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Items: 1 to 50 of 143

1.

Mitochondrial single-stranded DNA binding protein novel de novo SSBP1 mutation in a child with single large-scale mtDNA deletion (SLSMD) clinically manifesting as Pearson, Kearns-Sayre, and Leigh syndromes.

Gustafson MA, McCormick EM, Perera L, Longley MJ, Bai R, Kong J, Dulik M, Shen L, Goldstein AC, McCormack SE, Laskin BL, Leroy BP, Ortiz-Gonzalez XR, Ellington MG, Copeland WC, Falk MJ.

PLoS One. 2019 Sep 3;14(9):e0221829. doi: 10.1371/journal.pone.0221829. eCollection 2019.

2.

Epigenetic aging is accelerated in alcohol use disorder and regulated by genetic variation in APOL2.

Luo A, Jung J, Longley M, Rosoff DB, Charlet K, Muench C, Lee J, Hodgkinson CA, Goldman D, Horvath S, Kaminsky ZA, Lohoff FW.

Neuropsychopharmacology. 2019 Aug 29. doi: 10.1038/s41386-019-0500-y. [Epub ahead of print]

PMID:
31466081
3.

Association of High-Intensity Binge Drinking With Lipid and Liver Function Enzyme Levels.

Rosoff DB, Charlet K, Jung J, Lee J, Muench C, Luo A, Longley M, Mauro KL, Lohoff FW.

JAMA Netw Open. 2019 Jun 5;2(6):e195844. doi: 10.1001/jamanetworkopen.2019.5844.

4.

PCSK9 is Increased in Cerebrospinal Fluid of Individuals With Alcohol Use Disorder.

Lee JS, Rosoff D, Luo A, Longley M, Phillips M, Charlet K, Muench C, Jung J, Lohoff FW.

Alcohol Clin Exp Res. 2019 Jun;43(6):1163-1169. doi: 10.1111/acer.14039. Epub 2019 May 3.

PMID:
30933362
5.

A comparison of fixation methods for supracondylar and distal humeral shaft fractures of the dog and cat.

Longley M, Chase D, Calvo I, Hall J, Langley-Hobbs SJ, Farrell M.

Can Vet J. 2018 Dec;59(12):1299-1304.

6.

Incidence and types of preceding and subsequent fractures in cats with patellar fracture and dental anomaly syndrome.

Reyes NA, Longley M, Bailey S, Langley-Hobbs SJ.

J Feline Med Surg. 2019 Aug;21(8):750-764. doi: 10.1177/1098612X18800837. Epub 2018 Oct 22.

PMID:
30345863
7.

Single-molecule DREEM imaging reveals DNA wrapping around human mitochondrial single-stranded DNA binding protein.

Kaur P, Longley MJ, Pan H, Wang H, Copeland WC.

Nucleic Acids Res. 2018 Nov 30;46(21):11287-11302. doi: 10.1093/nar/gky875.

8.

Systematic review update of observational studies further supports aspirin role in cancer treatment: Time to share evidence and decision-making with patients?

Elwood PC, Pickering JE, Morgan G, Galante J, Weightman AL, Morris D, Longley M, Mason M, Adams R, Dolwani S, Chia W K J, Lanas A.

PLoS One. 2018 Sep 25;13(9):e0203957. doi: 10.1371/journal.pone.0203957. eCollection 2018.

9.

Skull pathology in 10 cats with patellar fracture and dental anomaly syndrome.

Howes C, Longley M, Reyes N, Major AC, Gracis M, Fulton Scanlan A, Bailey S, Langley-Hobbs SJ.

J Feline Med Surg. 2019 Aug;21(8):793-800. doi: 10.1177/1098612X18797368. Epub 2018 Sep 10.

PMID:
30196748
10.

Characterization of the human homozygous R182W POLG2 mutation in mitochondrial DNA depletion syndrome.

Hoff KE, DeBalsi KL, Sanchez-Quintero MJ, Longley MJ, Hirano M, Naini AB, Copeland WC.

PLoS One. 2018 Aug 29;13(8):e0203198. doi: 10.1371/journal.pone.0203198. eCollection 2018.

11.

The C-terminal tail of the NEIL1 DNA glycosylase interacts with the human mitochondrial single-stranded DNA binding protein.

Sharma N, Chakravarthy S, Longley MJ, Copeland WC, Prakash A.

DNA Repair (Amst). 2018 May;65:11-19. doi: 10.1016/j.dnarep.2018.02.012. Epub 2018 Mar 6.

12.

Healthy living and cancer: evidence from UK Biobank.

Elwood PC, Whitmarsh A, Gallacher J, Bayer A, Adams R, Heslop L, Pickering J, Morgan G, Galante J, Dolwani S, Longley M, Roberts ZE.

Ecancermedicalscience. 2018 Jan 4;12:792. doi: 10.3332/ecancer.2018.792. eCollection 2018.

13.

DNA polymerase β: A missing link of the base excision repair machinery in mammalian mitochondria.

Prasad R, Çağlayan M, Dai DP, Nadalutti CA, Zhao ML, Gassman NR, Janoshazi AK, Stefanick DF, Horton JK, Krasich R, Longley MJ, Copeland WC, Griffith JD, Wilson SH.

DNA Repair (Amst). 2017 Dec;60:77-88. doi: 10.1016/j.dnarep.2017.10.011. Epub 2017 Oct 28.

14.

Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts.

Çaglayan M, Prasad R, Krasich R, Longley MJ, Kadoda K, Tsuda M, Sasanuma H, Takeda S, Tano K, Copeland WC, Wilson SH.

Nucleic Acids Res. 2017 Sep 29;45(17):10079-10088. doi: 10.1093/nar/gkx654.

15.

An open source device for operant licking in rats.

Longley M, Willis EL, Tay CX, Chen H.

PeerJ. 2017 Feb 14;5:e2981. doi: 10.7717/peerj.2981. eCollection 2017.

16.

Synergistic Effects of the in cis T251I and P587L Mitochondrial DNA Polymerase γ Disease Mutations.

DeBalsi KL, Longley MJ, Hoff KE, Copeland WC.

J Biol Chem. 2017 Mar 10;292(10):4198-4209. doi: 10.1074/jbc.M116.773341. Epub 2017 Feb 2.

17.

Biomechanical evaluation of simulated feline patellar fracture repairs.

Longley M, Langley-Hobbs S, Tarlton J.

Vet Comp Orthop Traumatol. 2017 Mar 20;30(2):125-130. doi: 10.3415/VCOT-16-03-0050. Epub 2017 Jan 17.

PMID:
28094421
18.

Systematic Review and Meta-Analysis of Randomised Trials to Ascertain Fatal Gastrointestinal Bleeding Events Attributable to Preventive Low-Dose Aspirin: No Evidence of Increased Risk.

Elwood PC, Morgan G, Galante J, Chia JW, Dolwani S, Graziano JM, Kelson M, Lanas A, Longley M, Phillips CJ, Pickering J, Roberts SE, Soon SS, Steward W, Morris D, Weightman AL.

PLoS One. 2016 Nov 15;11(11):e0166166. doi: 10.1371/journal.pone.0166166. eCollection 2016.

19.

United Kingdom: Health System Review.

Cylus J, Richardson E, Findley L, Longley M, O'Neill C, Steel D.

Health Syst Transit. 2015;17(5):1-126.

20.

Analysis of Translesion DNA Synthesis by the Mitochondrial DNA Polymerase γ.

Copeland WC, Kasiviswanathan R, Longley MJ.

Methods Mol Biol. 2016;1351:19-26. doi: 10.1007/978-1-4939-3040-1_2.

21.

Retained and persistent deciduous teeth in cats.

Langley-Hobbs SJ, Longley M, Gracis M.

Vet Rec. 2015 Jan 24;176(4):106. doi: 10.1136/vr.h343. No abstract available.

PMID:
25614551
22.

End blame game between managers and doctors.

Banfield P, Longley M.

Health Serv J. 2014 Mar 21;123(6391):16-7. No abstract available.

PMID:
24956726
23.

Distribution of neural plasticity in cerebellum-dependent motor learning.

Longley M, Yeo CH.

Prog Brain Res. 2014;210:79-101. doi: 10.1016/B978-0-444-63356-9.00004-2.

PMID:
24916290
24.

Mitochondrial genome maintenance in health and disease.

Copeland WC, Longley MJ.

DNA Repair (Amst). 2014 Jul;19:190-8. doi: 10.1016/j.dnarep.2014.03.010. Epub 2014 Apr 26. Review.

25.

Healthy lifestyles reduce the incidence of chronic diseases and dementia: evidence from the Caerphilly cohort study.

Elwood P, Galante J, Pickering J, Palmer S, Bayer A, Ben-Shlomo Y, Longley M, Gallacher J.

PLoS One. 2013 Dec 9;8(12):e81877. doi: 10.1371/journal.pone.0081877. eCollection 2013.

26.

Evaluating the role of Cardiac Genetics Nurses in inherited cardiac conditions services using a Maturity Matrix.

Kirk M, Simpson A, Llewellyn M, Tonkin E, Cohen D, Longley M.

Eur J Cardiovasc Nurs. 2014 Oct;13(5):418-28. doi: 10.1177/1474515113502748. Epub 2013 Sep 6.

27.

United Kingdom (Wales): Health system review.

Longley M, Riley N, Davies P, Hernandez-Quevedo C.

Health Syst Transit. 2012;14(11):xiii-xviii, 1-84.

28.

What is your diagnosis? Feline metaphyseal osteopathy or capital femoral physeal dysplasia.

Longley MJ, Marshall WG.

J Am Vet Med Assoc. 2013 Feb 1;242(3):315-6. doi: 10.2460/javma.242.3.315. No abstract available.

PMID:
23327172
29.

Prophylactic aspirin and public health.

Elwood P, Longley M.

J Public Health (Oxf). 2012 Aug;34(3):320-1. doi: 10.1093/pubmed/fds051. Epub 2012 Jun 21. No abstract available.

PMID:
22722094
30.

Aspirin for the older person: report of a meeting at the Royal Society of Medicine, London, 3rd November 2011.

Armitage J, Cuzick J, Elwood P, Longley M, Perkins A, Spencer K, Turner H, Porch S, Lyness S, Kennedy J, Henderson G.

Ecancermedicalscience. 2012;6:245. doi: 10.3332/ecancer.2012.245. Epub 2012 Feb 28.

31.

A p.R369G POLG2 mutation associated with adPEO and multiple mtDNA deletions causes decreased affinity between polymerase γ subunits.

Craig K, Young MJ, Blakely EL, Longley MJ, Turnbull DM, Copeland WC, Taylor RW.

Mitochondrion. 2012 Mar;12(2):313-9. doi: 10.1016/j.mito.2011.11.006. Epub 2011 Dec 4.

32.

A national health inequalities fund for Wales: concept, design and implementation.

Longley M, Llewellyn M, Beddow T, Cohen D, Corson J, Warner M.

Health Policy. 2011 Dec;103(2-3):141-8. doi: 10.1016/j.healthpol.2011.08.001. Epub 2011 Sep 15.

PMID:
21920620
33.

Biochemical analysis of human POLG2 variants associated with mitochondrial disease.

Young MJ, Longley MJ, Li FY, Kasiviswanathan R, Wong LJ, Copeland WC.

Hum Mol Genet. 2011 Aug 1;20(15):3052-66. doi: 10.1093/hmg/ddr209. Epub 2011 May 9.

34.

No reductions and some improvements in South African lay HIV/AIDS counsellors' motivational interviewing competence one year after brief training.

Evangeli M, Longley M, Swartz L.

AIDS Care. 2011 Mar;23(3):269-73. doi: 10.1080/09540121.2010.507747.

PMID:
21347889
35.

Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity.

Longley MJ, Humble MM, Sharief FS, Copeland WC.

J Biol Chem. 2010 Sep 24;285(39):29690-702. doi: 10.1074/jbc.M110.151795. Epub 2010 Jul 20.

36.

Meeting report: Identification of biomarkers for early detection of mitochondrial dysfunction.

Shaughnessy DT, Worth L Jr, Lawler CP, McAllister KA, Longley MJ, Copeland WC.

Mitochondrion. 2010 Aug;10(5):579-81. doi: 10.1016/j.mito.2010.02.001. Epub 2010 Mar 1. No abstract available.

PMID:
20197119
37.

Purification and functional characterization of human mitochondrial DNA polymerase gamma harboring disease mutations.

Kasiviswanathan R, Longley MJ, Young MJ, Copeland WC.

Methods. 2010 Aug;51(4):379-84. doi: 10.1016/j.ymeth.2010.02.015. Epub 2010 Feb 20. Review.

38.

My health: whose responsibility? A jury decides.

Elwood P, Longley M.

J Epidemiol Community Health. 2010 Sep;64(9):761-4. doi: 10.1136/jech.2009.087767. Epub 2009 Nov 5.

PMID:
19897471
39.

Preparation of human mitochondrial single-stranded DNA-binding protein.

Longley MJ, Smith LA, Copeland WC.

Methods Mol Biol. 2009;554:73-85. doi: 10.1007/978-1-59745-521-3_5.

40.

Hyper-use of the ED.

Shiber JR, Longley MB, Brewer KL.

Am J Emerg Med. 2009 Jun;27(5):588-94. doi: 10.1016/j.ajem.2008.05.006.

PMID:
19497466
41.

Surgical compared with nonoperative treatment for lumbar degenerative spondylolisthesis. four-year results in the Spine Patient Outcomes Research Trial (SPORT) randomized and observational cohorts.

Weinstein JN, Lurie JD, Tosteson TD, Zhao W, Blood EA, Tosteson AN, Birkmeyer N, Herkowitz H, Longley M, Lenke L, Emery S, Hu SS.

J Bone Joint Surg Am. 2009 Jun;91(6):1295-304. doi: 10.2106/JBJS.H.00913.

42.

Disease mutations in the human mitochondrial DNA polymerase thumb subdomain impart severe defects in mitochondrial DNA replication.

Kasiviswanathan R, Longley MJ, Chan SS, Copeland WC.

J Biol Chem. 2009 Jul 17;284(29):19501-10. doi: 10.1074/jbc.M109.011940. Epub 2009 May 28.

43.

Human DNA polymerase theta possesses 5'-dRP lyase activity and functions in single-nucleotide base excision repair in vitro.

Prasad R, Longley MJ, Sharief FS, Hou EW, Copeland WC, Wilson SH.

Nucleic Acids Res. 2009 Apr;37(6):1868-77. doi: 10.1093/nar/gkp035. Epub 2009 Feb 2.

44.

Surgical treatment of spinal stenosis with and without degenerative spondylolisthesis: cost-effectiveness after 2 years.

Tosteson AN, Lurie JD, Tosteson TD, Skinner JS, Herkowitz H, Albert T, Boden SD, Bridwell K, Longley M, Andersson GB, Blood EA, Grove MR, Weinstein JN; SPORT Investigators.

Ann Intern Med. 2008 Dec 16;149(12):845-53.

45.

DNA2 resolves expanding flap in mitochondrial base excision repair.

Copeland WC, Longley MJ.

Mol Cell. 2008 Nov 21;32(4):457-8. doi: 10.1016/j.molcel.2008.11.007.

46.

Corrective osteotomies in spine surgery.

Gill JB, Levin A, Burd T, Longley M.

J Bone Joint Surg Am. 2008 Nov;90(11):2509-20. doi: 10.2106/JBJS.H.00081. Review.

PMID:
18978421
47.

Long patch base excision repair in mammalian mitochondrial genomes.

Szczesny B, Tann AW, Longley MJ, Copeland WC, Mitra S.

J Biol Chem. 2008 Sep 26;283(39):26349-56. doi: 10.1074/jbc.M803491200. Epub 2008 Jul 17.

48.

SPORT lumbar intervertebral disk herniation and back pain: does treatment, location, or morphology matter?

Pearson AM, Blood EA, Frymoyer JW, Herkowitz H, Abdu WA, Woodward R, Longley M, Emery SE, Lurie JD, Tosteson TD, Weinstein JN.

Spine (Phila Pa 1976). 2008 Feb 15;33(4):428-35. doi: 10.1097/BRS.0b013e31816469de.

49.

Progressive external ophthalmoplegia and vision and hearing loss in a patient with mutations in POLG2 and OPA1.

Ferraris S, Clark S, Garelli E, Davidzon G, Moore SA, Kardon RH, Bienstock RJ, Longley MJ, Mancuso M, Gutiérrez Ríos P, Hirano M, Copeland WC, DiMauro S.

Arch Neurol. 2008 Jan;65(1):125-31. doi: 10.1001/archneurol.2007.9.

50.

Potent achiral agonists of the ghrelin (growth hormone secretagogue) receptor. Part I: Lead identification.

Heightman TD, Scott JS, Longley M, Bordas V, Dean DK, Elliott R, Hutley G, Witherington J, Abberley L, Passingham B, Berlanga M, de Los Frailes M, Wise A, Powney B, Muir A, McKay F, Butler S, Winborn K, Gardner C, Darton J, Campbell C, Sanger G.

Bioorg Med Chem Lett. 2007 Dec 1;17(23):6584-7. Epub 2007 Sep 25.

PMID:
17942309

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