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Items: 1 to 50 of 458

1.

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.

Resnick E, Bradley A, Gan J, Douangamath A, Krojer T, Sethi R, Geurink PP, Aimon A, Amitai G, Bellini D, Bennett J, Fairhead M, Fedorov O, Gabizon R, Gan J, Guo J, Plotnikov A, Reznik N, Ruda GF, Díaz-Sáez L, Straub VM, Szommer T, Velupillai S, Zaidman D, Zhang Y, Coker AR, Dowson CG, Barr HM, Wang C, Huber KVM, Brennan PE, Ovaa H, von Delft F, London N.

J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.

2.

Nrf2 activation via Keap1 deletion or sulforaphane treatment reduces Ova-induced sinonasal inflammation.

London NR Jr, Tharakan A, Mendiola M, Chen M, Dobzanski A, Sussan TE, Zaykaner M, Han AH, Lane AP, Sidhaye V, Biswal S, Ramanathan M Jr.

Allergy. 2019 Mar 6. doi: 10.1111/all.13766. [Epub ahead of print] No abstract available.

PMID:
30843229
3.

Patient reported outcomes and implant survivorship after Total knee arthroplasty with the persona knee implant system: two year follow up.

Mathijssen NMC, Verburg H, London NJ, Landsiedl M, Dominkus M.

BMC Musculoskelet Disord. 2019 Mar 4;20(1):97. doi: 10.1186/s12891-019-2470-y.

4.

Outcomes of small-gauge vitreoretinal surgery without scleral-depressed shaving of the vitreous base in the era of wide-angle viewing systems.

Tabandeh H, London NJS, Boyer DS, Flynn HW Jr.

Br J Ophthalmol. 2019 Feb 15. doi: 10.1136/bjophthalmol-2018-313626. [Epub ahead of print]

PMID:
30770355
5.

Impact of high- versus low-risk genotype on sinonasal radiographic disease in cystic fibrosis.

Halderman AA, Lee S, London NR, Day A, Jain R, Moore JA, Lin SY.

Laryngoscope. 2019 Apr;129(4):788-793. doi: 10.1002/lary.27595. Epub 2018 Dec 14.

PMID:
30549259
6.

Aeroallergens, air pollutants, and chronic rhinitis and rhinosinusitis.

London NR Jr, Lina I, Ramanathan M Jr.

World J Otorhinolaryngol Head Neck Surg. 2018 Nov 10;4(3):209-215. doi: 10.1016/j.wjorl.2018.08.006. eCollection 2018 Sep. Review.

7.

Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor.

Shraga A, Olshvang E, Davidzohn N, Khoshkenar P, Germain N, Shurrush K, Carvalho S, Avram L, Albeck S, Unger T, Lefker B, Subramanyam C, Hudkins RL, Mitchell A, Shulman Z, Kinoshita T, London N.

Cell Chem Biol. 2019 Jan 17;26(1):98-108.e5. doi: 10.1016/j.chembiol.2018.10.011. Epub 2018 Nov 15.

PMID:
30449673
8.

Determining the effect of low-dose isotretinoin on proliferative vitreoretinopathy: the DELIVER trial.

London NJS, Kaiser RS, Khan MA, Alshareef RA, Khuthaila M, Shahlaee A, Obeid A, London VA, DeCroos FC, Gupta OP, Hsu J, Vander JF, Spirn MJ, Regillo CD.

Br J Ophthalmol. 2018 Oct 31. pii: bjophthalmol-2018-312839. doi: 10.1136/bjophthalmol-2018-312839. [Epub ahead of print]

PMID:
30381390
9.

Sinuses and Common Rhinologic Conditions.

London NR Jr, Ramanathan M Jr.

Med Clin North Am. 2018 Nov;102(6):993-1000. doi: 10.1016/j.mcna.2018.06.003. Epub 2018 Aug 18. Review.

PMID:
30342616
10.

Deletion of Nrf2 enhances susceptibility to eosinophilic sinonasal inflammation in a murine model of rhinosinusitis.

London NR Jr, Tharakan A, Mendiola M, Sussan TE, Chen M, Dobzanski A, Lane AP, Sidhaye V, Biswal S, Ramanathan M Jr.

Int Forum Allergy Rhinol. 2019 Jan;9(1):114-119. doi: 10.1002/alr.22222. Epub 2018 Oct 3.

PMID:
30281933
11.

Technique for reconstruction of large clival defects through an endoscopic-assisted tunneled retropharyngeal approach.

London NR Jr, Ishii M, Gallia G, Boahene KDO.

Int Forum Allergy Rhinol. 2018 Dec;8(12):1454-1458. doi: 10.1002/alr.22187. Epub 2018 Aug 2.

PMID:
30070438
12.

Development and Implementation of an Inpatient Otolaryngology Consultation Service at an Academic Medical Center.

Huddle MG, London NR Jr, Stewart CM.

South Med J. 2018 Feb;111(2):118-122. doi: 10.14423/SMJ.0000000000000763.

PMID:
29394430
13.

Characterization of a novel, papain-inducible murine model of eosinophilic rhinosinusitis.

Tharakan A, Dobzanski A, London NR Jr, Khalil SM, Surya N, Lane AP, Ramanathan M Jr.

Int Forum Allergy Rhinol. 2018 Apr;8(4):513-521. doi: 10.1002/alr.22072. Epub 2018 Jan 17.

14.

Novel K-Ras G12C Switch-II Covalent Binders Destabilize Ras and Accelerate Nucleotide Exchange.

Nnadi CI, Jenkins ML, Gentile DR, Bateman LA, Zaidman D, Balius TE, Nomura DK, Burke JE, Shokat KM, London N.

J Chem Inf Model. 2018 Feb 26;58(2):464-471. doi: 10.1021/acs.jcim.7b00399. Epub 2018 Jan 31.

15.

The Role of the Sinonasal Epithelium in Allergic Rhinitis.

London NR Jr, Ramanathan M Jr.

Otolaryngol Clin North Am. 2017 Dec;50(6):1043-1050. doi: 10.1016/j.otc.2017.08.002. Epub 2017 Oct 6. Review.

16.

Results of the First American Prospective Study of Intravenous Iron in Oral Iron-Intolerant Iron-Deficient Gravidas.

Auerbach M, James SE, Nicoletti M, Lenowitz S, London N, Bahrain HF, Derman R, Smith S.

Am J Med. 2017 Dec;130(12):1402-1407. doi: 10.1016/j.amjmed.2017.06.025. Epub 2017 Jul 21.

PMID:
28739199
17.

In silico analysis of pathways activation landscape in oral squamous cell carcinoma and oral leukoplakia.

Makarev E, Schubert AD, Kanherkar RR, London N, Teka M, Ozerov I, Lezhnina K, Bedi A, Ravi R, Mehra R, Hoque MO, Sloma I, Gaykalova DA, Csoka AB, Sidransky D, Zhavoronkov A, Izumchenko E.

Cell Death Discov. 2017 May 22;3:17022. doi: 10.1038/cddiscovery.2017.22. eCollection 2017.

18.

Innate immunity and chronic rhinosinusitis: What we have learned from animal models.

London NR Jr, Lane AP.

Laryngoscope Investig Otolaryngol. 2016 Jun;1(3):49-56. doi: 10.1002/lio2.21. Epub 2016 Jun 10.

19.

Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation.

Ziarek JJ, Kleist AB, London N, Raveh B, Montpas N, Bonneterre J, St-Onge G, DiCosmo-Ponticello CJ, Koplinski CA, Roy I, Stephens B, Thelen S, Veldkamp CT, Coffman FD, Cohen MC, Dwinell MB, Thelen M, Peterson FC, Heveker N, Volkman BF.

Sci Signal. 2017 Mar 21;10(471). pii: eaah5756. doi: 10.1126/scisignal.aah5756.

20.

Airborne Particulate Matter Induces Nonallergic Eosinophilic Sinonasal Inflammation in Mice.

Ramanathan M Jr, London NR Jr, Tharakan A, Surya N, Sussan TE, Rao X, Lin SY, Toskala E, Rajagopalan S, Biswal S.

Am J Respir Cell Mol Biol. 2017 Jul;57(1):59-65. doi: 10.1165/rcmb.2016-0351OC.

21.

Nuclear erythroid 2-related factor 2 activation inhibits house dust mite-induced sinonasal epithelial cell barrier dysfunction.

London NR Jr, Tharakan A, Lane AP, Biswal S, Ramanathan M Jr.

Int Forum Allergy Rhinol. 2017 May;7(5):536-541. doi: 10.1002/alr.21916. Epub 2017 Feb 2.

PMID:
28151586
22.

Bactericidal antibiotics promote oxidative damage and programmed cell death in sinonasal epithelial cells.

Kohanski MA, Tharakan A, London NR, Lane AP, Ramanathan M Jr.

Int Forum Allergy Rhinol. 2017 Apr;7(4):359-364. doi: 10.1002/alr.21914. Epub 2017 Jan 24.

23.

Air pollutant-mediated disruption of sinonasal epithelial cell barrier function is reversed by activation of the Nrf2 pathway.

London NR Jr, Tharakan A, Rule AM, Lane AP, Biswal S, Ramanathan M Jr.

J Allergy Clin Immunol. 2016 Dec;138(6):1736-1738.e4. doi: 10.1016/j.jaci.2016.06.027. Epub 2016 Jul 27. No abstract available.

PMID:
27576127
24.

Ranibizumab Treatment for Pigment Epithelial Detachment Secondary to Neovascular Age-Related Macular Degeneration: Post Hoc Analysis of the HARBOR Study.

Sarraf D, London NJ, Khurana RN, Dugel PU, Gune S, Hill L, Tuomi L.

Ophthalmology. 2016 Oct;123(10):2213-24. doi: 10.1016/j.ophtha.2016.07.007. Epub 2016 Aug 23.

25.

The Role of Innate Immunity and Aeroallergens in Chronic Rhinosinusitis.

London NR Jr, Tharakan A, Ramanathan M Jr.

Adv Otorhinolaryngol. 2016;79:69-77. doi: 10.1159/000445132. Epub 2016 Jul 28. Review.

PMID:
27466848
26.

Differential Diagnosis of Chronic Rhinosinusitis with Nasal Polyps.

London NR Jr, Reh DD.

Adv Otorhinolaryngol. 2016;79:1-12. doi: 10.1159/000444957. Epub 2016 Jul 28. Review.

PMID:
27466841
27.

Drugs, Inflammation, and the Eye.

Cunningham ET Jr, London NJ, Moorthy R, Garg SJ, Zierhut M.

Ocul Immunol Inflamm. 2016;24(2):125-7. doi: 10.3109/09273948.2016.1160683. No abstract available.

PMID:
27074544
28.

The Treatment Paradigm for the Implantable Miniature Telescope.

Hau VS, London N, Dalton M.

Ophthalmol Ther. 2016 Jun;5(1):21-30. doi: 10.1007/s40123-016-0047-5. Epub 2016 Apr 11. Review.

29.

Safety and efficacy of rapid (1,000 mg in 1 hr) intravenous iron dextran for treatment of maternal iron deficient anemia of pregnancy.

Wong L, Smith S, Gilstrop M, Derman R, Auerbach S, London N, Lenowitz S, Bahrain H, McClintock J, Auerbach M.

Am J Hematol. 2016 Jun;91(6):590-3. doi: 10.1002/ajh.24361. Epub 2016 Apr 13.

30.

Ultrasonography alone can reliably locate parathyroid tumours and facilitates minimally invasive parathyroidectomy.

Butt HZ, Husainy MA, Bolia A, London NJ.

Ann R Coll Surg Engl. 2015 Sep;97(6):420-4. doi: 10.1308/003588415X14181254790202. Epub 2015 Aug 14.

31.

Virtual Screening for UDP-Galactopyranose Mutase Ligands Identifies a New Class of Antimycobacterial Agents.

Kincaid VA, London N, Wangkanont K, Wesener DA, Marcus SA, Héroux A, Nedyalkova L, Talaat AM, Forest KT, Shoichet BK, Kiessling LL.

ACS Chem Biol. 2015 Oct 16;10(10):2209-18. doi: 10.1021/acschembio.5b00370. Epub 2015 Aug 17.

32.

Diagnostic and Therapeutic Challenges.

Introini U, Casalino G, Parodi MB, Bandello F, London NJ.

Retina. 2016 Feb;36(2):422-7. doi: 10.1097/IAE.0000000000000591. No abstract available.

PMID:
26066702
33.

No demonstrable benefit for coronal alignment outcomes in PSI knee arthroplasty: A systematic review and meta-analysis.

Mannan A, Smith TO, Sagar C, London NJ, Molitor PJ.

Orthop Traumatol Surg Res. 2015 Jun;101(4):461-8. doi: 10.1016/j.otsr.2014.12.018. Epub 2015 Mar 20. Review.

34.

Erratum: Covalent docking of large libraries for the discovery of chemical probes.

London N, Miller RM, Krishnan S, Uchida K, Irwin JJ, Eidam O, Gibold L, Cimermančič P, Bonnet R, Shoichet BK, Taunton J.

Nat Chem Biol. 2015 Mar;11(3):235. doi: 10.1038/nchembio0315-235b. No abstract available.

PMID:
25689339
35.

Covalent docking predicts substrates for haloalkanoate dehalogenase superfamily phosphatases.

London N, Farelli JD, Brown SD, Liu C, Huang H, Korczynska M, Al-Obaidi NF, Babbitt PC, Almo SC, Allen KN, Shoichet BK.

Biochemistry. 2015 Jan 20;54(2):528-37. doi: 10.1021/bi501140k. Epub 2015 Jan 5.

36.

Rationally Designed Macrocyclic Peptides as Synergistic Agonists of LPS-Induced Inflammatory Response.

Gao M, London N, Cheng K, Tamura R, Jin J, Schueler-Furman O, Yin H.

Tetrahedron. 2014 Oct 21;70(42):7664-7668. doi: 10.1016/j.tet.2014.07.026.

37.

Accuracy and early outcomes in medial unicompartmental knee arthroplasty performed using patient specific instrumentation.

Bell SW, Stoddard J, Bennett C, London NJ.

Knee. 2014;21 Suppl 1:S33-6. doi: 10.1016/S0968-0160(14)50007-5. Review.

PMID:
25382366
38.

Leukemia presenting as serous retinal detachment.

Smith AG, London NJ, Pao K, Lipkowitz J, Kurup SK, Garg SJ.

Retin Cases Brief Rep. 2014 Fall;8(4):279-82. doi: 10.1097/ICB.0000000000000074. Review.

PMID:
25372528
39.

Covalent docking of large libraries for the discovery of chemical probes.

London N, Miller RM, Krishnan S, Uchida K, Irwin JJ, Eidam O, Gibold L, Cimermančič P, Bonnet R, Shoichet BK, Taunton J.

Nat Chem Biol. 2014 Dec;10(12):1066-72. doi: 10.1038/nchembio.1666. Epub 2014 Oct 26. Erratum in: Nat Chem Biol. 2015 Mar;11(3):235.

40.

Signalling dynamics in the spindle checkpoint response.

London N, Biggins S.

Nat Rev Mol Cell Biol. 2014 Nov;15(11):736-47. doi: 10.1038/nrm3888. Epub 2014 Oct 10. Review.

41.

Mortality in patients with AIDS-related cytomegalovirus retinitis in Myanmar.

Tun N, Smithuis FM, London N, Drew WL, Heiden D.

Clin Infect Dis. 2014 Dec 1;59(11):1650-1. doi: 10.1093/cid/ciu648. Epub 2014 Aug 13. No abstract available.

42.

Effect of topical aqueous suppression on intraocular gas duration after pure perfluoropropane injection in nonvitrectomized eyes with retinal detachment.

Hsu J, Gerstenblith AT, London NJ, Garg SJ, Spirn MJ, Maguire JI, Park C, Sivalingam A.

Retina. 2014 Dec;34(12):2458-61. doi: 10.1097/IAE.0000000000000244.

PMID:
25072647
43.

Pars plana vitrectomy and scleral buckle versus pars plana vitrectomy alone for patients with rhegmatogenous retinal detachment at high risk for proliferative vitreoretinopathy.

Storey P, Alshareef R, Khuthaila M, London N, Leiby B, DeCroos C, Kaiser R; Wills PVR Study Group.

Retina. 2014 Oct;34(10):1945-51. doi: 10.1097/IAE.0000000000000216.

PMID:
24999720
44.

Prediction of substrates for glutathione transferases by covalent docking.

Dong GQ, Calhoun S, Fan H, Kalyanaraman C, Branch MC, Mashiyama ST, London N, Jacobson MP, Babbitt PC, Shoichet BK, Armstrong RN, Sali A.

J Chem Inf Model. 2014 Jun 23;54(6):1687-99. doi: 10.1021/ci5001554. Epub 2014 May 16.

45.

Mad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpoint.

London N, Biggins S.

Genes Dev. 2014 Jan 15;28(2):140-52. doi: 10.1101/gad.233700.113. Epub 2014 Jan 8.

46.

The role of vascular endothelial growth factor and vascular stability in diseases of the ear.

London NR, Gurgel RK.

Laryngoscope. 2014 Aug;124(8):E340-6. doi: 10.1002/lary.24564. Epub 2014 Jan 28. Review.

PMID:
24347479
47.

Druggable protein-protein interactions--from hot spots to hot segments.

London N, Raveh B, Schueler-Furman O.

Curr Opin Chem Biol. 2013 Dec;17(6):952-9. doi: 10.1016/j.cbpa.2013.10.011. Epub 2013 Oct 31. Review.

PMID:
24183815
48.

Peptide docking and structure-based characterization of peptide binding: from knowledge to know-how.

London N, Raveh B, Schueler-Furman O.

Curr Opin Struct Biol. 2013 Dec;23(6):894-902. doi: 10.1016/j.sbi.2013.07.006. Epub 2013 Oct 15. Review.

PMID:
24138780
49.

Drug-induced uveitis.

Moorthy RS, London NJ, Garg SJ, Cunningham ET Jr.

Curr Opin Ophthalmol. 2013 Nov;24(6):589-97. doi: 10.1097/01.icu.0000434534.32063.5c. Review.

PMID:
24100371
50.

Procedural risk following carotid endarterectomy in the hyperacute period after onset of symptoms.

Sharpe R, Sayers RD, London NJ, Bown MJ, McCarthy MJ, Nasim A, Davies RS, Naylor AR.

Eur J Vasc Endovasc Surg. 2013 Nov;46(5):519-24. doi: 10.1016/j.ejvs.2013.08.014. Epub 2013 Sep 5.

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