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Items: 1 to 50 of 76

1.

Structure-function relationships of the Mre11 protein in the control of DNA end bridging and processing.

Marsella A, Cassani C, Casari E, Tisi R, Longhese MP.

Curr Genet. 2018 Jun 19. doi: 10.1007/s00294-018-0861-5. [Epub ahead of print] Review.

PMID:
29922906
2.

Tel1/ATM prevents degradation of replication forks that reverse after topoisomerase poisoning.

Menin L, Ursich S, Trovesi C, Zellweger R, Lopes M, Longhese MP, Clerici M.

EMBO Rep. 2018 May 8. pii: e201745535. doi: 10.15252/embr.201745535. [Epub ahead of print]

PMID:
29739811
3.

Structurally distinct Mre11 domains mediate MRX functions in resection, end-tethering and DNA damage resistance.

Cassani C, Gobbini E, Vertemara J, Wang W, Marsella A, Sung P, Tisi R, Zampella G, Longhese MP.

Nucleic Acids Res. 2018 Apr 6;46(6):2990-3008. doi: 10.1093/nar/gky086.

4.

Rad9/53BP1 protects stalled replication forks from degradation in Mec1/ATR-defective cells.

Villa M, Bonetti D, Carraro M, Longhese MP.

EMBO Rep. 2018 Feb;19(2):351-367. doi: 10.15252/embr.201744910. Epub 2018 Jan 4.

PMID:
29301856
5.

Analysis of De Novo Telomere Addition by Southern Blot.

Bonetti D, Longhese MP.

Methods Mol Biol. 2018;1672:363-373. doi: 10.1007/978-1-4939-7306-4_25.

PMID:
29043636
6.

PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response.

Ferrari E, Bruhn C, Peretti M, Cassani C, Carotenuto WV, Elgendy M, Shubassi G, Lucca C, Bermejo R, Varasi M, Minucci S, Longhese MP, Foiani M.

Mol Cell. 2017 Jul 20;67(2):266-281.e4. doi: 10.1016/j.molcel.2017.05.027. Epub 2017 Jun 22.

7.

The RNA binding protein Npl3 promotes resection of DNA double-strand breaks by regulating the levels of Exo1.

Colombo CV, Trovesi C, Menin L, Longhese MP, Clerici M.

Nucleic Acids Res. 2017 Jun 20;45(11):6530-6545. doi: 10.1093/nar/gkx347.

8.

Functions and regulation of the MRX complex at DNA double-strand breaks.

Gobbini E, Cassani C, Villa M, Bonetti D, Longhese MP.

Microb Cell. 2016 Jul 27;3(8):329-337. doi: 10.15698/mic2016.08.517. Review.

9.

Regulation of telomere metabolism by the RNA processing protein Xrn1.

Cesena D, Cassani C, Rizzo E, Lisby M, Bonetti D, Longhese MP.

Nucleic Acids Res. 2017 Apr 20;45(7):3860-3874. doi: 10.1093/nar/gkx072.

10.

Coupling end resection with the checkpoint response at DNA double-strand breaks.

Villa M, Cassani C, Gobbini E, Bonetti D, Longhese MP.

Cell Mol Life Sci. 2016 Oct;73(19):3655-63. doi: 10.1007/s00018-016-2262-6. Epub 2016 May 3. Review.

PMID:
27141941
11.

Tel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand Breaks.

Cassani C, Gobbini E, Wang W, Niu H, Clerici M, Sung P, Longhese MP.

PLoS Biol. 2016 Feb 22;14(2):e1002387. doi: 10.1371/journal.pbio.1002387. eCollection 2016 Feb.

12.

Sae2 Function at DNA Double-Strand Breaks Is Bypassed by Dampening Tel1 or Rad53 Activity.

Gobbini E, Villa M, Gnugnoli M, Menin L, Clerici M, Longhese MP.

PLoS Genet. 2015 Nov 19;11(11):e1005685. doi: 10.1371/journal.pgen.1005685. eCollection 2015 Nov.

13.

Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae.

Manfrini N, Clerici M, Wery M, Colombo CV, Descrimes M, Morillon A, d'Adda di Fagagna F, Longhese MP.

Elife. 2015 Jul 31;4. doi: 10.7554/eLife.08942.

14.

Escape of Sgs1 from Rad9 inhibition reduces the requirement for Sae2 and functional MRX in DNA end resection.

Bonetti D, Villa M, Gobbini E, Cassani C, Tedeschi G, Longhese MP.

EMBO Rep. 2015 Mar;16(3):351-61. doi: 10.15252/embr.201439764. Epub 2015 Jan 30.

15.

RNA-processing proteins regulate Mec1/ATR activation by promoting generation of RPA-coated ssDNA.

Manfrini N, Trovesi C, Wery M, Martina M, Cesena D, Descrimes M, Morillon A, d'Adda di Fagagna F, Longhese MP.

EMBO Rep. 2015 Feb;16(2):221-31. doi: 10.15252/embr.201439458. Epub 2014 Dec 19.

16.

Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing.

Rossiello F, Herbig U, Longhese MP, Fumagalli M, d'Adda di Fagagna F.

Curr Opin Genet Dev. 2014 Jun;26:89-95. doi: 10.1016/j.gde.2014.06.009. Epub 2014 Aug 11. Review.

17.

Saccharomyces cerevisiae Rif1 cooperates with MRX-Sae2 in promoting DNA-end resection.

Martina M, Bonetti D, Villa M, Lucchini G, Longhese MP.

EMBO Rep. 2014 Jun;15(6):695-704. doi: 10.1002/embr.201338338. Epub 2014 Apr 1.

18.

Telomere uncapping at the crossroad between cell cycle arrest and carcinogenesis.

Gobbini E, Trovesi C, Cassani C, Longhese MP.

Mol Cell Oncol. 2014 Jul 28;1(1):e29901. doi: 10.4161/mco.29901. eCollection 2014. Review.

19.

Mec1/ATR regulates the generation of single-stranded DNA that attenuates Tel1/ATM signaling at DNA ends.

Clerici M, Trovesi C, Galbiati A, Lucchini G, Longhese MP.

EMBO J. 2014 Feb 3;33(3):198-216. doi: 10.1002/embj.201386041. Epub 2013 Dec 19.

20.

Telomere-end processing: mechanisms and regulation.

Bonetti D, Martina M, Falcettoni M, Longhese MP.

Chromosoma. 2013 Oct 12. [Epub ahead of print]

PMID:
24122006
21.

Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks.

Gobbini E, Cesena D, Galbiati A, Lockhart A, Longhese MP.

DNA Repair (Amst). 2013 Oct;12(10):791-9. doi: 10.1016/j.dnarep.2013.07.009. Epub 2013 Aug 13. Review.

PMID:
23953933
22.

Regulation of the DNA damage response by cyclin-dependent kinases.

Trovesi C, Manfrini N, Falcettoni M, Longhese MP.

J Mol Biol. 2013 Nov 29;425(23):4756-66. doi: 10.1016/j.jmb.2013.04.013. Epub 2013 Apr 17. Review.

PMID:
23603016
23.

Tbf1 and Vid22 promote resection and non-homologous end joining of DNA double-strand break ends.

Bonetti D, Anbalagan S, Lucchini G, Clerici M, Longhese MP.

EMBO J. 2013 Jan 23;32(2):275-89. doi: 10.1038/emboj.2012.327. Epub 2012 Dec 7.

24.

G(1)/S and G(2)/M cyclin-dependent kinase activities commit cells to death in the absence of the S-phase checkpoint.

Manfrini N, Gobbini E, Baldo V, Trovesi C, Lucchini G, Longhese MP.

Mol Cell Biol. 2012 Dec;32(24):4971-85. doi: 10.1128/MCB.00956-12. Epub 2012 Oct 8.

25.

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation.

Fumagalli M, Rossiello F, Clerici M, Barozzi S, Cittaro D, Kaplunov JM, Bucci G, Dobreva M, Matti V, Beausejour CM, Herbig U, Longhese MP, d'Adda di Fagagna F.

Nat Cell Biol. 2012 Mar 18;14(4):355-65. doi: 10.1038/ncb2466. Erratum in: Nat Cell Biol. 2012 May;14(5):555.

26.

A balance between Tel1 and Rif2 activities regulates nucleolytic processing and elongation at telomeres.

Martina M, Clerici M, Baldo V, Bonetti D, Lucchini G, Longhese MP.

Mol Cell Biol. 2012 May;32(9):1604-17. doi: 10.1128/MCB.06547-11. Epub 2012 Feb 21.

27.

The role of shelterin in maintaining telomere integrity.

Longhese MP, Anbalagan S, Martina M, Bonetti D.

Front Biosci (Landmark Ed). 2012 Jan 1;17:1715-28. Review.

PMID:
22201831
28.

Distinct Cdk1 requirements during single-strand annealing, noncrossover, and crossover recombination.

Trovesi C, Falcettoni M, Lucchini G, Clerici M, Longhese MP.

PLoS Genet. 2011 Aug;7(8):e1002263. doi: 10.1371/journal.pgen.1002263. Epub 2011 Aug 25.

29.

Rif1 supports the function of the CST complex in yeast telomere capping.

Anbalagan S, Bonetti D, Lucchini G, Longhese MP.

PLoS Genet. 2011 Mar;7(3):e1002024. doi: 10.1371/journal.pgen.1002024. Epub 2011 Mar 17.

30.

The MRX complex plays multiple functions in resection of Yku- and Rif2-protected DNA ends.

Bonetti D, Clerici M, Manfrini N, Lucchini G, Longhese MP.

PLoS One. 2010 Nov 30;5(11):e14142. doi: 10.1371/journal.pone.0014142.

31.

Mechanisms and regulation of DNA end resection.

Longhese MP, Bonetti D, Manfrini N, Clerici M.

EMBO J. 2010 Sep 1;29(17):2864-74. doi: 10.1038/emboj.2010.165. Epub 2010 Jul 20. Review.

32.

Shelterin-like proteins and Yku inhibit nucleolytic processing of Saccharomyces cerevisiae telomeres.

Bonetti D, Clerici M, Anbalagan S, Martina M, Lucchini G, Longhese MP.

PLoS Genet. 2010 May 27;6(5):e1000966. doi: 10.1371/journal.pgen.1000966.

33.

Processing of meiotic DNA double strand breaks requires cyclin-dependent kinase and multiple nucleases.

Manfrini N, Guerini I, Citterio A, Lucchini G, Longhese MP.

J Biol Chem. 2010 Apr 9;285(15):11628-37. doi: 10.1074/jbc.M110.104083. Epub 2010 Feb 11.

34.

Dephosphorylation of gamma H2A by Glc7/protein phosphatase 1 promotes recovery from inhibition of DNA replication.

Bazzi M, Mantiero D, Trovesi C, Lucchini G, Longhese MP.

Mol Cell Biol. 2010 Jan;30(1):131-45. doi: 10.1128/MCB.01000-09.

35.

Multiple pathways regulate 3' overhang generation at S. cerevisiae telomeres.

Bonetti D, Martina M, Clerici M, Lucchini G, Longhese MP.

Mol Cell. 2009 Jul 10;35(1):70-81. doi: 10.1016/j.molcel.2009.05.015.

36.

DNA double-strand breaks in meiosis: checking their formation, processing and repair.

Longhese MP, Bonetti D, Guerini I, Manfrini N, Clerici M.

DNA Repair (Amst). 2009 Sep 2;8(9):1127-38. doi: 10.1016/j.dnarep.2009.04.005. Epub 2009 May 22. Review.

PMID:
19464965
37.

The Mec1p and Tel1p checkpoint kinases allow humanized yeast to tolerate chronic telomere dysfunctions by suppressing telomere fusions.

di Domenico EG, Auriche C, Viscardi V, Longhese MP, Gilson E, Ascenzioni F.

DNA Repair (Amst). 2009 Feb 1;8(2):209-18. doi: 10.1016/j.dnarep.2008.10.005. Epub 2008 Nov 28.

PMID:
19007917
38.

The Yku70-Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle.

Clerici M, Mantiero D, Guerini I, Lucchini G, Longhese MP.

EMBO Rep. 2008 Aug;9(8):810-8. doi: 10.1038/embor.2008.121. Epub 2008 Jul 4.

39.

Role of the Saccharomyces cerevisiae Rad53 checkpoint kinase in signaling double-strand breaks during the meiotic cell cycle.

Cartagena-Lirola H, Guerini I, Manfrini N, Lucchini G, Longhese MP.

Mol Cell Biol. 2008 Jul;28(14):4480-93. doi: 10.1128/MCB.00375-08. Epub 2008 May 27.

40.

DNA damage response at functional and dysfunctional telomeres.

Longhese MP.

Genes Dev. 2008 Jan 15;22(2):125-40. doi: 10.1101/gad.1626908. Review.

41.

Surveillance mechanisms monitoring chromosome breaks during mitosis and meiosis.

Longhese MP, Guerini I, Baldo V, Clerici M.

DNA Repair (Amst). 2008 Apr 2;7(4):545-57. Epub 2007 Oct 24. Review.

PMID:
17962087
42.

Dominant TEL1-hy mutations compensate for Mec1 lack of functions in the DNA damage response.

Baldo V, Testoni V, Lucchini G, Longhese MP.

Mol Cell Biol. 2008 Jan;28(1):358-75. Epub 2007 Oct 22.

43.

MRX-dependent DNA damage response to short telomeres.

Viscardi V, Bonetti D, Cartagena-Lirola H, Lucchini G, Longhese MP.

Mol Biol Cell. 2007 Aug;18(8):3047-58. Epub 2007 May 30.

44.

Dual role for Saccharomyces cerevisiae Tel1 in the checkpoint response to double-strand breaks.

Mantiero D, Clerici M, Lucchini G, Longhese MP.

EMBO Rep. 2007 Apr;8(4):380-7. Epub 2007 Mar 9.

45.
46.

Budding Yeast Sae2 is an In Vivo Target of the Mec1 and Tel1 Checkpoint Kinases During Meiosis.

Cartagena-Lirola H, Guerini I, Viscardi V, Lucchini G, Longhese MP.

Cell Cycle. 2006 Jul;5(14):1549-59. Epub 2006 Jul 17.

PMID:
16861895
47.

The cellular response to chromosome breakage.

Longhese MP, Mantiero D, Clerici M.

Mol Microbiol. 2006 Jun;60(5):1099-108. Review.

48.

The Saccharomyces cerevisiae 14-3-3 proteins are required for the G1/S transition, actin cytoskeleton organization and cell wall integrity.

Lottersberger F, Panza A, Lucchini G, Piatti S, Longhese MP.

Genetics. 2006 Jun;173(2):661-75. Epub 2006 Apr 28.

49.

The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signalling.

Clerici M, Mantiero D, Lucchini G, Longhese MP.

EMBO Rep. 2006 Feb;7(2):212-8.

50.

The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends.

Clerici M, Mantiero D, Lucchini G, Longhese MP.

J Biol Chem. 2005 Nov 18;280(46):38631-8. Epub 2005 Sep 13.

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