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mTORC1 Activation Requires DRAM-1 by Facilitating Lysosomal Amino Acid Efflux.

Beaumatin F, O'Prey J, Barthet VJA, Zunino B, Parvy JP, Bachmann AM, O'Prey M, Kania E, Gonzalez PS, Macintosh R, Lao LY, Nixon C, Lopez J, Long JS, Tait SWG, Ryan KM.

Mol Cell. 2019 Aug 12. pii: S1097-2765(19)30551-9. doi: 10.1016/j.molcel.2019.07.021. [Epub ahead of print]


ANP32 Proteins Are Essential for Influenza Virus Replication in Human Cells.

Staller E, Sheppard CM, Neasham PJ, Mistry B, Peacock TP, Goldhill DH, Long JS, Barclay WS.

J Virol. 2019 Aug 13;93(17). pii: e00217-19. doi: 10.1128/JVI.00217-19. Print 2019 Sep 1.


Species specific differences in use of ANP32 proteins by influenza A virus.

Long JS, Idoko-Akoh A, Mistry B, Goldhill D, Staller E, Schreyer J, Ross C, Goodbourn S, Shelton H, Skinner MA, Sang H, McGrew MJ, Barclay W.

Elife. 2019 Jun 4;8. pii: e45066. doi: 10.7554/eLife.45066.


Identification and Validation of Novel Autophagy Regulators Using an Endogenous Readout siGENOME Screen.

New M, Van Acker T, Jiang M, Saunders R, Long JS, Sakamaki JI, Ryan KM, Howell M, Tooze SA.

Methods Mol Biol. 2019;1880:359-374. doi: 10.1007/978-1-4939-8873-0_24.


Publisher Correction: Host and viral determinants of influenza A virus species specificity.

Long JS, Mistry B, Haslam SM, Barclay WS.

Nat Rev Microbiol. 2019 Jan;17(2):124. doi: 10.1038/s41579-018-0140-y.


Host and viral determinants of influenza A virus species specificity.

Long JS, Mistry B, Haslam SM, Barclay WS.

Nat Rev Microbiol. 2019 Jan;17(2):67-81. doi: 10.1038/s41579-018-0115-z. Review. Erratum in: Nat Rev Microbiol. 2018 Dec 18;:.


Assays to Measure the Activity of Influenza Virus Polymerase.

Te Velthuis AJW, Long JS, Barclay WS.

Methods Mol Biol. 2018;1836:343-374. doi: 10.1007/978-1-4939-8678-1_17.


Internal genes of a highly pathogenic H5N1 influenza virus determine high viral replication in myeloid cells and severe outcome of infection in mice.

Li H, Bradley KC, Long JS, Frise R, Ashcroft JW, Hartgroves LC, Shelton H, Makris S, Johansson C, Cao B, Barclay WS.

PLoS Pathog. 2018 Jan 4;14(1):e1006821. doi: 10.1371/journal.ppat.1006821. eCollection 2018 Jan.


Emerging roles of transcriptional programs in autophagy regulation.

Sakamaki JI, Long JS, New M, Van Acker T, Tooze SA, Ryan KM.

Transcription. 2018;9(2):131-136. doi: 10.1080/21541264.2017.1372045. Epub 2017 Nov 3. Review.


DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose.

Mrschtik M, O'Prey J, Lao LY, Long JS, Beaumatin F, Strachan D, O'Prey M, Skommer J, Ryan KM.

Cell Death Differ. 2017 Aug;24(8):1470. doi: 10.1038/cdd.2017.57. Epub 2017 Jun 23.


Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function.

Sakamaki JI, Wilkinson S, Hahn M, Tasdemir N, O'Prey J, Clark W, Hedley A, Nixon C, Long JS, New M, Van Acker T, Tooze SA, Lowe SW, Dikic I, Ryan KM.

Mol Cell. 2017 May 18;66(4):517-532.e9. doi: 10.1016/j.molcel.2017.04.027.


Molecular Pathways Controlling Autophagy in Pancreatic Cancer.

New M, Van Acker T, Long JS, Sakamaki JI, Ryan KM, Tooze SA.

Front Oncol. 2017 Mar 3;7:28. doi: 10.3389/fonc.2017.00028. eCollection 2017. Review.


Application of CRISPR/Cas9 to Autophagy Research.

O'Prey J, Sakamaki J, Baudot AD, New M, Van Acker T, Tooze SA, Long JS, Ryan KM.

Methods Enzymol. 2017;588:79-108. doi: 10.1016/bs.mie.2016.09.076. Epub 2016 Dec 1.


Species difference in ANP32A underlies influenza A virus polymerase host restriction.

Long JS, Giotis ES, Moncorgé O, Frise R, Mistry B, James J, Morisson M, Iqbal M, Vignal A, Skinner MA, Barclay WS.

Nature. 2016 Jan 7;529(7584):101-4. doi: 10.1038/nature16474.


The Theory of Industrial Society and Cultural Schemata: Does the "Cultural Myth of Stigma" Underlie the WHO Schizophrenia Paradox?

Pescosolido BA, Martin JK, Olafsdottir S, Long JS, Kafadar K, Medina TR.

AJS. 2015 Nov;121(3):783-825.


Men with Sexual Problems and Their Partners: Findings from the International Survey of Relationships.

Rosen RC, Heiman JR, Long JS, Fisher WA, Sand MS.

Arch Sex Behav. 2016 Jan;45(1):159-73. doi: 10.1007/s10508-015-0568-3. Epub 2015 Jul 31.


DRAM-3 modulates autophagy and promotes cell survival in the absence of glucose.

Mrschtik M, O'Prey J, Lao LY, Long JS, Beaumatin F, Strachan D, O'Prey M, Skommer J, Ryan KM.

Cell Death Differ. 2015 Oct;22(10):1714-26. doi: 10.1038/cdd.2015.26. Epub 2015 May 1. Erratum in: Cell Death Differ. 2017 Jun 30;(8):1470.


p73 engages A2B receptor signalling to prime cancer cells to chemotherapy-induced death.

Long JS, Schoonen PM, Graczyk D, O'Prey J, Ryan KM.

Oncogene. 2015 Oct 1;34(40):5152-62. doi: 10.1038/onc.2014.436. Epub 2015 Feb 9.


Loss of autophagy causes a synthetic lethal deficiency in DNA repair.

Liu EY, Xu N, O'Prey J, Lao LY, Joshi S, Long JS, O'Prey M, Croft DR, Beaumatin F, Baudot AD, Mrschtik M, Rosenfeldt M, Zhang Y, Gillespie DA, Ryan KM.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):773-8. doi: 10.1073/pnas.1409563112. Epub 2015 Jan 7.


One-way trip: influenza virus' adaptation to gallinaceous poultry may limit its pandemic potential.

Long JS, Benfield CT, Barclay WS.

Bioessays. 2015 Feb;37(2):204-12. doi: 10.1002/bies.201400133. Epub 2014 Dec 28. Erratum in: Bioessays. 2015 Apr;37(4):463.


Individual and Partner Correlates of Sexual Satisfaction and Relationship Happiness in Midlife Couples: Dyadic Analysis of the International Survey of Relationships.

Fisher WA, Donahue KL, Long JS, Heiman JR, Rosen RC, Sand MS.

Arch Sex Behav. 2015 Aug;44(6):1609-20. doi: 10.1007/s10508-014-0426-8. Epub 2014 Nov 5.


Polymerase δ-interacting protein 2 promotes postischemic neovascularization of the mouse hindlimb.

Amanso AM, Lassègue B, Joseph G, Landázuri N, Long JS, Weiss D, Taylor WR, Griendling KK.

Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1548-55. doi: 10.1161/ATVBAHA.114.303873. Epub 2014 May 22.


Poldip2 knockout results in perinatal lethality, reduced cellular growth and increased autophagy of mouse embryonic fibroblasts.

Brown DI, Lassègue B, Lee M, Zafari R, Long JS, Saavedra HI, Griendling KK.

PLoS One. 2014 May 5;9(5):e96657. doi: 10.1371/journal.pone.0096657. eCollection 2014.


Viral determinants of influenza A virus host range.

Cauldwell AV, Long JS, Moncorgé O, Barclay WS.

J Gen Virol. 2014 Jun;95(Pt 6):1193-210. doi: 10.1099/vir.0.062836-0. Epub 2014 Feb 28. Review.


E2F1 drives chemotherapeutic drug resistance via ABCG2.

Rosenfeldt MT, Bell LA, Long JS, O'Prey J, Nixon C, Roberts F, Dufès C, Ryan KM.

Oncogene. 2014 Aug 7;33(32):4164-72. doi: 10.1038/onc.2013.470. Epub 2013 Nov 25.


The effect of the PB2 mutation 627K on highly pathogenic H5N1 avian influenza virus is dependent on the virus lineage.

Long JS, Howard WA, Núñez A, Moncorgé O, Lycett S, Banks J, Barclay WS.

J Virol. 2013 Sep;87(18):9983-96. doi: 10.1128/JVI.01399-13. Epub 2013 Jul 10.


Polymerase delta interacting protein 2 sustains vascular structure and function.

Sutliff RL, Hilenski LL, Amanso AM, Parastatidis I, Dikalova AE, Hansen L, Datla SR, Long JS, El-Ali AM, Joseph G, Gleason RL Jr, Taylor WR, Hart CM, Griendling KK, Lassègue B.

Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2154-61. doi: 10.1161/ATVBAHA.113.301913. Epub 2013 Jul 3. Erratum in: Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):e132.


The bone morphogenic protein inhibitor, noggin, reduces glycemia and vascular inflammation in db/db mice.

Koga M, Engberding N, Dikalova AE, Chang KH, Seidel-Rogol B, Long JS, Lassègue B, Jo H, Griendling KK.

Am J Physiol Heart Circ Physiol. 2013 Sep 1;305(5):H747-55. doi: 10.1152/ajpheart.00825.2012. Epub 2013 Jun 28.


Extracellular adenosine sensing-a metabolic cell death priming mechanism downstream of p53.

Long JS, Crighton D, O'Prey J, Mackay G, Zheng L, Palmer TM, Gottlieb E, Ryan KM.

Mol Cell. 2013 May 9;50(3):394-406. doi: 10.1016/j.molcel.2013.03.016. Epub 2013 Apr 18.


The "backbone" of stigma: identifying the global core of public prejudice associated with mental illness.

Pescosolido BA, Medina TR, Martin JK, Long JS.

Am J Public Health. 2013 May;103(5):853-60. doi: 10.2105/AJPH.2012.301147. Epub 2013 Mar 14.


Investigation of influenza virus polymerase activity in pig cells.

Moncorgé O, Long JS, Cauldwell AV, Zhou H, Lycett SJ, Barclay WS.

J Virol. 2013 Jan;87(1):384-94. doi: 10.1128/JVI.01633-12. Epub 2012 Oct 17.


Expression of sphingosine 1-phosphate receptor 4 and sphingosine kinase 1 is associated with outcome in oestrogen receptor-negative breast cancer.

Ohotski J, Long JS, Orange C, Elsberger B, Mallon E, Doughty J, Pyne S, Pyne NJ, Edwards J.

Br J Cancer. 2012 Apr 10;106(8):1453-9. doi: 10.1038/bjc.2012.98. Epub 2012 Mar 29. Erratum in: Br J Cancer. 2012 Aug 7;107(4):756.


New frontiers in promoting tumour cell death: targeting apoptosis, necroptosis and autophagy.

Long JS, Ryan KM.

Oncogene. 2012 Dec 6;31(49):5045-60. doi: 10.1038/onc.2012.7. Epub 2012 Feb 6. Review.


Sphingosine 1-phosphate signalling in cancer.

Pyne NJ, Tonelli F, Lim KG, Long JS, Edwards J, Pyne S.

Biochem Soc Trans. 2012 Feb;40(1):94-100. doi: 10.1042/BST20110602. Review.


Crowd intelligence for the classification of fractures and beyond.

Bernstein J, Long JS, Veillette C, Ahn J.

PLoS One. 2011;6(11):e27620. doi: 10.1371/journal.pone.0027620. Epub 2011 Nov 23.


Sexual satisfaction and relationship happiness in midlife and older couples in five countries.

Heiman JR, Long JS, Smith SN, Fisher WA, Sand MS, Rosen RC.

Arch Sex Behav. 2011 Aug;40(4):741-53. doi: 10.1007/s10508-010-9703-3. Epub 2011 Jan 26.


p53 and senescence: a little goes a long way.

Long JS, Ryan KM.

Cell Cycle. 2010 Oct 15;9(20):4050-1. No abstract available.


p53 and senescence: A little goes a long way.

Long JS, Ryan KM.

Cell Cycle. 2010 Oct;9(20):4050-1. Epub 2010 Oct 15. No abstract available.


Sexual well-being: a comparison of U.S. black and white women in heterosexual relationships.

Bancroft J, Long JS, McCabe J.

Arch Sex Behav. 2011 Aug;40(4):725-40. doi: 10.1007/s10508-010-9679-z. Epub 2010 Oct 17.


The sphingosine kinase 1 inhibitor 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole induces proteasomal degradation of sphingosine kinase 1 in mammalian cells.

Loveridge C, Tonelli F, Leclercq T, Lim KG, Long JS, Berdyshev E, Tate RJ, Natarajan V, Pitson SM, Pyne NJ, Pyne S.

J Biol Chem. 2010 Dec 10;285(50):38841-52. doi: 10.1074/jbc.M110.127993. Epub 2010 Oct 6.


High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients.

Watson C, Long JS, Orange C, Tannahill CL, Mallon E, McGlynn LM, Pyne S, Pyne NJ, Edwards J.

Am J Pathol. 2010 Nov;177(5):2205-15. doi: 10.2353/ajpath.2010.100220. Epub 2010 Oct 1.


"A disease like any other"? A decade of change in public reactions to schizophrenia, depression, and alcohol dependence.

Pescosolido BA, Martin JK, Long JS, Medina TR, Phelan JC, Link BG.

Am J Psychiatry. 2010 Nov;167(11):1321-30. doi: 10.1176/appi.ajp.2010.09121743. Epub 2010 Sep 15.


Sphingosine 1-phosphate receptor 4 uses HER2 (ERBB2) to regulate extracellular signal regulated kinase-1/2 in MDA-MB-453 breast cancer cells.

Long JS, Fujiwara Y, Edwards J, Tannahill CL, Tigyi G, Pyne S, Pyne NJ.

J Biol Chem. 2010 Nov 12;285(46):35957-66. doi: 10.1074/jbc.M110.117945. Epub 2010 Sep 13.


Sphingosine kinase 1 induces tolerance to human epidermal growth factor receptor 2 and prevents formation of a migratory phenotype in response to sphingosine 1-phosphate in estrogen receptor-positive breast cancer cells.

Long JS, Edwards J, Watson C, Tovey S, Mair KM, Schiff R, Natarajan V, Pyne NJ, Pyne S.

Mol Cell Biol. 2010 Aug;30(15):3827-41. doi: 10.1128/MCB.01133-09. Epub 2010 Jun 1.


New aspects of sphingosine 1-phosphate signaling in mammalian cells.

Pyne NJ, Long JS, Lee SC, Loveridge C, Gillies L, Pyne S.

Adv Enzyme Regul. 2009;49(1):214-21. doi: 10.1016/j.advenzreg.2009.01.011. Review. No abstract available.


Sphingosine 1-phosphate regulation of extracellular signal-regulated kinase-1/2 in embryonic stem cells.

Rodgers A, Mormeneo D, Long JS, Delgado A, Pyne NJ, Pyne S.

Stem Cells Dev. 2009 Nov;18(9):1319-30. doi: 10.1089/scd.2009.0023.


The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division.

Gillies L, Lee SC, Long JS, Ktistakis N, Pyne NJ, Pyne S.

Cell Signal. 2009 May;21(5):675-84. doi: 10.1016/j.cellsig.2009.01.023. Epub 2009 Jan 12.


Direct electrochemistry of horseradish peroxidase immobilized in a chitosan-[C4mim][BF4] film: determination of electrode kinetic parameters.

Long JS, Silvester DS, Wildgoose GG, Surkus AE, Flechsig GU, Compton RG.

Bioelectrochemistry. 2008 Nov;74(1):183-7. doi: 10.1016/j.bioelechem.2008.07.008. Epub 2008 Aug 7.


Lipid phosphate phosphatases form homo- and hetero-oligomers: catalytic competency, subcellular distribution and function.

Long JS, Pyne NJ, Pyne S.

Biochem J. 2008 Apr 15;411(2):371-7. doi: 10.1042/BJ20071607.


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