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Items: 22

1.

26S Proteasomes are rapidly activated by diverse hormones and physiological states that raise cAMP and cause Rpn6 phosphorylation.

VerPlank JJS, Lokireddy S, Zhao J, Goldberg AL.

Proc Natl Acad Sci U S A. 2019 Feb 19. pii: 201809254. doi: 10.1073/pnas.1809254116. [Epub ahead of print]

PMID:
30782827
2.

Impairment of protein degradation and proteasome function in hereditary neuropathies.

VerPlank JJS, Lokireddy S, Feltri ML, Goldberg AL, Wrabetz L.

Glia. 2018 Feb;66(2):379-395. doi: 10.1002/glia.23251. Epub 2017 Oct 27.

3.

cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteins.

Lokireddy S, Kukushkin NV, Goldberg AL.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):E7176-85. doi: 10.1073/pnas.1522332112. Epub 2015 Dec 15.

4.

1) Myostatin is a novel tumoral factor that induces cancer cachexia.

Lokireddy S, Wijesoma IW, Bonala S, Wei M, Sze SK, McFarlane C, Kambadur R, Sharma M.

Biochem J. 2015 Feb 15;466(1):201. No abstract available.

PMID:
25656055
5.
6.

Negative auto-regulation of myostatin expression is mediated by Smad3 and microRNA-27.

McFarlane C, Vajjala A, Arigela H, Lokireddy S, Ge X, Bonala S, Manickam R, Kambadur R, Sharma M.

PLoS One. 2014 Jan 31;9(1):e87687. doi: 10.1371/journal.pone.0087687. eCollection 2014.

7.

Myostatin induces insulin resistance via Casitas B-lineage lymphoma b (Cblb)-mediated degradation of insulin receptor substrate 1 (IRS1) protein in response to high calorie diet intake.

Bonala S, Lokireddy S, McFarlane C, Patnam S, Sharma M, Kambadur R.

J Biol Chem. 2014 Mar 14;289(11):7654-70. doi: 10.1074/jbc.M113.529925. Epub 2014 Jan 22. Retraction in: J Biol Chem. 2016 Jul 1;291(27):14392.

8.

Myostatin augments muscle-specific ring finger protein-1 expression through an NF-kB independent mechanism in SMAD3 null muscle.

Sriram S, Subramanian S, Juvvuna PK, Ge X, Lokireddy S, McFarlane CD, Wahli W, Kambadur R, Sharma M.

Mol Endocrinol. 2014 Mar;28(3):317-30. doi: 10.1210/me.2013-1179. Epub 2014 Jan 17. Erratum in: Mol Endocrinol. 2016 Feb;30(2):272-3.

9.

Pid1 induces insulin resistance in both human and mouse skeletal muscle during obesity.

Bonala S, McFarlane C, Ang J, Lim R, Lee M, Chua H, Lokireddy S, Sreekanth P, Leow MK, Meng KC, Shyong TE, Lee YS, Gluckman PD, Sharma M, Kambadur R.

Mol Endocrinol. 2013 Sep;27(9):1518-35. doi: 10.1210/me.2013-1048. Epub 2013 Aug 8. Erratum in: Mol Endocrinol. 2015 Jan;29(1):153. Retraction in: Mol Endocrinol. 2016 Aug;30(8):949.

10.

Muscle-specific microRNA1 (miR1) targets heat shock protein 70 (HSP70) during dexamethasone-mediated atrophy.

Kukreti H, Amuthavalli K, Harikumar A, Sathiyamoorthy S, Feng PZ, Anantharaj R, Tan SL, Lokireddy S, Bonala S, Sriram S, McFarlane C, Kambadur R, Sharma M.

J Biol Chem. 2013 Mar 1;288(9):6663-78. doi: 10.1074/jbc.M112.390369. Epub 2013 Jan 6.

11.

The ubiquitin ligase Mul1 induces mitophagy in skeletal muscle in response to muscle-wasting stimuli.

Lokireddy S, Wijesoma IW, Teng S, Bonala S, Gluckman PD, McFarlane C, Sharma M, Kambadur R.

Cell Metab. 2012 Nov 7;16(5):613-24. doi: 10.1016/j.cmet.2012.10.005. Retraction in: Cell Metab. 2015 Dec 1;22(6):1090.

12.

Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting.

Lokireddy S, Wijesoma IW, Sze SK, McFarlane C, Kambadur R, Sharma M.

Am J Physiol Cell Physiol. 2012 Sep 1;303(5):C512-29. doi: 10.1152/ajpcell.00402.2011. Epub 2012 Jun 6. Erratum in: Am J Physiol Cell Physiol. 2014 Dec 15;307(12):C1151.

13.

Myostatin is a novel tumoral factor that induces cancer cachexia.

Lokireddy S, Wijesoma IW, Bonala S, Wei M, Sze SK, McFarlane C, Kambadur R, Sharma M.

Biochem J. 2012 Aug 15;446(1):23-36. doi: 10.1042/BJ20112024. Erratum in: Biochem J. 2015 Feb 15;466(1):201. Retraction in: Lokireddy S, Wijesoma IW, Bonala S, Wei M, Sze SK, McFarlane C, Kambadur R, Sharma M. Biochem J. 2016 Apr 15;473(8):1111.

14.

Peroxisome proliferator-activated receptor β/δ induces myogenesis by modulating myostatin activity.

Bonala S, Lokireddy S, Arigela H, Teng S, Wahli W, Sharma M, McFarlane C, Kambadur R.

J Biol Chem. 2012 Apr 13;287(16):12935-51. doi: 10.1074/jbc.M111.319145. Epub 2012 Feb 23. Retraction in: J Biol Chem. 2016 Jul 1;291(27):14391.

15.

Myostatin induces degradation of sarcomeric proteins through a Smad3 signaling mechanism during skeletal muscle wasting.

Lokireddy S, McFarlane C, Ge X, Zhang H, Sze SK, Sharma M, Kambadur R.

Mol Endocrinol. 2011 Nov;25(11):1936-49. doi: 10.1210/me.2011-1124. Epub 2011 Sep 29. Erratum in: Mol Endocrinol. 2015 Jan;29(1):153. Retraction in: Mol Endocrinol. 2016 Feb;30(2):274.

16.

Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice.

Zhang C, McFarlane C, Lokireddy S, Masuda S, Ge X, Gluckman PD, Sharma M, Kambadur R.

Diabetologia. 2012 Jan;55(1):183-93. doi: 10.1007/s00125-011-2304-4. Epub 2011 Sep 17. Erratum in: Diabetologia. 2015 Mar;58(3):643.

PMID:
21927895
17.

Myostatin promotes the wasting of human myoblast cultures through promoting ubiquitin-proteasome pathway-mediated loss of sarcomeric proteins.

Lokireddy S, Mouly V, Butler-Browne G, Gluckman PD, Sharma M, Kambadur R, McFarlane C.

Am J Physiol Cell Physiol. 2011 Dec;301(6):C1316-24. doi: 10.1152/ajpcell.00114.2011. Epub 2011 Sep 7. Erratum in: Am J Physiol Cell Physiol. 2014 Dec 15;307(12):C1152.

18.

Human myostatin negatively regulates human myoblast growth and differentiation.

McFarlane C, Hui GZ, Amanda WZ, Lau HY, Lokireddy S, Xiaojia G, Mouly V, Butler-Browne G, Gluckman PD, Sharma M, Kambadur R.

Am J Physiol Cell Physiol. 2011 Jul;301(1):C195-203. doi: 10.1152/ajpcell.00012.2011. Epub 2011 Apr 20. Erratum in: Am J Physiol Cell Physiol. 2014 Dec 15;307(12):C1154.

19.

Smad3 signaling is required for satellite cell function and myogenic differentiation of myoblasts.

Ge X, McFarlane C, Vajjala A, Lokireddy S, Ng ZH, Tan CK, Tan NS, Wahli W, Sharma M, Kambadur R.

Cell Res. 2011 Nov;21(11):1591-604. doi: 10.1038/cr.2011.72. Epub 2011 Apr 19.

20.

Myostatin-deficient mice exhibit reduced insulin resistance through activating the AMP-activated protein kinase signalling pathway.

Zhang C, McFarlane C, Lokireddy S, Bonala S, Ge X, Masuda S, Gluckman PD, Sharma M, Kambadur R.

Diabetologia. 2011 Jun;54(6):1491-501. doi: 10.1007/s00125-011-2079-7. Epub 2011 Feb 24. Erratum in: Diabetologia. 2015 Mar;58(3):643.

PMID:
21347623
21.

Genetic predisposition to chikungunya--a blood group study in chikungunya affected families.

Lokireddy S, Sarojamma V, Ramakrishna V.

Virol J. 2009 Jun 16;6:77. doi: 10.1186/1743-422X-6-77.

22.

Connective tissue metabolism in chikungunya patients.

Lokireddy S, Vemula S, Vadde R.

Virol J. 2008 Feb 27;5:31. doi: 10.1186/1743-422X-5-31.

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