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SIRT3 Regulates Macrophage-Mediated Inflammation in Diabetic Wound Repair.

Boniakowski AM, denDekker AD, Davis FM, Joshi A, Kimball AS, Schaller M, Allen R, Bermick J, Nycz D, Skinner ME, Robinson S, Obi AT, Moore BB, Gudjonsson JE, Lombard D, Kunkel SL, Gallagher KA.

J Invest Dermatol. 2019 Jun 15. pii: S0022-202X(19)31756-7. doi: 10.1016/j.jid.2019.05.017. [Epub ahead of print]


Malignant Peripheral Nerve Sheath Tumors: From Epigenome to Bedside.

Korfhage J, Lombard DB.

Mol Cancer Res. 2019 Jul;17(7):1417-1428. doi: 10.1158/1541-7786.MCR-19-0147. Epub 2019 Apr 25. Review.


Combined MAPK Pathway and HDAC Inhibition Breaks Melanoma.

Lombard DB, Cierpicki T, Grembecka J.

Cancer Discov. 2019 Apr;9(4):469-471. doi: 10.1158/2159-8290.CD-19-0069.


A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.

Chefetz I, Grimley E, Yang K, Hong L, Vinogradova EV, Suciu R, Kovalenko I, Karnak D, Morgan CA, Chtcherbinine M, Buchman C, Huddle B, Barraza S, Morgan M, Bernstein KA, Yoon E, Lombard DB, Bild A, Mehta G, Romero I, Chiang CY, Landen C, Cravatt B, Hurley TD, Larsen SD, Buckanovich RJ.

Cell Rep. 2019 Mar 12;26(11):3061-3075.e6. doi: 10.1016/j.celrep.2019.02.032.


Association of the POT1 Germline Missense Variant p.I78T With Familial Melanoma.

Wong K, Robles-Espinoza CD, Rodriguez D, Rudat SS, Puig S, Potrony M, Wong CC, Hewinson J, Aguilera P, Puig-Butille JA, Bressac-de Paillerets B, Zattara H, van der Weyden L, Fletcher CDM, Brenn T, Arends MJ, Quesada V, Newton-Bishop JA, Lopez-Otin C, Bishop DT, Harms PW, Johnson TM, Durham AB, Lombard DB, Adams DJ.

JAMA Dermatol. 2019 May 1;155(5):604-609. doi: 10.1001/jamadermatol.2018.3662.


Mitochondrial Deacetylase SIRT3 Plays an Important Role in Donor T Cell Responses after Experimental Allogeneic Hematopoietic Transplantation.

Toubai T, Tamaki H, Peltier DC, Rossi C, Oravecz-Wilson K, Liu C, Zajac C, Wu J, Sun Y, Fujiwara H, Henig I, Kim S, Lombard DB, Reddy P.

J Immunol. 2018 Dec 1;201(11):3443-3455. doi: 10.4049/jimmunol.1800148. Epub 2018 Nov 2.


Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology.

Kumar S, Lombard DB.

Crit Rev Biochem Mol Biol. 2018 Jun;53(3):311-334. doi: 10.1080/10409238.2018.1458071. Epub 2018 Apr 11. Review.


Sirtuin 6 Builds a Wall Against Inflammation, Trumping Diabetes.

Giblin W, Lombard DB.

Diabetes. 2017 Oct;66(10):2535-2537. doi: 10.2337/dbi17-0025. No abstract available.


Factors Associated with Smokeless Tobacco Use among Pregnant Women in Rural Areas of the Southern Terai, Nepal.

Singh JK, Acharya D, Kadel R, Adhikari S, Lombard D, Koirala S, Paudel R.

J Nepal Health Res Counc. 2017 Jan;15(35):12-19.


Emerging Roles for SIRT5 in Metabolism and Cancer.

Bringman-Rodenbarger LR, Guo AH, Lyssiotis CA, Lombard DB.

Antioxid Redox Signal. 2018 Mar 10;28(8):677-690. doi: 10.1089/ars.2017.7264. Epub 2017 Oct 26.


ACSF3 and Mal(onate)-Adapted Mitochondria.

Lombard DB, Zhao Y.

Cell Chem Biol. 2017 Jun 22;24(6):649-650. doi: 10.1016/j.chembiol.2017.06.004.


Cycling around Lysine Modifications.

Kumar S, Lombard DB.

Trends Biochem Sci. 2017 Jul;42(7):501-503. doi: 10.1016/j.tibs.2017.05.006. Epub 2017 Jun 6.


For Certain, SIRT4 Activities!

Kumar S, Lombard DB.

Trends Biochem Sci. 2017 Jul;42(7):499-501. doi: 10.1016/j.tibs.2017.05.008. Epub 2017 Jun 3.


SIRT3 as a regulator of hepatic autophagy.

Cho CS, Lombard DB, Lee JH.

Hepatology. 2017 Sep;66(3):700-702. doi: 10.1002/hep.29271. Epub 2017 Jul 20. No abstract available.


MODEM: A comprehensive approach to modelling outcome and costs impacts of interventions for dementia. Protocol paper.

Comas-Herrera A, Knapp M, Wittenberg R, Banerjee S, Bowling A, Grundy E, Jagger C, Farina N, Lombard D, Lorenz K, McDaid D; MODEM Project group.

BMC Health Serv Res. 2017 Jan 11;17(1):25. doi: 10.1186/s12913-016-1945-x.


Generation and Purification of Catalytically Active Recombinant Sirtuin5 (SIRT5) Protein.

Kumar S, Lombard DB.

Methods Mol Biol. 2016;1436:241-57. doi: 10.1007/978-1-4939-3667-0_16.


Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation.

Xie Z, Zhang D, Chung D, Tang Z, Huang H, Dai L, Qi S, Li J, Colak G, Chen Y, Xia C, Peng C, Ruan H, Kirkey M, Wang D, Jensen LM, Kwon OK, Lee S, Pletcher SD, Tan M, Lombard DB, White KP, Zhao H, Li J, Roeder RG, Yang X, Zhao Y.

Mol Cell. 2016 Apr 21;62(2):194-206. doi: 10.1016/j.molcel.2016.03.036.


Finding Ponce de Leon's Pill: Challenges in Screening for Anti-Aging Molecules.

Kumar S, Lombard DB.

F1000Res. 2016 Mar 29;5. pii: F1000 Faculty Rev-406. doi: 10.12688/f1000research.7821.1. eCollection 2016. Review.


Effects of digital engagement on the quality of life of older people.

Damant J, Knapp M, Freddolino P, Lombard D.

Health Soc Care Community. 2017 Nov;25(6):1679-1703. doi: 10.1111/hsc.12335. Epub 2016 Feb 25. Review.


Identification of sirtuin 5 inhibitors by ultrafast microchip electrophoresis using nanoliter volume samples.

Guetschow ED, Kumar S, Lombard DB, Kennedy RT.

Anal Bioanal Chem. 2016 Jan;408(3):721-31. doi: 10.1007/s00216-015-9206-0. Epub 2015 Dec 3.



Novgorodov SA, Riley CL, Keffler JA, Yu J, Kindy MS, Macklin WB, Lombard DB, Gudz TI.

J Biol Chem. 2016 Jan 22;291(4):1957-73. doi: 10.1074/jbc.M115.668228. Epub 2015 Nov 30.


Acetyl-ed question in mitochondrial biology?

Lombard DB, Dash BP, Kumar S.

EMBO J. 2015 Nov 3;34(21):2597-600. doi: 10.15252/embj.201592927. Epub 2015 Sep 14. No abstract available.


Proteomic and Biochemical Studies of Lysine Malonylation Suggest Its Malonic Aciduria-associated Regulatory Role in Mitochondrial Function and Fatty Acid Oxidation.

Colak G, Pougovkina O, Dai L, Tan M, Te Brinke H, Huang H, Cheng Z, Park J, Wan X, Liu X, Yue WW, Wanders RJ, Locasale JW, Lombard DB, de Boer VC, Zhao Y.

Mol Cell Proteomics. 2015 Nov;14(11):3056-71. doi: 10.1074/mcp.M115.048850. Epub 2015 Aug 28.


Sirtuin 1 Regulates Dendritic Cell Activation and Autophagy during Respiratory Syncytial Virus-Induced Immune Responses.

Owczarczyk AB, Schaller MA, Reed M, Rasky AJ, Lombard DB, Lukacs NW.

J Immunol. 2015 Aug 15;195(4):1637-46. doi: 10.4049/jimmunol.1500326. Epub 2015 Jul 8.


Mitochondrial sirtuins and their relationships with metabolic disease and cancer.

Kumar S, Lombard DB.

Antioxid Redox Signal. 2015 Apr 20;22(12):1060-77. doi: 10.1089/ars.2014.6213. Epub 2015 Feb 10. Review.


Identification of a common founder couple for 40 South African Afrikaner families with Parkinson's disease.

Geldenhuys G, Glanzmann B, Lombard D, Boolay S, Carr J, Bardien S.

S Afr Med J. 2014 May 12;104(6):413-9. doi: 10.7196/samj.7747.


Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming.

Zwaans BM, Lombard DB.

Dis Model Mech. 2014 Sep;7(9):1023-32. doi: 10.1242/dmm.016287. Epub 2014 Aug 1. Review.


Implementation of ultrasonic sensing for high resolution measurement of binary gas mixture fractions.

Bates R, Battistin M, Berry S, Bitadze A, Bonneau P, Bousson N, Boyd G, Bozza G, Crespo-Lopez O, Da Riva E, Degeorge C, Deterre C, DiGirolamo B, Doubek M, Favre G, Godlewski J, Hallewell G, Hasib A, Katunin S, Langevin N, Lombard D, Mathieu M, McMahon S, Nagai K, Pearson B, Robinson D, Rossi C, Rozanov A, Strauss M, Vitek M, Vacek V, Zwalinski L.

Sensors (Basel). 2014 Jun 24;14(6):11260-76. doi: 10.3390/s140611260.


Sirtuins: guardians of mammalian healthspan.

Giblin W, Skinner ME, Lombard DB.

Trends Genet. 2014 Jul;30(7):271-86. doi: 10.1016/j.tig.2014.04.007. Epub 2014 May 28. Review.


Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.

Tan M, Peng C, Anderson KA, Chhoy P, Xie Z, Dai L, Park J, Chen Y, Huang H, Zhang Y, Ro J, Wagner GR, Green MF, Madsen AS, Schmiesing J, Peterson BS, Xu G, Ilkayeva OR, Muehlbauer MJ, Braulke T, Mühlhausen C, Backos DS, Olsen CA, McGuire PJ, Pletcher SD, Lombard DB, Hirschey MD, Zhao Y.

Cell Metab. 2014 Apr 1;19(4):605-17. doi: 10.1016/j.cmet.2014.03.014.


Cross-talk between sirtuin and mammalian target of rapamycin complex 1 (mTORC1) signaling in the regulation of S6 kinase 1 (S6K1) phosphorylation.

Hong S, Zhao B, Lombard DB, Fingar DC, Inoki K.

J Biol Chem. 2014 May 9;289(19):13132-41. doi: 10.1074/jbc.M113.520734. Epub 2014 Mar 20.


SIRT3: as simple as it seems?

Lombard DB, Zwaans BM.

Gerontology. 2014;60(1):56-64. doi: 10.1159/000354382. Epub 2013 Oct 25. Review.


Screening of two indel polymorphisms in the 5'UTR of the DJ-1 gene in South African Parkinson's disease patients.

Glanzmann B, Lombard D, Carr J, Bardien S.

J Neural Transm (Vienna). 2014 Feb;121(2):135-8. doi: 10.1007/s00702-013-1094-x. Epub 2013 Sep 20.


Mass spectrometry-based detection of protein acetylation.

Li Y, Silva JC, Skinner ME, Lombard DB.

Methods Mol Biol. 2013;1077:81-104. doi: 10.1007/978-1-62703-637-5_6.


Towards a consumer-informed research agenda for aphasia: preliminary work.

Hinckley J, Boyle E, Lombard D, Bartels-Tobin L.

Disabil Rehabil. 2014;36(12):1042-50. doi: 10.3109/09638288.2013.829528. Epub 2013 Sep 3.


SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.

Mol Cell. 2013 Jun 27;50(6):919-30. doi: 10.1016/j.molcel.2013.06.001.


Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases.

Wirth M, Karaca S, Wenzel D, Ho L, Tishkoff D, Lombard DB, Verdin E, Urlaub H, Jedrusik-Bode M, Fischle W.

Mitochondrion. 2013 Nov;13(6):705-20. doi: 10.1016/j.mito.2013.02.002. Epub 2013 Feb 21.


The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.

Sebastián C, Zwaans BM, Silberman DM, Gymrek M, Goren A, Zhong L, Ram O, Truelove J, Guimaraes AR, Toiber D, Cosentino C, Greenson JK, MacDonald AI, McGlynn L, Maxwell F, Edwards J, Giacosa S, Guccione E, Weissleder R, Bernstein BE, Regev A, Shiels PG, Lombard DB, Mostoslavsky R.

Cell. 2012 Dec 7;151(6):1185-99. doi: 10.1016/j.cell.2012.10.047.


The NAD-dependent deacetylase SIRT2 is required for programmed necrosis.

Narayan N, Lee IH, Borenstein R, Sun J, Wong R, Tong G, Fergusson MM, Liu J, Rovira II, Cheng HL, Wang G, Gucek M, Lombard D, Alt FW, Sack MN, Murphy E, Cao L, Finkel T.

Nature. 2012 Dec 13;492(7428):199-204. doi: 10.1038/nature11700. Epub 2012 Nov 28. Retraction in: Nature. 2014 Feb 27;506(7489):516.


Factors influencing the development of early- or late-onset Parkinson's disease in a cohort of South African patients.

van der Merwe C, Haylett W, Harvey J, Lombard D, Bardien S, Carr J.

S Afr Med J. 2012 Oct 1;102(11 Pt 1):848-51. doi: 10.7196/samj.5879.


The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.

Sundaresan NR, Vasudevan P, Zhong L, Kim G, Samant S, Parekh V, Pillai VB, Ravindra PV, Gupta M, Jeevanandam V, Cunningham JM, Deng CX, Lombard DB, Mostoslavsky R, Gupta MP.

Nat Med. 2012 Nov;18(11):1643-50. doi: 10.1038/nm.2961. Epub 2012 Oct 21.


C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress.

Chiang WC, Tishkoff DX, Yang B, Wilson-Grady J, Yu X, Mazer T, Eckersdorff M, Gygi SP, Lombard DB, Hsu AL.

PLoS Genet. 2012 Sep;8(9):e1002948. doi: 10.1371/journal.pgen.1002948. Epub 2012 Sep 13.


Ageing: Sorting out the sirtuins.

Lombard DB, Miller RA.

Nature. 2012 Mar 7;483(7388):166-7. doi: 10.1038/nature10950. No abstract available.


Comparison of histological measures of skin photoaging.

Hughes MC, Bredoux C, Salas F, Lombard D, Strutton GM, Fourtanier A, Green AC.

Dermatology. 2011;223(2):140-51. doi: 10.1159/000332425. Epub 2011 Oct 11.


Mutations in the parkin gene are a minor cause of Parkinson's disease in the South African population.

Haylett WL, Keyser RJ, du Plessis MC, van der Merwe C, Blanckenberg J, Lombard D, Carr J, Bardien S.

Parkinsonism Relat Disord. 2012 Jan;18(1):89-92. doi: 10.1016/j.parkreldis.2011.09.022. Epub 2011 Oct 12.


Ageing: longevity hits a roadblock.

Lombard DB, Pletcher SD, Cantó C, Auwerx J.

Nature. 2011 Sep 21;477(7365):410-1. doi: 10.1038/477410a. No abstract available.


The first identification of lysine malonylation substrates and its regulatory enzyme.

Peng C, Lu Z, Xie Z, Cheng Z, Chen Y, Tan M, Luo H, Zhang Y, He W, Yang K, Zwaans BM, Tishkoff D, Ho L, Lombard D, He TC, Dai J, Verdin E, Ye Y, Zhao Y.

Mol Cell Proteomics. 2011 Dec;10(12):M111.012658. doi: 10.1074/mcp.M111.012658. Epub 2011 Sep 9.


Mitochondrial sirtuins in the regulation of mitochondrial activity and metabolic adaptation.

Lombard DB, Tishkoff DX, Bao J.

Handb Exp Pharmacol. 2011;206:163-88. doi: 10.1007/978-3-642-21631-2_8. Review.


Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production.

Jing E, Emanuelli B, Hirschey MD, Boucher J, Lee KY, Lombard D, Verdin EM, Kahn CR.

Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14608-13. doi: 10.1073/pnas.1111308108. Epub 2011 Aug 22.

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