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Getting a Taste for Parasites in the Gut.

Loke P, Cadwell K.

Immunity. 2018 Jul 17;49(1):16-18. doi: 10.1016/j.immuni.2018.07.002.


Assessing the Mouse Intestinal Microbiota in Settings of Type-2 Immune Responses.

Tang MS, Bowcutt R, Loke P.

Methods Mol Biol. 2018;1799:359-370. doi: 10.1007/978-1-4939-7896-0_26.


Rapid environmental effects on gut nematode susceptibility in rewilded mice.

Leung JM, Budischak SA, Chung The H, Hansen C, Bowcutt R, Neill R, Shellman M, Loke P, Graham AL.

PLoS Biol. 2018 Mar 8;16(3):e2004108. doi: 10.1371/journal.pbio.2004108. eCollection 2018 Mar.


Recent Advances in Type-2-Cell-Mediated Immunity: Insights from Helminth Infection.

Harris NL, Loke P.

Immunity. 2018 Feb 20;48(2):396. doi: 10.1016/j.immuni.2018.02.011. No abstract available.


Recent Advances in Type-2-Cell-Mediated Immunity: Insights from Helminth Infection.

Harris NL, Loke P.

Immunity. 2017 Dec 19;47(6):1024-1036. doi: 10.1016/j.immuni.2017.11.015. Review. Erratum in: Immunity. 2018 Feb 20;48(2):396.


Atypical activation of dendritic cells by Plasmodium falciparum.

Götz A, Tang MS, Ty MC, Arama C, Ongoiba A, Doumtabe D, Traore B, Crompton PD, Loke P, Rodriguez A.

Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):E10568-E10577. doi: 10.1073/pnas.1708383114. Epub 2017 Nov 21.


Integrated Analysis of Biopsies from Inflammatory Bowel Disease Patients Identifies SAA1 as a Link Between Mucosal Microbes with TH17 and TH22 Cells.

Tang MS, Bowcutt R, Leung JM, Wolff MJ, Gundra UM, Hudesman D, Malter LB, Poles MA, Chen LA, Pei Z, Neto AG, Abidi WM, Ullman T, Mayer L, Bonneau RA, Cho I, Loke P.

Inflamm Bowel Dis. 2017 Sep;23(9):1544-1554. doi: 10.1097/MIB.0000000000001208.


By CyTOF: Heterogeneity of Human Monocytes.

Loke P, Niewold TB.

Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1423-1424. doi: 10.1161/ATVBAHA.117.309645. No abstract available.


Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression.

Rahman K, Vengrenyuk Y, Ramsey SA, Vila NR, Girgis NM, Liu J, Gusarova V, Gromada J, Weinstock A, Moore KJ, Loke P, Fisher EA.

J Clin Invest. 2017 Aug 1;127(8):2904-2915. doi: 10.1172/JCI75005. Epub 2017 Jun 26.


Vitamin A mediates conversion of monocyte-derived macrophages into tissue-resident macrophages during alternative activation.

Gundra UM, Girgis NM, Gonzalez MA, San Tang M, Van Der Zande HJP, Lin JD, Ouimet M, Ma LJ, Poles J, Vozhilla N, Fisher EA, Moore KJ, Loke P.

Nat Immunol. 2017 Jun;18(6):642-653. doi: 10.1038/ni.3734. Epub 2017 Apr 24.


Reduced microbial diversity in adult survivors of childhood acute lymphoblastic leukemia and microbial associations with increased immune activation.

Chua LL, Rajasuriar R, Azanan MS, Abdullah NK, Tang MS, Lee SC, Woo YL, Lim YA, Ariffin H, Loke P.

Microbiome. 2017 Mar 20;5(1):35. doi: 10.1186/s40168-017-0250-1.


Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K).

Castanedo GM, Blaquiere N, Beresini M, Bravo B, Brightbill H, Chen J, Cui HF, Eigenbrot C, Everett C, Feng J, Godemann R, Gogol E, Hymowitz S, Johnson A, Kayagaki N, Kohli PB, Knüppel K, Kraemer J, Krüger S, Loke P, McEwan P, Montalbetti C, Roberts DA, Smith M, Steinbacher S, Sujatha-Bhaskar S, Takahashi R, Wang X, Wu LC, Zhang Y, Staben ST.

J Med Chem. 2017 Jan 26;60(2):627-640. doi: 10.1021/acs.jmedchem.6b01363. Epub 2017 Jan 12.


A Commensal Protozoan Strikes a Balance in the Gut.

Loke P, Lim YAL.

Cell Host Microbe. 2016 Oct 12;20(4):417-419. doi: 10.1016/j.chom.2016.09.016.


Fecal microbial transplantation in a pediatric case of recurrent Clostridium difficile infection and specific antibody deficiency.

Loke P, Heine RG, McWilliam V, Cameron DJ, Tang ML, Allen KJ.

Pediatr Allergy Immunol. 2016 Dec;27(8):872-874. doi: 10.1111/pai.12619. Epub 2016 Sep 16. No abstract available.


Statewide prevalence of school children at risk of anaphylaxis and rate of adrenaline autoinjector activation in Victorian government schools, Australia.

Loke P, Koplin J, Beck C, Field M, Dharmage SC, Tang ML, Allen KJ.

J Allergy Clin Immunol. 2016 Aug;138(2):529-35. doi: 10.1016/j.jaci.2016.02.014. Epub 2016 Apr 12.


Helminth infection promotes colonization resistance via type 2 immunity.

Ramanan D, Bowcutt R, Lee SC, Tang MS, Kurtz ZD, Ding Y, Honda K, Gause WC, Blaser MJ, Bonneau RA, Lim YA, Loke P, Cadwell K.

Science. 2016 Apr 29;352(6285):608-12. doi: 10.1126/science.aaf3229. Epub 2016 Apr 14.


Monocyte-mediated defense against bacteria, fungi, and parasites.

Lauvau G, Loke P, Hohl TM.

Semin Immunol. 2015 Dec;27(6):397-409. doi: 10.1016/j.smim.2016.03.014. Epub 2016 Mar 25. Review.


Can Helminth Infection Reverse Microbial Dysbiosis?

Loke P, Lim YAL.

Trends Parasitol. 2015 Nov;31(11):534-535. doi: 10.1016/


MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis.

Ouimet M, Ediriweera HN, Gundra UM, Sheedy FJ, Ramkhelawon B, Hutchison SB, Rinehold K, van Solingen C, Fullerton MD, Cecchini K, Rayner KJ, Steinberg GR, Zamore PD, Fisher EA, Loke P, Moore KJ.

J Clin Invest. 2015 Oct 26;125(12):4334-48. doi: 10.1172/JCI81676.


Effect of ethnicity and socioeconomic variation to the gut microbiota composition among pre-adolescent in Malaysia.

Chong CW, Ahmad AF, Lim YA, Teh CS, Yap IK, Lee SC, Chin YT, Loke P, Chua KH.

Sci Rep. 2015 Aug 20;5:13338. doi: 10.1038/srep13338.


Helminths and the microbiota: parts of the hygiene hypothesis.

Loke P, Lim YA.

Parasite Immunol. 2015 Jun;37(6):314-23. doi: 10.1111/pim.12193. Review.


Isolation and cytokine analysis of lamina propria lymphocytes from mucosal biopsies of the human colon.

Bowcutt R, Malter LB, Chen LA, Wolff MJ, Robertson I, Rifkin DB, Poles M, Cho I, Loke P.

J Immunol Methods. 2015 Jun;421:27-35. doi: 10.1016/j.jim.2015.02.012. Epub 2015 Mar 10.


Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915).

Takahashi H, Riether D, Bartolozzi A, Bosanac T, Berger V, Binetti R, Broadwater J, Chen Z, Crux R, De Lombaert S, Dave R, Dines JA, Fadra-Khan T, Flegg A, Garrigou M, Hao MH, Huber J, Hutzler JM, Kerr S, Kotey A, Liu W, Lo HY, Loke PL, Mahaney PE, Morwick TM, Napier S, Olague A, Pack E, Padyana AK, Thomson DS, Tye H, Wu L, Zindell RM, Abeywardane A, Simpson T.

J Med Chem. 2015 Feb 26;58(4):1669-90. doi: 10.1021/jm501185j. Epub 2015 Feb 11.


Inferred metagenomic comparison of mucosal and fecal microbiota from individuals undergoing routine screening colonoscopy reveals similar differences observed during active inflammation.

Tang MS, Poles J, Leung JM, Wolff MJ, Davenport M, Lee SC, Lim YA, Chua KH, Loke P, Cho I.

Gut Microbes. 2015;6(1):48-56. doi: 10.1080/19490976.2014.1000080. Epub 2015 Jan 20.


Experimental cerebral malaria pathogenesis--hemodynamics at the blood brain barrier.

Nacer A, Movila A, Sohet F, Girgis NM, Gundra UM, Loke P, Daneman R, Frevert U.

PLoS Pathog. 2014 Dec 4;10(12):e1004528. doi: 10.1371/journal.ppat.1004528. eCollection 2014 Dec.


Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences.

Cox LM, Yamanishi S, Sohn J, Alekseyenko AV, Leung JM, Cho I, Kim SG, Li H, Gao Z, Mahana D, Zárate Rodriguez JG, Rogers AB, Robine N, Loke P, Blaser MJ.

Cell. 2014 Aug 14;158(4):705-721. doi: 10.1016/j.cell.2014.05.052.


Bacterial sensor Nod2 prevents inflammation of the small intestine by restricting the expansion of the commensal Bacteroides vulgatus.

Ramanan D, Tang MS, Bowcutt R, Loke P, Cadwell K.

Immunity. 2014 Aug 21;41(2):311-24. doi: 10.1016/j.immuni.2014.06.015. Epub 2014 Jul 31.


Ly6C(high) monocytes become alternatively activated macrophages in schistosome granulomas with help from CD4+ cells.

Girgis NM, Gundra UM, Ward LN, Cabrera M, Frevert U, Loke P.

PLoS Pathog. 2014 Jun 26;10(6):e1004080. doi: 10.1371/journal.ppat.1004080. eCollection 2014 Jun.


Helminth colonization is associated with increased diversity of the gut microbiota.

Lee SC, Tang MS, Lim YA, Choy SH, Kurtz ZD, Cox LM, Gundra UM, Cho I, Bonneau R, Blaser MJ, Chua KH, Loke P.

PLoS Negl Trop Dis. 2014 May 22;8(5):e2880. doi: 10.1371/journal.pntd.0002880. eCollection 2014 May.


Systemic impact of intestinal helminth infections.

Mishra PK, Palma M, Bleich D, Loke P, Gause WC.

Mucosal Immunol. 2014 Jul;7(4):753-62. doi: 10.1038/mi.2014.23. Epub 2014 Apr 16. Review.


Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct.

Gundra UM, Girgis NM, Ruckerl D, Jenkins S, Ward LN, Kurtz ZD, Wiens KE, Tang MS, Basu-Roy U, Mansukhani A, Allen JE, Loke P.

Blood. 2014 May 15;123(20):e110-22. doi: 10.1182/blood-2013-08-520619. Epub 2014 Apr 2.


Parasites: what are they good for?

Stumhofer JS, Loke P.

Curr Immunol Rev. 2013 Aug 1;9(3):120-128.


Metabolic alterations to the mucosal microbiota in inflammatory bowel disease.

Davenport M, Poles J, Leung JM, Wolff MJ, Abidi WM, Ullman T, Mayer L, Cho I, Loke P.

Inflamm Bowel Dis. 2014 Apr;20(4):723-31. doi: 10.1097/MIB.0000000000000011.


Discordance between peripheral and colonic markers of inflammation during suppressive ART.

Dunham RM, Vujkovic-Cvijin I, Yukl SA, Broadhurst MJ, Loke P, Albright RG, Wong JK, Lederman MM, Somsouk M, Hunt PW, Martin JN, Deeks SG, McCune JM.

J Acquir Immune Defic Syndr. 2014 Feb 1;65(2):133-41. doi: 10.1097/01.qai.0000437172.08127.0b.


IL-22-producing CD4+ cells are depleted in actively inflamed colitis tissue.

Leung JM, Davenport M, Wolff MJ, Wiens KE, Abidi WM, Poles MA, Cho I, Ullman T, Mayer L, Loke P.

Mucosal Immunol. 2014 Jan;7(1):124-33. doi: 10.1038/mi.2013.31. Epub 2013 May 22.


Immune regulation during helminth infections.

Girgis NM, Gundra UM, Loke P.

PLoS Pathog. 2013;9(4):e1003250. doi: 10.1371/journal.ppat.1003250. Epub 2013 Apr 18. No abstract available.


Cutting edge: chronic inflammatory liver disease in mice expressing a CD28-specific ligand.

Corse E, Gottschalk RA, Park JS, Sepulveda MA, Loke P, Sullivan TJ, Johnson LK, Allison JP.

J Immunol. 2013 Jan 15;190(2):526-30. doi: 10.4049/jimmunol.1202621. Epub 2012 Dec 17.


A role for IL-22 in the relationship between intestinal helminths, gut microbiota and mucosal immunity.

Leung JM, Loke P.

Int J Parasitol. 2013 Mar;43(3-4):253-7. doi: 10.1016/j.ijpara.2012.10.015. Epub 2012 Nov 20. Review.


Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon.

Broadhurst MJ, Ardeshir A, Kanwar B, Mirpuri J, Gundra UM, Leung JM, Wiens KE, Vujkovic-Cvijin I, Kim CC, Yarovinsky F, Lerche NW, McCune JM, Loke P.

PLoS Pathog. 2012;8(11):e1003000. doi: 10.1371/journal.ppat.1003000. Epub 2012 Nov 15.


B7x in the periphery abrogates pancreas-specific damage mediated by self-reactive CD8 T cells.

Lee JS, Scandiuzzi L, Ray A, Wei J, Hofmeyer KA, Abadi YM, Loke P, Lin J, Yuan J, Serreze DV, Allison JP, Zang X.

J Immunol. 2012 Oct 15;189(8):4165-74. doi: 10.4049/jimmunol.1201241. Epub 2012 Sep 12.


Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice.

Broadhurst MJ, Leung JM, Lim KC, Girgis NM, Gundra UM, Fallon PG, Premenko-Lanier M, McKerrow JH, McCune JM, Loke P.

PLoS Pathog. 2012;8(8):e1002883. doi: 10.1371/journal.ppat.1002883. Epub 2012 Aug 23.


Accuracy of inter-hospital paediatric appendicitis referrals.

Loke P, Tantoco J, Ferguson P, Heloury Y, Kimber C, Oakley E, Cheng W.

Emerg Med Australas. 2012 Aug;24(4):414-9. doi: 10.1111/j.1742-6723.2012.01577.x. Epub 2012 Jun 19.


TH17, TH22 and Treg cells are enriched in the healthy human cecum.

Wolff MJ, Leung JM, Davenport M, Poles MA, Cho I, Loke P.

PLoS One. 2012;7(7):e41373. doi: 10.1371/journal.pone.0041373. Epub 2012 Jul 19.


Helminthic therapy: improving mucosal barrier function.

Wolff MJ, Broadhurst MJ, Loke P.

Trends Parasitol. 2012 May;28(5):187-94. doi: 10.1016/ Epub 2012 Mar 28. Review.


Tissue-specific expression of B7x protects from CD4 T cell-mediated autoimmunity.

Wei J, Loke P, Zang X, Allison JP.

J Exp Med. 2011 Aug 1;208(8):1683-94. doi: 10.1084/jem.20100639. Epub 2011 Jul 4.


IL-22+ CD4+ T cells are associated with therapeutic trichuris trichiura infection in an ulcerative colitis patient.

Broadhurst MJ, Leung JM, Kashyap V, McCune JM, Mahadevan U, McKerrow JH, Loke P.

Sci Transl Med. 2010 Dec 1;2(60):60ra88. doi: 10.1126/scitranslmed.3001500.


An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction.

East SP, Bamford S, Dietz MG, Eickmeier C, Flegg A, Ferger B, Gemkow MJ, Heilker R, Hengerer B, Kotey A, Loke P, Schänzle G, Schubert HD, Scott J, Whittaker M, Williams M, Zawadzki P, Gerlach K.

Bioorg Med Chem Lett. 2010 Aug 15;20(16):4901-5. doi: 10.1016/j.bmcl.2010.06.078. Epub 2010 Jun 25.


Gene expression patterns of dengue virus-infected children from nicaragua reveal a distinct signature of increased metabolism.

Loke P, Hammond SN, Leung JM, Kim CC, Batra S, Rocha C, Balmaseda A, Harris E.

PLoS Negl Trop Dis. 2010 Jun 15;4(6):e710. doi: 10.1371/journal.pntd.0000710.


Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease.

Favre D, Mold J, Hunt PW, Kanwar B, Loke P, Seu L, Barbour JD, Lowe MM, Jayawardene A, Aweeka F, Huang Y, Douek DC, Brenchley JM, Martin JN, Hecht FM, Deeks SG, McCune JM.

Sci Transl Med. 2010 May 19;2(32):32ra36. doi: 10.1126/scitranslmed.3000632.

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