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Items: 1 to 50 of 488

1.

Blood eosinophils and treatment response with triple and dual combination therapy in chronic obstructive pulmonary disease: analysis of the IMPACT trial.

Pascoe S, Barnes N, Brusselle G, Compton C, Criner GJ, Dransfield MT, Halpin DMG, Han MK, Hartley B, Lange P, Lettis S, Lipson DA, Lomas DA, Martinez FJ, Papi A, Roche N, van der Valk RJP, Wise R, Singh D.

Lancet Respir Med. 2019 Jul 4. pii: S2213-2600(19)30190-0. doi: 10.1016/S2213-2600(19)30190-0. [Epub ahead of print]

PMID:
31281061
2.

It's more than low BMI: prevalence of cachexia and associated mortality in COPD.

McDonald MN, Wouters EFM, Rutten E, Casaburi R, Rennard SI, Lomas DA, Bamman M, Celli B, Agusti A, Tal-Singer R, Hersh CP, Dransfield M, Silverman EK.

Respir Res. 2019 May 22;20(1):100. doi: 10.1186/s12931-019-1073-3.

3.

Does the gene matter? Genotype-phenotype and genotype-outcome associations in congenital melanocytic naevi.

Polubothu S, McGuire N, Al-Olabi L, Baird W, Bulstrode N, Chalker J, Josifova D, Lomas D, O'Hara J, Ong J, Rampling D, Stadnik P, Thomas A, Wedgeworth E, Sebire NJ, Kinsler VA.

Br J Dermatol. 2019 May 21. doi: 10.1111/bjd.18106. [Epub ahead of print]

PMID:
31111470
4.

How informed is our consent? Patient awareness of radiation and radical prostatectomy complications.

Lomas DJ, Ziegelmann MJ, Elliott DS.

Turk J Urol. 2018 Dec 20. doi: 10.5152/tud.2018.81522. [Epub ahead of print]

5.

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.

Sakornsakolpat P, Prokopenko D, Lamontagne M, Reeve NF, Guyatt AL, Jackson VE, Shrine N, Qiao D, Bartz TM, Kim DK, Lee MK, Latourelle JC, Li X, Morrow JD, Obeidat M, Wyss AB, Bakke P, Barr RG, Beaty TH, Belinsky SA, Brusselle GG, Crapo JD, de Jong K, DeMeo DL, Fingerlin TE, Gharib SA, Gulsvik A, Hall IP, Hokanson JE, Kim WJ, Lomas DA, London SJ, Meyers DA, O'Connor GT, Rennard SI, Schwartz DA, Sliwinski P, Sparrow D, Strachan DP, Tal-Singer R, Tesfaigzi Y, Vestbo J, Vonk JM, Yim JJ, Zhou X, Bossé Y, Manichaikul A, Lahousse L, Silverman EK, Boezen HM, Wain LV, Tobin MD, Hobbs BD, Cho MH; SpiroMeta Consortium; International COPD Genetics Consortium.

Nat Genet. 2019 Mar;51(3):494-505. doi: 10.1038/s41588-018-0342-2. Epub 2019 Feb 25.

PMID:
30804561
6.

New Therapeutic Targets for Alpha-1 Antitrypsin Deficiency.

Lomas DA.

Chronic Obstr Pulm Dis. 2018 Aug 6;5(4):233-243. doi: 10.15326/jcopdf.5.4.2017.0165.

7.

Quantifying normal human brain metabolism using hyperpolarized [1-13C]pyruvate and magnetic resonance imaging.

Grist JT, McLean MA, Riemer F, Schulte RF, Deen SS, Zaccagna F, Woitek R, Daniels CJ, Kaggie JD, Matys T, Patterson I, Slough R, Gill AB, Chhabra A, Eichenberger R, Laurent MC, Comment A, Gillard JH, Coles AJ, Tyler DJ, Wilkinson I, Basu B, Lomas DJ, Graves MJ, Brindle KM, Gallagher FA.

Neuroimage. 2019 Apr 1;189:171-179. doi: 10.1016/j.neuroimage.2019.01.027. Epub 2019 Jan 11.

8.

Characterisation of a type II functionally-deficient variant of alpha-1-antitrypsin discovered in the general population.

Laffranchi M, Elliston ELK, Gangemi F, Berardelli R, Lomas DA, Irving JA, Fra A.

PLoS One. 2019 Jan 11;14(1):e0206955. doi: 10.1371/journal.pone.0206955. eCollection 2019.

9.

Subtractive non-contrast-enhanced MRI of lower limb veins using multiple flow-dependent preparation strategies.

Li H, Priest AN, Patterson I, Graves MJ, Lomas DJ.

Magn Reson Med. 2019 Mar;81(3):1769-1783. doi: 10.1002/mrm.27530. Epub 2018 Nov 16.

PMID:
30444041
10.

Author Correction: α1-Antitrypsin deficiency.

Greene CM, Marciniak SJ, Teckman J, Ferrarotti I, Brantly ML, Lomas DA, Stoller JK, McElvaney NG.

Nat Rev Dis Primers. 2018 Oct 29;4(1):40. doi: 10.1038/s41572-018-0043-2.

PMID:
30374103
11.

In Vitro Approaches for the Assessment of Serpin Polymerization.

Elliston ELK, Lomas DA, Irving JA.

Methods Mol Biol. 2018;1826:87-107. doi: 10.1007/978-1-4939-8645-3_6.

PMID:
30194595
12.

Single-Inhaler Triple versus Dual Therapy in Patients with COPD.

Lipson DA, Criner GJ, Lomas DA.

N Engl J Med. 2018 Aug 9;379(6):592-593. doi: 10.1056/NEJMc1807380. No abstract available.

PMID:
30089077
13.

Whole exome sequencing analysis in severe chronic obstructive pulmonary disease.

Qiao D, Ameli A, Prokopenko D, Chen H, Kho AT, Parker MM, Morrow J, Hobbs BD, Liu Y, Beaty TH, Crapo JD, Barnes KC, Nickerson DA, Bamshad M, Hersh CP, Lomas DA, Agusti A, Make BJ, Calverley PMA, Donner CF, Wouters EF, Vestbo J, Paré PD, Levy RD, Rennard SI, Tal-Singer R, Spitz MR, Sharma A, Ruczinski I, Lange C, Silverman EK, Cho MH.

Hum Mol Genet. 2018 Nov 1;27(21):3801-3812. doi: 10.1093/hmg/ddy269.

PMID:
30060175
14.

hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency.

Segeritz CP, Rashid ST, de Brito MC, Serra MP, Ordonez A, Morell CM, Kaserman JE, Madrigal P, Hannan NRF, Gatto L, Tan L, Wilson AA, Lilley K, Marciniak SJ, Gooptu B, Lomas DA, Vallier L.

J Hepatol. 2018 Oct;69(4):851-860. doi: 10.1016/j.jhep.2018.05.028. Epub 2018 Jun 5.

15.

Infection risk of undergoing multiple penile prostheses: an analysis of referred patient surgical histories.

Montgomery BD, Lomas DJ, Ziegelmann MJ, Trost LW.

Int J Impot Res. 2018 Aug;30(4):147-152. doi: 10.1038/s41443-018-0026-6. Epub 2018 May 25.

PMID:
29795529
16.

Common and Rare Variants Genetic Association Analysis of Cigarettes per Day Among Ever-Smokers in Chronic Obstructive Pulmonary Disease Cases and Controls.

Lutz SM, Frederiksen B, Begum F, McDonald MN, Cho MH, Hobbs BD, Parker MM, DeMeo DL, Hersh CP, Ehringer MA, Young K, Jiang L, Foreman MG, Kinney GL, Make BJ, Lomas DA, Bakke P, Gulsvik A, Crapo JD, Silverman EK, Beaty TH, Hokanson JE; ECLIPSE and COPDGene Investigators.

Nicotine Tob Res. 2019 May 21;21(6):714-722. doi: 10.1093/ntr/nty095.

17.

α1-Antitrypsin Polymerizes in Alveolar Macrophages of Smokers With and Without α1-Antitrypsin Deficiency.

Bazzan E, Tinè M, Biondini D, Benetti R, Baraldo S, Turato G, Fagiuoli S, Sonzogni A, Rigobello C, Rea F, Calabrese F, Foschino-Barbaro MP, Miranda E, Lomas DA, Saetta M, Cosio MG.

Chest. 2018 Sep;154(3):607-616. doi: 10.1016/j.chest.2018.04.039. Epub 2018 May 12.

PMID:
29763589
18.

Single-inhaler triple therapy in symptomatic COPD patients: FULFIL subgroup analyses.

Halpin DMG, Birk R, Brealey N, Criner GJ, Dransfield MT, Hilton E, Lomas DA, Zhu CQ, Lipson DA.

ERJ Open Res. 2018 May 4;4(2). pii: 00119-2017. doi: 10.1183/23120541.00119-2017. eCollection 2018 Apr.

19.

Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD.

Lipson DA, Barnhart F, Brealey N, Brooks J, Criner GJ, Day NC, Dransfield MT, Halpin DMG, Han MK, Jones CE, Kilbride S, Lange P, Lomas DA, Martinez FJ, Singh D, Tabberer M, Wise RA, Pascoe SJ; IMPACT Investigators.

N Engl J Med. 2018 May 3;378(18):1671-1680. doi: 10.1056/NEJMoa1713901. Epub 2018 Apr 18.

20.

Fibrinogen does not relate to cardiovascular or muscle manifestations in COPD: cross-sectional data from the ERICA study.

Mohan D, Forman JR, Allinder M, McEniery CM, Bolton CE, Cockcroft JR, MacNee W, Fuld J, Marchong M, Gale NS, Fisk M, Nagarajan S, Cheriyan J, Lomas DA, Calverley PMA, Miller BE, Tal-Singer R, Wilkinson IB, Polkey MI; ERICA Consortium.

Thorax. 2018 Dec;73(12):1182-1185. doi: 10.1136/thoraxjnl-2018-211556. Epub 2018 Apr 4.

PMID:
29618495
21.

The p38 mitogen activated protein kinase inhibitor losmapimod in chronic obstructive pulmonary disease patients with systemic inflammation, stratified by fibrinogen: A randomised double-blind placebo-controlled trial.

Fisk M, Cheriyan J, Mohan D, Forman J, Mäki-Petäjä KM, McEniery CM, Fuld J, Rudd JHF, Hopkinson NS, Lomas DA, Cockcroft JR, Tal-Singer R, Polkey MI, Wilkinson IB.

PLoS One. 2018 Mar 22;13(3):e0194197. doi: 10.1371/journal.pone.0194197. eCollection 2018.

22.

Heteropolymerization of α-1-antitrypsin mutants in cell models mimicking heterozygosity.

Laffranchi M, Berardelli R, Ronzoni R, Lomas DA, Fra A.

Hum Mol Genet. 2018 May 15;27(10):1785-1793. doi: 10.1093/hmg/ddy090.

PMID:
29538751
23.

Once-Daily Triple Therapy in Patients with COPD: Patient-Reported Symptoms and Quality of Life.

Tabberer M, Lomas DA, Birk R, Brealey N, Zhu CQ, Pascoe S, Locantore N, Lipson DA.

Adv Ther. 2018 Jan;35(1):56-71. doi: 10.1007/s12325-017-0650-4. Epub 2018 Jan 8.

24.

Reply to Morice and Hart: Increased Propensity for Pneumonia with Fluticasone in Chronic Obstructive Pulmonary Disease.

Lipson DA, Barnacle H, Birk R, Brealey N, Locantore N, Lomas DA, Ludwig-Sengpiel A, Mohindra R, Tabberer M, Zhu CQ, Pascoe SJ.

Am J Respir Crit Care Med. 2018 May 1;197(9):1230-1231. doi: 10.1164/rccm.201711-2313LE. No abstract available.

PMID:
29241016
25.

An automated high-throughput system for phenotypic screening of chemical libraries on C. elegans and parasitic nematodes.

Partridge FA, Brown AE, Buckingham SD, Willis NJ, Wynne GM, Forman R, Else KJ, Morrison AA, Matthews JB, Russell AJ, Lomas DA, Sattelle DB.

Int J Parasitol Drugs Drug Resist. 2018 Apr;8(1):8-21. doi: 10.1016/j.ijpddr.2017.11.004. Epub 2017 Dec 2.

26.

Reply to Suissa and Ariel: The FULFIL Trial.

Lipson DA, Barnacle H, Birk R, Brealey N, Locantore N, Lomas DA, Ludwig-Sengpiel A, Mohindra R, Tabberer M, Zhu CQ, Pascoe SJ.

Am J Respir Crit Care Med. 2018 Feb 15;197(4):542-543. doi: 10.1164/rccm.201709-1831LE. No abstract available.

PMID:
28950068
27.

Gadofosveset-enhanced thoracic MR venography: a comparative study evaluating steady state imaging versus conventional first-pass time-resolved dynamic imaging.

See TC, Patterson AJ, Hilliard NJ, Soh E, Winterbottom AP, Patterson I, Parker RA, Graves MJ, Lomas DJ.

Acta Radiol. 2018 Apr;59(4):418-424. doi: 10.1177/0284185117720856. Epub 2017 Jul 14.

PMID:
28707958
28.

Reply: "FULFIL an Unmet Need in Chronic Obstructive Pulmonary Disease" and "Triple Therapy in Chronic Obstructive Pulmonary Disease".

Lipson DA, Barnacle H, Birk R, Brealey N, Locantore N, Lomas DA, Ludwig-Sengpiel A, Mohindra R, Tabberer M, Zhu CQ, Pascoe SJ.

Am J Respir Crit Care Med. 2017 Oct 15;196(8):1083-1084. doi: 10.1164/rccm.201704-0818LE. No abstract available.

PMID:
28534669
29.

A semi-automatic method for the extraction of the portal venous input function in quantitative dynamic contrast-enhanced CT of the liver.

Gill AB, Hilliard NJ, Hilliard ST, Graves MJ, Lomas DJ, Shaw A.

Br J Radiol. 2017 Jul;90(1075):20160875. doi: 10.1259/bjr.20160875. Epub 2017 Jun 20.

30.

The pathological Trento variant of alpha-1-antitrypsin (E75V) shows nonclassical behaviour during polymerization.

Miranda E, Ferrarotti I, Berardelli R, Laffranchi M, Cerea M, Gangemi F, Haq I, Ottaviani S, Lomas DA, Irving JA, Fra A.

FEBS J. 2017 Jul;284(13):2110-2126. doi: 10.1111/febs.14111. Epub 2017 Jun 8.

31.

Association between progressive hepatic morphology changes on serial MR imaging and clinical outcome in primary sclerosing cholangitis.

Kitzing YX, Whitley SA, Upponi SS, Srivastava B, Alexander GJ, Lomas DJ.

J Med Imaging Radiat Oncol. 2017 Oct;61(5):636-642. doi: 10.1111/1754-9485.12610. Epub 2017 Apr 22.

PMID:
28432731
32.

FULFIL Trial: Once-Daily Triple Therapy for Patients with Chronic Obstructive Pulmonary Disease.

Lipson DA, Barnacle H, Birk R, Brealey N, Locantore N, Lomas DA, Ludwig-Sengpiel A, Mohindra R, Tabberer M, Zhu CQ, Pascoe SJ.

Am J Respir Crit Care Med. 2017 Aug 15;196(4):438-446. doi: 10.1164/rccm.201703-0449OC.

PMID:
28375647
33.

Liver: Taking out the JuNK to treat α1-antitrypsin deficiency.

Rashid ST, Lomas DA.

Nat Rev Gastroenterol Hepatol. 2017 Apr;14(4):201-202. doi: 10.1038/nrgastro.2017.22. Epub 2017 Mar 8. No abstract available.

PMID:
28270697
34.

Genetic Association and Risk Scores in a Chronic Obstructive Pulmonary Disease Meta-analysis of 16,707 Subjects.

Busch R, Hobbs BD, Zhou J, Castaldi PJ, McGeachie MJ, Hardin ME, Hawrylkiewicz I, Sliwinski P, Yim JJ, Kim WJ, Kim DK, Agusti A, Make BJ, Crapo JD, Calverley PM, Donner CF, Lomas DA, Wouters EF, Vestbo J, Tal-Singer R, Bakke P, Gulsvik A, Litonjua AA, Sparrow D, Paré PD, Levy RD, Rennard SI, Beaty TH, Hokanson J, Silverman EK, Cho MH; National Emphysema Treatment Trial Genetics; Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-Points; International COPD Genetics Network; COPDGene Investigators.

Am J Respir Cell Mol Biol. 2017 Jul;57(1):35-46. doi: 10.1165/rcmb.2016-0331OC.

35.

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis.

Hobbs BD, de Jong K, Lamontagne M, Bossé Y, Shrine N, Artigas MS, Wain LV, Hall IP, Jackson VE, Wyss AB, London SJ, North KE, Franceschini N, Strachan DP, Beaty TH, Hokanson JE, Crapo JD, Castaldi PJ, Chase RP, Bartz TM, Heckbert SR, Psaty BM, Gharib SA, Zanen P, Lammers JW, Oudkerk M, Groen HJ, Locantore N, Tal-Singer R, Rennard SI, Vestbo J, Timens W, Paré PD, Latourelle JC, Dupuis J, O'Connor GT, Wilk JB, Kim WJ, Lee MK, Oh YM, Vonk JM, de Koning HJ, Leng S, Belinsky SA, Tesfaigzi Y, Manichaikul A, Wang XQ, Rich SS, Barr RG, Sparrow D, Litonjua AA, Bakke P, Gulsvik A, Lahousse L, Brusselle GG, Stricker BH, Uitterlinden AG, Ampleford EJ, Bleecker ER, Woodruff PG, Meyers DA, Qiao D, Lomas DA, Yim JJ, Kim DK, Hawrylkiewicz I, Sliwinski P, Hardin M, Fingerlin TE, Schwartz DA, Postma DS, MacNee W, Tobin MD, Silverman EK, Boezen HM, Cho MH; COPDGene Investigators; ECLIPSE Investigators; LifeLines Investigators; SPIROMICS Research Group; International COPD Genetics Network Investigators; UK BiLEVE Investigators; International COPD Genetics Consortium.

Nat Genet. 2017 Mar;49(3):426-432. doi: 10.1038/ng.3752. Epub 2017 Feb 6.

36.

Melanoma in congenital melanocytic naevi.

Kinsler VA, O'Hare P, Bulstrode N, Calonje JE, Chong WK, Hargrave D, Jacques T, Lomas D, Sebire NJ, Slater O.

Br J Dermatol. 2017 May;176(5):1131-1143. doi: 10.1111/bjd.15301. Epub 2017 Apr 4. Review.

37.

Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1.

McDonald MN, Won S, Mattheisen M, Castaldi PJ, Cho MH, Rutten E, Hardin M, Yip WK, Rennard SI, Lomas DA, Wouters EFM, Agusti A, Casaburi R, Lange CP, O'Connor G, Hersh CP, Silverman EK.

J Cachexia Sarcopenia Muscle. 2017 Jun;8(3):428-436. doi: 10.1002/jcsm.12171. Epub 2017 Jan 2.

38.

Richard L. Ehman, MD, President, Radiological Society of North America, 2017.

Lomas DJ.

Radiology. 2017 Jan;282(1):7-9. doi: 10.1148/radiol.2017164038. No abstract available.

PMID:
28005514
39.

The Control of Electromagnetic Fields at Work Regulations 2016 and medical MRI.

Keevil SF, Lomas DJ.

Br J Radiol. 2017 Feb;90(1070):20160813. doi: 10.1259/bjr.20160813. Epub 2016 Dec 12.

40.

Evaluation of velocity-sensitized and acceleration-sensitized NCE-MRA for below-knee peripheral arterial disease.

Shaida N, Priest AN, See TC, Winterbottom AP, Graves MJ, Lomas DJ.

J Magn Reson Imaging. 2017 Jun;45(6):1846-1853. doi: 10.1002/jmri.25533. Epub 2016 Nov 30.

PMID:
27902859
41.

Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency.

Ishii T, Angata T, Wan ES, Cho MH, Motegi T, Gao C, Ohtsubo K, Kitazume S, Gemma A, ParÉ PD, Lomas DA, Silverman EK, Taniguchi N, Kida K.

Respirology. 2017 May;22(4):684-690. doi: 10.1111/resp.12952. Epub 2016 Nov 22.

PMID:
27878892
42.

Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women.

Hardin M, Cho MH, Sharma S, Glass K, Castaldi PJ, McDonald ML, Aschard H, Senter-Sylvia J, Tantisira K, Weiss ST, Hersh CP, Morrow JD, Lomas D, Agusti A, Bakke P, Gulsvik A, O'Connor GT, Dupuis J, Hokanson J, Crapo JD, Beaty TH, Laird N, Silverman EK, DeMeo DL; COPDGene and Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-Points Investigators.

Am J Respir Cell Mol Biol. 2017 Mar;56(3):332-341. doi: 10.1165/rcmb.2016-0172OC.

43.

Profile of the Ammonium Acid Urate Stone Former Based on a Large Contemporary Cohort.

Lomas DJ, Jaeger CD, Krambeck AE.

Urology. 2017 Apr;102:43-47. doi: 10.1016/j.urology.2016.10.027. Epub 2016 Oct 24.

PMID:
27789299
44.

Comparison of breath-hold, respiratory navigated and free-breathing MR elastography of the liver.

Murphy IG, Graves MJ, Reid S, Patterson AJ, Patterson I, Priest AN, Lomas DJ.

Magn Reson Imaging. 2017 Apr;37:46-50. doi: 10.1016/j.mri.2016.10.011. Epub 2016 Oct 13.

PMID:
27746391
45.

Progressive myoclonus epilepsy associated with neuroserpin inclusion bodies (neuroserpinosis).

Roussel BD, Lomas DA, Crowther DC.

Epileptic Disord. 2016 Sep 1;18(S2):103-110. Review.

PMID:
27618835
46.

The endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z-α1-antitrypsin.

Dickens JA, Ordóñez A, Chambers JE, Beckett AJ, Patel V, Malzer E, Dominicus CS, Bradley J, Peden AA, Prior IA, Lomas DA, Marciniak SJ.

FASEB J. 2016 Dec;30(12):4083-4097. Epub 2016 Sep 6.

47.

Combined MR direct thrombus imaging and non-contrast magnetic resonance venography reveal the evolution of deep vein thrombosis: a feasibility study.

Mendichovszky IA, Priest AN, Bowden DJ, Hunter S, Joubert I, Hilborne S, Graves MJ, Baglin T, Lomas DJ.

Eur Radiol. 2017 Jun;27(6):2326-2332. doi: 10.1007/s00330-016-4555-4. Epub 2016 Aug 30.

48.

An ECLIPSE View of Alpha-1 Antitrypsin Deficiency.

Lomas DA.

Ann Am Thorac Soc. 2016 Aug;13 Suppl 4:S326-31. doi: 10.1513/AnnalsATS.201506-348KV. Review.

PMID:
27564668
49.

Development of a Conceptual Model of Disease Progression for Use in Economic Modeling of Chronic Obstructive Pulmonary Disease.

Tabberer M, Gonzalez-McQuire S, Muellerova H, Briggs AH, Rutten-van Mölken MPMH, Chambers M, Lomas DA.

Med Decis Making. 2017 May;37(4):440-452. doi: 10.1177/0272989X16662009. Epub 2016 Aug 2.

PMID:
27486218
50.

Ectopic Penile Prosthesis Reservoir Placement: An Anatomic Cadaver Model of the High Submuscular Technique.

Ziegelmann MJ, Viers BR, Lomas DJ, Westerman ME, Trost LW.

J Sex Med. 2016 Sep;13(9):1425-1431. doi: 10.1016/j.jsxm.2016.06.012. Epub 2016 Jul 27.

PMID:
27475239

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