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Items: 1 to 50 of 75

1.

Improving the Sequence Coverage of Integral Membrane Proteins during Hydrogen/Deuterium Exchange Mass Spectrometry Experiments.

Möller IR, Slivacka M, Hausner J, Nielsen AK, Pospíšilová E, Merkle PS, Lišková R, Polák M, Loland CJ, Kádek A, Man P, Rand KD.

Anal Chem. 2019 Sep 3;91(17):10970-10978. doi: 10.1021/acs.analchem.9b00973. Epub 2019 Aug 13.

PMID:
31408320
2.

Conformationally Restricted Monosaccharide-Cored Glycoside Amphiphiles: The Effect of Detergent Headgroup Variation on Membrane Protein Stability.

Sadaf A, Ramos M, Mortensen JS, Du Y, Bae HE, Munk CF, Hariharan P, Byrne B, Kobilka BK, Loland CJ, Guan L, Chae PS.

ACS Chem Biol. 2019 Aug 16;14(8):1717-1726. doi: 10.1021/acschembio.9b00166. Epub 2019 Jul 29.

PMID:
31305987
3.

Self-Assembly Behavior and Application of Terphenyl-Cored Trimaltosides for Membrane-Protein Studies: Impact of Detergent Hydrophobic Group Geometry on Protein Stability.

Ehsan M, Du Y, Mortensen JS, Hariharan P, Qu Q, Ghani L, Das M, Grethen A, Byrne B, Skiniotis G, Keller S, Loland CJ, Guan L, Kobilka BK, Chae PS.

Chemistry. 2019 Sep 2;25(49):11545-11554. doi: 10.1002/chem.201902468. Epub 2019 Aug 5.

PMID:
31243822
4.

Substrate-induced conformational dynamics of the dopamine transporter.

Nielsen AK, Möller IR, Wang Y, Rasmussen SGF, Lindorff-Larsen K, Rand KD, Loland CJ.

Nat Commun. 2019 Jun 20;10(1):2714. doi: 10.1038/s41467-019-10449-w.

5.

Correction: Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability.

Das M, Du Y, Mortensen JS, Ramos M, Ghani L, Lee HJ, Bae HE, Byrne B, Guan L, Loland CJ, Kobilka BK, Seok Chae P.

Org Biomol Chem. 2019 May 15;17(19):4919-4920. doi: 10.1039/c9ob90075f.

PMID:
31062815
6.

Conformational dynamics of the human serotonin transporter during substrate and drug binding.

Möller IR, Slivacka M, Nielsen AK, Rasmussen SGF, Gether U, Loland CJ, Rand KD.

Nat Commun. 2019 Apr 11;10(1):1687. doi: 10.1038/s41467-019-09675-z.

7.

Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study.

Ehsan M, Kumar A, Mortensen JS, Du Y, Hariharan P, Kumar KK, Ha B, Byrne B, Guan L, Kobilka BK, Loland CJ, Chae PS.

Chem Asian J. 2019 Jun 3;14(11):1926-1931. doi: 10.1002/asia.201900224. Epub 2019 Apr 10.

PMID:
30969484
8.

Trehalose-cored amphiphiles for membrane protein stabilization: importance of the detergent micelle size in GPCR stability.

Das M, Du Y, Mortensen JS, Ramos M, Ghani L, Lee HJ, Bae HE, Byrne B, Guan L, Loland CJ, Kobilka BK, Chae PS.

Org Biomol Chem. 2019 Mar 20;17(12):3249-3257. doi: 10.1039/c8ob03153c. Erratum in: Org Biomol Chem. 2019 May 15;17(19):4919-4920.

PMID:
30843907
9.

Asymmetric maltose neopentyl glycol amphiphiles for a membrane protein study: effect of detergent asymmetricity on protein stability.

Bae HE, Du Y, Hariharan P, Mortensen JS, Kumar KK, Ha B, Das M, Lee HS, Loland CJ, Guan L, Kobilka BK, Chae PS.

Chem Sci. 2018 Nov 5;10(4):1107-1116. doi: 10.1039/c8sc02560f. eCollection 2019 Jan 28.

10.

A comparative study of branched and linear mannitol-based amphiphiles on membrane protein stability.

Hussain H, Helton T, Du Y, Mortensen JS, Hariharan P, Ehsan M, Byrne B, Loland CJ, Kobilka BK, Guan L, Chae PS.

Analyst. 2018 Nov 19;143(23):5702-5710. doi: 10.1039/c8an01408f.

PMID:
30334564
11.

Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy.

Das M, Du Y, Mortensen JS, Hariharan P, Lee HS, Byrne B, Loland CJ, Guan L, Kobilka BK, Chae PS.

Chembiochem. 2018 Oct 18;19(20):2225-2232. doi: 10.1002/cbic.201800388. Epub 2018 Sep 21.

PMID:
30070754
12.

Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT.

Merkle PS, Gotfryd K, Cuendet MA, Leth-Espensen KZ, Gether U, Loland CJ, Rand KD.

Sci Adv. 2018 May 11;4(5):eaar6179. doi: 10.1126/sciadv.aar6179. eCollection 2018 May.

13.

An Engineered Lithocholate-Based Facial Amphiphile Stabilizes Membrane Proteins: Assessing the Impact of Detergent Customizability on Protein Stability.

Das M, Du Y, Mortensen JS, Bae HE, Byrne B, Loland CJ, Kobilka BK, Chae PS.

Chemistry. 2018 Jul 11;24(39):9860-9868. doi: 10.1002/chem.201801141. Epub 2018 Jun 13.

PMID:
29741269
14.

Steroid-Based Amphiphiles for Membrane Protein Study: The Importance of Alkyl Spacers for Protein Stability.

Ehsan M, Das M, Stern V, Du Y, Mortensen JS, Hariharan P, Byrne B, Loland CJ, Kobilka BK, Guan L, Chae PS.

Chembiochem. 2018 Jul 4;19(13):1433-1443. doi: 10.1002/cbic.201800106. Epub 2018 May 29.

PMID:
29660780
15.

Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study.

Sadaf A, Du Y, Santillan C, Mortensen JS, Molist I, Seven AB, Hariharan P, Skiniotis G, Loland CJ, Kobilka BK, Guan L, Byrne B, Chae PS.

Chem Sci. 2017 Dec 1;8(12):8315-8324. doi: 10.1039/c7sc03700g. Epub 2017 Oct 25.

16.

Vitamin E-based glycoside amphiphiles for membrane protein structural studies.

Ehsan M, Du Y, Molist I, Seven AB, Hariharan P, Mortensen JS, Ghani L, Loland CJ, Skiniotis G, Guan L, Byrne B, Kobilka BK, Chae PS.

Org Biomol Chem. 2018 Apr 4;16(14):2489-2498. doi: 10.1039/C8OB00270C.

17.

Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes.

Herborg F, Andreassen TF, Berlin F, Loland CJ, Gether U.

J Biol Chem. 2018 May 11;293(19):7250-7262. doi: 10.1074/jbc.RA118.001753. Epub 2018 Mar 20.

18.

Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders.

Zou MF, Cao J, Abramyan AM, Kopajtic T, Zanettini C, Guthrie DA, Rais R, Slusher BS, Shi L, Loland CJ, Newman AH.

J Med Chem. 2017 Dec 28;60(24):10172-10187. doi: 10.1021/acs.jmedchem.7b01454. Epub 2017 Dec 11.

19.

New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies.

Ehsan M, Ghani L, Du Y, Hariharan P, Mortensen JS, Ribeiro O, Hu H, Skiniotis G, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS.

Analyst. 2017 Oct 9;142(20):3889-3898. doi: 10.1039/c7an01168g.

20.

Tandem malonate-based glucosides (TMGs) for membrane protein structural studies.

Hussain H, Mortensen JS, Du Y, Santillan C, Ribeiro O, Go J, Hariharan P, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS.

Sci Rep. 2017 Jun 21;7(1):3963. doi: 10.1038/s41598-017-03809-3.

21.

Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region.

Das M, Du Y, Mortensen JS, Ribeiro O, Hariharan P, Guan L, Loland CJ, Kobilka BK, Byrne B, Chae PS.

Chem Sci. 2017 Feb 1;8(2):1169-1177. doi: 10.1039/c6sc02981g. Epub 2016 Oct 5.

22.

The Isomeric Preference of an Atypical Dopamine Transporter Inhibitor Contributes to Its Selection of the Transporter Conformation.

Abramyan AM, Stolzenberg S, Li Z, Loland CJ, Noé F, Shi L.

ACS Chem Neurosci. 2017 Aug 16;8(8):1735-1746. doi: 10.1021/acschemneuro.7b00094. Epub 2017 May 4.

PMID:
28441487
23.

Resorcinarene-Based Facial Glycosides: Implication of Detergent Flexibility on Membrane-Protein Stability.

Hussain H, Du Y, Tikhonova E, Mortensen JS, Ribeiro O, Santillan C, Das M, Ehsan M, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS.

Chemistry. 2017 May 17;23(28):6724-6729. doi: 10.1002/chem.201605016. Epub 2017 Apr 20.

24.

Conformationally Preorganized Diastereomeric Norbornane-Based Maltosides for Membrane Protein Study: Implications of Detergent Kink for Micellar Properties.

Das M, Du Y, Ribeiro O, Hariharan P, Mortensen JS, Patra D, Skiniotis G, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS.

J Am Chem Soc. 2017 Mar 1;139(8):3072-3081. doi: 10.1021/jacs.6b11997. Epub 2017 Feb 20.

25.

Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR.

Erlendsson S, Gotfryd K, Larsen FH, Mortensen JS, Geiger MA, van Rossum BJ, Oschkinat H, Gether U, Teilum K, Loland CJ.

Elife. 2017 Jan 24;6. pii: e19314. doi: 10.7554/eLife.19314.

26.

X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT.

Topiol S, Bang-Andersen B, Sanchez C, Plenge P, Loland CJ, Juhl K, Larsen K, Bregnedal P, Bøgesø KP.

Bioorg Med Chem Lett. 2017 Feb 1;27(3):470-478. doi: 10.1016/j.bmcl.2016.12.037. Epub 2016 Dec 21.

PMID:
28041833
27.

Isomeric Detergent Comparison for Membrane Protein Stability: Importance of Inter-Alkyl-Chain Distance and Alkyl Chain Length.

Cho KH, Hariharan P, Mortensen JS, Du Y, Nielsen AK, Byrne B, Kobilka BK, Loland CJ, Guan L, Chae PS.

Chembiochem. 2016 Dec 14;17(24):2334-2339. doi: 10.1002/cbic.201600429. Epub 2016 Nov 7.

28.

Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.

Cao J, Slack RD, Bakare OM, Burzynski C, Rais R, Slusher BS, Kopajtic T, Bonifazi A, Ellenberger MP, Yano H, He Y, Bi GH, Xi ZX, Loland CJ, Newman AH.

J Med Chem. 2016 Dec 8;59(23):10676-10691. Epub 2016 Nov 28.

29.

The Environment Shapes the Inner Vestibule of LeuT.

Sohail A, Jayaraman K, Venkatesan S, Gotfryd K, Daerr M, Gether U, Loland CJ, Wanner KT, Freissmuth M, Sitte HH, Sandtner W, Stockner T.

PLoS Comput Biol. 2016 Nov 11;12(11):e1005197. doi: 10.1371/journal.pcbi.1005197. eCollection 2016 Nov.

30.

Mesitylene-Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy.

Cho KH, Ribeiro O, Du Y, Tikhonova E, Mortensen JS, Markham K, Hariharan P, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS.

Chemistry. 2016 Dec 23;22(52):18833-18839. doi: 10.1002/chem.201603338. Epub 2016 Nov 17.

31.

Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation.

Bae HE, Mortensen JS, Ribeiro O, Du Y, Ehsan M, Kobilka BK, Loland CJ, Byrne B, Chae PS.

Chem Commun (Camb). 2016 Oct 4;52(81):12104-12107.

32.

Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter.

Billesbølle CB, Mortensen JS, Sohail A, Schmidt SG, Shi L, Sitte HH, Gether U, Loland CJ.

Nat Commun. 2016 Sep 28;7:12755. doi: 10.1038/ncomms12755.

33.

Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290.

Khelashvili G, Schmidt SG, Shi L, Javitch JA, Gether U, Loland CJ, Weinstein H.

J Biol Chem. 2016 Sep 16;291(38):19786-99. doi: 10.1074/jbc.M116.731455. Epub 2016 Jul 29.

34.

A Class of Rigid Linker-bearing Glucosides for Membrane Protein Structural Study.

Sadaf A, Mortensen JS, Capaldi S, Tikhonova E, Hariharan P, de Castro Ribeiro O, Loland CJ, Guan L, Byrne B, Chae PS.

Chem Sci. 2016 Mar 1;7(3):1933-1939. Epub 2015 Dec 16.

35.

Accessible Mannitol-Based Amphiphiles (MNAs) for Membrane Protein Solubilisation and Stabilisation.

Hussain H, Du Y, Scull NJ, Mortensen JS, Tarrasch J, Bae HE, Loland CJ, Byrne B, Kobilka BK, Chae PS.

Chemistry. 2016 May 17;22(21):7068-73. doi: 10.1002/chem.201600533. Epub 2016 Apr 13.

36.

Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies.

Ehsan M, Du Y, Scull NJ, Tikhonova E, Tarrasch J, Mortensen JS, Loland CJ, Skiniotis G, Guan L, Byrne B, Kobilka BK, Chae PS.

J Am Chem Soc. 2016 Mar 23;138(11):3789-96. doi: 10.1021/jacs.5b13233. Epub 2016 Mar 11.

37.

Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5-HT transporter.

Larsen MA, Plenge P, Andersen J, Eildal JN, Kristensen AS, Bøgesø KP, Gether U, Strømgaard K, Bang-Andersen B, Loland CJ.

Br J Pharmacol. 2016 Mar;173(5):925-36. doi: 10.1111/bph.13411. Epub 2016 Feb 8.

38.

Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter.

Billesbølle CB, Krüger MB, Shi L, Quick M, Li Z, Stolzenberg S, Kniazeff J, Gotfryd K, Mortensen JS, Javitch JA, Weinstein H, Loland CJ, Gether U.

J Biol Chem. 2015 Oct 30;290(44):26725-38. doi: 10.1074/jbc.M115.677658. Epub 2015 Sep 11.

39.

Grafted biomembranes containing membrane proteins--the case of the leucine transporter.

Jagalski V, Barker RD, Thygesen MB, Gotfryd K, Krüger MB, Shi L, Maric S, Bovet N, Moulin M, Haertlein M, Pomorski TG, Loland CJ, Cárdenas M.

Soft Matter. 2015 Oct 21;11(39):7707-11. doi: 10.1039/c5sm01490e. Epub 2015 Sep 1.

PMID:
26325086
40.

Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation.

Cho KH, Du Y, Scull NJ, Hariharan P, Gotfryd K, Loland CJ, Guan L, Byrne B, Kobilka BK, Chae PS.

Chemistry. 2015 Jul 6;21(28):10008-13. doi: 10.1002/chem.201501083. Epub 2015 May 26.

41.

Deoxycholate-Based Glycosides (DCGs) for Membrane Protein Stabilisation.

Bae HE, Gotfryd K, Thomas J, Hussain H, Ehsan M, Go J, Loland CJ, Byrne B, Chae PS.

Chembiochem. 2015 Jul 6;16(10):1454-9. doi: 10.1002/cbic.201500151. Epub 2015 May 7.

PMID:
25953685
42.

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters.

Stolzenberg S, Quick M, Zhao C, Gotfryd K, Khelashvili G, Gether U, Loland CJ, Javitch JA, Noskov S, Weinstein H, Shi L.

J Biol Chem. 2015 May 29;290(22):13992-4003. doi: 10.1074/jbc.M114.625343. Epub 2015 Apr 13.

43.

Maltose neopentyl glycol-3 (MNG-3) analogues for membrane protein study.

Cho KH, Husri M, Amin A, Gotfryd K, Lee HJ, Go J, Kim JW, Loland CJ, Guan L, Byrne B, Chae PS.

Analyst. 2015 May 7;140(9):3157-63. doi: 10.1039/c5an00240k. Epub 2015 Mar 27.

44.

A conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporter.

Pedersen AV, Andreassen TF, Loland CJ.

J Biol Chem. 2014 Dec 12;289(50):35003-14. doi: 10.1074/jbc.M114.586982. Epub 2014 Oct 22.

45.

The use of LeuT as a model in elucidating binding sites for substrates and inhibitors in neurotransmitter transporters.

Loland CJ.

Biochim Biophys Acta. 2015 Mar;1850(3):500-10. doi: 10.1016/j.bbagen.2014.04.011. Epub 2014 Apr 24. Review.

PMID:
24769398
46.

Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analogues.

Okunola-Bakare OM, Cao J, Kopajtic T, Katz JL, Loland CJ, Shi L, Newman AH.

J Med Chem. 2014 Feb 13;57(3):1000-13. doi: 10.1021/jm401754x. Epub 2014 Feb 4.

47.

Design and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding sites.

Banala AK, Zhang P, Plenge P, Cyriac G, Kopajtic T, Katz JL, Loland CJ, Newman AH.

J Med Chem. 2013 Dec 12;56(23):9709-24. doi: 10.1021/jm4014136. Epub 2013 Dec 2.

48.

Novel tripod amphiphiles for membrane protein analysis.

Chae PS, Kruse AC, Gotfryd K, Rana RR, Cho KH, Rasmussen SG, Bae HE, Chandra R, Gether U, Guan L, Kobilka BK, Loland CJ, Byrne B, Gellman SH.

Chemistry. 2013 Nov 11;19(46):15645-51. doi: 10.1002/chem.201301423. Epub 2013 Oct 2.

49.

A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter.

Zhang P, Jørgensen TN, Loland CJ, Newman AH.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):323-6. doi: 10.1016/j.bmcl.2012.10.089. Epub 2012 Nov 1.

50.

Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study.

Chae PS, Rana RR, Gotfryd K, Rasmussen SG, Kruse AC, Cho KH, Capaldi S, Carlsson E, Kobilka B, Loland CJ, Gether U, Banerjee S, Byrne B, Lee JK, Gellman SH.

Chem Commun (Camb). 2013 Mar 21;49(23):2287-9. doi: 10.1039/c2cc36844g. Erratum in: Chem Commun (Camb). 2013 Dec 28;49(100):11821-2.

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