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Items: 20


Differential contribution of pyruvate carboxylation to anaplerosis and cataplerosis during non-gluconeogenic and gluconeogenic conditions in HepG2 cells.

Wattanavanitchakorn S, Ansari IH, El Azzouny M, Longacre MJ, Stoker SW, MacDonald MJ, Jitrapakdee S.

Arch Biochem Biophys. 2019 Nov 15;676:108124. doi: 10.1016/ Epub 2019 Oct 2.


Characterization of Acyl-CoA synthetase isoforms in pancreatic beta cells: Gene silencing shows participation of ACSL3 and ACSL4 in insulin secretion.

Ansari IH, Longacre MJ, Stoker SW, Kendrick MA, O'Neill LM, Zitur LJ, Fernandez LA, Ntambi JM, MacDonald MJ.

Arch Biochem Biophys. 2017 Mar 15;618:32-43. doi: 10.1016/ Epub 2017 Feb 11.


Mass spectrometry analysis shows the biosynthetic pathways supported by pyruvate carboxylase in highly invasive breast cancer cells.

Phannasil P, Ansari IH, El Azzouny M, Longacre MJ, Rattanapornsompong K, Burant CF, MacDonald MJ, Jitrapakdee S.

Biochim Biophys Acta Mol Basis Dis. 2017 Feb;1863(2):537-551. doi: 10.1016/j.bbadis.2016.11.021. Epub 2016 Nov 24.


Knockdown of ATP citrate lyase in pancreatic beta cells does not inhibit insulin secretion or glucose flux and implicates the acetoacetate pathway in insulin secretion.

El Azzouny M, Longacre MJ, Ansari IH, Kennedy RT, Burant CF, MacDonald MJ.

Mol Metab. 2016 Aug 8;5(10):980-987. doi: 10.1016/j.molmet.2016.07.011. eCollection 2016 Oct.


Discovery of a Genetic Metabolic Cause for Mauriac Syndrome in Type 1 Diabetes.

MacDonald MJ, Hasan NM, Ansari IU, Longacre MJ, Kendrick MA, Stoker SW.

Diabetes. 2016 Jul;65(7):2051-9. doi: 10.2337/db16-0099. Epub 2016 Apr 5.


Characterization of P4 ATPase Phospholipid Translocases (Flippases) in Human and Rat Pancreatic Beta Cells: THEIR GENE SILENCING INHIBITS INSULIN SECRETION.

Ansari IU, Longacre MJ, Paulusma CC, Stoker SW, Kendrick MA, MacDonald MJ.

J Biol Chem. 2015 Sep 18;290(38):23110-23. doi: 10.1074/jbc.M115.655027. Epub 2015 Aug 3.


Mitochondrial malic enzyme 3 is important for insulin secretion in pancreatic β-cells.

Hasan NM, Longacre MJ, Stoker SW, Kendrick MA, MacDonald MJ.

Mol Endocrinol. 2015 Mar;29(3):396-410. doi: 10.1210/me.2014-1249. Epub 2015 Jan 16.


Knockdown of both mitochondrial isocitrate dehydrogenase enzymes in pancreatic beta cells inhibits insulin secretion.

MacDonald MJ, Brown LJ, Longacre MJ, Stoker SW, Kendrick MA, Hasan NM.

Biochim Biophys Acta. 2013 Nov;1830(11):5104-11. doi: 10.1016/j.bbagen.2013.07.013. Epub 2013 Jul 20. Erratum in: Biochim Biophys Acta. 2013. doi: 10.1016/j.bbagen.2013.09.024. Hasan, Noaman M [added]. Biochim Biophys Acta. 2015 Jun;1850(6):1343.


High level of ATP citrate lyase expression in human and rat pancreatic islets.

MacDonald MJ, Longacre MJ, Warner TF, Thonpho A.

Horm Metab Res. 2013 May;45(5):391-3. doi: 10.1055/s-0032-1329987. Epub 2012 Dec 7.


Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell line.

Hasan NM, Longacre MJ, Stoker SW, Kendrick MA, Druckenbrod NR, Laychock SG, Mastrandrea LD, MacDonald MJ.

Arch Biochem Biophys. 2012 Feb 1;518(1):23-30. doi: 10.1016/ Epub 2011 Dec 4.


Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets.

MacDonald MJ, Longacre MJ, Stoker SW, Kendrick M, Thonpho A, Brown LJ, Hasan NM, Jitrapakdee S, Fukao T, Hanson MS, Fernandez LA, Odorico J.

J Biol Chem. 2011 May 27;286(21):18383-96. doi: 10.1074/jbc.M111.241182. Epub 2011 Mar 22.


Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: knockdown of SCOT inhibits insulin release in rat insulinoma cells.

Hasan NM, Longacre MJ, Seed Ahmed M, Kendrick MA, Gu H, Ostenson CG, Fukao T, MacDonald MJ.

Arch Biochem Biophys. 2010 Jul;499(1-2):62-8. doi: 10.1016/ Epub 2010 May 9.


Chronic reduction of the cytosolic or mitochondrial NAD(P)-malic enzyme does not affect insulin secretion in a rat insulinoma cell line.

Brown LJ, Longacre MJ, Hasan NM, Kendrick MA, Stoker SW, Macdonald MJ.

J Biol Chem. 2009 Dec 18;284(51):35359-67. doi: 10.1074/jbc.M109.040394.


Mitochondrial malic enzyme (ME2) in pancreatic islets of the human, rat and mouse and clonal insulinoma cells.

MacDonald MJ, Longacre MJ, Kendrick MA.

Arch Biochem Biophys. 2009 Aug 15;488(2):100-4.


Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes.

MacDonald MJ, Longacre MJ, Langberg EC, Tibell A, Kendrick MA, Fukao T, Ostenson CG.

Diabetologia. 2009 Jun;52(6):1087-91. doi: 10.1007/s00125-009-1319-6. Epub 2009 Mar 19.


Impaired anaplerosis and insulin secretion in insulinoma cells caused by small interfering RNA-mediated suppression of pyruvate carboxylase.

Hasan NM, Longacre MJ, Stoker SW, Boonsaen T, Jitrapakdee S, Kendrick MA, Wallace JC, MacDonald MJ.

J Biol Chem. 2008 Oct 17;283(42):28048-59. doi: 10.1074/jbc.M804170200. Epub 2008 Aug 12.


Studies with leucine, beta-hydroxybutyrate and ATP citrate lyase-deficient beta cells support the acetoacetate pathway of insulin secretion.

Macdonald MJ, Hasan NM, Longacre MJ.

Biochim Biophys Acta. 2008 Jul-Aug;1780(7-8):966-72. doi: 10.1016/j.bbagen.2008.03.017. Epub 2008 Apr 4.


Acetoacetate and beta-hydroxybutyrate in combination with other metabolites release insulin from INS-1 cells and provide clues about pathways in insulin secretion.

MacDonald MJ, Longacre MJ, Stoker SW, Brown LJ, Hasan NM, Kendrick MA.

Am J Physiol Cell Physiol. 2008 Feb;294(2):C442-50. Epub 2007 Dec 26.


Recovery of soluble dietary fiber is dependent on the method of analysis.

Marlett JA, Chesters JG, Longacre MJ, Bogdanske JJ.

Am J Clin Nutr. 1989 Sep;50(3):479-85.


Oat fiber: composition versus physiological function in rats.

Shinnick FL, Longacre MJ, Ink SL, Marlett JA.

J Nutr. 1988 Feb;118(2):144-51.


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