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Items: 1 to 50 of 66

1.

A comparative study of branched and linear mannitol-based amphiphiles on membrane protein stability.

Hussain H, Helton T, Du Y, Mortensen JS, Hariharan P, Ehsan M, Byrne B, Loland CJ, Kobilka BK, Guan L, Chae PS.

Analyst. 2018 Oct 18. doi: 10.1039/c8an01408f. [Epub ahead of print]

PMID:
30334564
2.

Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy.

Das M, Du Y, Mortensen JS, Hariharan P, Lee HS, Byrne B, Loland CJ, Guan L, Kobilka BK, Chae PS.

Chembiochem. 2018 Oct 18;19(20):2225-2232. doi: 10.1002/cbic.201800388. Epub 2018 Sep 21.

PMID:
30070754
3.

Substrate-modulated unwinding of transmembrane helices in the NSS transporter LeuT.

Merkle PS, Gotfryd K, Cuendet MA, Leth-Espensen KZ, Gether U, Loland CJ, Rand KD.

Sci Adv. 2018 May 11;4(5):eaar6179. doi: 10.1126/sciadv.aar6179. eCollection 2018 May.

4.

An Engineered Lithocholate-Based Facial Amphiphile Stabilizes Membrane Proteins: Assessing the Impact of Detergent Customizability on Protein Stability.

Das M, Du Y, Mortensen JS, Bae HE, Byrne B, Loland CJ, Kobilka BK, Chae PS.

Chemistry. 2018 Jul 11;24(39):9860-9868. doi: 10.1002/chem.201801141. Epub 2018 Jun 13.

PMID:
29741269
5.

Steroid-Based Amphiphiles for Membrane Protein Study: The Importance of Alkyl Spacers for Protein Stability.

Ehsan M, Das M, Stern V, Du Y, Mortensen JS, Hariharan P, Byrne B, Loland CJ, Kobilka BK, Guan L, Chae PS.

Chembiochem. 2018 Jul 4;19(13):1433-1443. doi: 10.1002/cbic.201800106. Epub 2018 May 29.

PMID:
29660780
6.

Dendronic trimaltoside amphiphiles (DTMs) for membrane protein study.

Sadaf A, Du Y, Santillan C, Mortensen JS, Molist I, Seven AB, Hariharan P, Skiniotis G, Loland CJ, Kobilka BK, Guan L, Byrne B, Chae PS.

Chem Sci. 2017 Dec 1;8(12):8315-8324. doi: 10.1039/c7sc03700g. Epub 2017 Oct 25.

7.

Vitamin E-based glycoside amphiphiles for membrane protein structural studies.

Ehsan M, Du Y, Molist I, Seven AB, Hariharan P, Mortensen JS, Ghani L, Loland CJ, Skiniotis G, Guan L, Byrne B, Kobilka BK, Chae PS.

Org Biomol Chem. 2018 Apr 4;16(14):2489-2498. doi: 10.1039/C8OB00270C.

PMID:
29564464
8.

Neuropsychiatric disease-associated genetic variants of the dopamine transporter display heterogeneous molecular phenotypes.

Herborg F, Andreassen TF, Berlin F, Loland CJ, Gether U.

J Biol Chem. 2018 May 11;293(19):7250-7262. doi: 10.1074/jbc.RA118.001753. Epub 2018 Mar 20.

PMID:
29559554
9.

Structure-Activity Relationship Studies on a Series of 3α-[Bis(4-fluorophenyl)methoxy]tropanes and 3α-[Bis(4-fluorophenyl)methylamino]tropanes As Novel Atypical Dopamine Transporter (DAT) Inhibitors for the Treatment of Cocaine Use Disorders.

Zou MF, Cao J, Abramyan AM, Kopajtic T, Zanettini C, Guthrie DA, Rais R, Slusher BS, Shi L, Loland CJ, Newman AH.

J Med Chem. 2017 Dec 28;60(24):10172-10187. doi: 10.1021/acs.jmedchem.7b01454. Epub 2017 Dec 11.

PMID:
29227643
10.

New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies.

Ehsan M, Ghani L, Du Y, Hariharan P, Mortensen JS, Ribeiro O, Hu H, Skiniotis G, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS.

Analyst. 2017 Oct 9;142(20):3889-3898. doi: 10.1039/c7an01168g.

11.

Tandem malonate-based glucosides (TMGs) for membrane protein structural studies.

Hussain H, Mortensen JS, Du Y, Santillan C, Ribeiro O, Go J, Hariharan P, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS.

Sci Rep. 2017 Jun 21;7(1):3963. doi: 10.1038/s41598-017-03809-3.

12.

Butane-1,2,3,4-tetraol-based amphiphilic stereoisomers for membrane protein study: importance of chirality in the linker region.

Das M, Du Y, Mortensen JS, Ribeiro O, Hariharan P, Guan L, Loland CJ, Kobilka BK, Byrne B, Chae PS.

Chem Sci. 2017 Feb 1;8(2):1169-1177. doi: 10.1039/c6sc02981g. Epub 2016 Oct 5.

13.

The Isomeric Preference of an Atypical Dopamine Transporter Inhibitor Contributes to Its Selection of the Transporter Conformation.

Abramyan AM, Stolzenberg S, Li Z, Loland CJ, Noé F, Shi L.

ACS Chem Neurosci. 2017 Aug 16;8(8):1735-1746. doi: 10.1021/acschemneuro.7b00094. Epub 2017 May 4.

PMID:
28441487
14.

Resorcinarene-Based Facial Glycosides: Implication of Detergent Flexibility on Membrane-Protein Stability.

Hussain H, Du Y, Tikhonova E, Mortensen JS, Ribeiro O, Santillan C, Das M, Ehsan M, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS.

Chemistry. 2017 May 17;23(28):6724-6729. doi: 10.1002/chem.201605016. Epub 2017 Apr 20.

15.

Conformationally Preorganized Diastereomeric Norbornane-Based Maltosides for Membrane Protein Study: Implications of Detergent Kink for Micellar Properties.

Das M, Du Y, Ribeiro O, Hariharan P, Mortensen JS, Patra D, Skiniotis G, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS.

J Am Chem Soc. 2017 Mar 1;139(8):3072-3081. doi: 10.1021/jacs.6b11997. Epub 2017 Feb 20.

16.

Direct assessment of substrate binding to the Neurotransmitter:Sodium Symporter LeuT by solid state NMR.

Erlendsson S, Gotfryd K, Larsen FH, Mortensen JS, Geiger MA, van Rossum BJ, Oschkinat H, Gether U, Teilum K, Loland CJ.

Elife. 2017 Jan 24;6. pii: e19314. doi: 10.7554/eLife.19314.

17.

X-ray structure based evaluation of analogs of citalopram: Compounds with increased affinity and selectivity compared with R-citalopram for the allosteric site (S2) on hSERT.

Topiol S, Bang-Andersen B, Sanchez C, Plenge P, Loland CJ, Juhl K, Larsen K, Bregnedal P, Bøgesø KP.

Bioorg Med Chem Lett. 2017 Feb 1;27(3):470-478. doi: 10.1016/j.bmcl.2016.12.037. Epub 2016 Dec 21.

PMID:
28041833
18.

Isomeric Detergent Comparison for Membrane Protein Stability: Importance of Inter-Alkyl-Chain Distance and Alkyl Chain Length.

Cho KH, Hariharan P, Mortensen JS, Du Y, Nielsen AK, Byrne B, Kobilka BK, Loland CJ, Guan L, Chae PS.

Chembiochem. 2016 Dec 14;17(24):2334-2339. doi: 10.1002/cbic.201600429. Epub 2016 Nov 7.

19.

Novel and High Affinity 2-[(Diphenylmethyl)sulfinyl]acetamide (Modafinil) Analogues as Atypical Dopamine Transporter Inhibitors.

Cao J, Slack RD, Bakare OM, Burzynski C, Rais R, Slusher BS, Kopajtic T, Bonifazi A, Ellenberger MP, Yano H, He Y, Bi GH, Xi ZX, Loland CJ, Newman AH.

J Med Chem. 2016 Dec 8;59(23):10676-10691. Epub 2016 Nov 28.

20.

The Environment Shapes the Inner Vestibule of LeuT.

Sohail A, Jayaraman K, Venkatesan S, Gotfryd K, Daerr M, Gether U, Loland CJ, Wanner KT, Freissmuth M, Sitte HH, Sandtner W, Stockner T.

PLoS Comput Biol. 2016 Nov 11;12(11):e1005197. doi: 10.1371/journal.pcbi.1005197. eCollection 2016 Nov.

21.

Mesitylene-Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy.

Cho KH, Ribeiro O, Du Y, Tikhonova E, Mortensen JS, Markham K, Hariharan P, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae PS.

Chemistry. 2016 Dec 23;22(52):18833-18839. doi: 10.1002/chem.201603338. Epub 2016 Nov 17.

22.

Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation.

Bae HE, Mortensen JS, Ribeiro O, Du Y, Ehsan M, Kobilka BK, Loland CJ, Byrne B, Chae PS.

Chem Commun (Camb). 2016 Oct 4;52(81):12104-12107.

23.

Transition metal ion FRET uncovers K+ regulation of a neurotransmitter/sodium symporter.

Billesbølle CB, Mortensen JS, Sohail A, Schmidt SG, Shi L, Sitte HH, Gether U, Loland CJ.

Nat Commun. 2016 Sep 28;7:12755. doi: 10.1038/ncomms12755.

24.

Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290.

Khelashvili G, Schmidt SG, Shi L, Javitch JA, Gether U, Loland CJ, Weinstein H.

J Biol Chem. 2016 Sep 16;291(38):19786-99. doi: 10.1074/jbc.M116.731455. Epub 2016 Jul 29.

25.

A Class of Rigid Linker-bearing Glucosides for Membrane Protein Structural Study.

Sadaf A, Mortensen JS, Capaldi S, Tikhonova E, Hariharan P, de Castro Ribeiro O, Loland CJ, Guan L, Byrne B, Chae PS.

Chem Sci. 2016 Mar 1;7(3):1933-1939. Epub 2015 Dec 16.

26.

Accessible Mannitol-Based Amphiphiles (MNAs) for Membrane Protein Solubilisation and Stabilisation.

Hussain H, Du Y, Scull NJ, Mortensen JS, Tarrasch J, Bae HE, Loland CJ, Byrne B, Kobilka BK, Chae PS.

Chemistry. 2016 May 17;22(21):7068-73. doi: 10.1002/chem.201600533. Epub 2016 Apr 13.

27.

Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies.

Ehsan M, Du Y, Scull NJ, Tikhonova E, Tarrasch J, Mortensen JS, Loland CJ, Skiniotis G, Guan L, Byrne B, Kobilka BK, Chae PS.

J Am Chem Soc. 2016 Mar 23;138(11):3789-96. doi: 10.1021/jacs.5b13233. Epub 2016 Mar 11.

28.

Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the 5-HT transporter.

Larsen MA, Plenge P, Andersen J, Eildal JN, Kristensen AS, Bøgesø KP, Gether U, Strømgaard K, Bang-Andersen B, Loland CJ.

Br J Pharmacol. 2016 Mar;173(5):925-36. doi: 10.1111/bph.13411. Epub 2016 Feb 8.

29.

Substrate-induced unlocking of the inner gate determines the catalytic efficiency of a neurotransmitter:sodium symporter.

Billesbølle CB, Krüger MB, Shi L, Quick M, Li Z, Stolzenberg S, Kniazeff J, Gotfryd K, Mortensen JS, Javitch JA, Weinstein H, Loland CJ, Gether U.

J Biol Chem. 2015 Oct 30;290(44):26725-38. doi: 10.1074/jbc.M115.677658. Epub 2015 Sep 11.

30.

Grafted biomembranes containing membrane proteins--the case of the leucine transporter.

Jagalski V, Barker RD, Thygesen MB, Gotfryd K, Krüger MB, Shi L, Maric S, Bovet N, Moulin M, Haertlein M, Pomorski TG, Loland CJ, Cárdenas M.

Soft Matter. 2015 Oct 21;11(39):7707-11. doi: 10.1039/c5sm01490e. Epub 2015 Sep 1.

PMID:
26325086
31.

Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation.

Cho KH, Du Y, Scull NJ, Hariharan P, Gotfryd K, Loland CJ, Guan L, Byrne B, Kobilka BK, Chae PS.

Chemistry. 2015 Jul 6;21(28):10008-13. doi: 10.1002/chem.201501083. Epub 2015 May 26.

32.

Deoxycholate-Based Glycosides (DCGs) for Membrane Protein Stabilisation.

Bae HE, Gotfryd K, Thomas J, Hussain H, Ehsan M, Go J, Loland CJ, Byrne B, Chae PS.

Chembiochem. 2015 Jul 6;16(10):1454-9. doi: 10.1002/cbic.201500151. Epub 2015 May 7.

PMID:
25953685
33.

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters.

Stolzenberg S, Quick M, Zhao C, Gotfryd K, Khelashvili G, Gether U, Loland CJ, Javitch JA, Noskov S, Weinstein H, Shi L.

J Biol Chem. 2015 May 29;290(22):13992-4003. doi: 10.1074/jbc.M114.625343. Epub 2015 Apr 13.

34.

Maltose neopentyl glycol-3 (MNG-3) analogues for membrane protein study.

Cho KH, Husri M, Amin A, Gotfryd K, Lee HJ, Go J, Kim JW, Loland CJ, Guan L, Byrne B, Chae PS.

Analyst. 2015 May 7;140(9):3157-63. doi: 10.1039/c5an00240k. Epub 2015 Mar 27.

35.

A conserved salt bridge between transmembrane segments 1 and 10 constitutes an extracellular gate in the dopamine transporter.

Pedersen AV, Andreassen TF, Loland CJ.

J Biol Chem. 2014 Dec 12;289(50):35003-14. doi: 10.1074/jbc.M114.586982. Epub 2014 Oct 22.

36.

The use of LeuT as a model in elucidating binding sites for substrates and inhibitors in neurotransmitter transporters.

Loland CJ.

Biochim Biophys Acta. 2015 Mar;1850(3):500-10. doi: 10.1016/j.bbagen.2014.04.011. Epub 2014 Apr 24. Review.

PMID:
24769398
37.

Elucidation of structural elements for selectivity across monoamine transporters: novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analogues.

Okunola-Bakare OM, Cao J, Kopajtic T, Katz JL, Loland CJ, Shi L, Newman AH.

J Med Chem. 2014 Feb 13;57(3):1000-13. doi: 10.1021/jm401754x. Epub 2014 Feb 4.

38.

Design and synthesis of 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile (citalopram) analogues as novel probes for the serotonin transporter S1 and S2 binding sites.

Banala AK, Zhang P, Plenge P, Cyriac G, Kopajtic T, Katz JL, Loland CJ, Newman AH.

J Med Chem. 2013 Dec 12;56(23):9709-24. doi: 10.1021/jm4014136. Epub 2013 Dec 2.

39.

Novel tripod amphiphiles for membrane protein analysis.

Chae PS, Kruse AC, Gotfryd K, Rana RR, Cho KH, Rasmussen SG, Bae HE, Chandra R, Gether U, Guan L, Kobilka BK, Loland CJ, Byrne B, Gellman SH.

Chemistry. 2013 Nov 11;19(46):15645-51. doi: 10.1002/chem.201301423. Epub 2013 Oct 2.

40.

A rhodamine-labeled citalopram analogue as a high-affinity fluorescent probe for the serotonin transporter.

Zhang P, Jørgensen TN, Loland CJ, Newman AH.

Bioorg Med Chem Lett. 2013 Jan 1;23(1):323-6. doi: 10.1016/j.bmcl.2012.10.089. Epub 2012 Nov 1.

41.

Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study.

Chae PS, Rana RR, Gotfryd K, Rasmussen SG, Kruse AC, Cho KH, Capaldi S, Carlsson E, Kobilka B, Loland CJ, Gether U, Banerjee S, Byrne B, Lee JK, Gellman SH.

Chem Commun (Camb). 2013 Mar 21;49(23):2287-9. doi: 10.1039/c2cc36844g. Erratum in: Chem Commun (Camb). 2013 Dec 28;49(100):11821-2.

42.

Steric hindrance mutagenesis in the conserved extracellular vestibule impedes allosteric binding of antidepressants to the serotonin transporter.

Plenge P, Shi L, Beuming T, Te J, Newman AH, Weinstein H, Gether U, Loland CJ.

J Biol Chem. 2012 Nov 16;287(47):39316-26. doi: 10.1074/jbc.M112.371765. Epub 2012 Sep 24.

43.

A virtual high-throughput screening approach to the discovery of novel inhibitors of the bacterial leucine transporter, LeuT.

Simmons KJ, Gotfryd K, Billesbølle CB, Loland CJ, Gether U, Fishwick CW, Johnson AP.

Mol Membr Biol. 2013 Mar;30(2):184-94. doi: 10.3109/09687688.2012.710341. Epub 2012 Aug 21.

PMID:
22908980
44.

A new class of amphiphiles bearing rigid hydrophobic groups for solubilization and stabilization of membrane proteins.

Chae PS, Rasmussen SG, Rana RR, Gotfryd K, Kruse AC, Manglik A, Cho KH, Nurva S, Gether U, Guan L, Loland CJ, Byrne B, Kobilka BK, Gellman SH.

Chemistry. 2012 Jul 27;18(31):9485-90. doi: 10.1002/chem.201200069. Epub 2012 Jun 22. No abstract available. Erratum in: Chemistry. 2013 Apr 15;19(16):4964.

45.

R-modafinil (armodafinil): a unique dopamine uptake inhibitor and potential medication for psychostimulant abuse.

Loland CJ, Mereu M, Okunola OM, Cao J, Prisinzano TE, Mazier S, Kopajtic T, Shi L, Katz JL, Tanda G, Newman AH.

Biol Psychiatry. 2012 Sep 1;72(5):405-13. doi: 10.1016/j.biopsych.2012.03.022. Epub 2012 Apr 25.

46.

Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice.

Sørensen G, Jensen M, Weikop P, Dencker D, Christiansen SH, Loland CJ, Bengtsen CH, Petersen JH, Fink-Jensen A, Wörtwein G, Woldbye DP.

Psychopharmacology (Berl). 2012 Aug;222(4):565-77. doi: 10.1007/s00213-012-2651-y. Epub 2012 Feb 25.

PMID:
22367168
47.

SLC6 neurotransmitter transporters: structure, function, and regulation.

Kristensen AS, Andersen J, Jørgensen TN, Sørensen L, Eriksen J, Loland CJ, Strømgaard K, Gether U.

Pharmacol Rev. 2011 Sep;63(3):585-640. doi: 10.1124/pr.108.000869. Epub 2011 Jul 13. Review.

48.

Tandem facial amphiphiles for membrane protein stabilization.

Chae PS, Gotfryd K, Pacyna J, Miercke LJ, Rasmussen SG, Robbins RA, Rana RR, Loland CJ, Kobilka B, Stroud R, Byrne B, Gether U, Gellman SH.

J Am Chem Soc. 2010 Dec 1;132(47):16750-2. doi: 10.1021/ja1072959. Epub 2010 Nov 4. Erratum in: J Am Chem Soc. 2013 Aug 28;135(34):12922.

49.

Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins.

Chae PS, Rasmussen SG, Rana RR, Gotfryd K, Chandra R, Goren MA, Kruse AC, Nurva S, Loland CJ, Pierre Y, Drew D, Popot JL, Picot D, Fox BG, Guan L, Gether U, Byrne B, Kobilka B, Gellman SH.

Nat Methods. 2010 Dec;7(12):1003-8. doi: 10.1038/nmeth.1526. Epub 2010 Oct 31.

50.

The binding sites for benztropines and dopamine in the dopamine transporter overlap.

Bisgaard H, Larsen MA, Mazier S, Beuming T, Newman AH, Weinstein H, Shi L, Loland CJ, Gether U.

Neuropharmacology. 2011 Jan;60(1):182-90. doi: 10.1016/j.neuropharm.2010.08.021. Epub 2010 Sep 6.

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