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Items: 25


Association of the colorectal CpG island methylator phenotype with molecular features, risk factors, and family history.

Weisenberger DJ, Levine AJ, Long TI, Buchanan DD, Walters R, Clendenning M, Rosty C, Joshi AD, Stern MC, LeMarchand L, Lindor NM, Daftary D, Gallinger S, Selander T, Bapat B, Newcomb PA, Campbell PT, Casey G, Ahnen DJ, Baron JA, Haile RW, Hopper JL, Young JP, Laird PW, Siegmund KD; Colon Cancer Family Registry.

Cancer Epidemiol Biomarkers Prev. 2015 Mar;24(3):512-519. doi: 10.1158/1055-9965.EPI-14-1161. Epub 2015 Jan 13.


Cancer risks for the relatives of colorectal cancer cases with a methylated MLH1 promoter region: data from the Colorectal Cancer Family Registry.

Levine AJ, Win AK, Buchanan DD, Jenkins MA, Baron JA, Young JP, Long TI, Weisenberger DJ, Laird PW, McCall RL, Duggan DJ, Haile RW.

Cancer Prev Res (Phila). 2012 Feb;5(2):328-35. doi: 10.1158/1940-6207.CAPR-11-0419. Epub 2011 Dec 5.


Epigenetic subgroups of esophageal and gastric adenocarcinoma with differential GATA5 DNA methylation associated with clinical and lifestyle factors.

Wang X, Kang GH, Campan M, Weisenberger DJ, Long TI, Cozen W, Bernstein L, Wu AH, Siegmund KD, Shibata D, Laird PW.

PLoS One. 2011;6(10):e25985. doi: 10.1371/journal.pone.0025985. Epub 2011 Oct 20.


Frequency of deletions of EPCAM (TACSTD1) in MSH2-associated Lynch syndrome cases.

Rumilla K, Schowalter KV, Lindor NM, Thomas BC, Mensink KA, Gallinger S, Holter S, Newcomb PA, Potter JD, Jenkins MA, Hopper JL, Long TI, Weisenberger DJ, Haile RW, Casey G, Laird PW, Le Marchand L, Thibodeau SN.

J Mol Diagn. 2011 Jan;13(1):93-9. doi: 10.1016/j.jmoldx.2010.11.011. Epub 2010 Dec 23.


DNA methylation as a biomarker for cardiovascular disease risk.

Kim M, Long TI, Arakawa K, Wang R, Yu MC, Laird PW.

PLoS One. 2010 Mar 15;5(3):e9692. doi: 10.1371/journal.pone.0009692.


Hormone therapy, DNA methylation and colon cancer.

Wu AH, Siegmund KD, Long TI, Cozen W, Wan P, Tseng CC, Shibata D, Laird PW.

Carcinogenesis. 2010 Jun;31(6):1060-7. doi: 10.1093/carcin/bgq009. Epub 2010 Jan 11.


Molecular characterization of MSI-H colorectal cancer by MLHI promoter methylation, immunohistochemistry, and mismatch repair germline mutation screening.

Poynter JN, Siegmund KD, Weisenberger DJ, Long TI, Thibodeau SN, Lindor N, Young J, Jenkins MA, Hopper JL, Baron JA, Buchanan D, Casey G, Levine AJ, Le Marchand L, Gallinger S, Bapat B, Potter JD, Newcomb PA, Haile RW, Laird PW; Colon Cancer Family Registry Investigators.

Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3208-15. doi: 10.1158/1055-9965.EPI-08-0512.


DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight.

Weisenberger DJ, Trinh BN, Campan M, Sharma S, Long TI, Ananthnarayan S, Liang G, Esteva FJ, Hortobagyi GN, McCormick F, Jones PA, Laird PW.

Nucleic Acids Res. 2008 Aug;36(14):4689-98. doi: 10.1093/nar/gkn455. Epub 2008 Jul 15.


DNA methylation profiles of gastric carcinoma characterized by quantitative DNA methylation analysis.

Kang GH, Lee S, Cho NY, Gandamihardja T, Long TI, Weisenberger DJ, Campan M, Laird PW.

Lab Invest. 2008 Feb;88(2):161-70. Epub 2007 Dec 24.


DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons.

Siegmund KD, Connor CM, Campan M, Long TI, Weisenberger DJ, Biniszkiewicz D, Jaenisch R, Laird PW, Akbarian S.

PLoS One. 2007 Sep 19;2(9):e895.


CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer.

Weisenberger DJ, Siegmund KD, Campan M, Young J, Long TI, Faasse MA, Kang GH, Widschwendter M, Weener D, Buchanan D, Koh H, Simms L, Barker M, Leggett B, Levine J, Kim M, French AJ, Thibodeau SN, Jass J, Haile R, Laird PW.

Nat Genet. 2006 Jul;38(7):787-93. Epub 2006 Jun 25.


Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors.

Ehrlich M, Woods CB, Yu MC, Dubeau L, Yang F, Campan M, Weisenberger DJ, Long T, Youn B, Fiala ES, Laird PW.

Oncogene. 2006 Apr 27;25(18):2636-45.


Analysis of repetitive element DNA methylation by MethyLight.

Weisenberger DJ, Campan M, Long TI, Kim M, Woods C, Fiala E, Ehrlich M, Laird PW.

Nucleic Acids Res. 2005 Dec 2;33(21):6823-36. Print 2005.


Sex differential in methylation patterns of selected genes in Singapore Chinese.

Sarter B, Long TI, Tsong WH, Koh WP, Yu MC, Laird PW.

Hum Genet. 2005 Aug;117(4):402-3. Epub 2005 Jun 1.


Distinct DNA methylation profiles in malignant mesothelioma, lung adenocarcinoma, and non-tumor lung.

Tsou JA, Shen LY, Siegmund KD, Long TI, Laird PW, Seneviratne CK, Koss MN, Pass HI, Hagen JA, Laird-Offringa IA.

Lung Cancer. 2005 Feb;47(2):193-204.


Dnmt1 deficiency leads to enhanced microsatellite instability in mouse embryonic stem cells.

Kim M, Trinh BN, Long TI, Oghamian S, Laird PW.

Nucleic Acids Res. 2004 Oct 27;32(19):5742-9. Print 2004.


Prolonged culture of normal chorionic villus cells yields ICF syndrome-like chromatin decondensation and rearrangements.

Tsien F, Fiala ES, Youn B, Long TI, Laird PW, Weissbecker K, Ehrlich M.

Cytogenet Genome Res. 2002;98(1):13-21.


Hypomethylation and hypermethylation of DNA in Wilms tumors.

Ehrlich M, Jiang G, Fiala E, Dome JS, Yu MC, Long TI, Youn B, Sohn OS, Widschwendter M, Tomlinson GE, Chintagumpala M, Champagne M, Parham D, Liang G, Malik K, Laird PW.

Oncogene. 2002 Sep 26;21(43):6694-702.


DNA methyltransferase deficiency modifies cancer susceptibility in mice lacking DNA mismatch repair.

Trinh BN, Long TI, Nickel AE, Shibata D, Laird PW.

Mol Cell Biol. 2002 May;22(9):2906-17.


Rebuilding a damaged heart: long-term survival of transplanted neonatal rat cardiomyocytes after myocardial infarction and effect on cardiac function.

Müller-Ehmsen J, Peterson KL, Kedes L, Whittaker P, Dow JS, Long TI, Laird PW, Kloner RA.

Circulation. 2002 Apr 9;105(14):1720-6.


Hierarchical clustering of lung cancer cell lines using DNA methylation markers.

Virmani AK, Tsou JA, Siegmund KD, Shen LY, Long TI, Laird PW, Gazdar AF, Laird-Offringa IA.

Cancer Epidemiol Biomarkers Prev. 2002 Mar;11(3):291-7.


Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium.

Müller-Ehmsen J, Whittaker P, Kloner RA, Dow JS, Sakoda T, Long TI, Laird PW, Kedes L.

J Mol Cell Cardiol. 2002 Feb;34(2):107-16.


DNA methylation analysis by MethyLight technology.

Trinh BN, Long TI, Laird PW.

Methods. 2001 Dec;25(4):456-62.


Epigenetic patterns in the progression of esophageal adenocarcinoma.

Eads CA, Lord RV, Wickramasinghe K, Long TI, Kurumboor SK, Bernstein L, Peters JH, DeMeester SR, DeMeester TR, Skinner KA, Laird PW.

Cancer Res. 2001 Apr 15;61(8):3410-8.


Fields of aberrant CpG island hypermethylation in Barrett's esophagus and associated adenocarcinoma.

Eads CA, Lord RV, Kurumboor SK, Wickramasinghe K, Skinner ML, Long TI, Peters JH, DeMeester TR, Danenberg KD, Danenberg PV, Laird PW, Skinner KA.

Cancer Res. 2000 Sep 15;60(18):5021-6.

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