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Items: 9

1.

Pharmacokinetics, Safety, Tolerability, and Pharmacodynamics of Alicapistat, a Selective Inhibitor of Human Calpains 1 and 2 for the Treatment of Alzheimer Disease: An Overview of Phase 1 Studies.

Lon HK, Mendonca N, Goss S, Othman AA, Locke C, Jin Z, Rendenbach-Mueller B.

Clin Pharmacol Drug Dev. 2019 Apr;8(3):290-303. doi: 10.1002/cpdd.598. Epub 2018 Jul 27.

PMID:
30052328
2.

Oligonucleotide-Based Drug Development: Considerations for Clinical Pharmacology and Immunogenicity.

Wang J, Lon HK, Lee SL, Burckart GJ, Pisetsky DS.

Ther Innov Regul Sci. 2015 Nov;49(6):861-868. doi: 10.1177/2168479015592195.

PMID:
30222372
3.

Modeling effects of dexamethasone on disease progression of bone mineral density in collagen-induced arthritic rats.

Lon HK, DuBois DC, Earp JC, Almon RR, Jusko WJ.

Pharmacol Res Perspect. 2015 Oct;3(5):e00169. doi: 10.1002/prp2.169. Epub 2015 Aug 3.

4.
5.

Pharmacokinetics, pharmacodynamics and toxicities of methotrexate in healthy and collagen-induced arthritic rats.

Liu DY, Lon HK, Wang YL, DuBois DC, Almon RR, Jusko WJ.

Biopharm Drug Dispos. 2013 May;34(4):203-14. doi: 10.1002/bdd.1838. Epub 2013 Apr 7.

6.

Pharmacokinetic/pharmacodynamic modeling in inflammation.

Lon HK, Liu D, Jusko WJ.

Crit Rev Biomed Eng. 2012;40(4):295-312. Review.

7.

Population pharmacokinetic-pharmacodynamic-disease progression model for effects of anakinra in Lewis rats with collagen-induced arthritis.

Liu D, Lon HK, Dubois DC, Almon RR, Jusko WJ.

J Pharmacokinet Pharmacodyn. 2011 Dec;38(6):769-86. doi: 10.1007/s10928-011-9219-z. Epub 2011 Oct 16.

8.

Pharmacokinetic-pharmacodynamic disease progression model for effect of etanercept in Lewis rats with collagen-induced arthritis.

Lon HK, Liu D, Zhang Q, DuBois DC, Almon RR, Jusko WJ.

Pharm Res. 2011 Jul;28(7):1622-30. doi: 10.1007/s11095-011-0396-7. Epub 2011 Mar 1.

9.

Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice.

Felmlee MA, Lon HK, Gonzalez FJ, Yu AM.

Drug Metab Dispos. 2008 Feb;36(2):435-41. Epub 2007 Nov 29. Erratum in: Drug Metab Dispos. 2009 Jul;37(7):1563.

PMID:
18048490

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