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Items: 27

1.

Jak-Stat Signaling Induced by Interleukin-6 Family Cytokines in Hepatocellular Carcinoma.

Lokau J, Schoeder V, Haybaeck J, Garbers C.

Cancers (Basel). 2019 Nov 1;11(11). pii: E1704. doi: 10.3390/cancers11111704. Review.

2.

Differences in Shedding of the Interleukin-11 Receptor by the Proteases ADAM9, ADAM10, ADAM17, Meprin α, Meprin β and MT1-MMP.

Sammel M, Peters F, Lokau J, Scharfenberg F, Werny L, Linder S, Garbers C, Rose-John S, Becker-Pauly C.

Int J Mol Sci. 2019 Jul 26;20(15). pii: E3677. doi: 10.3390/ijms20153677.

3.

Activation of Toll-like Receptor 2 (TLR2) induces Interleukin-6 trans-signaling.

Flynn CM, Garbers Y, Lokau J, Wesch D, Schulte DM, Laudes M, Lieb W, Aparicio-Siegmund S, Garbers C.

Sci Rep. 2019 May 13;9(1):7306. doi: 10.1038/s41598-019-43617-5.

4.

Activating mutations of the gp130/JAK/STAT pathway in human diseases.

Lokau J, Garbers C.

Adv Protein Chem Struct Biol. 2019;116:283-309. doi: 10.1016/bs.apcsb.2018.11.007. Epub 2018 Dec 27.

PMID:
31036294
5.

The metalloprotease ADAM17 in inflammation and cancer.

Düsterhöft S, Lokau J, Garbers C.

Pathol Res Pract. 2019 Jun;215(6):152410. doi: 10.1016/j.prp.2019.04.002. Epub 2019 Apr 6. Review.

PMID:
30992230
6.

Therapeutic blockade of the interleukin-6 receptor (IL-6R) allows sIL-6R generation by proteolytic cleavage.

Prenissl N, Lokau J, Rose-John S, Haybaeck J, Garbers C.

Cytokine. 2019 Feb;114:1-5. doi: 10.1016/j.cyto.2018.11.023. Epub 2018 Dec 14.

7.

Mutations in Craniosynostosis Patients Cause Defective Interleukin-11 Receptor Maturation and Drive Craniosynostosis-like Disease in Mice.

Agthe M, Brügge J, Garbers Y, Wandel M, Kespohl B, Arnold P, Flynn CM, Lokau J, Aparicio-Siegmund S, Bretscher C, Rose-John S, Waetzig GH, Putoczki T, Grötzinger J, Garbers C.

Cell Rep. 2018 Oct 2;25(1):10-18.e5. doi: 10.1016/j.celrep.2018.09.005.

8.

The length of the interleukin-11 receptor stalk determines its capacity for classic signaling.

Lokau J, Garbers C.

J Biol Chem. 2018 Apr 27;293(17):6398-6409. doi: 10.1074/jbc.RA118.001879. Epub 2018 Mar 9.

9.

ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.

Schmidt S, Schumacher N, Schwarz J, Tangermann S, Kenner L, Schlederer M, Sibilia M, Linder M, Altendorf-Hofmann A, Knösel T, Gruber ES, Oberhuber G, Bolik J, Rehman A, Sinha A, Lokau J, Arnold P, Cabron AS, Zunke F, Becker-Pauly C, Preaudet A, Nguyen P, Huynh J, Afshar-Sterle S, Chand AL, Westermann J, Dempsey PJ, Garbers C, Schmidt-Arras D, Rosenstiel P, Putoczki T, Ernst M, Rose-John S.

J Exp Med. 2018 Apr 2;215(4):1205-1225. doi: 10.1084/jem.20171696. Epub 2018 Feb 22.

10.

The SNP rs4252548 (R112H) which is associated with reduced human height compromises the stability of IL-11.

Lokau J, Göttert S, Arnold P, Düsterhöft S, Massa López D, Grötzinger J, Garbers C.

Biochim Biophys Acta Mol Cell Res. 2018 Mar;1865(3):496-506. doi: 10.1016/j.bbamcr.2017.12.003. Epub 2017 Dec 10.

11.

Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome.

Lokau J, Flynn CM, Garbers C.

Biochem Biophys Res Commun. 2017 Sep 16;491(2):296-302. doi: 10.1016/j.bbrc.2017.07.106. Epub 2017 Jul 20.

PMID:
28735867
12.

Proteolytic control of Interleukin-11 and Interleukin-6 biology.

Lokau J, Agthe M, Flynn CM, Garbers C.

Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt B):2105-2117. doi: 10.1016/j.bbamcr.2017.06.008. Epub 2017 Jun 16. Review.

13.

Meprin Metalloproteases Generate Biologically Active Soluble Interleukin-6 Receptor to Induce Trans-Signaling.

Arnold P, Boll I, Rothaug M, Schumacher N, Schmidt F, Wichert R, Schneppenheim J, Lokau J, Pickhinke U, Koudelka T, Tholey A, Rabe B, Scheller J, Lucius R, Garbers C, Rose-John S, Becker-Pauly C.

Sci Rep. 2017 Mar 9;7:44053. doi: 10.1038/srep44053.

14.

Enhancing Interleukin-6 and Interleukin-11 receptor cleavage.

Lokau J, Wandel M, Garbers C.

Int J Biochem Cell Biol. 2017 Apr;85:6-14. doi: 10.1016/j.biocel.2017.01.014. Epub 2017 Jan 29.

PMID:
28143719
15.

Proteolytic Origin of the Soluble Human IL-6R In Vivo and a Decisive Role of N-Glycosylation.

Riethmueller S, Somasundaram P, Ehlers JC, Hung CW, Flynn CM, Lokau J, Agthe M, Düsterhöft S, Zhu Y, Grötzinger J, Lorenzen I, Koudelka T, Yamamoto K, Pickhinke U, Wichert R, Becker-Pauly C, Rädisch M, Albrecht A, Hessefort M, Stahnke D, Unverzagt C, Rose-John S, Tholey A, Garbers C.

PLoS Biol. 2017 Jan 6;15(1):e2000080. doi: 10.1371/journal.pbio.2000080. eCollection 2017 Jan.

16.

Erratum: Control of ADAM17 activity by regulation of its cellular localisation.

Lorenzen I, Lokau J, Korpys Y, Oldefest M, Flynn CM, Künzel U, Garbers C, Freeman M, Grötzinger J, Düsterhöft S.

Sci Rep. 2016 Nov 21;6:37364. doi: 10.1038/srep37364. No abstract available.

17.

Control of ADAM17 activity by regulation of its cellular localisation.

Lorenzen I, Lokau J, Korpys Y, Oldefest M, Flynn CM, Künzel U, Garbers C, Freeman M, Grötzinger J, Düsterhöft S.

Sci Rep. 2016 Oct 12;6:35067. doi: 10.1038/srep35067. Erratum in: Sci Rep. 2016 Nov 21;6:37364.

18.

Circulating Soluble IL-6R but Not ADAM17 Activation Drives Mononuclear Cell Migration in Tissue Inflammation.

Schumacher N, Schmidt S, Schwarz J, Dohr D, Lokau J, Scheller J, Garbers C, Chalaris A, Rose-John S, Rabe B.

J Immunol. 2016 Nov 1;197(9):3705-3715. Epub 2016 Oct 3.

19.

Generation of Soluble Interleukin-11 and Interleukin-6 Receptors: A Crucial Function for Proteases during Inflammation.

Lokau J, Agthe M, Garbers C.

Mediators Inflamm. 2016;2016:1785021. doi: 10.1155/2016/1785021. Epub 2016 Jul 14. Review.

20.

Transcytosis of IL-11 and Apical Redirection of gp130 Is Mediated by IL-11α Receptor.

Monhasery N, Moll J, Cuman C, Franke M, Lamertz L, Nitz R, Görg B, Häussinger D, Lokau J, Floss DM, Piekorz R, Dimitriadis E, Garbers C, Scheller J.

Cell Rep. 2016 Jul 26;16(4):1067-1081. doi: 10.1016/j.celrep.2016.06.062. Epub 2016 Jul 14.

21.

Cleavage Site Localization Differentially Controls Interleukin-6 Receptor Proteolysis by ADAM10 and ADAM17.

Riethmueller S, Ehlers JC, Lokau J, Düsterhöft S, Knittler K, Dombrowsky G, Grötzinger J, Rabe B, Rose-John S, Garbers C.

Sci Rep. 2016 May 6;6:25550. doi: 10.1038/srep25550.

22.

Proteolytic Cleavage Governs Interleukin-11 Trans-signaling.

Lokau J, Nitz R, Agthe M, Monhasery N, Aparicio-Siegmund S, Schumacher N, Wolf J, Möller-Hackbarth K, Waetzig GH, Grötzinger J, Müller-Newen G, Rose-John S, Scheller J, Garbers C.

Cell Rep. 2016 Feb 23;14(7):1761-1773. doi: 10.1016/j.celrep.2016.01.053. Epub 2016 Feb 11.

23.

Modular organization of Interleukin-6 and Interleukin-11 α-receptors.

Nitz R, Lokau J, Aparicio-Siegmund S, Scheller J, Garbers C.

Biochimie. 2015 Dec;119:175-82. doi: 10.1016/j.biochi.2015.11.005. Epub 2015 Nov 10.

PMID:
26551279
24.

Recombinant p35 from bacteria can form Interleukin (IL-)12, but Not IL-35.

Aparicio-Siegmund S, Moll JM, Lokau J, Grusdat M, Schröder J, Plöhn S, Rose-John S, Grötzinger J, Lang PA, Scheller J, Garbers C.

PLoS One. 2014 Sep 26;9(9):e107990. doi: 10.1371/journal.pone.0107990. eCollection 2014.

25.

The interleukin-6 receptor Asp358Ala single nucleotide polymorphism rs2228145 confers increased proteolytic conversion rates by ADAM proteases.

Garbers C, Monhasery N, Aparicio-Siegmund S, Lokau J, Baran P, Nowell MA, Jones SA, Rose-John S, Scheller J.

Biochim Biophys Acta. 2014 Sep;1842(9):1485-94. doi: 10.1016/j.bbadis.2014.05.018. Epub 2014 May 27.

26.

A disintegrin and metalloprotease 17 dynamic interaction sequence, the sweet tooth for the human interleukin 6 receptor.

Düsterhöft S, Höbel K, Oldefest M, Lokau J, Waetzig GH, Chalaris A, Garbers C, Scheller J, Rose-John S, Lorenzen I, Grötzinger J.

J Biol Chem. 2014 Jun 6;289(23):16336-48. doi: 10.1074/jbc.M114.557322. Epub 2014 Apr 30.

27.

The membrane-proximal domain of A Disintegrin and Metalloprotease 17 (ADAM17) is responsible for recognition of the interleukin-6 receptor and interleukin-1 receptor II.

Lorenzen I, Lokau J, Düsterhöft S, Trad A, Garbers C, Scheller J, Rose-John S, Grötzinger J.

FEBS Lett. 2012 Apr 24;586(8):1093-100. doi: 10.1016/j.febslet.2012.03.012. Epub 2012 Mar 21.

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