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Items: 1 to 50 of 148

1.

Loss of STEP61 couples disinhibition to N-methyl-d-aspartate receptor potentiation in rodent and human spinal pain processing.

Dedek A, Xu J, Kandegedara CM, Lorenzo LÉ, Godin AG, De Koninck Y, Lombroso PJ, Tsai EC, Hildebrand ME.

Brain. 2019 Jun 1;142(6):1535-1546. doi: 10.1093/brain/awz105.

2.

The Tyrosine Phosphatase STEP Is Involved in Age-Related Memory Decline.

Castonguay D, Dufort-Gervais J, Ménard C, Chatterjee M, Quirion R, Bontempi B, Schneider JS, Arnsten AFT, Nairn AC, Norris CM, Ferland G, Bézard E, Gaudreau P, Lombroso PJ, Brouillette J.

Curr Biol. 2018 Apr 2;28(7):1079-1089.e4. doi: 10.1016/j.cub.2018.02.047. Epub 2018 Mar 22.

3.

Glutathione-Responsive Selenosulfide Prodrugs as a Platform Strategy for Potent and Selective Mechanism-Based Inhibition of Protein Tyrosine Phosphatases.

Tjin CC, Otley KD, Baguley TD, Kurup P, Xu J, Nairn AC, Lombroso PJ, Ellman JA.

ACS Cent Sci. 2017 Dec 27;3(12):1322-1328. doi: 10.1021/acscentsci.7b00486. Epub 2017 Dec 6.

4.

X-ray Characterization and Structure-Based Optimization of Striatal-Enriched Protein Tyrosine Phosphatase Inhibitors.

Witten MR, Wissler L, Snow M, Geschwindner S, Read JA, Brandon NJ, Nairn AC, Lombroso PJ, Käck H, Ellman JA.

J Med Chem. 2017 Nov 22;60(22):9299-9319. doi: 10.1021/acs.jmedchem.7b01292. Epub 2017 Nov 8.

5.

Molecular underpinnings of neurodegenerative disorders: striatal-enriched protein tyrosine phosphatase signaling and synaptic plasticity.

Lombroso PJ, Ogren M, Kurup P, Nairn AC.

F1000Res. 2016 Dec 29;5. pii: F1000 Faculty Rev-2932. doi: 10.12688/f1000research.8571.1. eCollection 2016. Review.

6.

STEP inhibition reverses behavioral, electrophysiologic, and synaptic abnormalities in Fmr1 KO mice.

Chatterjee M, Kurup PK, Lundbye CJ, Hugger Toft AK, Kwon J, Benedict J, Kamceva M, Banke TG, Lombroso PJ.

Neuropharmacology. 2018 Jan;128:43-53. doi: 10.1016/j.neuropharm.2017.09.026. Epub 2017 Sep 21.

PMID:
28943283
7.

Synaptic NMDA Receptor Activation Induces Ubiquitination and Degradation of STEP61.

Xu J, Kurup P, Nairn AC, Lombroso PJ.

Mol Neurobiol. 2018 Apr;55(4):3096-3111. doi: 10.1007/s12035-017-0555-x. Epub 2017 May 2.

8.

Intra-prelimbic cortical inhibition of striatal-enriched tyrosine phosphatase suppresses cocaine seeking in rats.

Siemsen BM, Lombroso PJ, McGinty JF.

Addict Biol. 2018 Jan;23(1):219-229. doi: 10.1111/adb.12504. Epub 2017 Mar 28.

9.

Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing.

Hildebrand ME, Xu J, Dedek A, Li Y, Sengar AS, Beggs S, Lombroso PJ, Salter MW.

Cell Rep. 2016 Dec 6;17(10):2753-2765. doi: 10.1016/j.celrep.2016.11.024.

10.

Outbred CD1 mice are as suitable as inbred C57BL/6J mice in performing social tasks.

Hsieh LS, Wen JH, Miyares L, Lombroso PJ, Bordey A.

Neurosci Lett. 2017 Jan 10;637:142-147. doi: 10.1016/j.neulet.2016.11.035. Epub 2016 Nov 18.

11.

STEP activation by Gαq coupled GPCRs opposes Src regulation of NMDA receptors containing the GluN2A subunit.

Tian M, Xu J, Lei G, Lombroso PJ, Jackson MF, MacDonald JF.

Sci Rep. 2016 Nov 18;6:36684. doi: 10.1038/srep36684.

12.

Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models.

Xu J, Hartley BJ, Kurup P, Phillips A, Topol A, Xu M, Ononenyi C, Foscue E, Ho SM, Baguley TD, Carty N, Barros CS, Müller U, Gupta S, Gochman P, Rapoport J, Ellman JA, Pittenger C, Aronow B, Nairn AC, Nestor MW, Lombroso PJ, Brennand KJ.

Mol Psychiatry. 2018 Feb;23(2):271-281. doi: 10.1038/mp.2016.163. Epub 2016 Oct 18.

13.

Role of Striatal-Enriched Tyrosine Phosphatase in Neuronal Function.

Kamceva M, Benedict J, Nairn AC, Lombroso PJ.

Neural Plast. 2016;2016:8136925. doi: 10.1155/2016/8136925. Epub 2016 Apr 12. Review.

14.

Inhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice.

Xu J, Kurup P, Baguley TD, Foscue E, Ellman JA, Nairn AC, Lombroso PJ.

Cell Mol Life Sci. 2016 Apr;73(7):1503-14. doi: 10.1007/s00018-015-2057-1. Epub 2015 Oct 8.

15.

Regulation of STEP61 and tyrosine-phosphorylation of NMDA and AMPA receptors during homeostatic synaptic plasticity.

Jang SS, Royston SE, Xu J, Cavaretta JP, Vest MO, Lee KY, Lee S, Jeong HG, Lombroso PJ, Chung HJ.

Mol Brain. 2015 Sep 22;8(1):55. doi: 10.1186/s13041-015-0148-4.

16.

Down-regulation of BDNF in cell and animal models increases striatal-enriched protein tyrosine phosphatase 61 (STEP61 ) levels.

Xu J, Kurup P, Azkona G, Baguley TD, Saavedra A, Nairn AC, Ellman JA, Pérez-Navarro E, Lombroso PJ.

J Neurochem. 2016 Jan;136(2):285-94. doi: 10.1111/jnc.13295. Epub 2015 Sep 17.

17.

Striatal-enriched protein tyrosine phosphatase modulates nociception: evidence from genetic deletion and pharmacological inhibition.

Azkona G, Saavedra A, Aira Z, Aluja D, Xifró X, Baguley T, Alberch J, Ellman JA, Lombroso PJ, Azkue JJ, Pérez-Navarro E.

Pain. 2016 Feb;157(2):377-86. doi: 10.1097/j.pain.0000000000000329.

18.

BDNF Induces Striatal-Enriched Protein Tyrosine Phosphatase 61 Degradation Through the Proteasome.

Saavedra A, Puigdellívol M, Tyebji S, Kurup P, Xu J, Ginés S, Alberch J, Lombroso PJ, Pérez-Navarro E.

Mol Neurobiol. 2016 Aug;53(6):4261-4273. doi: 10.1007/s12035-015-9335-7. Epub 2015 Jul 30.

19.

Striatal-enriched protein tyrosine phosphatase controls responses to aversive stimuli: implication for ethanol drinking.

Legastelois R, Darcq E, Wegner SA, Lombroso PJ, Ron D.

PLoS One. 2015 May 20;10(5):e0127408. doi: 10.1371/journal.pone.0127408. eCollection 2015.

20.

Striatal-enriched protein tyrosine phosphatase regulates the PTPα/Fyn signaling pathway.

Xu J, Kurup P, Foscue E, Lombroso PJ.

J Neurochem. 2015 Aug;134(4):629-41. doi: 10.1111/jnc.13160. Epub 2015 May 25.

21.

Synthesis of benzopentathiepin analogs and their evaluation as inhibitors of the phosphatase STEP.

Baguley TD, Nairn AC, Lombroso PJ, Ellman JA.

Bioorg Med Chem Lett. 2015 Mar 1;25(5):1044-6. doi: 10.1016/j.bmcl.2015.01.020. Epub 2015 Jan 20.

22.

STEP61 is a substrate of the E3 ligase parkin and is upregulated in Parkinson's disease.

Kurup PK, Xu J, Videira RA, Ononenyi C, Baltazar G, Lombroso PJ, Nairn AC.

Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):1202-7. doi: 10.1073/pnas.1417423112. Epub 2015 Jan 12.

23.

Rapid regulation of endoplasmic reticulum dynamics in dendritic spines by NMDA receptor activation.

Ng AN, Doherty AJ, Lombroso PJ, Emptage NJ, Collingridge GL.

Mol Brain. 2014 Aug 19;7:60. doi: 10.1186/s13041-014-0060-3.

24.

Disruption of striatal-enriched protein tyrosine phosphatase (STEP) function in neuropsychiatric disorders.

Karasawa T, Lombroso PJ.

Neurosci Res. 2014 Dec;89:1-9. doi: 10.1016/j.neures.2014.08.018. Epub 2014 Sep 10. Review.

25.

Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease.

Xu J, Chatterjee M, Baguley TD, Brouillette J, Kurup P, Ghosh D, Kanyo J, Zhang Y, Seyb K, Ononenyi C, Foscue E, Anderson GM, Gresack J, Cuny GD, Glicksman MA, Greengard P, Lam TT, Tautz L, Nairn AC, Ellman JA, Lombroso PJ.

PLoS Biol. 2014 Aug 5;12(8):e1001923. doi: 10.1371/journal.pbio.1001923. eCollection 2014 Aug.

26.

Alterations in STriatal-Enriched protein tyrosine Phosphatase expression, activation, and downstream signaling in early and late stages of the YAC128 Huntington's disease mouse model.

Gladding CM, Fan J, Zhang LY, Wang L, Xu J, Li EH, Lombroso PJ, Raymond LA.

J Neurochem. 2014 Jul;130(1):145-59. doi: 10.1111/jnc.12700. Epub 2014 Apr 2.

27.

Individualized assessments in treatment research: an examination of parent-nominated target problems in the treatment of disruptive behaviors in youth with Tourette syndrome.

McGuire JF, Sukhodolsky DG, Bearss K, Grantz H, Pachler M, Lombroso PJ, Scahill L.

Child Psychiatry Hum Dev. 2014 Dec;45(6):686-94. doi: 10.1007/s10578-014-0437-7.

PMID:
24477478
28.

Neuroprotective role of a brain-enriched tyrosine phosphatase, STEP, in focal cerebral ischemia.

Deb I, Manhas N, Poddar R, Rajagopal S, Allan AM, Lombroso PJ, Rosenberg GA, Candelario-Jalil E, Paul S.

J Neurosci. 2013 Nov 6;33(45):17814-26. doi: 10.1523/JNEUROSCI.2346-12.2013.

29.

Substrate-based fragment identification for the development of selective, nonpeptidic inhibitors of striatal-enriched protein tyrosine phosphatase.

Baguley TD, Xu HC, Chatterjee M, Nairn AC, Lombroso PJ, Ellman JA.

J Med Chem. 2013 Oct 10;56(19):7636-50. doi: 10.1021/jm401037h. Epub 2013 Oct 1.

30.

Striatal-enriched protein tyrosine phosphatase-STEPs toward understanding chronic stress-induced activation of corticotrophin releasing factor neurons in the rat bed nucleus of the stria terminalis.

Dabrowska J, Hazra R, Guo JD, Li C, Dewitt S, Xu J, Lombroso PJ, Rainnie DG.

Biol Psychiatry. 2013 Dec 1;74(11):817-26. doi: 10.1016/j.biopsych.2013.07.032. Epub 2013 Sep 5.

31.

Cocaine-induced changes of synaptic transmission in the striatum are modulated by adenosine A2A receptors and involve the tyrosine phosphatase STEP.

Chiodi V, Mallozzi C, Ferrante A, Chen JF, Lombroso PJ, Di Stasi AM, Popoli P, Domenici MR.

Neuropsychopharmacology. 2014 Feb;39(3):569-78. doi: 10.1038/npp.2013.229. Epub 2013 Aug 30.

32.

A common STEP in the synaptic pathology of diverse neuropsychiatric disorders.

Johnson MA, Lombroso PJ.

Yale J Biol Med. 2012 Dec;85(4):481-90. Epub 2012 Dec 13. Review.

33.

The tyrosine phosphatase STEP constrains amygdala-dependent memory formation and neuroplasticity.

Olausson P, Venkitaramani DV, Moran TD, Salter MW, Taylor JR, Lombroso PJ.

Neuroscience. 2012 Dec 6;225:1-8. doi: 10.1016/j.neuroscience.2012.07.069. Epub 2012 Aug 9.

34.

Striatal-enriched protein tyrosine phosphatase in Alzheimer's disease.

Xu J, Kurup P, Nairn AC, Lombroso PJ.

Adv Pharmacol. 2012;64:303-25. doi: 10.1016/B978-0-12-394816-8.00009-X. Review.

35.

The tyrosine phosphatase STEP: implications in schizophrenia and the molecular mechanism underlying antipsychotic medications.

Carty NC, Xu J, Kurup P, Brouillette J, Goebel-Goody SM, Austin DR, Yuan P, Chen G, Correa PR, Haroutunian V, Pittenger C, Lombroso PJ.

Transl Psychiatry. 2012 Jul 10;2:e137. doi: 10.1038/tp.2012.63.

36.

Striatal-enriched protein-tyrosine phosphatase (STEP) regulates Pyk2 kinase activity.

Xu J, Kurup P, Bartos JA, Patriarchi T, Hell JW, Lombroso PJ.

J Biol Chem. 2012 Jun 15;287(25):20942-56. doi: 10.1074/jbc.M112.368654. Epub 2012 Apr 27.

37.

Tourette syndrome in youth with and without obsessive compulsive disorder and attention deficit hyperactivity disorder.

Lebowitz ER, Motlagh MG, Katsovich L, King RA, Lombroso PJ, Grantz H, Lin H, Bentley MJ, Gilbert DL, Singer HS, Coffey BJ; Tourette Syndrome Study Group, Kurlan RM, Leckman JF.

Eur Child Adolesc Psychiatry. 2012 Aug;21(8):451-7. Epub 2012 Apr 28.

38.

Calpain and STriatal-Enriched protein tyrosine phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model.

Gladding CM, Sepers MD, Xu J, Zhang LY, Milnerwood AJ, Lombroso PJ, Raymond LA.

Hum Mol Genet. 2012 Sep 1;21(17):3739-52. doi: 10.1093/hmg/dds154. Epub 2012 Apr 20.

39.

Genetic manipulation of STEP reverses behavioral abnormalities in a fragile X syndrome mouse model.

Goebel-Goody SM, Wilson-Wallis ED, Royston S, Tagliatela SM, Naegele JR, Lombroso PJ.

Genes Brain Behav. 2012 Jul;11(5):586-600. doi: 10.1111/j.1601-183X.2012.00781.x. Epub 2012 Apr 6.

40.

Protein phosphatases and Alzheimer's disease.

Braithwaite SP, Stock JB, Lombroso PJ, Nairn AC.

Prog Mol Biol Transl Sci. 2012;106:343-79. doi: 10.1016/B978-0-12-396456-4.00012-2. Review.

41.

Therapeutic implications for striatal-enriched protein tyrosine phosphatase (STEP) in neuropsychiatric disorders.

Goebel-Goody SM, Baum M, Paspalas CD, Fernandez SM, Carty NC, Kurup P, Lombroso PJ.

Pharmacol Rev. 2012 Jan;64(1):65-87. doi: 10.1124/pr.110.003053. Epub 2011 Nov 16. Review.

42.

Inhibition of hematopoietic protein tyrosine phosphatase augments and prolongs ERK1/2 and p38 activation.

Sergienko E, Xu J, Liu WH, Dahl R, Critton DA, Su Y, Brown BT, Chan X, Yang L, Bobkova EV, Vasile S, Yuan H, Rascon J, Colayco S, Sidique S, Cosford ND, Chung TD, Mustelin T, Page R, Lombroso PJ, Tautz L.

ACS Chem Biol. 2012 Feb 17;7(2):367-77. doi: 10.1021/cb2004274. Epub 2011 Nov 17.

43.

Taking STEPs forward to understand fragile X syndrome.

Goebel-Goody SM, Lombroso PJ.

Results Probl Cell Differ. 2012;54:223-41. doi: 10.1007/978-3-642-21649-7_12. Review.

44.

Reduced levels of the tyrosine phosphatase STEP block β amyloid-mediated GluA1/GluA2 receptor internalization.

Zhang Y, Kurup P, Xu J, Anderson GM, Greengard P, Nairn AC, Lombroso PJ.

J Neurochem. 2011 Nov;119(3):664-72. doi: 10.1111/j.1471-4159.2011.07450.x. Epub 2011 Sep 21.

45.

The Role of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) in Cognition.

Fitzpatrick CJ, Lombroso PJ.

Front Neuroanat. 2011 Jul 29;5:47. doi: 10.3389/fnana.2011.00047. eCollection 2011.

46.

Transport of animals between rooms: a little-noted aspect of laboratory procedure that may interfere with memory.

Moura PJ, Venkitaramani DV, Tashev R, Lombroso PJ, Xavier GF.

Behav Processes. 2011 Sep;88(1):12-9. doi: 10.1016/j.beproc.2011.06.008. Epub 2011 Jul 3.

PMID:
21729741
47.

Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicity.

Saavedra A, Giralt A, Rué L, Xifró X, Xu J, Ortega Z, Lucas JJ, Lombroso PJ, Alberch J, Pérez-Navarro E.

J Neurosci. 2011 Jun 1;31(22):8150-62. doi: 10.1523/JNEUROSCI.3446-10.2011.

48.

Striatal-enriched protein tyrosine phosphatase (STEP) knockout mice have enhanced hippocampal memory.

Venkitaramani DV, Moura PJ, Picciotto MR, Lombroso PJ.

Eur J Neurosci. 2011 Jun;33(12):2288-98. doi: 10.1111/j.1460-9568.2011.07687.x. Epub 2011 Apr 19.

49.

Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase.

Hicklin TR, Wu PH, Radcliffe RA, Freund RK, Goebel-Goody SM, Correa PR, Proctor WR, Lombroso PJ, Browning MD.

Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6650-5. doi: 10.1073/pnas.1017856108. Epub 2011 Apr 4.

50.

Streptococcal upper respiratory tract infections and exacerbations of tic and obsessive-compulsive symptoms: a prospective longitudinal study.

Leckman JF, King RA, Gilbert DL, Coffey BJ, Singer HS, Dure LS 4th, Grantz H, Katsovich L, Lin H, Lombroso PJ, Kawikova I, Johnson DR, Kurlan RM, Kaplan EL.

J Am Acad Child Adolesc Psychiatry. 2011 Feb;50(2):108-118.e3. doi: 10.1016/j.jaac.2010.10.011. Epub 2010 Dec 31.

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