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Human NK cell receptor KIR2DS4 detects a conserved bacterial epitope presented by HLA-C.

Sim MJW, Rajagopalan S, Altmann DM, Boyton RJ, Sun PD, Long EO.

Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12964-12973. doi: 10.1073/pnas.1903781116. Epub 2019 May 28.


CD28 Homolog Is a Strong Activator of Natural Killer Cells for Lysis of B7H7+ Tumor Cells.

Zhuang X, Long EO.

Cancer Immunol Res. 2019 Jun;7(6):939-951. doi: 10.1158/2326-6066.CIR-18-0733. Epub 2019 Apr 24.


Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malaria.

Hart GT, Tran TM, Theorell J, Schlums H, Arora G, Rajagopalan S, Sangala ADJ, Welsh KJ, Traore B, Pierce SK, Crompton PD, Bryceson YT, Long EO.

J Exp Med. 2019 Jun 3;216(6):1280-1290. doi: 10.1084/jem.20181681. Epub 2019 Apr 12.


Cell atlas reveals the landscape of early pregnancy.

Rajagopalan S, Long EO.

Nature. 2018 Nov;563(7731):337-338. doi: 10.1038/d41586-018-07317-w. No abstract available.


Cutting Edge: Quantitative Determination of CD40L Threshold for IL-12 and IL-23 Production from Dendritic Cells.

Abdi K, Laky K, Padhan K, Petrovas C, Skinner J, Kabat J, Dorward DW, Brzostowski J, Long EO, Trinchieri G, Varma R.

J Immunol. 2018 Nov 15;201(10):2879-2884. doi: 10.4049/jimmunol.1800721. Epub 2018 Oct 12.


NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody-dependent cellular cytotoxicity.

Arora G, Hart GT, Manzella-Lapeira J, Doritchamou JY, Narum DL, Thomas LM, Brzostowski J, Rajagopalan S, Doumbo OK, Traore B, Miller LH, Pierce SK, Duffy PE, Crompton PD, Desai SA, Long EO.

Elife. 2018 Jun 26;7. pii: e36806. doi: 10.7554/eLife.36806.


Complement factor P: promoting the antibacterial activity of natural killer cells.

Zhuang X, Long EO.

Cell Mol Immunol. 2017 Oct;14(10):797-799. doi: 10.1038/cmi.2017.60. Epub 2017 Jul 24. No abstract available.


Canonical and Cross-reactive Binding of NK Cell Inhibitory Receptors to HLA-C Allotypes Is Dictated by Peptides Bound to HLA-C.

Sim MJ, Malaker SA, Khan A, Stowell JM, Shabanowitz J, Peterson ME, Rajagopalan S, Hunt DF, Altmann DM, Long EO, Boyton RJ.

Front Immunol. 2017 Mar 14;8:193. doi: 10.3389/fimmu.2017.00193. eCollection 2017.


Zinc-Induced Polymerization of Killer-Cell Ig-like Receptor into Filaments Promotes Its Inhibitory Function at Cytotoxic Immunological Synapses.

Kumar S, Rajagopalan S, Sarkar P, Dorward DW, Peterson ME, Liao HS, Guillermier C, Steinhauser ML, Vogel SS, Long EO.

Mol Cell. 2016 Apr 7;62(1):21-33. doi: 10.1016/j.molcel.2016.03.009.


Ionomycin Treatment Renders NK Cells Hyporesponsive.

Romera-Cárdenas G, Thomas LM, Lopez-Cobo S, García-Cuesta EM, Long EO, Reyburn HT.

PLoS One. 2016 Mar 23;11(3):e0150998. doi: 10.1371/journal.pone.0150998. eCollection 2016.


KIR2DL3 and KIR2DL1 show similar impact on licensing of human NK cells.

Sim MJ, Stowell J, Sergeant R, Altmann DM, Long EO, Boyton RJ.

Eur J Immunol. 2016 Jan;46(1):185-91. doi: 10.1002/eji.201545757. Epub 2015 Nov 2.


NK Cell Proliferation Induced by IL-15 Transpresentation Is Negatively Regulated by Inhibitory Receptors.

Anton OM, Vielkind S, Peterson ME, Tagaya Y, Long EO.

J Immunol. 2015 Nov 15;195(10):4810-21. doi: 10.4049/jimmunol.1500414. Epub 2015 Oct 9.


Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps.

Mitra S, Ring AM, Amarnath S, Spangler JB, Li P, Ju W, Fischer S, Oh J, Spolski R, Weiskopf K, Kohrt H, Foley JE, Rajagopalan S, Long EO, Fowler DH, Waldmann TA, Garcia KC, Leonard WJ.

Immunity. 2015 May 19;42(5):826-38. doi: 10.1016/j.immuni.2015.04.018.


A single amino acid change in inhibitory killer cell Ig-like receptor results in constitutive receptor self-association and phosphorylation.

Kumar S, Sarkar P, Sim MJ, Rajagopalan S, Vogel SS, Long EO.

J Immunol. 2015 Jan 15;194(2):817-26. doi: 10.4049/jimmunol.1401830. Epub 2014 Dec 12.


A signaling network stimulated by β2 integrin promotes the polarization of lytic granules in cytotoxic cells.

Zhang M, March ME, Lane WS, Long EO.

Sci Signal. 2014 Oct 7;7(346):ra96. doi: 10.1126/scisignal.2005629.


Comment on "Killer Ig-like receptor 2DL4 does not mediate NK Cell IFN-γ responses to soluble HLA-G preparations".

Rajagopalan S, Long EO.

J Immunol. 2014 May 1;192(9):4003. doi: 10.4049/jimmunol.1400430. No abstract available.


TNFR-associated factor 6 and TGF-β-activated kinase 1 control signals for a senescence response by an endosomal NK cell receptor.

Rajagopalan S, Lee EC, DuPrie ML, Long EO.

J Immunol. 2014 Jan 15;192(2):714-21. doi: 10.4049/jimmunol.1302384. Epub 2013 Dec 11.


Found: a cellular activating ligand for NKp44.

Rajagopalan S, Long EO.

Blood. 2013 Oct 24;122(17):2921-2. doi: 10.1182/blood-2013-09-523696.


Pillars article: Recruitment of tyrosine phosphatase HCP by the killer cell inhibitory receptor. Immunity. 1996. 4: 77-85.

Burshtyn DN, Scharenberg AM, Wagtmann N, Rajagopalan S, Berrada K, Yi T, Kinet JP, Long EO.

J Immunol. 2013 Oct 1;191(7):3491-9. No abstract available.


Cutting edge: NK cell licensing modulates adhesion to target cells.

Thomas LM, Peterson ME, Long EO.

J Immunol. 2013 Oct 15;191(8):3981-5. doi: 10.4049/jimmunol.1301159. Epub 2013 Sep 13.


A positive role for senescence in reproduction?

Rajagopalan S, Long EO.

Aging (Albany NY). 2013 Feb;5(2):96-7. No abstract available.


Controlling natural killer cell responses: integration of signals for activation and inhibition.

Long EO, Kim HS, Liu D, Peterson ME, Rajagopalan S.

Annu Rev Immunol. 2013;31:227-58. doi: 10.1146/annurev-immunol-020711-075005. Review.


Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling.

Rajagopalan S, Long EO.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20596-601. doi: 10.1073/pnas.1208248109. Epub 2012 Nov 26.


KIR2DL4 (CD158d): An activation receptor for HLA-G.

Rajagopalan S, Long EO.

Front Immunol. 2012 Aug 20;3:258. doi: 10.3389/fimmu.2012.00258. eCollection 2012.


The adaptor protein Crk controls activation and inhibition of natural killer cells.

Liu D, Peterson ME, Long EO.

Immunity. 2012 Apr 20;36(4):600-11. doi: 10.1016/j.immuni.2012.03.007. Epub 2012 Mar 29.


Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions.

Ombrello MJ, Remmers EF, Sun G, Freeman AF, Datta S, Torabi-Parizi P, Subramanian N, Bunney TD, Baxendale RW, Martins MS, Romberg N, Komarow H, Aksentijevich I, Kim HS, Ho J, Cruse G, Jung MY, Gilfillan AM, Metcalfe DD, Nelson C, O'Brien M, Wisch L, Stone K, Douek DC, Gandhi C, Wanderer AA, Lee H, Nelson SF, Shianna KV, Cirulli ET, Goldstein DB, Long EO, Moir S, Meffre E, Holland SM, Kastner DL, Katan M, Hoffman HM, Milner JD.

N Engl J Med. 2012 Jan 26;366(4):330-8. doi: 10.1056/NEJMoa1102140. Epub 2012 Jan 11.


Palmitoylation of MICA, a ligand for NKG2D, mediates its recruitment to membrane microdomains and promotes its shedding.

Agüera-González S, Gross CC, Fernández-Messina L, Ashiru O, Esteso G, Hang HC, Reyburn HT, Long EO, Valés-Gómez M.

Eur J Immunol. 2011 Dec;41(12):3667-76. doi: 10.1002/eji.201141645. Epub 2011 Nov 3.


ICAM-1: getting a grip on leukocyte adhesion.

Long EO.

J Immunol. 2011 May 1;186(9):5021-3. doi: 10.4049/jimmunol.1100646. Review. No abstract available.


Two modes of lytic granule fusion during degranulation by natural killer cells.

Liu D, Martina JA, Wu XS, Hammer JA 3rd, Long EO.

Immunol Cell Biol. 2011 Aug;89(6):728-38. doi: 10.1038/icb.2010.167. Epub 2011 Apr 12.


Cutting edge: NKG2D-dependent cytotoxicity is controlled by ligand distribution in the target cell membrane.

Martinez E, Brzostowski JA, Long EO, Gross CC.

J Immunol. 2011 May 15;186(10):5538-42. doi: 10.4049/jimmunol.1002254. Epub 2011 Apr 4.


β2 integrin induces TCRζ-Syk-phospholipase C-γ phosphorylation and paxillin-dependent granule polarization in human NK cells.

March ME, Long EO.

J Immunol. 2011 Mar 1;186(5):2998-3005. doi: 10.4049/jimmunol.1002438. Epub 2011 Jan 26.


Distinct role of rab27a in granule movement at the plasma membrane and in the cytosol of NK cells.

Liu D, Meckel T, Long EO.

PLoS One. 2010 Sep 21;5(9):e12870. doi: 10.1371/journal.pone.0012870.


Lytic granule polarization, rather than degranulation, is the preferred target of inhibitory receptors in NK cells.

Das A, Long EO.

J Immunol. 2010 Oct 15;185(8):4698-704. doi: 10.4049/jimmunol.1001220. Epub 2010 Sep 10.


Signal transduction during activation and inhibition of natural killer cells.

Watzl C, Long EO.

Curr Protoc Immunol. 2010 Aug;Chapter 11:Unit 11.9B. doi: 10.1002/0471142735.im1109bs90. Review.


Tethering of intercellular adhesion molecule on target cells is required for LFA-1-dependent NK cell adhesion and granule polarization.

Gross CC, Brzostowski JA, Liu D, Long EO.

J Immunol. 2010 Sep 1;185(5):2918-26. doi: 10.4049/jimmunol.1000761. Epub 2010 Jul 30.


Cytotoxic immunological synapses.

Dustin ML, Long EO.

Immunol Rev. 2010 May;235(1):24-34. doi: 10.1111/j.0105-2896.2010.00904.x. Review.


Antagonizing inhibition gets NK cells going.

Rajagopalan S, Long EO.

Proc Natl Acad Sci U S A. 2010 Jun 8;107(23):10333-4. doi: 10.1073/pnas.1005636107. Epub 2010 Jun 2. No abstract available.


Synergistic signals for natural cytotoxicity are required to overcome inhibition by c-Cbl ubiquitin ligase.

Kim HS, Das A, Gross CC, Bryceson YT, Long EO.

Immunity. 2010 Feb 26;32(2):175-86. doi: 10.1016/j.immuni.2010.02.004.


DNA-PKcs controls an endosomal signaling pathway for a proinflammatory response by natural killer cells.

Rajagopalan S, Moyle MW, Joosten I, Long EO.

Sci Signal. 2010 Feb 23;3(110):ra14. doi: 10.1126/scisignal.2000467.


Functional analysis of human NK cells by flow cytometry.

Bryceson YT, Fauriat C, Nunes JM, Wood SM, Björkström NK, Long EO, Ljunggren HG.

Methods Mol Biol. 2010;612:335-52. doi: 10.1007/978-1-60761-362-6_23.


Use of transfected Drosophila S2 cells to study NK cell activation.

March ME, Gross CC, Long EO.

Methods Mol Biol. 2010;612:67-88. doi: 10.1007/978-1-60761-362-6_6.


Regulation of human NK-cell cytokine and chemokine production by target cell recognition.

Fauriat C, Long EO, Ljunggren HG, Bryceson YT.

Blood. 2010 Mar 18;115(11):2167-76. doi: 10.1182/blood-2009-08-238469. Epub 2009 Dec 1.


Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors.

Bryceson YT, Ljunggren HG, Long EO.

Blood. 2009 Sep 24;114(13):2657-66. doi: 10.1182/blood-2009-01-201632. Epub 2009 Jul 23.


Integrin-dependent organization and bidirectional vesicular traffic at cytotoxic immune synapses.

Liu D, Bryceson YT, Meckel T, Vasiliver-Shamis G, Dustin ML, Long EO.

Immunity. 2009 Jul 17;31(1):99-109. doi: 10.1016/j.immuni.2009.05.009.


Inhibitory receptor signaling via tyrosine phosphorylation of the adaptor Crk.

Peterson ME, Long EO.

Immunity. 2008 Oct 17;29(4):578-88. doi: 10.1016/j.immuni.2008.07.014. Epub 2008 Oct 2.


Recruitment of activation receptors at inhibitory NK cell immune synapses.

Schleinitz N, March ME, Long EO.

PLoS One. 2008 Sep 26;3(9):e3278. doi: 10.1371/journal.pone.0003278.


Negative signaling by inhibitory receptors: the NK cell paradigm.

Long EO.

Immunol Rev. 2008 Aug;224:70-84. doi: 10.1111/j.1600-065X.2008.00660.x. Review.


Line of attack: NK cell specificity and integration of signals.

Bryceson YT, Long EO.

Curr Opin Immunol. 2008 Jun;20(3):344-52. doi: 10.1016/j.coi.2008.03.005. Epub 2008 Apr 23. Review.


Inhibitory receptor gp49B regulates eosinophil infiltration during allergic inflammation.

Norris HH, Peterson ME, Stebbins CC, McConchie BW, Bundoc VG, Trivedi S, Hodges MG, Anthony RM, Urban JF Jr, Long EO, Keane-Myers AM.

J Leukoc Biol. 2007 Dec;82(6):1531-41. Epub 2007 Aug 30.


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