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Items: 46

1.

Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception.

Long JZ, Roche AM, Berdan CA, Louie SM, Roberts AJ, Svensson KJ, Dou FY, Bateman LA, Mina AI, Deng Z, Jedrychowski MP, Lin H, Kamenecka TM, Asara JM, Griffin PR, Banks AS, Nomura DK, Spiegelman BM.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6937-E6945. doi: 10.1073/pnas.1803389115. Epub 2018 Jul 2.

2.

Discovery of Hydrolysis-Resistant Isoindoline N-Acyl Amino Acid Analogues that Stimulate Mitochondrial Respiration.

Lin H, Long JZ, Roche AM, Svensson KJ, Dou FY, Chang MR, Strutzenberg T, Ruiz C, Cameron MD, Novick SJ, Berdan CA, Louie SM, Nomura DK, Spiegelman BM, Griffin PR, Kamenecka TM.

J Med Chem. 2018 Apr 12;61(7):3224-3230. doi: 10.1021/acs.jmedchem.8b00029. Epub 2018 Mar 22.

3.

Cdkal1, a type 2 diabetes susceptibility gene, regulates mitochondrial function in adipose tissue.

Palmer CJ, Bruckner RJ, Paulo JA, Kazak L, Long JZ, Mina AI, Deng Z, LeClair KB, Hall JA, Hong S, Zushin PH, Smith KL, Gygi SP, Hagen S, Cohen DE, Banks AS.

Mol Metab. 2017 Oct;6(10):1212-1225. doi: 10.1016/j.molmet.2017.07.013. Epub 2017 Jul 31.

4.

[Association between phage-mediated shiga toxin and molecular distribution of CRISPR in Escherichia coli O26 ∶ H11 or NM].

Long JZ, Xu YK, Duan GC, Liang WJ, Liu HY, Chen SY, Xi YL, Wang PF, Wang YF.

Zhonghua Liu Xing Bing Xue Za Zhi. 2017 Jul 10;38(7):944-949. doi: 10.3760/cma.j.issn.0254-6450.2017.07.019. Chinese.

PMID:
28738471
5.

Do Adipocytes Emerge from Mural Progenitors?

Vishvanath L, Long JZ, Spiegelman BM, Gupta RK.

Cell Stem Cell. 2017 May 4;20(5):585-586. doi: 10.1016/j.stem.2017.03.013.

6.

The Cancer Drug Dasatinib Increases PGC-1α in Adipose Tissue but Has Adverse Effects on Glucose Tolerance in Obese Mice.

Sylow L, Long JZ, Lokurkar IA, Zeng X, Richter EA, Spiegelman BM.

Endocrinology. 2016 Nov;157(11):4184-4191. Epub 2016 Sep 2.

7.

The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria.

Long JZ, Svensson KJ, Bateman LA, Lin H, Kamenecka T, Lokurkar IA, Lou J, Rao RR, Chang MR, Jedrychowski MP, Paulo JA, Gygi SP, Griffin PR, Nomura DK, Spiegelman BM.

Cell. 2016 Jul 14;166(2):424-435. doi: 10.1016/j.cell.2016.05.071. Epub 2016 Jun 30.

8.

A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function.

Svensson KJ, Long JZ, Jedrychowski MP, Cohen P, Lo JC, Serag S, Kir S, Shinoda K, Tartaglia JA, Rao RR, Chédotal A, Kajimura S, Gygi SP, Spiegelman BM.

Cell Metab. 2016 Mar 8;23(3):454-66. doi: 10.1016/j.cmet.2016.01.008. Epub 2016 Feb 11.

9.

Endocannabinoid Catabolic Enzymes Play Differential Roles in Thermal Homeostasis in Response to Environmental or Immune Challenge.

Nass SR, Long JZ, Schlosburg JE, Cravatt BF, Lichtman AH, Kinsey SG.

J Neuroimmune Pharmacol. 2015 Jun;10(2):364-70. doi: 10.1007/s11481-015-9593-1. Epub 2015 Feb 27.

10.

Blockade of 2-arachidonoylglycerol hydrolysis produces antidepressant-like effects and enhances adult hippocampal neurogenesis and synaptic plasticity.

Zhang Z, Wang W, Zhong P, Liu SJ, Long JZ, Zhao L, Gao HQ, Cravatt BF, Liu QS.

Hippocampus. 2015 Jan;25(1):16-26. doi: 10.1002/hipo.22344. Epub 2014 Aug 27.

11.

Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis.

Rao RR, Long JZ, White JP, Svensson KJ, Lou J, Lokurkar I, Jedrychowski MP, Ruas JL, Wrann CD, Lo JC, Camera DM, Lachey J, Gygi S, Seehra J, Hawley JA, Spiegelman BM.

Cell. 2014 Jun 5;157(6):1279-91. doi: 10.1016/j.cell.2014.03.065.

12.

Prolonged monoacylglycerol lipase blockade causes equivalent cannabinoid receptor type 1 receptor-mediated adaptations in fatty acid amide hydrolase wild-type and knockout mice.

Schlosburg JE, Kinsey SG, Ignatowska-Jankowska B, Ramesh D, Abdullah RA, Tao Q, Booker L, Long JZ, Selley DE, Cravatt BF, Lichtman AH.

J Pharmacol Exp Ther. 2014 Aug;350(2):196-204. doi: 10.1124/jpet.114.212753. Epub 2014 May 21.

13.

A smooth muscle-like origin for beige adipocytes.

Long JZ, Svensson KJ, Tsai L, Zeng X, Roh HC, Kong X, Rao RR, Lou J, Lokurkar I, Baur W, Castellot JJ Jr, Rosen ED, Spiegelman BM.

Cell Metab. 2014 May 6;19(5):810-20. doi: 10.1016/j.cmet.2014.03.025. Epub 2014 Apr 4.

14.

Monoacylglycerol lipase inhibition blocks chronic stress-induced depressive-like behaviors via activation of mTOR signaling.

Zhong P, Wang W, Pan B, Liu X, Zhang Z, Long JZ, Zhang HT, Cravatt BF, Liu QS.

Neuropsychopharmacology. 2014 Jun;39(7):1763-76. doi: 10.1038/npp.2014.24. Epub 2014 Jan 30.

15.

Control of experimental spasticity by targeting the degradation of endocannabinoids using selective fatty acid amide hydrolase inhibitors.

Pryce G, Cabranes A, Fernández-Ruiz J, Bisogno T, Di Marzo V, Long JZ, Cravatt BF, Giovannoni G, Baker D.

Mult Scler. 2013 Dec;19(14):1896-904. doi: 10.1177/1352458513485982. Epub 2013 Apr 26.

PMID:
23625705
16.

Comparison of FASTlab 18F-FDG production using phosphate and citrate buffer cassettes.

Long JZ, Jacobson MS, Hung JC.

J Nucl Med Technol. 2013 Mar;41(1):32-4. doi: 10.2967/jnmt.112.112649. Epub 2013 Jan 14.

17.

ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC.

Blankman JL, Long JZ, Trauger SA, Siuzdak G, Cravatt BF.

Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1500-5. doi: 10.1073/pnas.1217121110. Epub 2013 Jan 7.

18.

Dual fatty acid amide hydrolase and monoacylglycerol lipase blockade produces THC-like Morris water maze deficits in mice.

Wise LE, Long KA, Abdullah RA, Long JZ, Cravatt BF, Lichtman AH.

ACS Chem Neurosci. 2012 May 16;3(5):369-78. doi: 10.1021/cn200130s. Epub 2012 Jan 27.

19.

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis.

Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, Højlund K, Gygi SP, Spiegelman BM.

Nature. 2012 Jan 11;481(7382):463-8. doi: 10.1038/nature10777.

20.

Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation.

Nomura DK, Morrison BE, Blankman JL, Long JZ, Kinsey SG, Marcondes MC, Ward AM, Hahn YK, Lichtman AH, Conti B, Cravatt BF.

Science. 2011 Nov 11;334(6057):809-13. doi: 10.1126/science.1209200. Epub 2011 Oct 20.

21.

Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids.

Long JZ, Cisar JS, Milliken D, Niessen S, Wang C, Trauger SA, Siuzdak G, Cravatt BF.

Nat Chem Biol. 2011 Sep 18;7(11):763-5. doi: 10.1038/nchembio.659.

22.

Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer.

Nomura DK, Lombardi DP, Chang JW, Niessen S, Ward AM, Long JZ, Hoover HH, Cravatt BF.

Chem Biol. 2011 Jul 29;18(7):846-56. doi: 10.1016/j.chembiol.2011.05.009.

23.

Blockade of endocannabinoid hydrolytic enzymes attenuates precipitated opioid withdrawal symptoms in mice.

Ramesh D, Ross GR, Schlosburg JE, Owens RA, Abdullah RA, Kinsey SG, Long JZ, Nomura DK, Sim-Selley LJ, Cravatt BF, Akbarali HI, Lichtman AH.

J Pharmacol Exp Ther. 2011 Oct;339(1):173-85. doi: 10.1124/jpet.111.181370. Epub 2011 Jun 30.

24.

The metabolic serine hydrolases and their functions in mammalian physiology and disease.

Long JZ, Cravatt BF.

Chem Rev. 2011 Oct 12;111(10):6022-63. doi: 10.1021/cr200075y. Epub 2011 Jun 23. Review. No abstract available.

25.

Inhibition of monoacylglycerol lipase attenuates nonsteroidal anti-inflammatory drug-induced gastric hemorrhages in mice.

Kinsey SG, Nomura DK, O'Neal ST, Long JZ, Mahadevan A, Cravatt BF, Grider JR, Lichtman AH.

J Pharmacol Exp Ther. 2011 Sep;338(3):795-802. doi: 10.1124/jpet.110.175778. Epub 2011 Jun 9.

26.

The fatty acid amide hydrolase (FAAH) inhibitor PF-3845 acts in the nervous system to reverse LPS-induced tactile allodynia in mice.

Booker L, Kinsey SG, Abdullah RA, Blankman JL, Long JZ, Ezzili C, Boger DL, Cravatt BF, Lichtman AH.

Br J Pharmacol. 2012 Apr;165(8):2485-96. doi: 10.1111/j.1476-5381.2011.01445.x.

27.

Inhibition of monoacylglycerol lipase attenuates vomiting in Suncus murinus and 2-arachidonoyl glycerol attenuates nausea in rats.

Sticht MA, Long JZ, Rock EM, Limebeer CL, Mechoulam R, Cravatt BF, Parker LA.

Br J Pharmacol. 2012 Apr;165(8):2425-35. doi: 10.1111/j.1476-5381.2011.01407.x.

28.

Reversible competitive α-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics.

Ezzili C, Mileni M, McGlinchey N, Long JZ, Kinsey SG, Hochstatter DG, Stevens RC, Lichtman AH, Cravatt BF, Bilsky EJ, Boger DL.

J Med Chem. 2011 Apr 28;54(8):2805-22. doi: 10.1021/jm101597x. Epub 2011 Mar 23.

29.

Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay.

Kinsey SG, O'Neal ST, Long JZ, Cravatt BF, Lichtman AH.

Pharmacol Biochem Behav. 2011 Mar;98(1):21-7. doi: 10.1016/j.pbb.2010.12.002. Epub 2010 Dec 8.

30.

An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase.

Long JZ, LaCava M, Jin X, Cravatt BF.

J Lipid Res. 2011 Feb;52(2):337-44. doi: 10.1194/jlr.M012153. Epub 2010 Nov 19.

31.

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system.

Schlosburg JE, Blankman JL, Long JZ, Nomura DK, Pan B, Kinsey SG, Nguyen PT, Ramesh D, Booker L, Burston JJ, Thomas EA, Selley DE, Sim-Selley LJ, Liu QS, Lichtman AH, Cravatt BF.

Nat Neurosci. 2010 Sep;13(9):1113-9. doi: 10.1038/nn.2616. Epub 2010 Aug 22.

32.

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors.

Marrs WR, Blankman JL, Horne EA, Thomazeau A, Lin YH, Coy J, Bodor AL, Muccioli GG, Hu SS, Woodruff G, Fung S, Lafourcade M, Alexander JP, Long JZ, Li W, Xu C, Möller T, Mackie K, Manzoni OJ, Cravatt BF, Stella N.

Nat Neurosci. 2010 Aug;13(8):951-7. doi: 10.1038/nn.2601. Epub 2010 Jul 25.

33.

Fatty acid amide hydrolase and monoacylglycerol lipase inhibitors produce anti-allodynic effects in mice through distinct cannabinoid receptor mechanisms.

Kinsey SG, Long JZ, Cravatt BF, Lichtman AH.

J Pain. 2010 Dec;11(12):1420-8. doi: 10.1016/j.jpain.2010.04.001. Epub 2010 Jun 16.

34.

Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases.

Long JZ, Jin X, Adibekian A, Li W, Cravatt BF.

J Med Chem. 2010 Feb 25;53(4):1830-42. doi: 10.1021/jm9016976.

35.

Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis.

Nomura DK, Long JZ, Niessen S, Hoover HS, Ng SW, Cravatt BF.

Cell. 2010 Jan 8;140(1):49-61. doi: 10.1016/j.cell.2009.11.027.

36.

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.

Long JZ, Nomura DK, Vann RE, Walentiny DM, Booker L, Jin X, Burston JJ, Sim-Selley LJ, Lichtman AH, Wiley JL, Cravatt BF.

Proc Natl Acad Sci U S A. 2009 Dec 1;106(48):20270-5. doi: 10.1073/pnas.0909411106. Epub 2009 Nov 16.

37.

Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons.

Straiker A, Hu SS, Long JZ, Arnold A, Wager-Miller J, Cravatt BF, Mackie K.

Mol Pharmacol. 2009 Dec;76(6):1220-7. doi: 10.1124/mol.109.059030. Epub 2009 Sep 18.

38.
39.

Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism.

Long JZ, Nomura DK, Cravatt BF.

Chem Biol. 2009 Jul 31;16(7):744-53. doi: 10.1016/j.chembiol.2009.05.009.

40.

C-H bond functionalization via hydride transfer: synthesis of dihydrobenzopyrans from ortho-vinylaryl akyl ethers.

McQuaid KM, Long JZ, Sames D.

Org Lett. 2009 Jul 16;11(14):2972-5. doi: 10.1021/ol900915p.

41.

Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain.

Kinsey SG, Long JZ, O'Neal ST, Abdullah RA, Poklis JL, Boger DL, Cravatt BF, Lichtman AH.

J Pharmacol Exp Ther. 2009 Sep;330(3):902-10. doi: 10.1124/jpet.109.155465. Epub 2009 Jun 5.

42.

Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice.

Schlosburg JE, Carlson BL, Ramesh D, Abdullah RA, Long JZ, Cravatt BF, Lichtman AH.

AAPS J. 2009 Jun;11(2):342-52. doi: 10.1208/s12248-009-9110-7. Epub 2009 May 9.

43.

Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.

Ahn K, Johnson DS, Mileni M, Beidler D, Long JZ, McKinney MK, Weerapana E, Sadagopan N, Liimatta M, Smith SE, Lazerwith S, Stiff C, Kamtekar S, Bhattacharya K, Zhang Y, Swaney S, Van Becelaere K, Stevens RC, Cravatt BF.

Chem Biol. 2009 Apr 24;16(4):411-20. doi: 10.1016/j.chembiol.2009.02.013.

44.

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects.

Long JZ, Li W, Booker L, Burston JJ, Kinsey SG, Schlosburg JE, Pavón FJ, Serrano AM, Selley DE, Parsons LH, Lichtman AH, Cravatt BF.

Nat Chem Biol. 2009 Jan;5(1):37-44. doi: 10.1038/nchembio.129. Epub 2008 Nov 23.

45.

In vivo imaging and differential localization of lipid-modified GFP-variant fusions in embryonic stem cells and mice.

Rhee JM, Pirity MK, Lackan CS, Long JZ, Kondoh G, Takeda J, Hadjantonakis AK.

Genesis. 2006 Apr;44(4):202-18.

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