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Items: 1 to 50 of 186

1.

Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C.

Lim XN, Shan C, Marzinek JK, Dong H, Ng TS, Ooi JSG, Fibriansah G, Wang J, Verma CS, Bond PJ, Shi PY, Lok SM.

PLoS Pathog. 2019 Sep 19;15(9):e1007996. doi: 10.1371/journal.ppat.1007996. eCollection 2019 Sep.

2.

Amelioration of Endoplasmic Reticulum Stress by Mesenchymal Stem Cells via Hepatocyte Growth Factor/c-Met Signaling in Obesity-Associated Kidney Injury.

Li B, Leung JCK, Chan LYY, Yiu WH, Li Y, Lok SWY, Liu WH, Chan KW, Tse HF, Lai KN, Tang SCW.

Stem Cells Transl Med. 2019 Sep;8(9):898-910. doi: 10.1002/sctm.18-0265. Epub 2019 May 3.

3.

FAM83D promotes ovarian cancer progression and its potential application in diagnosis of invasive ovarian cancer.

Zhang Q, Yu S, Lok SIS, Wong AST, Jiao Y, Lee LTO.

J Cell Mol Med. 2019 Jul;23(7):4569-4581. doi: 10.1111/jcmm.14360. Epub 2019 Apr 30.

4.

Structural perspectives of antibody-dependent enhancement of infection of dengue virus.

Morrone SR, Lok SM.

Curr Opin Virol. 2019 Jun;36:1-8. doi: 10.1016/j.coviro.2019.02.002. Epub 2019 Mar 4. Review.

PMID:
30844538
5.

Demonstrating the feasibility of collecting secondary, de-identified data on Australian patients receiving treatment as part of a Medicine Access Program.

Lok SW, De Boer R, Cordwell C, Marx G, Fox P, Hasovits C, Rutovitz J, Harold M, Tran B, Wong HL, Gibbs P.

Intern Med J. 2019 Feb 28. doi: 10.1111/imj.14265. [Epub ahead of print]

PMID:
30816606
6.

A Phase Ib Dose-Escalation and Expansion Study of the BCL2 Inhibitor Venetoclax Combined with Tamoxifen in ER and BCL2-Positive Metastatic Breast Cancer.

Lok SW, Whittle JR, Vaillant F, Teh CE, Lo LL, Policheni AN, Bergin ART, Desai J, Ftouni S, Gandolfo LC, Liew D, Liu HK, Mann GB, Moodie K, Murugasu A, Pal B, Roberts AW, Rosenthal MA, Shackleton K, Silva MJ, Siow ZR, Smyth GK, Taylor L, Travers A, Yeo B, Yeung MM, Bujak AZ, Dawson SJ, Gray DHD, Visvader JE, Lindeman GJ.

Cancer Discov. 2019 Mar;9(3):354-369. doi: 10.1158/2159-8290.CD-18-1151. Epub 2018 Dec 5.

PMID:
30518523
7.

Mechanism of Enhanced Immature Dengue Virus Attachment to Endosomal Membrane Induced by prM Antibody.

Wirawan M, Fibriansah G, Marzinek JK, Lim XX, Ng TS, Sim AYL, Zhang Q, Kostyuchenko VA, Shi J, Smith SA, Verma CS, Anand G, Crowe JE Jr, Bond PJ, Lok SM.

Structure. 2019 Feb 5;27(2):253-267.e8. doi: 10.1016/j.str.2018.10.009. Epub 2018 Nov 21.

PMID:
30471923
8.

Effects of Physical Activity Program on cognitive function and sleep quality in elderly with mild cognitive impairment: A randomized controlled trial.

Bademli K, Lok N, Canbaz M, Lok S.

Perspect Psychiatr Care. 2019 Jul;55(3):401-408. doi: 10.1111/ppc.12324. Epub 2018 Nov 14.

PMID:
30430592
9.

Flat-lying antibody prevents disease enhancement.

Lok SM.

Nat Immunol. 2018 Nov;19(11):1150-1152. doi: 10.1038/s41590-018-0239-3. No abstract available.

PMID:
30323339
10.

Mismatch repair deficiency assessment by immunohistochemistry: for Lynch syndrome screening and beyond.

Wong HL, Christie M, Gately L, Tie J, Lee B, Semira C, Lok SW, Wong R, Gibbs P.

Future Oncol. 2018 Nov;14(26):2725-2739. doi: 10.2217/fon-2018-0319. Epub 2018 Jul 13. Review.

PMID:
30004261
11.

Previous Bevacizumab and Efficacy of Later Anti-Epidermal Growth Factor Receptor Antibodies in Metastatic Colorectal Cancer: Results From a Large International Registry.

Burge M, Semira C, Lee B, Lee M, Kosmider S, Wong R, Shapiro J, Ma B, Dean AP, Zimet AS, Steel SA, Lok SW, Torres J, Eastgate M, Wong HL, Gibbs P.

Clin Colorectal Cancer. 2018 Sep;17(3):e593-e599. doi: 10.1016/j.clcc.2018.05.009. Epub 2018 Jun 1.

PMID:
29958812
12.

Inhibiting EBV: The Key to Carefree Smooching.

Lok SM.

Immunity. 2018 Apr 17;48(4):623-625. doi: 10.1016/j.immuni.2018.03.036.

13.

Activated renal tubular Wnt/β-catenin signaling triggers renal inflammation during overload proteinuria.

Wong DWL, Yiu WH, Chan KW, Li Y, Li B, Lok SWY, Taketo MM, Igarashi P, Chan LYY, Leung JCK, Lai KN, Tang SCW.

Kidney Int. 2018 Jun;93(6):1367-1383. doi: 10.1016/j.kint.2017.12.017. Epub 2018 Mar 28.

14.

Common Features of Enveloped Viruses and Implications for Immunogen Design for Next-Generation Vaccines.

Rey FA, Lok SM.

Cell. 2018 Mar 8;172(6):1319-1334. doi: 10.1016/j.cell.2018.02.054. Review.

15.

Whole transcriptome analysis reveals differential gene expression profile reflecting macrophage polarization in response to influenza A H5N1 virus infection.

Zhang N, Bao YJ, Tong AH, Zuyderduyn S, Bader GD, Malik Peiris JS, Lok S, Lee SM.

BMC Med Genomics. 2018 Feb 23;11(1):20. doi: 10.1186/s12920-018-0335-0.

16.

A Comprehensive Workflow for Read Depth-Based Identification of Copy-Number Variation from Whole-Genome Sequence Data.

Trost B, Walker S, Wang Z, Thiruvahindrapuram B, MacDonald JR, Sung WWL, Pereira SL, Whitney J, Chan AJS, Pellecchia G, Reuter MS, Lok S, Yuen RKC, Marshall CR, Merico D, Scherer SW.

Am J Hum Genet. 2018 Jan 4;102(1):142-155. doi: 10.1016/j.ajhg.2017.12.007.

17.

CD-loop Extension in Zika Virus Envelope Protein Key for Stability and Pathogenesis.

Gallichotte EN, Dinnon KH 3rd, Lim XN, Ng TS, Lim EXY, Menachery VD, Lok SM, Baric RS.

J Infect Dis. 2017 Dec 5;216(10):1196-1204. doi: 10.1093/infdis/jix473.

18.

A Human Bi-specific Antibody against Zika Virus with High Therapeutic Potential.

Wang J, Bardelli M, Espinosa DA, Pedotti M, Ng TS, Bianchi S, Simonelli L, Lim EXY, Foglierini M, Zatta F, Jaconi S, Beltramello M, Cameroni E, Fibriansah G, Shi J, Barca T, Pagani I, Rubio A, Broccoli V, Vicenzi E, Graham V, Pullan S, Dowall S, Hewson R, Jurt S, Zerbe O, Stettler K, Lanzavecchia A, Sallusto F, Cavalli A, Harris E, Lok SM, Varani L, Corti D.

Cell. 2017 Sep 21;171(1):229-241.e15. doi: 10.1016/j.cell.2017.09.002.

19.

New class of precision antimicrobials redefines role of Clostridium difficile S-layer in virulence and viability.

Kirk JA, Gebhart D, Buckley AM, Lok S, Scholl D, Douce GR, Govoni GR, Fagan RP.

Sci Transl Med. 2017 Sep 6;9(406). pii: eaah6813. doi: 10.1126/scitranslmed.aah6813.

20.

Epitope and Paratope Mapping Reveals Temperature-Dependent Alterations in the Dengue-Antibody Interface.

Lim XX, Chandramohan A, Lim XE, Crowe JE Jr, Lok SM, Anand GS.

Structure. 2017 Sep 5;25(9):1391-1402.e3. doi: 10.1016/j.str.2017.07.007. Epub 2017 Aug 17.

21.

Unsweetened IgG Is Bad for Dengue Patients.

Lok SM.

Cell Host Microbe. 2017 Mar 8;21(3):312-314. doi: 10.1016/j.chom.2017.02.011.

22.

Prevalence of allergen sensitization in 1000 adults in Saskatchewan.

Lok SD, Davis BE, Cockcroft DW.

Allergy Asthma Clin Immunol. 2017 Feb 8;13:9. doi: 10.1186/s13223-017-0181-1. eCollection 2017.

23.

Conformational changes in intact dengue virus reveal serotype-specific expansion.

Lim XX, Chandramohan A, Lim XY, Bag N, Sharma KK, Wirawan M, Wohland T, Lok SM, Anand GS.

Nat Commun. 2017 Feb 10;8:14339. doi: 10.1038/ncomms14339.

24.

The effect of physical activity on depressive symptoms and quality of life among elderly nursing home residents: Randomized controlled trial.

Lok N, Lok S, Canbaz M.

Arch Gerontol Geriatr. 2017 May - Jun;70:92-98. doi: 10.1016/j.archger.2017.01.008. Epub 2017 Jan 16.

PMID:
28110207
25.

De Novo Genome and Transcriptome Assembly of the Canadian Beaver (Castor canadensis).

Lok S, Paton TA, Wang Z, Kaur G, Walker S, Yuen RK, Sung WW, Whitney J, Buchanan JA, Trost B, Singh N, Apresto B, Chen N, Coole M, Dawson TJ, Ho K, Hu Z, Pullenayegum S, Samler K, Shipstone A, Tsoi F, Wang T, Pereira SL, Rostami P, Ryan CA, Tong AH, Ng K, Sundaravadanam Y, Simpson JT, Lim BK, Engstrom MD, Dutton CJ, Kerr KC, Franke M, Rapley W, Wintle RF, Scherer SW.

G3 (Bethesda). 2017 Feb 9;7(2):755-773. doi: 10.1534/g3.116.038208.

26.

Correction: Chromosomal-Level Assembly of the Asian Seabass Genome Using Long Sequence Reads and Multi-layered Scaffolding.

Vij S, Kuhl H, Kuznetsova IS, Komissarov A, Yurchenko AA, Van Heusden P, Singh S, Thevasagayam NM, Prakki SR, Purushothaman K, Saju JM, Jiang J, Mbandi SK, Jonas M, Hin Yan Tong A, Mwangi S, Lau D, Ngoh SY, Liew WC, Shen X, Hon LS, Drake JP, Boitano M, Hall R, Chin CS, Lachumanan R, Korlach J, Trifonov V, Kabilov M, Tupikin A, Green D, Moxon S, Garvin T, Sedlazeck FJ, Vurture GW, Gopalapillai G, Katneni VK, Noble TH, Scaria V, Sivasubbu S, Jerry DR, O'Brien SJ, Schatz MC, Dalmay T, Turner SW, Lok S, Christoffels A, Orbán L.

PLoS Genet. 2016 Dec 9;12(12):e1006500. doi: 10.1371/journal.pgen.1006500. eCollection 2016 Dec.

27.

Neutralization mechanism of a highly potent antibody against Zika virus.

Zhang S, Kostyuchenko VA, Ng TS, Lim XN, Ooi JSG, Lambert S, Tan TY, Widman DG, Shi J, Baric RS, Lok SM.

Nat Commun. 2016 Nov 24;7:13679. doi: 10.1038/ncomms13679.

28.

Insights into kinetic mechanism of Janus kinase 3 and its inhibition by tofacitinib.

Hekmatnejad M, Conwell S, Lok SM, Kutach A, Shaw D, Fang E, Swinney DC.

Arch Biochem Biophys. 2016 Dec 15;612:22-34. doi: 10.1016/j.abb.2016.08.012. Epub 2016 Aug 20.

PMID:
27555492
29.

Interactome-transcriptome analysis discovers signatures complementary to GWAS Loci of Type 2 Diabetes.

Li JW, Lee HM, Wang Y, Tong AH, Yip KY, Tsui SK, Lok S, Ozaki R, Luk AO, Kong AP, So WY, Ma RC, Chan JC, Chan TF.

Sci Rep. 2016 Oct 18;6:35228. doi: 10.1038/srep35228.

30.

RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers.

Nolan E, Vaillant F, Branstetter D, Pal B, Giner G, Whitehead L, Lok SW, Mann GB; Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab), Rohrbach K, Huang LY, Soriano R, Smyth GK, Dougall WC, Visvader JE, Lindeman GJ.

Nat Med. 2016 Aug;22(8):933-9. doi: 10.1038/nm.4118. Epub 2016 Jun 20.

PMID:
27322743
31.

Structure of the thermally stable Zika virus.

Kostyuchenko VA, Lim EX, Zhang S, Fibriansah G, Ng TS, Ooi JS, Shi J, Lok SM.

Nature. 2016 May 19;533(7603):425-8. doi: 10.1038/nature17994. Epub 2016 Apr 19.

PMID:
27093288
32.

Chromosomal-Level Assembly of the Asian Seabass Genome Using Long Sequence Reads and Multi-layered Scaffolding.

Vij S, Kuhl H, Kuznetsova IS, Komissarov A, Yurchenko AA, Van Heusden P, Singh S, Thevasagayam NM, Prakki SR, Purushothaman K, Saju JM, Jiang J, Mbandi SK, Jonas M, Hin Yan Tong A, Mwangi S, Lau D, Ngoh SY, Liew WC, Shen X, Hon LS, Drake JP, Boitano M, Hall R, Chin CS, Lachumanan R, Korlach J, Trifonov V, Kabilov M, Tupikin A, Green D, Moxon S, Garvin T, Sedlazeck FJ, Vurture GW, Gopalapillai G, Kumar Katneni V, Noble TH, Scaria V, Sivasubbu S, Jerry DR, O'Brien SJ, Schatz MC, Dalmay T, Turner SW, Lok S, Christoffels A, Orbán L.

PLoS Genet. 2016 Apr 15;12(4):e1005954. doi: 10.1371/journal.pgen.1005954. eCollection 2016 Apr. Erratum in: PLoS Genet. 2016 Dec 9;12 (12 ):e1006500.

33.

Giant Aortic Mural Thrombus.

Lok SY, Bhagwat K, Smith JA, Troupis J, Joshi P.

J Card Surg. 2016 May;31(5):351. doi: 10.1111/jocs.12748. Epub 2016 Apr 5. No abstract available.

PMID:
27059689
34.

The development of therapeutic antibodies against dengue virus.

Fibriansah G, Lok SM.

Antiviral Res. 2016 Apr;128:7-19. doi: 10.1016/j.antiviral.2016.01.002. Epub 2016 Jan 19. Review.

PMID:
26794397
35.

The Interplay of Dengue Virus Morphological Diversity and Human Antibodies.

Lok SM.

Trends Microbiol. 2016 Apr;24(4):284-293. doi: 10.1016/j.tim.2015.12.004. Epub 2015 Dec 30. Review.

PMID:
26747581
36.

Letter to the Editor.

Lok SM.

Curr Opin Virol. 2015 Dec;15:129. doi: 10.1016/j.coviro.2015.10.006. Epub 2015 Dec 6. No abstract available.

PMID:
26651148
37.

MicroRNA Expression in Myocardial Tissue and Plasma of Patients with End-Stage Heart Failure during LVAD Support: Comparison of Continuous and Pulsatile Devices.

Lok SI, de Jonge N, van Kuik J, van Geffen AJ, Huibers MM, van der Weide P, Siera E, Winkens B, Doevendans PA, de Weger RA, da Costa Martins PA.

PLoS One. 2015 Oct 2;10(10):e0136404. doi: 10.1371/journal.pone.0136404. eCollection 2015.

38.

Targeting BCL-2 to enhance vulnerability to therapy in estrogen receptor-positive breast cancer.

Merino D, Lok SW, Visvader JE, Lindeman GJ.

Oncogene. 2016 Apr 14;35(15):1877-87. doi: 10.1038/onc.2015.287. Epub 2015 Aug 10. Review.

PMID:
26257067
39.

Docetaxel in very elderly men with metastatic castration-resistant prostate cancer.

Wong HL, Lok SW, Wong S, Parente P, Rosenthal M.

Prostate Int. 2015 Jun;3(2):42-6. doi: 10.1016/j.prnil.2015.03.003. Epub 2015 Mar 19.

40.
41.

DENGUE VIRUS. Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers.

Fibriansah G, Ibarra KD, Ng TS, Smith SA, Tan JL, Lim XN, Ooi JS, Kostyuchenko VA, Wang J, de Silva AM, Harris E, Crowe JE Jr, Lok SM.

Science. 2015 Jul 3;349(6243):88-91. doi: 10.1126/science.aaa8651.

42.

A modified R-type bacteriocin specifically targeting Clostridium difficile prevents colonization of mice without affecting gut microbiota diversity.

Gebhart D, Lok S, Clare S, Tomas M, Stares M, Scholl D, Donskey CJ, Lawley TD, Govoni GR.

MBio. 2015 Mar 24;6(2). pii: e02368-14. doi: 10.1128/mBio.02368-14.

43.

Dengue Virus Infection with Highly Neutralizing Levels of Cross-Reactive Antibodies Causes Acute Lethal Small Intestinal Pathology without a High Level of Viremia in Mice.

Watanabe S, Chan KW, Wang J, Rivino L, Lok SM, Vasudevan SG.

J Virol. 2015 Jun;89(11):5847-61. doi: 10.1128/JVI.00216-15. Epub 2015 Mar 18.

44.

Tissue-specific transcriptome assemblies of the marine medaka Oryzias melastigma and comparative analysis with the freshwater medaka Oryzias latipes.

Lai KP, Li JW, Wang SY, Chiu JM, Tse A, Lau K, Lok S, Au DW, Tse WK, Wong CK, Chan TF, Kong RY, Wu RS.

BMC Genomics. 2015 Feb 27;16:135. doi: 10.1186/s12864-015-1325-7.

45.

A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins.

Fibriansah G, Tan JL, Smith SA, de Alwis R, Ng TS, Kostyuchenko VA, Jadi RS, Kukkaro P, de Silva AM, Crowe JE, Lok SM.

Nat Commun. 2015 Feb 20;6:6341. doi: 10.1038/ncomms7341.

46.

Myocardial fibrosis and pro-fibrotic markers in end-stage heart failure patients during continuous-flow left ventricular assist device support.

Lok SI, Nous FM, van Kuik J, van der Weide P, Winkens B, Kemperman H, Huisman A, Lahpor JR, de Weger RA, de Jonge N.

Eur J Cardiothorac Surg. 2015 Sep;48(3):407-15. doi: 10.1093/ejcts/ezu539. Epub 2015 Jan 21.

PMID:
25609773
47.

Identification and expression profiling of microRNAs in the brain, liver and gonads of marine medaka (Oryzias melastigma) and in response to hypoxia.

Lau K, Lai KP, Bao JY, Zhang N, Tse A, Tong A, Li JW, Lok S, Kong RY, Lui WY, Wong A, Wu RS.

PLoS One. 2014 Oct 28;9(10):e110698. doi: 10.1371/journal.pone.0110698. eCollection 2014. Erratum in: PLoS One. 2015;10(1):e0117543.

48.

Key roles of the Escherichia coli AhpC C-terminus in assembly and catalysis of alkylhydroperoxide reductase, an enzyme essential for the alleviation of oxidative stress.

Dip PV, Kamariah N, Nartey W, Beushausen C, Kostyuchenko VA, Ng TS, Lok SM, Saw WG, Eisenhaber F, Eisenhaber B, Grüber G.

Biochim Biophys Acta. 2014 Dec;1837(12):1932-1943. doi: 10.1016/j.bbabio.2014.08.007.

49.

Plasma levels of alpha-1-antichymotrypsin are elevated in patients with chronic heart failure, but are of limited prognostic value.

Lok SI, Lok DJ, van der Weide P, Winkens B, Bruggink-André de la Porte PW, Doevendans PA, de Weger RA, van der Meer P, de Jonge N.

Neth Heart J. 2014 Sep;22(9):391-5. doi: 10.1007/s12471-014-0584-2.

50.

Translation of clinical trial outcomes to metastatic colorectal cancer patients in community practice.

Lok SW, Wong HL, Kosmider S, Field K, Tie J, Desai J, Bae S, Tacey M, Skinner I, Jones I, Gibbs P.

Asia Pac J Clin Oncol. 2014 Dec;10(4):361-7. doi: 10.1111/ajco.12260. Epub 2014 Aug 17.

PMID:
25131961

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