polarity Complex Promotes Epithelial Proliferation via Overlapping Mechanisms.

Schimizzi GV, Maher MT, Loza AJ, Longmore GD.

PLoS One. 2016 Jul 25;11(7):e0159881. doi: 10.1371/journal.pone.0159881. eCollection 2016.


The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis.

Corsa CA, Brenot A, Grither WR, Van Hove S, Loza AJ, Zhang K, Ponik SM, Liu Y, DeNardo DG, Eliceiri KW, Keely PJ, Longmore GD.

Cell Rep. 2016 Jun 14;15(11):2510-23. doi: 10.1016/j.celrep.2016.05.033. Epub 2016 Jun 2.


Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis.

Li-Villarreal N, Forbes MM, Loza AJ, Chen J, Ma T, Helde K, Moens CB, Shin J, Sawada A, Hindes AE, Dubrulle J, Schier AF, Longmore GD, Marlow FL, Solnica-Krezel L.

Development. 2016 May 15;143(10):1832. doi: 10.1242/dev.138859. Epub 2016 Apr 28. No abstract available.


Mechanical signals regulate and activate SNAIL1 protein to control the fibrogenic response of cancer-associated fibroblasts.

Zhang K, Grither WR, Van Hove S, Biswas H, Ponik SM, Eliceiri KW, Keely PJ, Longmore GD.

J Cell Sci. 2016 May 15;129(10):1989-2002. doi: 10.1242/jcs.180539. Epub 2016 Apr 12. Erratum in: J Cell Sci. 2019 May 2;132(9):.


Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development.

Luo X, Fu Y, Loza AJ, Murali B, Leahy KM, Ruhland MK, Gang M, Su X, Zamani A, Shi Y, Lavine KJ, Ornitz DM, Weilbaecher KN, Long F, Novack DV, Faccio R, Longmore GD, Stewart SA.

Cell Rep. 2016 Jan 5;14(1):82-92. doi: 10.1016/j.celrep.2015.12.016. Epub 2015 Dec 24.


Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusions.

Fraley SI, Wu PH, He L, Feng Y, Krisnamurthy R, Longmore GD, Wirtz D.

Sci Rep. 2015 Oct 1;5:14580. doi: 10.1038/srep14580.


Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis.

Li-Villarreal N, Forbes MM, Loza AJ, Chen J, Ma T, Helde K, Moens CB, Shin J, Sawada A, Hindes AE, Dubrulle J, Schier AF, Longmore GD, Marlow FL, Solnica-Krezel L.

Development. 2015 Aug 1;142(15):2704-18. doi: 10.1242/dev.119800. Epub 2015 Jul 9. Erratum in: Development. 2016 May 15;143(10 ):1832.


Ajuba proteins.

Schimizzi GV, Longmore GD.

Curr Biol. 2015 Jun 1;25(11):R445-6. doi: 10.1016/j.cub.2015.02.034.


Transient SNAIL1 expression is necessary for metastatic competence in breast cancer.

Tran HD, Luitel K, Kim M, Zhang K, Longmore GD, Tran DD.

Cancer Res. 2014 Nov 1;74(21):6330-40. doi: 10.1158/0008-5472.CAN-14-0923. Epub 2014 Aug 27.


Rho1 regulates adherens junction remodeling by promoting recycling endosome formation through activation of myosin II.

Yashiro H, Loza AJ, Skeath JB, Longmore GD.

Mol Biol Cell. 2014 Oct 1;25(19):2956-69. doi: 10.1091/mbc.E14-04-0894. Epub 2014 Jul 30.


β-Catenin serves as a clutch between low and high intercellular E-cadherin bond strengths.

Bajpai S, Feng Y, Wirtz D, Longmore GD.

Biophys J. 2013 Nov 19;105(10):2289-300. doi: 10.1016/j.bpj.2013.09.044.


Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability.

Viñas-Castells R, Frías Á, Robles-Lanuza E, Zhang K, Longmore GD, García de Herreros A, Díaz VM.

Nucleic Acids Res. 2014 Jan;42(2):1079-94. doi: 10.1093/nar/gkt935. Epub 2013 Oct 23.


The Arp2/3 complex mediates multigeneration dendritic protrusions for efficient 3-dimensional cancer cell migration.

Giri A, Bajpai S, Trenton N, Jayatilaka H, Longmore GD, Wirtz D.

FASEB J. 2013 Oct;27(10):4089-99. doi: 10.1096/fj.12-224352. Epub 2013 Jun 24.


The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis.

Zhang K, Corsa CA, Ponik SM, Prior JL, Piwnica-Worms D, Eliceiri KW, Keely PJ, Longmore GD.

Nat Cell Biol. 2013 Jun;15(6):677-87. doi: 10.1038/ncb2743. Epub 2013 May 5.


α-actinin1 and 4 tyrosine phosphorylation is critical for stress fiber establishment, maintenance and focal adhesion maturation.

Feng Y, Ngu H, Alford SK, Ward M, Yin F, Longmore GD.

Exp Cell Res. 2013 May 1;319(8):1124-35. doi: 10.1016/j.yexcr.2013.02.009. Epub 2013 Feb 27.


The LINC-anchored actin cap connects the extracellular milieu to the nucleus for ultrafast mechanotransduction.

Chambliss AB, Khatau SB, Erdenberger N, Robinson DK, Hodzic D, Longmore GD, Wirtz D.

Sci Rep. 2013;3:1087. doi: 10.1038/srep01087. Epub 2013 Jan 18.


Actin cap associated focal adhesions and their distinct role in cellular mechanosensing.

Kim DH, Khatau SB, Feng Y, Walcott S, Sun SX, Longmore GD, Wirtz D.

Sci Rep. 2012;2:555. doi: 10.1038/srep00555. Epub 2012 Aug 3.


Mismatch in mechanical and adhesive properties induces pulsating cancer cell migration in epithelial monolayer.

Lee MH, Wu PH, Staunton JR, Ros R, Longmore GD, Wirtz D.

Biophys J. 2012 Jun 20;102(12):2731-41. doi: 10.1016/j.bpj.2012.05.005. Epub 2012 Jun 19.


Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners.

Fraley SI, Feng Y, Giri A, Longmore GD, Wirtz D.

Nat Commun. 2012 Mar 6;3:719. doi: 10.1038/ncomms1711.


The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.

Foxler DE, Bridge KS, James V, Webb TM, Mee M, Wong SC, Feng Y, Constantin-Teodosiu D, Petursdottir TE, Bjornsson J, Ingvarsson S, Ratcliffe PJ, Longmore GD, Sharp TV.

Nat Cell Biol. 2012 Jan 29;14(2):201-8. doi: 10.1038/ncb2424.


Temporal and spatial cooperation of Snail1 and Twist1 during epithelial-mesenchymal transition predicts for human breast cancer recurrence.

Tran DD, Corsa CA, Biswas H, Aft RL, Longmore GD.

Mol Cancer Res. 2011 Dec;9(12):1644-57. doi: 10.1158/1541-7786.MCR-11-0371. Epub 2011 Oct 17.


Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation.

Zhang K, Rodriguez-Aznar E, Yabuta N, Owen RJ, Mingot JM, Nojima H, Nieto MA, Longmore GD.

EMBO J. 2012 Jan 4;31(1):29-43. doi: 10.1038/emboj.2011.357. Epub 2011 Sep 27.


A multifunctional lentiviral-based gene knockdown with concurrent rescue that controls for off-target effects of RNAi.

Feng Y, Nie L, Thakur MD, Su Q, Chi Z, Zhao Y, Longmore GD.

Genomics Proteomics Bioinformatics. 2010 Dec;8(4):238-45. doi: 10.1016/S1672-0229(10)60025-3.


Context-dependent compensatory proliferation in epithelial homeostasis and tumorigenesis.

Warner SJ, Longmore GD.

Cell Cycle. 2010 Oct 15;9(20):4037-8. Epub 2010 Oct 7. No abstract available.


LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing.

James V, Zhang Y, Foxler DE, de Moor CH, Kong YW, Webb TM, Self TJ, Feng Y, Lagos D, Chu CY, Rana TM, Morley SJ, Longmore GD, Bushell M, Sharp TV.

Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12499-504. doi: 10.1073/pnas.0914987107. Epub 2010 Jun 28.


A distinctive role for focal adhesion proteins in three-dimensional cell motility.

Fraley SI, Feng Y, Krishnamurthy R, Kim DH, Celedon A, Longmore GD, Wirtz D.

Nat Cell Biol. 2010 Jun;12(6):598-604. doi: 10.1038/ncb2062. Epub 2010 May 16.


The Cdc42/Par6/aPKC polarity complex regulates apoptosis-induced compensatory proliferation in epithelia.

Warner SJ, Yashiro H, Longmore GD.

Curr Biol. 2010 Apr 27;20(8):677-86. doi: 10.1016/j.cub.2010.03.025. Epub 2010 Apr 8.


Prediction of sphingosine 1-phosphate-stimulated endothelial cell migration rates using biochemical measurements.

Alford SK, Wang Y, Feng Y, Longmore GD, Elbert DL.

Ann Biomed Eng. 2010 Aug;38(8):2775-90. doi: 10.1007/s10439-010-0014-6. Epub 2010 Apr 1.


Ajuba LIM proteins are negative regulators of the Hippo signaling pathway.

Das Thakur M, Feng Y, Jagannathan R, Seppa MJ, Skeath JB, Longmore GD.

Curr Biol. 2010 Apr 13;20(7):657-62. doi: 10.1016/j.cub.2010.02.035. Epub 2010 Mar 18.


LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling.

Hou Z, Peng H, White DE, Negorev DG, Maul GG, Feng Y, Longmore GD, Waxman S, Zelent A, Rauscher FJ 3rd.

Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2938-43. doi: 10.1073/pnas.0908656107. Epub 2010 Jan 26.


Effect of focal adhesion proteins on endothelial cell adhesion, motility and orientation response to cyclic strain.

Ngu H, Feng Y, Lu L, Oswald SJ, Longmore GD, Yin FC.

Ann Biomed Eng. 2010 Jan;38(1):208-22. doi: 10.1007/s10439-009-9826-7. Epub 2009 Oct 27.


Cdc42 antagonizes Rho1 activity at adherens junctions to limit epithelial cell apical tension.

Warner SJ, Longmore GD.

J Cell Biol. 2009 Oct 5;187(1):119-33. doi: 10.1083/jcb.200906047.


Erythroid-stimulating agents in cancer therapy: potential dangers and biologic mechanisms.

Hadland BK, Longmore GD.

J Clin Oncol. 2009 Sep 1;27(25):4217-26. doi: 10.1200/JCO.2008.21.6945. Epub 2009 Jul 27. Review.


Distinct functions for Rho1 in maintaining adherens junctions and apical tension in remodeling epithelia.

Warner SJ, Longmore GD.

J Cell Biol. 2009 Jun 15;185(6):1111-25. doi: 10.1083/jcb.200901029. Epub 2009 Jun 8.


Loss of alpha-catenin decreases the strength of single E-cadherin bonds between human cancer cells.

Bajpai S, Feng Y, Krishnamurthy R, Longmore GD, Wirtz D.

J Biol Chem. 2009 Jul 3;284(27):18252-9. doi: 10.1074/jbc.M109.000661. Epub 2009 May 19.


p38delta Mitogen-activated protein kinase is essential for skin tumor development in mice.

Schindler EM, Hindes A, Gribben EL, Burns CJ, Yin Y, Lin MH, Owen RJ, Longmore GD, Kissling GE, Arthur JS, Efimova T.

Cancer Res. 2009 Jun 1;69(11):4648-55. doi: 10.1158/0008-5472.CAN-08-4455. Epub 2009 May 19.


The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development.

Sharp TV, Al-Attar A, Foxler DE, Ding L, de A Vallim TQ, Zhang Y, Nijmeh HS, Webb TM, Nicholson AG, Zhang Q, Kraja A, Spendlove I, Osborne J, Mardis E, Longmore GD.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19932-7. doi: 10.1073/pnas.0805003105. Epub 2008 Dec 5.

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