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Items: 1 to 50 of 61

1.

"MPNST Epigenetics"-Response.

Korfhage J, Lombard DB.

Mol Cancer Res. 2019 Oct;17(10):2140. doi: 10.1158/1541-7786.MCR-19-0788. No abstract available.

PMID:
31575728
2.

Malignant Peripheral Nerve Sheath Tumors: From Epigenome to Bedside.

Korfhage J, Lombard DB.

Mol Cancer Res. 2019 Jul;17(7):1417-1428. doi: 10.1158/1541-7786.MCR-19-0147. Epub 2019 Apr 25. Review.

PMID:
31023785
3.

Combined MAPK Pathway and HDAC Inhibition Breaks Melanoma.

Lombard DB, Cierpicki T, Grembecka J.

Cancer Discov. 2019 Apr;9(4):469-471. doi: 10.1158/2159-8290.CD-19-0069.

PMID:
30936219
4.

A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.

Chefetz I, Grimley E, Yang K, Hong L, Vinogradova EV, Suciu R, Kovalenko I, Karnak D, Morgan CA, Chtcherbinine M, Buchman C, Huddle B, Barraza S, Morgan M, Bernstein KA, Yoon E, Lombard DB, Bild A, Mehta G, Romero I, Chiang CY, Landen C, Cravatt B, Hurley TD, Larsen SD, Buckanovich RJ.

Cell Rep. 2019 Mar 12;26(11):3061-3075.e6. doi: 10.1016/j.celrep.2019.02.032.

5.

Association of the POT1 Germline Missense Variant p.I78T With Familial Melanoma.

Wong K, Robles-Espinoza CD, Rodriguez D, Rudat SS, Puig S, Potrony M, Wong CC, Hewinson J, Aguilera P, Puig-Butille JA, Bressac-de Paillerets B, Zattara H, van der Weyden L, Fletcher CDM, Brenn T, Arends MJ, Quesada V, Newton-Bishop JA, Lopez-Otin C, Bishop DT, Harms PW, Johnson TM, Durham AB, Lombard DB, Adams DJ.

JAMA Dermatol. 2019 May 1;155(5):604-609. doi: 10.1001/jamadermatol.2018.3662.

PMID:
30586141
6.

Mitochondrial Deacetylase SIRT3 Plays an Important Role in Donor T Cell Responses after Experimental Allogeneic Hematopoietic Transplantation.

Toubai T, Tamaki H, Peltier DC, Rossi C, Oravecz-Wilson K, Liu C, Zajac C, Wu J, Sun Y, Fujiwara H, Henig I, Kim S, Lombard DB, Reddy P.

J Immunol. 2018 Dec 1;201(11):3443-3455. doi: 10.4049/jimmunol.1800148. Epub 2018 Nov 2.

7.

Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology.

Kumar S, Lombard DB.

Crit Rev Biochem Mol Biol. 2018 Jun;53(3):311-334. doi: 10.1080/10409238.2018.1458071. Epub 2018 Apr 11. Review.

8.

Sirtuin 6 Builds a Wall Against Inflammation, Trumping Diabetes.

Giblin W, Lombard DB.

Diabetes. 2017 Oct;66(10):2535-2537. doi: 10.2337/dbi17-0025. No abstract available.

9.

Emerging Roles for SIRT5 in Metabolism and Cancer.

Bringman-Rodenbarger LR, Guo AH, Lyssiotis CA, Lombard DB.

Antioxid Redox Signal. 2018 Mar 10;28(8):677-690. doi: 10.1089/ars.2017.7264. Epub 2017 Oct 26.

10.

ACSF3 and Mal(onate)-Adapted Mitochondria.

Lombard DB, Zhao Y.

Cell Chem Biol. 2017 Jun 22;24(6):649-650. doi: 10.1016/j.chembiol.2017.06.004.

11.

Cycling around Lysine Modifications.

Kumar S, Lombard DB.

Trends Biochem Sci. 2017 Jul;42(7):501-503. doi: 10.1016/j.tibs.2017.05.006. Epub 2017 Jun 6.

12.

For Certain, SIRT4 Activities!

Kumar S, Lombard DB.

Trends Biochem Sci. 2017 Jul;42(7):499-501. doi: 10.1016/j.tibs.2017.05.008. Epub 2017 Jun 3.

13.

SIRT3 as a regulator of hepatic autophagy.

Cho CS, Lombard DB, Lee JH.

Hepatology. 2017 Sep;66(3):700-702. doi: 10.1002/hep.29271. Epub 2017 Jul 20. No abstract available.

14.

Generation and Purification of Catalytically Active Recombinant Sirtuin5 (SIRT5) Protein.

Kumar S, Lombard DB.

Methods Mol Biol. 2016;1436:241-57. doi: 10.1007/978-1-4939-3667-0_16.

15.

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation.

Xie Z, Zhang D, Chung D, Tang Z, Huang H, Dai L, Qi S, Li J, Colak G, Chen Y, Xia C, Peng C, Ruan H, Kirkey M, Wang D, Jensen LM, Kwon OK, Lee S, Pletcher SD, Tan M, Lombard DB, White KP, Zhao H, Li J, Roeder RG, Yang X, Zhao Y.

Mol Cell. 2016 Apr 21;62(2):194-206. doi: 10.1016/j.molcel.2016.03.036.

16.

Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules.

Kumar S, Lombard DB.

F1000Res. 2016 Mar 29;5. pii: F1000 Faculty Rev-406. doi: 10.12688/f1000research.7821.1. eCollection 2016. Review.

17.

Identification of sirtuin 5 inhibitors by ultrafast microchip electrophoresis using nanoliter volume samples.

Guetschow ED, Kumar S, Lombard DB, Kennedy RT.

Anal Bioanal Chem. 2016 Jan;408(3):721-31. doi: 10.1007/s00216-015-9206-0. Epub 2015 Dec 3.

18.

SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY.

Novgorodov SA, Riley CL, Keffler JA, Yu J, Kindy MS, Macklin WB, Lombard DB, Gudz TI.

J Biol Chem. 2016 Jan 22;291(4):1957-73. doi: 10.1074/jbc.M115.668228. Epub 2015 Nov 30.

19.

Acetyl-ed question in mitochondrial biology?

Lombard DB, Dash BP, Kumar S.

EMBO J. 2015 Nov 3;34(21):2597-600. doi: 10.15252/embj.201592927. Epub 2015 Sep 14. No abstract available.

20.

Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation.

Colak G, Pougovkina O, Dai L, Tan M, Te Brinke H, Huang H, Cheng Z, Park J, Wan X, Liu X, Yue WW, Wanders RJ, Locasale JW, Lombard DB, de Boer VC, Zhao Y.

Mol Cell Proteomics. 2015 Nov;14(11):3056-71. doi: 10.1074/mcp.M115.048850. Epub 2015 Aug 28.

21.

Sirtuin 1 Regulates Dendritic Cell Activation and Autophagy during Respiratory Syncytial Virus-Induced Immune Responses.

Owczarczyk AB, Schaller MA, Reed M, Rasky AJ, Lombard DB, Lukacs NW.

J Immunol. 2015 Aug 15;195(4):1637-46. doi: 10.4049/jimmunol.1500326. Epub 2015 Jul 8.

22.

Mitochondrial sirtuins and their relationships with metabolic disease and cancer.

Kumar S, Lombard DB.

Antioxid Redox Signal. 2015 Apr 20;22(12):1060-77. doi: 10.1089/ars.2014.6213. Epub 2015 Feb 10. Review.

23.

Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming.

Zwaans BM, Lombard DB.

Dis Model Mech. 2014 Sep;7(9):1023-32. doi: 10.1242/dmm.016287. Epub 2014 Aug 1. Review.

24.

Sirtuins: guardians of mammalian healthspan.

Giblin W, Skinner ME, Lombard DB.

Trends Genet. 2014 Jul;30(7):271-86. doi: 10.1016/j.tig.2014.04.007. Epub 2014 May 28. Review.

25.

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.

Tan M, Peng C, Anderson KA, Chhoy P, Xie Z, Dai L, Park J, Chen Y, Huang H, Zhang Y, Ro J, Wagner GR, Green MF, Madsen AS, Schmiesing J, Peterson BS, Xu G, Ilkayeva OR, Muehlbauer MJ, Braulke T, Mühlhausen C, Backos DS, Olsen CA, McGuire PJ, Pletcher SD, Lombard DB, Hirschey MD, Zhao Y.

Cell Metab. 2014 Apr 1;19(4):605-17. doi: 10.1016/j.cmet.2014.03.014.

26.

Cross-talk between sirtuin and mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation.

Hong S, Zhao B, Lombard DB, Fingar DC, Inoki K.

J Biol Chem. 2014 May 9;289(19):13132-41. doi: 10.1074/jbc.M113.520734. Epub 2014 Mar 20.

27.

SIRT3: as simple as it seems?

Lombard DB, Zwaans BM.

Gerontology. 2014;60(1):56-64. doi: 10.1159/000354382. Epub 2013 Oct 25. Review.

28.

Mass spectrometry-based detection of protein acetylation.

Li Y, Silva JC, Skinner ME, Lombard DB.

Methods Mol Biol. 2013;1077:81-104. doi: 10.1007/978-1-62703-637-5_6.

29.

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.

Mol Cell. 2013 Jun 27;50(6):919-30. doi: 10.1016/j.molcel.2013.06.001.

30.

Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases.

Wirth M, Karaca S, Wenzel D, Ho L, Tishkoff D, Lombard DB, Verdin E, Urlaub H, Jedrusik-Bode M, Fischle W.

Mitochondrion. 2013 Nov;13(6):705-20. doi: 10.1016/j.mito.2013.02.002. Epub 2013 Feb 21.

31.

The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.

Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R.

Cell. 2012 Dec 7;151(6):1185-99. doi: 10.1016/j.cell.2012.10.047.

32.

The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.

Sundaresan NR, Vasudevan P, Zhong L, Kim G, Samant S, Parekh V, Pillai VB, Ravindra PV, Gupta M, Jeevanandam V, Cunningham JM, Deng CX, Lombard DB, Mostoslavsky R, Gupta MP.

Nat Med. 2012 Nov;18(11):1643-50. doi: 10.1038/nm.2961. Epub 2012 Oct 21.

33.

C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress.

Chiang WC, Tishkoff DX, Yang B, Wilson-Grady J, Yu X, Mazer T, Eckersdorff M, Gygi SP, Lombard DB, Hsu AL.

PLoS Genet. 2012 Sep;8(9):e1002948. doi: 10.1371/journal.pgen.1002948. Epub 2012 Sep 13.

34.

Ageing: Sorting out the sirtuins.

Lombard DB, Miller RA.

Nature. 2012 Mar 7;483(7388):166-7. doi: 10.1038/nature10950. No abstract available.

PMID:
22367538
35.

Ageing: longevity hits a roadblock.

Lombard DB, Pletcher SD, Cantó C, Auwerx J.

Nature. 2011 Sep 21;477(7365):410-1. doi: 10.1038/477410a. No abstract available.

PMID:
21938058
36.

Mitochondrial sirtuins in the regulation of mitochondrial activity and metabolic adaptation.

Lombard DB, Tishkoff DX, Bao J.

Handb Exp Pharmacol. 2011;206:163-88. doi: 10.1007/978-3-642-21631-2_8. Review.

37.

SIRT3-dependent deacetylation exacerbates acetaminophen hepatotoxicity.

Lu Z, Bourdi M, Li JH, Aponte AM, Chen Y, Lombard DB, Gucek M, Pohl LR, Sack MN.

EMBO Rep. 2011 Jul 1;12(8):840-6. doi: 10.1038/embor.2011.121.

38.

SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production.

Shimazu T, Hirschey MD, Hua L, Dittenhafer-Reed KE, Schwer B, Lombard DB, Li Y, Bunkenborg J, Alt FW, Denu JM, Jacobson MP, Verdin E.

Cell Metab. 2010 Dec 1;12(6):654-61. doi: 10.1016/j.cmet.2010.11.003.

39.

Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.

Schwer B, Schumacher B, Lombard DB, Xiao C, Kurtev MV, Gao J, Schneider JI, Chai H, Bronson RT, Tsai LH, Deng CX, Alt FW.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21790-4. doi: 10.1073/pnas.1016306107. Epub 2010 Nov 22.

40.

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.

Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV Jr, Alt FW, Kahn CR, Verdin E.

Nature. 2010 Mar 4;464(7285):121-5. doi: 10.1038/nature08778.

41.

Sirtuins at the breaking point: SIRT6 in DNA repair.

Lombard DB.

Aging (Albany NY). 2009 Jan 20;1(1):12-6. No abstract available.

42.

The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability.

Yang B, Zwaans BM, Eckersdorff M, Lombard DB.

Cell Cycle. 2009 Aug 15;8(16):2662-3. Epub 2009 Aug 22. No abstract available.

43.

Calorie restriction alters mitochondrial protein acetylation.

Schwer B, Eckersdorff M, Li Y, Silva JC, Fermin D, Kurtev MV, Giallourakis C, Comb MJ, Alt FW, Lombard DB.

Aging Cell. 2009 Sep;8(5):604-6. doi: 10.1111/j.1474-9726.2009.00503.x. Epub 2009 Jul 9.

44.

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy.

Lee IH, Cao L, Mostoslavsky R, Lombard DB, Liu J, Bruns NE, Tsokos M, Alt FW, Finkel T.

Proc Natl Acad Sci U S A. 2008 Mar 4;105(9):3374-9. doi: 10.1073/pnas.0712145105. Epub 2008 Feb 22.

45.

SIRT6 in DNA repair, metabolism and ageing.

Lombard DB, Schwer B, Alt FW, Mostoslavsky R.

J Intern Med. 2008 Feb;263(2):128-41. doi: 10.1111/j.1365-2796.2007.01902.x.

46.

Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation.

Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV Jr, Weissman S, Verdin E, Schwer B.

Mol Cell Biol. 2007 Dec;27(24):8807-14. Epub 2007 Oct 8.

47.

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, Mills KD, Patel P, Hsu JT, Hong AL, Ford E, Cheng HL, Kennedy C, Nunez N, Bronson R, Frendewey D, Auerbach W, Valenzuela D, Karow M, Hottiger MO, Hursting S, Barrett JC, Guarente L, Mulligan R, Demple B, Yancopoulos GD, Alt FW.

Cell. 2006 Jan 27;124(2):315-29.

48.

H2AX prevents DNA breaks from progressing to chromosome breaks and translocations.

Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW.

Mol Cell. 2006 Jan 20;21(2):201-14.

49.

Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress.

Chua KF, Mostoslavsky R, Lombard DB, Pang WW, Saito S, Franco S, Kaushal D, Cheng HL, Fischer MR, Stokes N, Murphy MM, Appella E, Alt FW.

Cell Metab. 2005 Jul;2(1):67-76. Erratum in: Cell Metab. 2006 Jan;3(1):75.

50.

DNA repair, genome stability, and aging.

Lombard DB, Chua KF, Mostoslavsky R, Franco S, Gostissa M, Alt FW.

Cell. 2005 Feb 25;120(4):497-512. Review.

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